| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hypertension | D006973 | 115 associated lipids |
| Insulin Resistance | D007333 | 99 associated lipids |
Total
2
Tauroursodeoxycholic acid
Tauroursodeoxycholic acid is a lipid of Sterol Lipids (ST) class. Tauroursodeoxycholic acid is associated with abnormalities such as Hyperglycemia, Obesity, Wiskott-Aldrich Syndrome, neurogenic hypertension and Cholestatic liver disease. The involved functions are known as Cell Death, Apoptosis, Homeostasis, Process and mRNA Expression. Tauroursodeoxycholic acid often locates in Body tissue, Endoplasmic Reticulum, Hepatic, Blood and Protoplasm. The associated genes with Tauroursodeoxycholic acid are Homologous Gene and Mutant Proteins. The related lipids are cholanic acid, taurolithocholic acid 3-sulfate, Sterols, 7-dehydrocholesterol and tauromuricholic acid. The related experimental models are Disease model.
Cross Reference
Introduction
To understand associated biological information of Tauroursodeoxycholic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Tauroursodeoxycholic acid?
Tauroursodeoxycholic acid is suspected in Endothelial dysfunction, Hyperglycemia, Obesity, neurogenic hypertension, Cholestatic liver disease, Heart failure and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Diabetes (3)
- Am. J. Physiol. Heart Circ. Physiol. (1)
- Am. J. Physiol. Lung Cell Mol. Physiol. (1)
- Others (5)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Tauroursodeoxycholic acid
PubChem Associated disorders and diseases
What pathways are associated with Tauroursodeoxycholic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Tauroursodeoxycholic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Tauroursodeoxycholic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Tauroursodeoxycholic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Tauroursodeoxycholic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Tauroursodeoxycholic acid?
Disease model
Disease model are used in the study 'Bile Acids Reduce Prion Conversion, Reduce Neuronal Loss, and Prolong Male Survival in Models of Prion Disease.' (Cortez LM et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Tauroursodeoxycholic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Chen Y et al. | Effect of taurine-conjugated ursodeoxycholic acid on endoplasmic reticulum stress and apoptosis induced by advanced glycation end products in cultured mouse podocytes. | 2008 | Am. J. Nephrol. | pmid:18648192 |
| Marzioni M et al. | Ca2+-dependent cytoprotective effects of ursodeoxycholic and tauroursodeoxycholic acid on the biliary epithelium in a rat model of cholestasis and loss of bile ducts. | 2006 | Am. J. Pathol. | pmid:16436655 |
| Takeda N et al. | Altered unfolded protein response is implicated in the age-related exacerbation of proteinuria-induced proximal tubular cell damage. | 2013 | Am. J. Pathol. | pmid:23871833 |
| Stravitz RT et al. | Hepatocellular protein kinase C activation by bile acids: implications for regulation of cholesterol 7 alpha-hydroxylase. | 1996 | Am. J. Physiol. | pmid:8770045 |
| Alvaro D et al. | Effect of ursodeoxycholic acid on intracellular pH regulation in isolated rat bile duct epithelial cells. | 1993 | Am. J. Physiol. | pmid:8238362 |
| Garcia-Marin JJ et al. | Role of H+ transport in ursodeoxycholate-induced biliary HCO-3 secretion in the rat. | 1985 | Am. J. Physiol. | pmid:2994491 |
| Schroeder A et al. | Substrate specificity of the rat liver Na(+)-bile salt cotransporter in Xenopus laevis oocytes and in CHO cells. | 1998 | Am. J. Physiol. | pmid:9486191 |
| Farges O et al. | Permeability of the rat biliary tree to ursodeoxycholic acid. | 1989 | Am. J. Physiol. | pmid:2705526 |
| Zouboulis-Vafiadis I et al. | Conjugation is rate limiting in hepatic transport of ursodeoxycholate in the rat. | 1982 | Am. J. Physiol. | pmid:7114264 |
| Kitani K et al. | Tauroursodeoxycholate prevents biliary protein excretion induced by other bile salts in the rat. | 1985 | Am. J. Physiol. | pmid:2984943 |
| Bouscarel B et al. | Changes in G protein expression account for impaired modulation of hepatic cAMP formation after BDL. | 1998 | Am. J. Physiol. | pmid:9696716 |
| Deroubaix X et al. | Saturation of hepatic transport of taurocholate in rats in vivo. | 1991 | Am. J. Physiol. | pmid:1996639 |
| Eckhardt U et al. | Polyspecific substrate uptake by the hepatic organic anion transporter Oatp1 in stably transfected CHO cells. | 1999 | Am. J. Physiol. | pmid:10198348 |
| Kitani K et al. | Differing transport maxima values for taurine-conjugated bile salts in rats and hamsters. | 1986 | Am. J. Physiol. | pmid:3789151 |
| Xiao ZL et al. | Effects of bile acids on the muscle functions of guinea pig gallbladder. | 2002 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:12065295 |
| Chignard N et al. | Bile salts potentiate adenylyl cyclase activity and cAMP-regulated secretion in human gallbladder epithelium. | 2003 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:12421748 |
| Alpini G et al. | Tauroursodeoxycholate inhibits human cholangiocarcinoma growth via Ca2+-, PKC-, and MAPK-dependent pathways. | 2004 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:14701718 |
| Malo A et al. | Tauroursodeoxycholic acid reduces endoplasmic reticulum stress, trypsin activation, and acinar cell apoptosis while increasing secretion in rat pancreatic acini. | 2010 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:20671193 |
| Castro RE et al. | Differential regulation of cyclin D1 and cell death by bile acids in primary rat hepatocytes. | 2007 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:17431217 |
| Park SW et al. | Rab11, but not Rab4, facilitates cyclic AMP- and tauroursodeoxycholate-induced MRP2 translocation to the plasma membrane. | 2014 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:25190474 |