| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hypertension | D006973 | 115 associated lipids |
| Insulin Resistance | D007333 | 99 associated lipids |
Total
2
Tauroursodeoxycholic acid
Tauroursodeoxycholic acid is a lipid of Sterol Lipids (ST) class. Tauroursodeoxycholic acid is associated with abnormalities such as Hyperglycemia, Obesity, Wiskott-Aldrich Syndrome, neurogenic hypertension and Cholestatic liver disease. The involved functions are known as Cell Death, Apoptosis, Homeostasis, Process and mRNA Expression. Tauroursodeoxycholic acid often locates in Body tissue, Endoplasmic Reticulum, Hepatic, Blood and Protoplasm. The associated genes with Tauroursodeoxycholic acid are Homologous Gene and Mutant Proteins. The related lipids are cholanic acid, taurolithocholic acid 3-sulfate, Sterols, 7-dehydrocholesterol and tauromuricholic acid. The related experimental models are Disease model.
Cross Reference
Introduction
To understand associated biological information of Tauroursodeoxycholic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Tauroursodeoxycholic acid?
Tauroursodeoxycholic acid is suspected in Endothelial dysfunction, Hyperglycemia, Obesity, neurogenic hypertension, Cholestatic liver disease, Heart failure and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Diabetes (3)
- Am. J. Physiol. Heart Circ. Physiol. (1)
- Am. J. Physiol. Lung Cell Mol. Physiol. (1)
- Others (5)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Tauroursodeoxycholic acid
PubChem Associated disorders and diseases
What pathways are associated with Tauroursodeoxycholic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Tauroursodeoxycholic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Tauroursodeoxycholic acid?
Related references are published most in these journals:
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What lipids are associated with Tauroursodeoxycholic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Tauroursodeoxycholic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Tauroursodeoxycholic acid?
Disease model
Disease model are used in the study 'Bile Acids Reduce Prion Conversion, Reduce Neuronal Loss, and Prolong Male Survival in Models of Prion Disease.' (Cortez LM et al., 2015).
Related references are published most in these journals:
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NCBI Entrez Crosslinks
All references with Tauroursodeoxycholic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Luk AS et al. | Structural mechanisms of bile salt-induced growth of small unilamellar cholesterol-lecithin vesicles. | 1997 | Biochemistry | pmid:9153403 |
| van Nieuwerk CM et al. | The role of bile salt composition in liver pathology of mdr2 (-/-) mice: differences between males and females. | 1997 | J. Hepatol. | pmid:9148004 |
| van de Heijning BJ et al. | Membrane cholesterol content of cholesterol/phospholipid vesicles determines the susceptibility to both damage and protection by bile salts: implications for bile physiology. | 1997 | Eur J Gastroenterol Hepatol | pmid:9187880 |
| Setchell KD et al. | Bile acid concentrations in human and rat liver tissue and in hepatocyte nuclei. | 1997 | Gastroenterology | pmid:8978363 |
| Gilani SS et al. | Use of 1H NMR spectroscopy (T2 relaxation times) to examine the effects of conjugated ursodeoxycholic acid on phospholipid fluidity of human gallbladder bile. | 1997 | Biochem. Soc. Trans. | pmid:9056921 |
| Rao YP et al. | Activation of protein kinase C alpha and delta by bile acids: correlation with bile acid structure and diacylglycerol formation. | 1997 | J. Lipid Res. | pmid:9458268 |
| Balandraud-Pieri N et al. | Effects of tauroursodeoxycholate solutions on cyclosporin A bioavailability in rats. | 1997 | Drug Metab. Dispos. | pmid:9280397 |
| Arrese M et al. | Adaptive regulation of hepatic bile salt transport: role of bile salt hydrophobicity and microtubule-dependent vesicular pathway. | 1997 | J. Hepatol. | pmid:9075679 |
