| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hypertension | D006973 | 115 associated lipids |
| Insulin Resistance | D007333 | 99 associated lipids |
Total
2
Tauroursodeoxycholic acid
Tauroursodeoxycholic acid is a lipid of Sterol Lipids (ST) class. Tauroursodeoxycholic acid is associated with abnormalities such as Hyperglycemia, Obesity, Wiskott-Aldrich Syndrome, neurogenic hypertension and Cholestatic liver disease. The involved functions are known as Cell Death, Apoptosis, Homeostasis, Process and mRNA Expression. Tauroursodeoxycholic acid often locates in Body tissue, Endoplasmic Reticulum, Hepatic, Blood and Protoplasm. The associated genes with Tauroursodeoxycholic acid are Homologous Gene and Mutant Proteins. The related lipids are cholanic acid, taurolithocholic acid 3-sulfate, Sterols, 7-dehydrocholesterol and tauromuricholic acid. The related experimental models are Disease model.
Cross Reference
Introduction
To understand associated biological information of Tauroursodeoxycholic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Tauroursodeoxycholic acid?
Tauroursodeoxycholic acid is suspected in Endothelial dysfunction, Hyperglycemia, Obesity, neurogenic hypertension, Cholestatic liver disease, Heart failure and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Tauroursodeoxycholic acid
PubChem Associated disorders and diseases
What pathways are associated with Tauroursodeoxycholic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Tauroursodeoxycholic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Tauroursodeoxycholic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Tauroursodeoxycholic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Tauroursodeoxycholic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Tauroursodeoxycholic acid?
Disease model
Disease model are used in the study 'Bile Acids Reduce Prion Conversion, Reduce Neuronal Loss, and Prolong Male Survival in Models of Prion Disease.' (Cortez LM et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Tauroursodeoxycholic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Lenin R et al. | Amelioration of glucolipotoxicity-induced endoplasmic reticulum stress by a "chemical chaperone" in human THP-1 monocytes. | 2012 | Exp Diabetes Res | pmid:22550476 |
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| Fonseca MB et al. | c-Jun regulates the stability of anti-apoptotic ΔNp63 in amyloid-β-induced apoptosis. | 2012 | J. Alzheimers Dis. | pmid:22045494 |
| Brites D | The evolving landscape of neurotoxicity by unconjugated bilirubin: role of glial cells and inflammation. | 2012 | Front Pharmacol | pmid:22661946 |
| Mühlfeld S et al. | Short-term feedback regulation of bile salt uptake by bile salts in rodent liver. | 2012 | Hepatology | pmid:22806967 |
| Farrell GC et al. | NASH is an Inflammatory Disorder: Pathogenic, Prognostic and Therapeutic Implications. | 2012 | Gut Liver | pmid:22570745 |
| Achard CS and Laybutt DR | Lipid-induced endoplasmic reticulum stress in liver cells results in two distinct outcomes: adaptation with enhanced insulin signaling or insulin resistance. | 2012 | Endocrinology | pmid:22374970 |
| Brandes V et al. | Protection from Clostridium difficile toxin B-catalysed Rac1/Cdc42 glucosylation by tauroursodeoxycholic acid-induced Rac1/Cdc42 phosphorylation. | 2012 | Biol. Chem. | pmid:22628301 |
| Cursio R and Gugenheim J | Ischemia-Reperfusion Injury and Ischemic-Type Biliary Lesions following Liver Transplantation. | 2012 | J Transplant | pmid:22530107 |
| Obici L et al. | Doxycycline plus tauroursodeoxycholic acid for transthyretin amyloidosis: a phase II study. | 2012 | Amyloid | pmid:22551192 |
| Zhang T et al. | Chemical chaperone TUDCA preserves cone photoreceptors in a mouse model of Leber congenital amaurosis. | 2012 | Invest. Ophthalmol. Vis. Sci. | pmid:22531707 |
| Kim JS et al. | Tauroursodeoxycholic acid enhances the pre-implantation embryo development by reducing apoptosis in pigs. | 2012 | Reprod. Domest. Anim. | pmid:22151574 |
| Zhang JY et al. | Effect of endoplasmic reticulum stress on porcine oocyte maturation and parthenogenetic embryonic development in vitro. | 2012 | Biol. Reprod. | pmid:22190710 |
