| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hypertension | D006973 | 115 associated lipids |
| Insulin Resistance | D007333 | 99 associated lipids |
Total
2
Tauroursodeoxycholic acid
Tauroursodeoxycholic acid is a lipid of Sterol Lipids (ST) class. Tauroursodeoxycholic acid is associated with abnormalities such as Hyperglycemia, Obesity, Wiskott-Aldrich Syndrome, neurogenic hypertension and Cholestatic liver disease. The involved functions are known as Cell Death, Apoptosis, Homeostasis, Process and mRNA Expression. Tauroursodeoxycholic acid often locates in Body tissue, Endoplasmic Reticulum, Hepatic, Blood and Protoplasm. The associated genes with Tauroursodeoxycholic acid are Homologous Gene and Mutant Proteins. The related lipids are cholanic acid, taurolithocholic acid 3-sulfate, Sterols, 7-dehydrocholesterol and tauromuricholic acid. The related experimental models are Disease model.
Cross Reference
Introduction
To understand associated biological information of Tauroursodeoxycholic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Tauroursodeoxycholic acid?
Tauroursodeoxycholic acid is suspected in Endothelial dysfunction, Hyperglycemia, Obesity, neurogenic hypertension, Cholestatic liver disease, Heart failure and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Diabetes (3)
- Am. J. Physiol. Heart Circ. Physiol. (1)
- Am. J. Physiol. Lung Cell Mol. Physiol. (1)
- Others (5)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Tauroursodeoxycholic acid
PubChem Associated disorders and diseases
What pathways are associated with Tauroursodeoxycholic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Tauroursodeoxycholic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Tauroursodeoxycholic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Tauroursodeoxycholic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Tauroursodeoxycholic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Tauroursodeoxycholic acid?
Disease model
Disease model are used in the study 'Bile Acids Reduce Prion Conversion, Reduce Neuronal Loss, and Prolong Male Survival in Models of Prion Disease.' (Cortez LM et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Tauroursodeoxycholic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Setchell KD et al. | Bile acid concentrations in human and rat liver tissue and in hepatocyte nuclei. | 1997 | Gastroenterology | pmid:8978363 |
| Gilani SS et al. | Use of 1H NMR spectroscopy (T2 relaxation times) to examine the effects of conjugated ursodeoxycholic acid on phospholipid fluidity of human gallbladder bile. | 1997 | Biochem. Soc. Trans. | pmid:9056921 |
| Arrese M et al. | Adaptive regulation of hepatic bile salt transport: role of bile salt hydrophobicity and microtubule-dependent vesicular pathway. | 1997 | J. Hepatol. | pmid:9075679 |
| Takikawa H et al. | Effect of tauro-alpha-muricholate and tauro-beta-muricholate on oestradiol-17 beta-glucuronide-induced cholestasis in rats. | 1997 | J. Gastroenterol. Hepatol. | pmid:9076630 |
| Larghi A et al. | Ursodeoxycholic and tauro-ursodeoxycholic acids for the treatment of primary biliary cirrhosis: a pilot crossover study. | 1997 | Aliment. Pharmacol. Ther. | pmid:9146783 |
| van Nieuwerk CM et al. | The role of bile salt composition in liver pathology of mdr2 (-/-) mice: differences between males and females. | 1997 | J. Hepatol. | pmid:9148004 |
| Luk AS et al. | Structural mechanisms of bile salt-induced growth of small unilamellar cholesterol-lecithin vesicles. | 1997 | Biochemistry | pmid:9153403 |
| Loria P et al. | Effect of taurohyodeoxycholic acid on biliary lipid secretion in humans. | 1997 | Hepatology | pmid:9185744 |
| van de Heijning BJ et al. | Membrane cholesterol content of cholesterol/phospholipid vesicles determines the susceptibility to both damage and protection by bile salts: implications for bile physiology. | 1997 | Eur J Gastroenterol Hepatol | pmid:9187880 |
