Tauroursodeoxycholic acid

Tauroursodeoxycholic acid is a lipid of Sterol Lipids (ST) class. Tauroursodeoxycholic acid is associated with abnormalities such as Hyperglycemia, Obesity, Wiskott-Aldrich Syndrome, neurogenic hypertension and Cholestatic liver disease. The involved functions are known as Cell Death, Apoptosis, Homeostasis, Process and mRNA Expression. Tauroursodeoxycholic acid often locates in Body tissue, Endoplasmic Reticulum, Hepatic, Blood and Protoplasm. The associated genes with Tauroursodeoxycholic acid are Homologous Gene and Mutant Proteins. The related lipids are cholanic acid, taurolithocholic acid 3-sulfate, Sterols, 7-dehydrocholesterol and tauromuricholic acid. The related experimental models are Disease model.

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Introduction

To understand associated biological information of Tauroursodeoxycholic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Tauroursodeoxycholic acid?

Tauroursodeoxycholic acid is suspected in Endothelial dysfunction, Hyperglycemia, Obesity, neurogenic hypertension, Cholestatic liver disease, Heart failure and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Tauroursodeoxycholic acid

MeSH term MeSH ID Detail
Hypertension D006973 115 associated lipids
Insulin Resistance D007333 99 associated lipids
Total 2

PubChem Associated disorders and diseases

What pathways are associated with Tauroursodeoxycholic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Tauroursodeoxycholic acid?

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What functions are associated with Tauroursodeoxycholic acid?


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What lipids are associated with Tauroursodeoxycholic acid?

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What genes are associated with Tauroursodeoxycholic acid?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Tauroursodeoxycholic acid?

Disease model

Disease model are used in the study 'Bile Acids Reduce Prion Conversion, Reduce Neuronal Loss, and Prolong Male Survival in Models of Prion Disease.' (Cortez LM et al., 2015).

Related references are published most in these journals:

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NCBI Entrez Crosslinks

All references with Tauroursodeoxycholic acid

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Authors Title Published Journal PubMed Link
Nebe B et al. Induction of a physical linkage between integrins and the cytoskeleton depends on intracellular calcium in an epithelial cell line. 1996 Exp. Cell Res. pmid:8940254
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Takikawa H et al. Effects of ursodeoxycholate and its conjugates on biliary glutathione excretion in rats. 1996 Dig. Dis. Sci. pmid:8888706
Azer SA et al. Hepatoprotection in ethinylestradiol-treated rats is provided by tauroursodeoxycholic acid, but not by ursodeoxycholic acid. 1995 May-Jun J. Gastroenterol. Hepatol. pmid:7548801
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Angelico M et al. N-ethyl-tauroursodeoxycholic acid, a novel deconjugation-resistant bile salt analogue: effects of acute feeding in the rat. 1995 Hepatology pmid:7657297
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Kitani K et al. Tauro alpha-muricholate is as effective as tauro beta-muricholate and tauroursodeoxycholate in preventing taurochenodeoxycholate-induced liver damage in the rat. 1994 Hepatology pmid:8138240
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Shamburek RD and Schwartz CC Selective composition of biliary phosphatidylcholines is affected by secretion rate but not by bile acid hydrophobicity. 1993 J. Lipid Res. pmid:8263408
Beuers U et al. Tauroursodeoxycholic acid stimulates hepatocellular exocytosis and mobilizes extracellular Ca++ mechanisms defective in cholestasis. 1993 J. Clin. Invest. pmid:8254052
Pak JM and Lee SS Vasoactive effects of bile salts in cirrhotic rats: in vivo and in vitro studies. 1993 Hepatology pmid:8225224
Tsukahara K et al. Taurine conjugate of ursodeoxycholate plays a major role in the hepatoprotective effect against cholestasis induced by taurochenodeoxycholate in rats. 1993 Liver pmid:8259039
Ohiwa T et al. Tauroursodeoxycholate and tauro-beta-muricholate exert cytoprotection by reducing intrahepatocyte taurochenodeoxycholate content. 1993 Hepatology pmid:8383089
Bouchard G et al. Influence of oral treatment with ursodeoxycholic and tauroursodeoxycholic acids on estrogen-induced cholestasis in rats: effects on bile formation and liver plasma membranes. 1993 Liver pmid:8377596
Nakai T et al. Microtubule-independent choleresis and anti-cholestatic action of tauroursodeoxycholate in colchicine-treated rat liver. 1992 Biochem. J. pmid:1361125
Häussinger D et al. Cell volume and bile acid excretion. 1992 Biochem. J. pmid:1463469
Chazouillères O et al. Effect of bile acids on ischemia-reperfusion liver injury. 1991 J. Hepatol. pmid:1808225
Shefer S et al. Regulation of cholesterol 7 alpha-hydroxylase by hepatic 7 alpha-hydroxylated bile acid flux and newly synthesized cholesterol supply. 1991 J. Biol. Chem. pmid:1993648
Deroubaix X et al. Saturation of hepatic transport of taurocholate in rats in vivo. 1991 Am. J. Physiol. pmid:1996639
Schmucker DL et al. Hepatic injury induced by bile salts: correlation between biochemical and morphological events. 1990 Hepatology pmid:2227821
Schölmerich J et al. Tauroursodeoxycholate prevents taurolithocholate-induced cholestasis and toxicity in rat liver. 1990 J. Hepatol. pmid:2365980
Perez Barriocanal F et al. Influence of backward perfusion on ursodeoxycholate-induced choleresis in isolated in situ rat liver. 1990 J. Hepatol. pmid:2254627
Zhao XM and Montet JC Effects of bile salt supplementation on biliary secretion in estrogen-treated rats. 1990 J. Nutr. Biochem. pmid:15539232
Beuers U et al. Tauroursodeoxycholic acid inhibits the cytosolic Ca++ increase in human neutrophils stimulated by formyl-methionyl-leucyl-phenylalanine. 1990 Biochem. Biophys. Res. Commun. pmid:2222431
Utili R et al. Estradiol-17 beta-D-glucuronide (E-17G) cholestasis in perfused rat liver: fate of E-17G and choleretic responses to bile salts. 1990 Hepatology pmid:2347547
Aldini R et al. Uptake of bile acids by perfused rat liver: evidence of a structure-activity relationship. 1989 Hepatology pmid:2807164
Farges O et al. Permeability of the rat biliary tree to ursodeoxycholic acid. 1989 Am. J. Physiol. pmid:2705526
Marteau C et al. Effect of various bile salts on calcium concentration and calcium carbonate saturation of rat bile. 1988 J. Hepatol. pmid:3183351
Kitani K et al. Differing transport maxima values for taurine-conjugated bile salts in rats and hamsters. 1986 Am. J. Physiol. pmid:3789151
Alvaro D et al. Influence of tauroursodeoxycholic and taurodeoxycholic acids on hepatic metabolism and biliary secretion of phosphatidylcholine in the isolated rat liver. 1986 Biochim. Biophys. Acta pmid:3756193
Garcia-Marin JJ et al. Role of H+ transport in ursodeoxycholate-induced biliary HCO-3 secretion in the rat. 1985 Am. J. Physiol. pmid:2994491
Eto T and Tompkins RK Inhibition of pepsin activity by ursodeoxycholic acids and chenodeoxycholic acids. 1985 Am. J. Surg. pmid:3933371
Walker S et al. Absorption of urso- and chenodeoxycholic acid and their taurine and glycine conjugates in rat jejunum, ileum, and colon. 1985 Digestion pmid:4018444
Kitani K et al. Tauroursodeoxycholate prevents biliary protein excretion induced by other bile salts in the rat. 1985 Am. J. Physiol. pmid:2984943
Hofmann AF Medical treatment of cholesterol gallstones by bile desaturating agents. 1984 Sep-Oct Hepatology pmid:6384003
Stiehl A et al. Effect of ursodeoxycholic acid on biliary bile acid and bile lipid composition in gallstone patients. 1984 Jan-Feb Hepatology pmid:6693062
Watt SM and Simmonds WJ Effects of four taurine-conjugated bile acids on mucosal uptake and lymphatic absorption of cholesterol in the rat. 1984 J. Lipid Res. pmid:6736779
Barnwell SG et al. Effect of taurochenodeoxycholate or tauroursodeoxycholate upon biliary output of phospholipids and plasma-membrane enzymes, and the extent of cell damage, in isolated perfused rat livers. 1983 Biochem. J. pmid:6316931
Montet JC et al. Mixed micelle properties and intestinal cholesterol uptake. 1982 Biochimie pmid:7093350
Zouboulis-Vafiadis I et al. Conjugation is rate limiting in hepatic transport of ursodeoxycholate in the rat. 1982 Am. J. Physiol. pmid:7114264
Reynier MO et al. Intestinal cholesterol uptake from mixed micelles. In vitro effects of taurocholate, taurochenodeoxycholate and tauroursodeoxycholate. 1981 Biochim. Biophys. Acta pmid:7272324
Batta AK et al. Thin-layer chromatographic separation of conjugates of ursodeoxycholic acid from those of litho-, chenodeoxy-, deoxy-, and cholic acids. 1981 J. Lipid Res. pmid:7276746
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