| Gao X et al. | The nephroprotective effect of tauroursodeoxycholic acid on ischaemia/reperfusion-induced acute kidney injury by inhibiting endoplasmic reticulum stress. | 2012 | Basic Clin. Pharmacol. Toxicol. | pmid:22212133 |
| Zhang Y et al. | Organic anion transporting polypeptide 1a1 null mice are sensitive to cholestatic liver injury. | 2012 | Toxicol. Sci. | pmid:22461449 |
| Galán M et al. | A novel role for epidermal growth factor receptor tyrosine kinase and its downstream endoplasmic reticulum stress in cardiac damage and microvascular dysfunction in type 1 diabetes mellitus. | 2012 | Hypertension | pmid:22665120 |
| Nunes AF et al. | TUDCA, a bile acid, attenuates amyloid precursor protein processing and amyloid-β deposition in APP/PS1 mice. | 2012 | Mol. Neurobiol. | pmid:22438081 |
| Tang C et al. | Glucose-induced beta cell dysfunction in vivo in rats: link between oxidative stress and endoplasmic reticulum stress. | 2012 | Diabetologia | pmid:22396011 |
| van Heumen BW et al. | Celecoxib and tauro-ursodeoxycholic acid co-treatment inhibits cell growth in familial adenomatous polyposis derived LT97 colon adenoma cells. | 2012 | Exp. Cell Res. | pmid:22366264 |
| Henkel AS et al. | Reducing endoplasmic reticulum stress does not improve steatohepatitis in mice fed a methionine- and choline-deficient diet. | 2012 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:22556147 |
| Daood MJ et al. | Lipid peroxidation is not the primary mechanism of bilirubin-induced neurologic dysfunction in jaundiced Gunn rat pups. | 2012 | Pediatr. Res. | pmid:22902434 |
| Qi HP et al. | Ursodeoxycholic acid prevents selenite-induced oxidative stress and alleviates cataract formation: In vitro and in vivo studies. | 2012 | Mol. Vis. | pmid:22275806 |
| Min JH et al. | Oral solubilized ursodeoxycholic acid therapy in amyotrophic lateral sclerosis: a randomized cross-over trial. | 2012 | J. Korean Med. Sci. | pmid:22323869 |
| Bodewes FA et al. | Ursodeoxycholate modulates bile flow and bile salt pool independently from the cystic fibrosis transmembrane regulator (Cftr) in mice. | 2012 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:22301109 |
| Cheng F et al. | Refined Qingkailing Protects MCAO Mice from Endoplasmic Reticulum Stress-Induced Apoptosis with a Broad Time Window. | 2012 | Evid Based Complement Alternat Med | pmid:22536287 |
| Spitler KM et al. | Suppression of endoplasmic reticulum stress improves endothelium-dependent contractile responses in aorta of the spontaneously hypertensive rat. | 2013 | Am. J. Physiol. Heart Circ. Physiol. | pmid:23709602 |
| Dikkers A et al. | Scavenger receptor BI and ABCG5/G8 differentially impact biliary sterol secretion and reverse cholesterol transport in mice. | 2013 | Hepatology | pmid:23401258 |
| Gohlke H et al. | α5 β1-integrins are sensors for tauroursodeoxycholic acid in hepatocytes. | 2013 | Hepatology | pmid:22865233 |
| Wang R et al. | Defective canalicular transport and toxicity of dietary ursodeoxycholic acid in the abcb11-/- mouse: transport and gene expression studies. | 2013 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:23764895 |
| Pan XL et al. | Efficacy and safety of tauroursodeoxycholic acid in the treatment of liver cirrhosis: a double-blind randomized controlled trial. | 2013 | J. Huazhong Univ. Sci. Technol. Med. Sci. | pmid:23592128 |
| Kim KS et al. | Taurine may not alleviate hyperglycemia-mediated endoplasmic reticulum stress in human adipocytes. | 2013 | Adv. Exp. Med. Biol. | pmid:23392949 |
| Shin J et al. | SIRT7 represses Myc activity to suppress ER stress and prevent fatty liver disease. | 2013 | Cell Rep | pmid:24210820 |
| Belaidi E et al. | Endoplasmic reticulum stress contributes to heart protection induced by cyclophilin D inhibition. | 2013 | Basic Res. Cardiol. | pmid:23744057 |
| Ramalho RM et al. | Tauroursodeoxycholic acid suppresses amyloid β-induced synaptic toxicity in vitro and in APP/PS1 mice. | 2013 | Neurobiol. Aging | pmid:22621777 |
| Zhu Q et al. | Tauroursodeoxycholate, a chemical chaperone, prevents palmitate-induced apoptosis in pancreatic β-cells by reducing ER stress. | 2013 | Exp. Clin. Endocrinol. Diabetes | pmid:22972029 |
| Lo AC et al. | Tauroursodeoxycholic acid (TUDCA) supplementation prevents cognitive impairment and amyloid deposition in APP/PS1 mice. | 2013 | Neurobiol. Dis. | pmid:22974733 |
