| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hypertension | D006973 | 115 associated lipids |
| Insulin Resistance | D007333 | 99 associated lipids |
Total
2
Tauroursodeoxycholic acid
Tauroursodeoxycholic acid is a lipid of Sterol Lipids (ST) class. Tauroursodeoxycholic acid is associated with abnormalities such as Hyperglycemia, Obesity, Wiskott-Aldrich Syndrome, neurogenic hypertension and Cholestatic liver disease. The involved functions are known as Cell Death, Apoptosis, Homeostasis, Process and mRNA Expression. Tauroursodeoxycholic acid often locates in Body tissue, Endoplasmic Reticulum, Hepatic, Blood and Protoplasm. The associated genes with Tauroursodeoxycholic acid are Homologous Gene and Mutant Proteins. The related lipids are cholanic acid, taurolithocholic acid 3-sulfate, Sterols, 7-dehydrocholesterol and tauromuricholic acid. The related experimental models are Disease model.
Cross Reference
Introduction
To understand associated biological information of Tauroursodeoxycholic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Tauroursodeoxycholic acid?
Tauroursodeoxycholic acid is suspected in Endothelial dysfunction, Hyperglycemia, Obesity, neurogenic hypertension, Cholestatic liver disease, Heart failure and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Diabetes (3)
- Am. J. Physiol. Heart Circ. Physiol. (1)
- Am. J. Physiol. Lung Cell Mol. Physiol. (1)
- Others (5)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Tauroursodeoxycholic acid
PubChem Associated disorders and diseases
What pathways are associated with Tauroursodeoxycholic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Tauroursodeoxycholic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Tauroursodeoxycholic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Tauroursodeoxycholic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Tauroursodeoxycholic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Tauroursodeoxycholic acid?
Disease model
Disease model are used in the study 'Bile Acids Reduce Prion Conversion, Reduce Neuronal Loss, and Prolong Male Survival in Models of Prion Disease.' (Cortez LM et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Tauroursodeoxycholic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Dikkers A et al. | Scavenger receptor BI and ABCG5/G8 differentially impact biliary sterol secretion and reverse cholesterol transport in mice. | 2013 | Hepatology | pmid:23401258 |
| Gohlke H et al. | α5 β1-integrins are sensors for tauroursodeoxycholic acid in hepatocytes. | 2013 | Hepatology | pmid:22865233 |
| Pan XL et al. | Efficacy and safety of tauroursodeoxycholic acid in the treatment of liver cirrhosis: a double-blind randomized controlled trial. | 2013 | J. Huazhong Univ. Sci. Technol. Med. Sci. | pmid:23592128 |
| Kim KS et al. | Taurine may not alleviate hyperglycemia-mediated endoplasmic reticulum stress in human adipocytes. | 2013 | Adv. Exp. Med. Biol. | pmid:23392949 |
| Shin J et al. | SIRT7 represses Myc activity to suppress ER stress and prevent fatty liver disease. | 2013 | Cell Rep | pmid:24210820 |
| Belaidi E et al. | Endoplasmic reticulum stress contributes to heart protection induced by cyclophilin D inhibition. | 2013 | Basic Res. Cardiol. | pmid:23744057 |
| Zhu Q et al. | Tauroursodeoxycholate, a chemical chaperone, prevents palmitate-induced apoptosis in pancreatic β-cells by reducing ER stress. | 2013 | Exp. Clin. Endocrinol. Diabetes | pmid:22972029 |
| Lo AC et al. | Tauroursodeoxycholic acid (TUDCA) supplementation prevents cognitive impairment and amyloid deposition in APP/PS1 mice. | 2013 | Neurobiol. Dis. | pmid:22974733 |
| Malo A et al. | 4-Phenylbutyric acid reduces endoplasmic reticulum stress, trypsin activation, and acinar cell apoptosis while increasing secretion in rat pancreatic acini. | 2013 | Pancreas | pmid:22889983 |
| Omura T et al. | Sodium tauroursodeoxycholate prevents paraquat-induced cell death by suppressing endoplasmic reticulum stress responses in human lung epithelial A549 cells. | 2013 | Biochem. Biophys. Res. Commun. | pmid:23416354 |
| Beuers U | β1 integrin is a long-sought sensor for tauroursodeoxycholic acid. | 2013 | Hepatology | pmid:23456677 |
| Liang B et al. | Aberrant endoplasmic reticulum stress in vascular smooth muscle increases vascular contractility and blood pressure in mice deficient of AMP-activated protein kinase-α2 in vivo. | 2013 | Arterioscler. Thromb. Vasc. Biol. | pmid:23288166 |
| Dromparis P et al. | Attenuating endoplasmic reticulum stress as a novel therapeutic strategy in pulmonary hypertension. | 2013 | Circulation | pmid:23149668 |
| Panzhinskiy E et al. | Endoplasmic reticulum stress upregulates protein tyrosine phosphatase 1B and impairs glucose uptake in cultured myotubes. | 2013 | Diabetologia | pmid:23178931 |
| Yao XH et al. | Prenatal ethanol exposure causes glucose intolerance with increased hepatic gluconeogenesis and histone deacetylases in adult rat offspring: reversal by tauroursodeoxycholic acid. | 2013 | PLoS ONE | pmid:23544086 |
| Zhang J et al. | Autophagy is involved in endoplasmic reticulum stress-induced cell death of rat hepatocytes. | 2013 | J. Surg. Res. | pmid:23548375 |
| Mitra A et al. | Role of α-crystallin B as a regulatory switch in modulating cardiomyocyte apoptosis by mitochondria or endoplasmic reticulum during cardiac hypertrophy and myocardial infarction. | 2013 | Cell Death Dis | pmid:23559016 |
| Mališová L et al. | Ursodeoxycholic acid but not tauroursodeoxycholic acid inhibits proliferation and differentiation of human subcutaneous adipocytes. | 2013 | PLoS ONE | pmid:24312631 |
| Xu H et al. | The ER luminal binding protein (BiP) alleviates Cd(2+)-induced programmed cell death through endoplasmic reticulum stress-cell death signaling pathway in tobacco cells. | 2013 | J. Plant Physiol. | pmid:23867017 |
| Kohli R et al. | A surgical model in male obese rats uncovers protective effects of bile acids post-bariatric surgery. | 2013 | Endocrinology | pmid:23592746 |