| Takikawa H et al. | Effect of tauro-alpha-muricholate and tauro-beta-muricholate on oestradiol-17 beta-glucuronide-induced cholestasis in rats. | 1997 | J. Gastroenterol. Hepatol. | pmid:9076630 |
| Beuers U | Effects of bile acids on hepatocellular signaling and secretion. | 1997 Jul-Aug | Yale J Biol Med | pmid:9626754 |
| Roda A et al. | Taurohyodeoxycholic acid protects against taurochenodeoxycholic acid-induced cholestasis in the rat. | 1998 | Hepatology | pmid:9462652 |
| Sreejayan N and von Ritter C | Effect of bile acids on lipid peroxidation: the role of iron. | 1998 | Free Radic. Biol. Med. | pmid:9655521 |
| Benz C et al. | Effect of tauroursodeoxycholic acid on bile-acid-induced apoptosis and cytolysis in rat hepatocytes. | 1998 | J. Hepatol. | pmid:9537871 |
| Schroeder A et al. | Substrate specificity of the rat liver Na(+)-bile salt cotransporter in Xenopus laevis oocytes and in CHO cells. | 1998 | Am. J. Physiol. | pmid:9486191 |
| Peterson TC et al. | The inhibitory effect of ursodeoxycholic acid and pentoxifylline on platelet derived growth factor-stimulated proliferation is distinct from an effect by cyclic AMP. | 1998 | Immunopharmacology | pmid:9754904 |
| Klinkspoor JH et al. | Bile salts stimulate mucin secretion by cultured dog gallbladder epithelial cells independent of their detergent effect. | 1998 | Biochem. J. | pmid:9576876 |
| Vendemiale G et al. | Ethanol-induced changes of intracellular thiol compartmentation and protein redox status in the rat liver: effect of tauroursodeoxycholate. | 1998 | J. Hepatol. | pmid:9537863 |
| Bouscarel B et al. | Changes in G protein expression account for impaired modulation of hepatic cAMP formation after BDL. | 1998 | Am. J. Physiol. | pmid:9696716 |
| Yamaguchi Y et al. | Taurin-conjugated ursodeoxycholic acid has a reversible inhibitory effect on human keratinocyte growth. | 1998 | J. Dermatol. Sci. | pmid:9747660 |
| Ono T et al. | Tauroursodeoxycholic acid protects cholestasis in rat reperfused livers: its roles in hepatic calcium mobilization. | 1998 | Dig. Dis. Sci. | pmid:9790455 |
| Benz C et al. | Effect of S-adenosylmethionine versus tauroursodeoxycholic acid on bile acid-induced apoptosis and cytolysis in rat hepatocytes. | 1998 | Eur. J. Clin. Invest. | pmid:9726039 |
| Funaoka M et al. | Tauroursodeoxycholic acid enhances phagocytosis of the cultured rat Kupffer cell. | 1999 | J. Gastroenterol. Hepatol. | pmid:10440209 |
| Miyake H et al. | Partial characterization of mechanisms of cytoprotective action of hydrophilic bile salts against hydrophobic bile salts in rats: relation to canalicular membrane fluidity and packing density. | 1999 | Dig. Dis. Sci. | pmid:9952244 |
| Milkiewicz P et al. | Tauroursodeoxycholate and S-adenosyl-L-methionine exert an additive ameliorating effect on taurolithocholate-induced cholestasis: a study in isolated rat hepatocyte couplets. | 1999 | Hepatology | pmid:9918924 |
| Hertl M et al. | Tauroursodeoxycholate ameliorates reperfusion injury after pig liver transplantation. | 1999 | Transpl. Int. | pmid:10654358 |
| Invernizzi P et al. | Differences in the metabolism and disposition of ursodeoxycholic acid and of its taurine-conjugated species in patients with primary biliary cirrhosis. | 1999 | Hepatology | pmid:9918905 |
| Eckhardt U et al. | Polyspecific substrate uptake by the hepatic organic anion transporter Oatp1 in stably transfected CHO cells. | 1999 | Am. J. Physiol. | pmid:10198348 |
| Kurz AK et al. | Phosphoinositide 3-kinase-dependent Ras activation by tauroursodesoxycholate in rat liver. | 2000 | Biochem. J. | pmid:10926845 |
| Falasca L et al. | Tauroursodeoxycholate reduces ischemic damage in human allografts: a biochemical and ultrastructural study. | 2000 | Transplant. Proc. | pmid:10700964 |
| Benz C et al. | Effect of tauroursodeoxycholic acid on bile acid-induced apoptosis in primary human hepatocytes. | 2000 | Eur. J. Clin. Invest. | pmid:10691996 |