| Schulz S et al. | Progressive stages of mitochondrial destruction caused by cell toxic bile salts. | 2013 | Biochim. Biophys. Acta | pmid:23685124 |
| Malo A et al. | 4-Phenylbutyric acid reduces endoplasmic reticulum stress, trypsin activation, and acinar cell apoptosis while increasing secretion in rat pancreatic acini. | 2013 | Pancreas | pmid:22889983 |
| Omura T et al. | Sodium tauroursodeoxycholate prevents paraquat-induced cell death by suppressing endoplasmic reticulum stress responses in human lung epithelial A549 cells. | 2013 | Biochem. Biophys. Res. Commun. | pmid:23416354 |
| Beuers U | β1 integrin is a long-sought sensor for tauroursodeoxycholic acid. | 2013 | Hepatology | pmid:23456677 |
| Fang L et al. | Autophagy attenuates diabetic glomerular damage through protection of hyperglycemia-induced podocyte injury. | 2013 | PLoS ONE | pmid:23593240 |
| Turdi S et al. | Tauroursodeoxycholic acid mitigates high fat diet-induced cardiomyocyte contractile and intracellular Ca2+ anomalies. | 2013 | PLoS ONE | pmid:23667647 |
| Liang B et al. | Aberrant endoplasmic reticulum stress in vascular smooth muscle increases vascular contractility and blood pressure in mice deficient of AMP-activated protein kinase-α2 in vivo. | 2013 | Arterioscler. Thromb. Vasc. Biol. | pmid:23288166 |
| Dromparis P et al. | Attenuating endoplasmic reticulum stress as a novel therapeutic strategy in pulmonary hypertension. | 2013 | Circulation | pmid:23149668 |
| Panzhinskiy E et al. | Endoplasmic reticulum stress upregulates protein tyrosine phosphatase 1B and impairs glucose uptake in cultured myotubes. | 2013 | Diabetologia | pmid:23178931 |
| Yao XH et al. | Prenatal ethanol exposure causes glucose intolerance with increased hepatic gluconeogenesis and histone deacetylases in adult rat offspring: reversal by tauroursodeoxycholic acid. | 2013 | PLoS ONE | pmid:23544086 |
| Zhang J et al. | Autophagy is involved in endoplasmic reticulum stress-induced cell death of rat hepatocytes. | 2013 | J. Surg. Res. | pmid:23548375 |
| Mitra A et al. | Role of α-crystallin B as a regulatory switch in modulating cardiomyocyte apoptosis by mitochondria or endoplasmic reticulum during cardiac hypertrophy and myocardial infarction. | 2013 | Cell Death Dis | pmid:23559016 |
| Cai Z et al. | Endoplasmic reticulum stress participates in aortic valve calcification in hypercholesterolemic animals. | 2013 | Arterioscler. Thromb. Vasc. Biol. | pmid:23928865 |
| Mališová L et al. | Ursodeoxycholic acid but not tauroursodeoxycholic acid inhibits proliferation and differentiation of human subcutaneous adipocytes. | 2013 | PLoS ONE | pmid:24312631 |
| Gaspar JM et al. | Tauroursodeoxycholic acid protects retinal neural cells from cell death induced by prolonged exposure to elevated glucose. | 2013 | Neuroscience | pmid:24012838 |
| Xu H et al. | The ER luminal binding protein (BiP) alleviates Cd(2+)-induced programmed cell death through endoplasmic reticulum stress-cell death signaling pathway in tobacco cells. | 2013 | J. Plant Physiol. | pmid:23867017 |
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| Kohli R et al. | A surgical model in male obese rats uncovers protective effects of bile acids post-bariatric surgery. | 2013 | Endocrinology | pmid:23592746 |
| Fang L et al. | Involvement of endoplasmic reticulum stress in albuminuria induced inflammasome activation in renal proximal tubular cells. | 2013 | PLoS ONE | pmid:23977286 |
| Simoni P et al. | A new point-of-care portable immunosensor for non-invasive assessment of oro-ileal transit time by oral fluid tauroursodeoxycholate measurement after its oral load. | 2013 Jul-Aug | J Pharm Biomed Anal | pmid:23587552 |
| Oshitari T et al. | Increased expression of phosphorylated c-Jun and phosphorylated c-Jun N-terminal kinase associated with neuronal cell death in diabetic and high glucose exposed rat retinas. | 2014 | Brain Res. Bull. | pmid:24333191 |
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| Cho EJ et al. | Tauroursodeoxycholic acid attenuates progression of steatohepatitis in mice fed a methionine-choline-deficient diet. | 2014 | Dig. Dis. Sci. | pmid:24865256 |
| Xavier JM et al. | Tauroursodeoxycholic acid increases neural stem cell pool and neuronal conversion by regulating mitochondria-cell cycle retrograde signaling. | 2014 | Cell Cycle | pmid:25483094 |
