Tauroursodeoxycholic acid

Tauroursodeoxycholic acid is a lipid of Sterol Lipids (ST) class. Tauroursodeoxycholic acid is associated with abnormalities such as Hyperglycemia, Obesity, Wiskott-Aldrich Syndrome, neurogenic hypertension and Cholestatic liver disease. The involved functions are known as Cell Death, Apoptosis, Homeostasis, Process and mRNA Expression. Tauroursodeoxycholic acid often locates in Body tissue, Endoplasmic Reticulum, Hepatic, Blood and Protoplasm. The associated genes with Tauroursodeoxycholic acid are Homologous Gene and Mutant Proteins. The related lipids are cholanic acid, taurolithocholic acid 3-sulfate, Sterols, 7-dehydrocholesterol and tauromuricholic acid. The related experimental models are Disease model.

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Introduction

To understand associated biological information of Tauroursodeoxycholic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Tauroursodeoxycholic acid?

Tauroursodeoxycholic acid is suspected in Endothelial dysfunction, Hyperglycemia, Obesity, neurogenic hypertension, Cholestatic liver disease, Heart failure and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Tauroursodeoxycholic acid

MeSH term MeSH ID Detail
Hypertension D006973 115 associated lipids
Insulin Resistance D007333 99 associated lipids
Total 2

PubChem Associated disorders and diseases

What pathways are associated with Tauroursodeoxycholic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Tauroursodeoxycholic acid?

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What functions are associated with Tauroursodeoxycholic acid?


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What lipids are associated with Tauroursodeoxycholic acid?

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What genes are associated with Tauroursodeoxycholic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Tauroursodeoxycholic acid?

Disease model

Disease model are used in the study 'Bile Acids Reduce Prion Conversion, Reduce Neuronal Loss, and Prolong Male Survival in Models of Prion Disease.' (Cortez LM et al., 2015).

Related references are published most in these journals:

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NCBI Entrez Crosslinks

All references with Tauroursodeoxycholic acid

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Authors Title Published Journal PubMed Link
Klinkspoor JH et al. Bile salts stimulate mucin secretion by cultured dog gallbladder epithelial cells independent of their detergent effect. 1998 Biochem. J. pmid:9576876
Beuers U Effects of bile acids on hepatocellular signaling and secretion. 1997 Jul-Aug Yale J Biol Med pmid:9626754
Sreejayan N and von Ritter C Effect of bile acids on lipid peroxidation: the role of iron. 1998 Free Radic. Biol. Med. pmid:9655521
Bouscarel B et al. Changes in G protein expression account for impaired modulation of hepatic cAMP formation after BDL. 1998 Am. J. Physiol. pmid:9696716
Benz C et al. Effect of S-adenosylmethionine versus tauroursodeoxycholic acid on bile acid-induced apoptosis and cytolysis in rat hepatocytes. 1998 Eur. J. Clin. Invest. pmid:9726039
Yamaguchi Y et al. Taurin-conjugated ursodeoxycholic acid has a reversible inhibitory effect on human keratinocyte growth. 1998 J. Dermatol. Sci. pmid:9747660
Peterson TC et al. The inhibitory effect of ursodeoxycholic acid and pentoxifylline on platelet derived growth factor-stimulated proliferation is distinct from an effect by cyclic AMP. 1998 Immunopharmacology pmid:9754904
Ono T et al. Tauroursodeoxycholic acid protects cholestasis in rat reperfused livers: its roles in hepatic calcium mobilization. 1998 Dig. Dis. Sci. pmid:9790455
Invernizzi P et al. Differences in the metabolism and disposition of ursodeoxycholic acid and of its taurine-conjugated species in patients with primary biliary cirrhosis. 1999 Hepatology pmid:9918905
Milkiewicz P et al. Tauroursodeoxycholate and S-adenosyl-L-methionine exert an additive ameliorating effect on taurolithocholate-induced cholestasis: a study in isolated rat hepatocyte couplets. 1999 Hepatology pmid:9918924