| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hypertension | D006973 | 115 associated lipids |
| Insulin Resistance | D007333 | 99 associated lipids |
Total
2
Tauroursodeoxycholic acid
Tauroursodeoxycholic acid is a lipid of Sterol Lipids (ST) class. Tauroursodeoxycholic acid is associated with abnormalities such as Hyperglycemia, Obesity, Wiskott-Aldrich Syndrome, neurogenic hypertension and Cholestatic liver disease. The involved functions are known as Cell Death, Apoptosis, Homeostasis, Process and mRNA Expression. Tauroursodeoxycholic acid often locates in Body tissue, Endoplasmic Reticulum, Hepatic, Blood and Protoplasm. The associated genes with Tauroursodeoxycholic acid are Homologous Gene and Mutant Proteins. The related lipids are cholanic acid, taurolithocholic acid 3-sulfate, Sterols, 7-dehydrocholesterol and tauromuricholic acid. The related experimental models are Disease model.
Cross Reference
Introduction
To understand associated biological information of Tauroursodeoxycholic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Tauroursodeoxycholic acid?
Tauroursodeoxycholic acid is suspected in Endothelial dysfunction, Hyperglycemia, Obesity, neurogenic hypertension, Cholestatic liver disease, Heart failure and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Diabetes (3)
- Am. J. Physiol. Heart Circ. Physiol. (1)
- Am. J. Physiol. Lung Cell Mol. Physiol. (1)
- Others (5)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Tauroursodeoxycholic acid
PubChem Associated disorders and diseases
What pathways are associated with Tauroursodeoxycholic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Tauroursodeoxycholic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Tauroursodeoxycholic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Tauroursodeoxycholic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Tauroursodeoxycholic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Tauroursodeoxycholic acid?
Disease model
Disease model are used in the study 'Bile Acids Reduce Prion Conversion, Reduce Neuronal Loss, and Prolong Male Survival in Models of Prion Disease.' (Cortez LM et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Tauroursodeoxycholic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kok T et al. | Peroxisome proliferator-activated receptor alpha (PPARalpha)-mediated regulation of multidrug resistance 2 (Mdr2) expression and function in mice. | 2003 | Biochem. J. | pmid:12381268 |
| Kurz AK et al. | Phosphoinositide 3-kinase-dependent Ras activation by tauroursodesoxycholate in rat liver. | 2000 | Biochem. J. | pmid:10926845 |
| Nakai T et al. | Microtubule-independent choleresis and anti-cholestatic action of tauroursodeoxycholate in colchicine-treated rat liver. | 1992 | Biochem. J. | pmid:1361125 |
| Asamoto Y et al. | Bile-salt hydrophobicity is a key factor regulating rat liver plasma-membrane communication: relation to bilayer structure, fluidity and transporter expression and function. | 2001 | Biochem. J. | pmid:11672435 |
| Nathanson MH et al. | Stimulation of ATP secretion in the liver by therapeutic bile acids. | 2001 | Biochem. J. | pmid:11485545 |
| Klinkspoor JH et al. | Bile salts stimulate mucin secretion by cultured dog gallbladder epithelial cells independent of their detergent effect. | 1998 | Biochem. J. | pmid:9576876 |
| Barnwell SG et al. | Effect of taurochenodeoxycholate or tauroursodeoxycholate upon biliary output of phospholipids and plasma-membrane enzymes, and the extent of cell damage, in isolated perfused rat livers. | 1983 | Biochem. J. | pmid:6316931 |
| Thibault N and Ballet F | Effect of bile acids on intracellular calcium in isolated rat hepatocyte couplets. | 1993 | Biochem. Pharmacol. | pmid:8435088 |
| Veggi LM et al. | Dapsone-induced cholestasis and impairment of bile salt output in the rat. | 2002 | Biochem. Pharmacol. | pmid:11996898 |
| Gilani SS et al. | Use of 1H NMR spectroscopy (T2 relaxation times) to examine the effects of conjugated ursodeoxycholic acid on phospholipid fluidity of human gallbladder bile. | 1997 | Biochem. Soc. Trans. | pmid:9056921 |
| Luk AS et al. | Structural mechanisms of bile salt-induced growth of small unilamellar cholesterol-lecithin vesicles. | 1997 | Biochemistry | pmid:9153403 |
| Rodrigues CM et al. | Tauroursodeoxycholic acid prevents Bax-induced membrane perturbation and cytochrome C release in isolated mitochondria. | 2003 | Biochemistry | pmid:12627974 |
| Dreger SC et al. | Killing of rat basophilic leukemia cells by lethal toxin from Clostridium sordellii: critical role of phosphatidylinositide 3'-OH kinase/Akt signaling. | 2009 | Biochemistry | pmid:19199813 |
| Schulz F et al. | Prevention of Clostridium sordellii lethal toxin-induced apoptotic cell death by tauroursodeoxycholic acid. | 2009 | Biochemistry | pmid:19691300 |
| Solá S et al. | Modulation of nuclear steroid receptors by ursodeoxycholic acid inhibits TGF-beta1-induced E2F-1/p53-mediated apoptosis of rat hepatocytes. | 2004 | Biochemistry | pmid:15222754 |
| Albalak A et al. | Effects of submicellar bile salt concentrations on biological membrane permeability to low molecular weight non-ionic solutes. | 1996 | Biochemistry | pmid:8672496 |
| Macedo B et al. | Anti-apoptotic treatment reduces transthyretin deposition in a transgenic mouse model of Familial Amyloidotic Polyneuropathy. | 2008 | Biochim. Biophys. Acta | pmid:18572024 |
| Schulz S et al. | Progressive stages of mitochondrial destruction caused by cell toxic bile salts. | 2013 | Biochim. Biophys. Acta | pmid:23685124 |
| Carubbi F et al. | Comparative cytotoxic and cytoprotective effects of taurohyodeoxycholic acid (THDCA) and tauroursodeoxycholic acid (TUDCA) in HepG2 cell line. | 2002 | Biochim. Biophys. Acta | pmid:11923098 |
| Alvaro D et al. | Influence of tauroursodeoxycholic and taurodeoxycholic acids on hepatic metabolism and biliary secretion of phosphatidylcholine in the isolated rat liver. | 1986 | Biochim. Biophys. Acta | pmid:3756193 |