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| Laukens D et al. | Tauroursodeoxycholic acid inhibits experimental colitis by preventing early intestinal epithelial cell death. | 2014 | Lab. Invest. | pmid:25310532 |
| Park SW et al. | Rab11, but not Rab4, facilitates cyclic AMP- and tauroursodeoxycholate-induced MRP2 translocation to the plasma membrane. | 2014 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:25190474 |
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| Yanguas-Casás N et al. | Tauroursodeoxycholic acid reduces glial cell activation in an animal model of acute neuroinflammation. | 2014 | J Neuroinflammation | pmid:24645669 |
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| Tanaka Y et al. | The exacerbating roles of CCAAT/enhancer-binding protein homologous protein (CHOP) in the development of bleomycin-induced pulmonary fibrosis and the preventive effects of tauroursodeoxycholic acid (TUDCA) against pulmonary fibrosis in mice. | 2015 | Pharmacol. Res. | pmid:26005208 |
| Cortez LM et al. | Bile Acids Reduce Prion Conversion, Reduce Neuronal Loss, and Prolong Male Survival in Models of Prion Disease. | 2015 | J. Virol. | pmid:25972546 |
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| Sommerfeld A et al. | Tauroursodeoxycholate Protects Rat Hepatocytes from Bile Acid-Induced Apoptosis via β1-Integrin- and Protein Kinase A-Dependent Mechanisms. | 2015 | Cell. Physiol. Biochem. | pmid:26044599 |
| Dong Y et al. | Neuroprotective effects and impact on caspase-12 expression of tauroursodeoxycholic acid after acute spinal cord injury in rats. | 2015 | Int J Clin Exp Pathol | pmid:26884858 |
| Shi Z et al. | [Tauroursodeoxycholic acid suppresses endoplasmic reticulum stress in pulmonary tissues of intermittent hypoxia mice]. | 2015 | Zhong Nan Da Xue Xue Bao Yi Xue Ban | pmid:26643417 |
| Muramatsu-Kato K et al. | Undernourishment in utero Primes Hepatic Steatosis in Adult Mice Offspring on an Obesogenic Diet; Involvement of Endoplasmic Reticulum Stress. | 2015 | Sci Rep | pmid:26581663 |
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| Yu KN et al. | Titanium Dioxide Nanoparticles Induce Endoplasmic Reticulum Stress-Mediated Autophagic Cell Death via Mitochondria-Associated Endoplasmic Reticulum Membrane Disruption in Normal Lung Cells. | 2015 | PLoS ONE | pmid:26121477 |
| Bikbova G et al. | Altered Expression of NF- κ B and SP1 after Exposure to Advanced Glycation End-Products and Effects of Neurotrophic Factors in AGEs Exposed Rat Retinas. | 2015 | J Diabetes Res | pmid:26078979 |
| Cai Z et al. | Involvement of Endoplasmic Reticulum Stress-Mediated C/EBP Homologous Protein Activation in Coxsackievirus B3-Induced Acute Viral Myocarditis. | 2015 | Circ Heart Fail | pmid:25985795 |
| Oishi N et al. | XBP1 mitigates aminoglycoside-induced endoplasmic reticulum stress and neuronal cell death. | 2015 | Cell Death Dis | pmid:25973683 |
| Cheng S et al. | Pachymic acid inhibits growth and induces apoptosis of pancreatic cancer in vitro and in vivo by targeting ER stress. | 2015 | PLoS ONE | pmid:25915041 |
| Xu LH et al. | Critical Role of Endoplasmic Reticulum Stress in Chronic Intermittent Hypoxia-Induced Deficits in Synaptic Plasticity and Long-Term Memory. | 2015 | Antioxid. Redox Signal. | pmid:25843188 |
| Liu F et al. | Tauroursodeoxycholic acid attenuates inorganic phosphate-induced osteoblastic differentiation and mineralization in NIH3T3 fibroblasts by inhibiting the ER stress response PERK-eIF2α-ATF4 pathway. | 2015 | Drug Discov Ther | pmid:25788050 |
| Xia H et al. | Brain ACE2 overexpression reduces DOCA-salt hypertension independently of endoplasmic reticulum stress. | 2015 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:25519733 |
| Shi Z et al. | Vasonatrin peptide attenuates myocardial ischemia-reperfusion injury in diabetic rats and underlying mechanisms. | 2015 | Am. J. Physiol. Heart Circ. Physiol. | pmid:25485902 |
| Cho JG et al. | Tauroursodeoxycholic acid, a bile acid, promotes blood vessel repair by recruiting vasculogenic progenitor cells. | 2015 | Stem Cells | pmid:25407160 |
| Hakim F et al. | Chronic sleep fragmentation during the sleep period induces hypothalamic endoplasmic reticulum stress and PTP1b-mediated leptin resistance in male mice. | 2015 | Sleep | pmid:25325461 |