| Crocenzi FA et al. | Role of bile salts in colchicine-induced hepatotoxicity. Implications for hepatocellular integrity and function. | 1997 | Toxicology | pmid:9230445 |
| Balandraud-Pieri N et al. | Effects of tauroursodeoxycholate solutions on cyclosporin A bioavailability in rats. | 1997 | Drug Metab. Dispos. | pmid:9280397 |
| Ishizaki K et al. | Effect of sodium tauroursodeoxycholate (UR-906) on liver dysfunction in bile duct-ligated rats. | 1997 | Eur. J. Pharmacol. | pmid:9314037 |
| Schliess F et al. | Mitogen-activated protein kinases mediate the stimulation of bile acid secretion by tauroursodeoxycholate in rat liver. | 1997 | Gastroenterology | pmid:9322526 |
| Meier PJ et al. | Substrate specificity of sinusoidal bile acid and organic anion uptake systems in rat and human liver. | 1997 | Hepatology | pmid:9398014 |
| Rao YP et al. | Activation of protein kinase C alpha and delta by bile acids: correlation with bile acid structure and diacylglycerol formation. | 1997 | J. Lipid Res. | pmid:9458268 |
| Roda A et al. | Taurohyodeoxycholic acid protects against taurochenodeoxycholic acid-induced cholestasis in the rat. | 1998 | Hepatology | pmid:9462652 |
| Schroeder A et al. | Substrate specificity of the rat liver Na(+)-bile salt cotransporter in Xenopus laevis oocytes and in CHO cells. | 1998 | Am. J. Physiol. | pmid:9486191 |
| Takikawa H et al. | Absorption of unconjugated bile acids and tauroursodeoxycholate in the rat intestine. | 1997 | J. Gastroenterol. Hepatol. | pmid:9504891 |
| Vendemiale G et al. | Ethanol-induced changes of intracellular thiol compartmentation and protein redox status in the rat liver: effect of tauroursodeoxycholate. | 1998 | J. Hepatol. | pmid:9537863 |
| Benz C et al. | Effect of tauroursodeoxycholic acid on bile-acid-induced apoptosis and cytolysis in rat hepatocytes. | 1998 | J. Hepatol. | pmid:9537871 |
| Klinkspoor JH et al. | Bile salts stimulate mucin secretion by cultured dog gallbladder epithelial cells independent of their detergent effect. | 1998 | Biochem. J. | pmid:9576876 |
| Beuers U | Effects of bile acids on hepatocellular signaling and secretion. | 1997 Jul-Aug | Yale J Biol Med | pmid:9626754 |
| Sreejayan N and von Ritter C | Effect of bile acids on lipid peroxidation: the role of iron. | 1998 | Free Radic. Biol. Med. | pmid:9655521 |
| Bouscarel B et al. | Changes in G protein expression account for impaired modulation of hepatic cAMP formation after BDL. | 1998 | Am. J. Physiol. | pmid:9696716 |
| Benz C et al. | Effect of S-adenosylmethionine versus tauroursodeoxycholic acid on bile acid-induced apoptosis and cytolysis in rat hepatocytes. | 1998 | Eur. J. Clin. Invest. | pmid:9726039 |
| Yamaguchi Y et al. | Taurin-conjugated ursodeoxycholic acid has a reversible inhibitory effect on human keratinocyte growth. | 1998 | J. Dermatol. Sci. | pmid:9747660 |
| Peterson TC et al. | The inhibitory effect of ursodeoxycholic acid and pentoxifylline on platelet derived growth factor-stimulated proliferation is distinct from an effect by cyclic AMP. | 1998 | Immunopharmacology | pmid:9754904 |
| Ono T et al. | Tauroursodeoxycholic acid protects cholestasis in rat reperfused livers: its roles in hepatic calcium mobilization. | 1998 | Dig. Dis. Sci. | pmid:9790455 |
| Invernizzi P et al. | Differences in the metabolism and disposition of ursodeoxycholic acid and of its taurine-conjugated species in patients with primary biliary cirrhosis. | 1999 | Hepatology | pmid:9918905 |
| Milkiewicz P et al. | Tauroursodeoxycholate and S-adenosyl-L-methionine exert an additive ameliorating effect on taurolithocholate-induced cholestasis: a study in isolated rat hepatocyte couplets. | 1999 | Hepatology | pmid:9918924 |
| Miyake H et al. | Partial characterization of mechanisms of cytoprotective action of hydrophilic bile salts against hydrophobic bile salts in rats: relation to canalicular membrane fluidity and packing density. | 1999 | Dig. Dis. Sci. | pmid:9952244 |