(2r, 3s)-2-hydroxybutane-1,2,3-tricarboxylate;2-hydroxybutane-1,2,3-tricarboxylate;2-methylcitrate is a lipid of Fatty Acyls (FA) class.
We collected disease MeSH terms mapped to the references associated with (2r, 3s)-2-hydroxybutane-1,2,3-tricarboxylate;2-hydroxybutane-1,2,3-tricarboxylate;2-methylcitrate
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Vision Disorders | D014786 | 10 associated lipids |
| Metabolism, Inborn Errors | D008661 | 46 associated lipids |
| Amino Acid Metabolism, Inborn Errors | D000592 | 16 associated lipids |
| Pregnancy Complications | D011248 | 19 associated lipids |
| Mitochondrial Diseases | D028361 | 25 associated lipids |
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Monostori P et al. | Simultaneous determination of 3-hydroxypropionic acid, methylmalonic acid and methylcitric acid in dried blood spots: Second-tier LC-MS/MS assay for newborn screening of propionic acidemia, methylmalonic acidemias and combined remethylation disorders. | 2017 | PLoS ONE | pmid:28915261 |
| Wilson KA et al. | Inter-relations between 3-hydroxypropionate and propionate metabolism in rat liver: relevance to disorders of propionyl-CoA metabolism. | 2017 | Am. J. Physiol. Endocrinol. Metab. | pmid:28634175 |
| Amaral AU et al. | 2-Methylcitric acid impairs glutamate metabolism and induces permeability transition in brain mitochondria. | 2016 | J. Neurochem. | pmid:26800654 |
| Guenzel AJ et al. | Long-term sex-biased correction of circulating propionic acidemia disease markers by adeno-associated virus vectors. | 2015 | Hum. Gene Ther. | pmid:25654275 |
| Eoh H and Rhee KY | Methylcitrate cycle defines the bactericidal essentiality of isocitrate lyase for survival of Mycobacterium tuberculosis on fatty acids. | 2014 | Proc. Natl. Acad. Sci. U.S.A. | pmid:24639517 |
| Dutta S et al. | Root exudate-induced alterations in Bacillus cereus cell wall contribute to root colonization and plant growth promotion. | 2013 | PLoS ONE | pmid:24205213 |
| Limenitakis J et al. | The 2-methylcitrate cycle is implicated in the detoxification of propionate in Toxoplasma gondii. | 2013 | Mol. Microbiol. | pmid:23279335 |
| Imataka G et al. | Novel c.2216T > C (p.I739T) mutation in exon 13 and c.1481T > A (p.L494X) mutation in exon 8 of MUT gene in a female with methylmalonic acidemia. | 2013 | Cell Biochem. Biophys. | pmid:23479330 |
| Jafari P et al. | Brain damage in methylmalonic aciduria: 2-methylcitrate induces cerebral ammonium accumulation and apoptosis in 3D organotypic brain cell cultures. | 2013 | Orphanet J Rare Dis | pmid:23298464 |
| Masiewicz P et al. | A novel role of the PrpR as a transcription factor involved in the regulation of methylcitrate pathway in Mycobacterium tuberculosis. | 2012 | PLoS ONE | pmid:22916289 |
| Zwart SR et al. | Vision changes after spaceflight are related to alterations in folate- and vitamin B-12-dependent one-carbon metabolism. | 2012 | J. Nutr. | pmid:22298570 |
| Kasahara M et al. | Living-donor liver transplantation for propionic acidemia. | 2012 | Pediatr Transplant | pmid:22151065 |
| Plassmeier J et al. | Molecular characterization of PrpR, the transcriptional activator of propionate catabolism in Corynebacterium glutamicum. | 2012 | J. Biotechnol. | pmid:21933687 |
| Chandler RJ et al. | Adeno-associated virus serotype 8 gene transfer rescues a neonatal lethal murine model of propionic acidemia. | 2011 | Hum. Gene Ther. | pmid:20950151 |
