(2r, 3s)-2-hydroxybutane-1,2,3-tricarboxylate;2-hydroxybutane-1,2,3-tricarboxylate;2-methylcitrate

(2r, 3s)-2-hydroxybutane-1,2,3-tricarboxylate;2-hydroxybutane-1,2,3-tricarboxylate;2-methylcitrate is a lipid of Fatty Acyls (FA) class.

Cross Reference

There are no associated biomedical information in the current reference collection.

Current reference collection contains 221 references associated with (2r, 3s)-2-hydroxybutane-1,2,3-tricarboxylate;2-hydroxybutane-1,2,3-tricarboxylate;2-methylcitrate in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.

Here are additional resources we collected from PubChem and MeSH for (2r, 3s)-2-hydroxybutane-1,2,3-tricarboxylate;2-hydroxybutane-1,2,3-tricarboxylate;2-methylcitrate

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with (2r, 3s)-2-hydroxybutane-1,2,3-tricarboxylate;2-hydroxybutane-1,2,3-tricarboxylate;2-methylcitrate

MeSH term MeSH ID Detail
Mitochondrial Diseases D028361 25 associated lipids
Vision Disorders D014786 10 associated lipids
Pregnancy Complications D011248 19 associated lipids
Metabolism, Inborn Errors D008661 46 associated lipids
Amino Acid Metabolism, Inborn Errors D000592 16 associated lipids
Total 5

PubChem Biomolecular Interactions and Pathways

All references with (2r, 3s)-2-hydroxybutane-1,2,3-tricarboxylate;2-hydroxybutane-1,2,3-tricarboxylate;2-methylcitrate

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Authors Title Published Journal PubMed Link
Rocco CJ et al. Construction and use of new cloning vectors for the rapid isolation of recombinant proteins from Escherichia coli. 2008 Plasmid pmid:18295882
Zhang Y et al. Prenatal diagnosis of methylmalonic aciduria by analysis of organic acids and total homocysteine in amniotic fluid. 2008 Chin. Med. J. pmid:18298912
Lee SH et al. Roles of the glyoxylate and methylcitrate cycles in sexual development and virulence in the cereal pathogen Gibberella zeae. 2009 Eukaryotic Cell pmid:19525419
Pereira EM et al. Disruption of the 2-methylcitric acid cycle and evaluation of poly-3-hydroxybutyrate-co-3-hydroxyvalerate biosynthesis suggest alternate catabolic pathways of propionate in Burkholderia sacchari. 2009 Can. J. Microbiol. pmid:19767840
Domin N et al. Methylcitrate cycle activation during adaptation of Fusarium solani and Fusarium verticillioides to propionyl-CoA-generating carbon sources. 2009 Microbiology (Reading, Engl.) pmid:19661181
Rocco CJ and Escalante-Semerena JC In Salmonella enterica, 2-methylcitrate blocks gluconeogenesis. 2010 J. Bacteriol. pmid:19948794
Peplinski K et al. Investigations on the microbial catabolism of the organic sulfur compounds TDP and DTDP in Ralstonia eutropha H16 employing DNA microarrays. 2010 Appl. Microbiol. Biotechnol. pmid:20924576
Turgeon CT et al. Determination of total homocysteine, methylmalonic acid, and 2-methylcitric acid in dried blood spots by tandem mass spectrometry. 2010 Clin. Chem. pmid:20807894
Chandler RJ et al. Adeno-associated virus serotype 8 gene transfer rescues a neonatal lethal murine model of propionic acidemia. 2011 Hum. Gene Ther. pmid:20950151
Park JM et al. Genome-scale reconstruction and in silico analysis of the Ralstonia eutropha H16 for polyhydroxyalkanoate synthesis, lithoautotrophic growth, and 2-methyl citric acid production. 2011 BMC Syst Biol pmid:21711532
Chittori S et al. Crystal structure of Salmonella typhimurium 2-methylcitrate synthase: Insights on domain movement and substrate specificity. 2011 J. Struct. Biol. pmid:20970504
Masiewicz P et al. A novel role of the PrpR as a transcription factor involved in the regulation of methylcitrate pathway in Mycobacterium tuberculosis. 2012 PLoS ONE pmid:22916289
Zwart SR et al. Vision changes after spaceflight are related to alterations in folate- and vitamin B-12-dependent one-carbon metabolism. 2012 J. Nutr. pmid:22298570
Kasahara M et al. Living-donor liver transplantation for propionic acidemia. 2012 Pediatr Transplant pmid:22151065
Plassmeier J et al. Molecular characterization of PrpR, the transcriptional activator of propionate catabolism in Corynebacterium glutamicum. 2012 J. Biotechnol. pmid:21933687
Dutta S et al. Root exudate-induced alterations in Bacillus cereus cell wall contribute to root colonization and plant growth promotion. 2013 PLoS ONE pmid:24205213
Limenitakis J et al. The 2-methylcitrate cycle is implicated in the detoxification of propionate in Toxoplasma gondii. 2013 Mol. Microbiol. pmid:23279335
Imataka G et al. Novel c.2216T > C (p.I739T) mutation in exon 13 and c.1481T > A (p.L494X) mutation in exon 8 of MUT gene in a female with methylmalonic acidemia. 2013 Cell Biochem. Biophys. pmid:23479330
Jafari P et al. Brain damage in methylmalonic aciduria: 2-methylcitrate induces cerebral ammonium accumulation and apoptosis in 3D organotypic brain cell cultures. 2013 Orphanet J Rare Dis pmid:23298464
Eoh H and Rhee KY Methylcitrate cycle defines the bactericidal essentiality of isocitrate lyase for survival of Mycobacterium tuberculosis on fatty acids. 2014 Proc. Natl. Acad. Sci. U.S.A. pmid:24639517

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