| Piazza F et al. | Competition in liver transport between chenodeoxycholic acid and ursodeoxycholic acid as a mechanism for ursodeoxycholic acid and its amidates' protection of liver damage induced by chenodeoxycholic acid. | 2000 | Dig Liver Dis | pmid:11515630 |
| Rodrigues CM et al. | Tauroursodeoxycholic acid partially prevents apoptosis induced by 3-nitropropionic acid: evidence for a mitochondrial pathway independent of the permeability transition. | 2000 | J. Neurochem. | pmid:11080188 |
| Asamoto Y et al. | Bile-salt hydrophobicity is a key factor regulating rat liver plasma-membrane communication: relation to bilayer structure, fluidity and transporter expression and function. | 2001 | Biochem. J. | pmid:11672435 |
| Ejiri S et al. | Cellular distribution of thrombomodulin as an early marker for warm ischemic liver injury in porcine liver transplantation: protective effect of prostaglandin I2 analogue and tauroursodeoxycholic acid. | 2001 | Transplantation | pmid:11330532 |
| Moschetta A et al. | Cholesterol crystallization in model biles: effects of bile salt and phospholipid species composition. | 2001 | J. Lipid Res. | pmid:11483629 |
| Kurz AK et al. | Tauroursodesoxycholate-induced choleresis involves p38(MAPK) activation and translocation of the bile salt export pump in rats. | 2001 | Gastroenterology | pmid:11487550 |
| Ishizaki K et al. | Effect of sodium tauroursodeoxycholate on phalloidin-induced cholestasis in rats. | 2001 | Eur. J. Pharmacol. | pmid:11408049 |
| Danchenko E et al. | Effect of bile acids on the proliferative activity and apoptosis of rat hepatocytes. | 2001 | Exp. Toxicol. Pathol. | pmid:11484843 |
| Nathanson MH et al. | Stimulation of ATP secretion in the liver by therapeutic bile acids. | 2001 | Biochem. J. | pmid:11485545 |
| Crocenzi FA et al. | Beneficial effects of silymarin on estrogen-induced cholestasis in the rat: a study in vivo and in isolated hepatocyte couplets. | 2001 | Hepatology | pmid:11481618 |
| Milkiewicz P et al. | Effect of tauroursodeoxycholate and S-adenosyl-L-methionine on 17beta-estradiol glucuronide-induced cholestasis. | 2001 | J. Hepatol. | pmid:11281545 |
| Moschetta A et al. | Hydrophilic bile salts enhance differential distribution of sphingomyelin and phosphatidylcholine between micellar and vesicular phases: potential implications for their effects in vivo. | 2001 | J. Hepatol. | pmid:11394647 |
| Fimognari C et al. | Micronuclei induction, cell cycle delay and apoptosis as markers of cellular stress caused by ursodeoxycholic acid in human lymphocytes. | 2001 | Mutat. Res. | pmid:11448637 |
| Rodrigues CM et al. | Amyloid beta-peptide disrupts mitochondrial membrane lipid and protein structure: protective role of tauroursodeoxycholate. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11181071 |
| Keene CD et al. | A bile acid protects against motor and cognitive deficits and reduces striatal degeneration in the 3-nitropropionic acid model of Huntington's disease. | 2001 | Exp. Neurol. | pmid:11573988 |
| Ishigami F et al. | Bile salt tauroursodeoxycholic acid modulation of Bax translocation to mitochondria protects the liver from warm ischemia-reperfusion injury in the rat. | 2001 | Transplantation | pmid:11740392 |
| Beuers U et al. | Tauroursodeoxycholic acid inserts the apical conjugate export pump, Mrp2, into canalicular membranes and stimulates organic anion secretion by protein kinase C-dependent mechanisms in cholestatic rat liver. | 2001 | Hepatology | pmid:11343250 |
| Chignard N et al. | Bile acid transport and regulating functions in the human biliary epithelium. | 2001 | Hepatology | pmid:11230727 |
| Calmus Y and Podevin P | Tauroursodeoxycholic acid for the cytoprotection of liver grafts during cold storage: a new aspect of its anti-apoptotic properties? | 2001 | Transplantation | pmid:11408962 |
| Falasca L et al. | Protective role of tauroursodeoxycholate during harvesting and cold storage of human liver: a pilot study in transplant recipients. | 2001 | Transplantation | pmid:11397961 |