| Park JM et al. | Genome-scale reconstruction and in silico analysis of the Ralstonia eutropha H16 for polyhydroxyalkanoate synthesis, lithoautotrophic growth, and 2-methyl citric acid production. | 2011 | BMC Syst Biol | pmid:21711532 |
| Chittori S et al. | Crystal structure of Salmonella typhimurium 2-methylcitrate synthase: Insights on domain movement and substrate specificity. | 2011 | J. Struct. Biol. | pmid:20970504 |
| Rocco CJ and Escalante-Semerena JC | In Salmonella enterica, 2-methylcitrate blocks gluconeogenesis. | 2010 | J. Bacteriol. | pmid:19948794 |
| Peplinski K et al. | Investigations on the microbial catabolism of the organic sulfur compounds TDP and DTDP in Ralstonia eutropha H16 employing DNA microarrays. | 2010 | Appl. Microbiol. Biotechnol. | pmid:20924576 |
| Turgeon CT et al. | Determination of total homocysteine, methylmalonic acid, and 2-methylcitric acid in dried blood spots by tandem mass spectrometry. | 2010 | Clin. Chem. | pmid:20807894 |
| Lee SH et al. | Roles of the glyoxylate and methylcitrate cycles in sexual development and virulence in the cereal pathogen Gibberella zeae. | 2009 | Eukaryotic Cell | pmid:19525419 |
| Pereira EM et al. | Disruption of the 2-methylcitric acid cycle and evaluation of poly-3-hydroxybutyrate-co-3-hydroxyvalerate biosynthesis suggest alternate catabolic pathways of propionate in Burkholderia sacchari. | 2009 | Can. J. Microbiol. | pmid:19767840 |
| Domin N et al. | Methylcitrate cycle activation during adaptation of Fusarium solani and Fusarium verticillioides to propionyl-CoA-generating carbon sources. | 2009 | Microbiology (Reading, Engl.) | pmid:19661181 |
| Rocco CJ et al. | Construction and use of new cloning vectors for the rapid isolation of recombinant proteins from Escherichia coli. | 2008 | Plasmid | pmid:18295882 |
| Zhang Y et al. | Prenatal diagnosis of methylmalonic aciduria by analysis of organic acids and total homocysteine in amniotic fluid. | 2008 | Chin. Med. J. | pmid:18298912 |
| Garvey GS et al. | The three-dimensional crystal structure of the PrpF protein of Shewanella oneidensis complexed with trans-aconitate: insights into its biological function. | 2007 | Protein Sci. | pmid:17567742 |
| Plassmeier J et al. | Investigation of central carbon metabolism and the 2-methylcitrate cycle in Corynebacterium glutamicum by metabolic profiling using gas chromatography-mass spectrometry. | 2007 | J. Biotechnol. | pmid:17586079 |
| Krawczyk H and Gradowska W | 1H NMR spectra of methylcitric acid in urine. | 2007 | J. Inherit. Metab. Dis. | pmid:17295121 |
| Ewering C et al. | Metabolic engineering of strains of Ralstonia eutropha and Pseudomonas putida for biotechnological production of 2-methylcitric acid. | 2006 | Metab. Eng. | pmid:16876450 |
| Lee SK and Keasling JD | A propionate-inducible expression system for enteric bacteria. | 2005 | Appl. Environ. Microbiol. | pmid:16269719 |
| Campbell CD et al. | Two newborns with nutritional vitamin B12 deficiency: challenges in newborn screening for vitamin B12 deficiency. | 2005 | Haematologica | pmid:16464760 |
| Grimek TL and Escalante-Semerena JC | The acnD genes of Shewenella oneidensis and Vibrio cholerae encode a new Fe/S-dependent 2-methylcitrate dehydratase enzyme that requires prpF function in vivo. | 2004 | J. Bacteriol. | pmid:14702315 |
| Palacios S and Escalante-Semerena JC | 2-Methylcitrate-dependent activation of the propionate catabolic operon (prpBCDE) of Salmonella enterica by the PrpR protein. | 2004 | Microbiology (Reading, Engl.) | pmid:15528672 |
| Peters H et al. | A knock-out mouse model for methylmalonic aciduria resulting in neonatal lethality. | 2003 | J. Biol. Chem. | pmid:14555645 |
| Kölker S et al. | Methylmalonic acid, a biochemical hallmark of methylmalonic acidurias but no inhibitor of mitochondrial respiratory chain. | 2003 | J. Biol. Chem. | pmid:12972416 |
| Claes WA et al. | Identification of two prpDBC gene clusters in Corynebacterium glutamicum and their involvement in propionate degradation via the 2-methylcitrate cycle. | 2002 | J. Bacteriol. | pmid:11976302 |
| Brämer CO et al. | Identification of the 2-methylcitrate pathway involved in the catabolism of propionate in the polyhydroxyalkanoate-producing strain Burkholderia sacchari IPT101(T) and analysis of a mutant accumulating a copolyester with higher 3-hydroxyvalerate content. | 2002 | Appl. Environ. Microbiol. | pmid:11772636 |
| Okun JG et al. | Neurodegeneration in methylmalonic aciduria involves inhibition of complex II and the tricarboxylic acid cycle, and synergistically acting excitotoxicity. | 2002 | J. Biol. Chem. | pmid:11847233 |
| Blank L et al. | AcnC of Escherichia coli is a 2-methylcitrate dehydratase (PrpD) that can use citrate and isocitrate as substrates. | 2002 | Microbiology (Reading, Engl.) | pmid:11782506 |
| Henning BF et al. | Long-term effects of vitamin B(12), folate, and vitamin B(6) supplements in elderly people with normal serum vitamin B(12) concentrations. | 2001 Jan-Feb | Gerontology | pmid:11244289 |
| Horswill AR et al. | Studies of propionate toxicity in Salmonella enterica identify 2-methylcitrate as a potent inhibitor of cell growth. | 2001 | J. Biol. Chem. | pmid:11376009 |
| Horswill AR and Escalante-Semerena JC | In vitro conversion of propionate to pyruvate by Salmonella enterica enzymes: 2-methylcitrate dehydratase (PrpD) and aconitase Enzymes catalyze the conversion of 2-methylcitrate to 2-methylisocitrate. | 2001 | Biochemistry | pmid:11294638 |
| Brämer CO and Steinbüchel A | The methylcitric acid pathway in Ralstonia eutropha: new genes identified involved in propionate metabolism. | 2001 | Microbiology (Reading, Engl.) | pmid:11495997 |
| Horswill AR and Escalante-Semerena JC | Salmonella typhimurium LT2 catabolizes propionate via the 2-methylcitric acid cycle. | 1999 | J. Bacteriol. | pmid:10482501 |
| Henning BF et al. | Evidence of altered homocysteine metabolism in chronic renal failure. | 1999 | Nephron | pmid:10575293 |
| London RE et al. | Carbon-13 nuclear magnetic resonance study of metabolism of propionate by Escherichia coli. | 1999 | J. Bacteriol. | pmid:10348870 |
| Scalabrino G et al. | Enhanced levels of biochemical markers for cobalamin deficiency in totally gastrectomized rats: uncoupling of the enhancement from the severity of spongy vacuolation in spinal cord. | 1997 | Exp. Neurol. | pmid:9168827 |
| Naurath HJ et al. | Effects of vitamin B12, folate, and vitamin B6 supplements in elderly people with normal serum vitamin concentrations. | 1995 | Lancet | pmid:7603218 |
| Pronk JT et al. | Propionate metabolism in Saccharomyces cerevisiae: implications for the metabolon hypothesis. | 1994 | Microbiology (Reading, Engl.) | pmid:7912143 |
| Allen RH et al. | Elevation of 2-methylcitric acid I and II levels in serum, urine, and cerebrospinal fluid of patients with cobalamin deficiency. | 1993 | Metab. Clin. Exp. | pmid:8345822 |
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