(2r, 3s)-2-hydroxybutane-1,2,3-tricarboxylate;2-hydroxybutane-1,2,3-tricarboxylate;2-methylcitrate

(2r, 3s)-2-hydroxybutane-1,2,3-tricarboxylate;2-hydroxybutane-1,2,3-tricarboxylate;2-methylcitrate is a lipid of Fatty Acyls (FA) class.

Cross Reference

There are no associated biomedical information in the current reference collection.

Current reference collection contains 221 references associated with (2r, 3s)-2-hydroxybutane-1,2,3-tricarboxylate;2-hydroxybutane-1,2,3-tricarboxylate;2-methylcitrate in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.

Here are additional resources we collected from PubChem and MeSH for (2r, 3s)-2-hydroxybutane-1,2,3-tricarboxylate;2-hydroxybutane-1,2,3-tricarboxylate;2-methylcitrate

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with (2r, 3s)-2-hydroxybutane-1,2,3-tricarboxylate;2-hydroxybutane-1,2,3-tricarboxylate;2-methylcitrate

MeSH term MeSH ID Detail
Vision Disorders D014786 10 associated lipids
Metabolism, Inborn Errors D008661 46 associated lipids
Amino Acid Metabolism, Inborn Errors D000592 16 associated lipids
Pregnancy Complications D011248 19 associated lipids
Mitochondrial Diseases D028361 25 associated lipids
Total 5

PubChem Biomolecular Interactions and Pathways

All references with (2r, 3s)-2-hydroxybutane-1,2,3-tricarboxylate;2-hydroxybutane-1,2,3-tricarboxylate;2-methylcitrate

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Authors Title Published Journal PubMed Link
pmid:16997619
Krawczyk H and Gradowska W 1H NMR spectra of methylcitric acid in urine. 2007 J. Inherit. Metab. Dis. pmid:17295121
Garvey GS et al. The three-dimensional crystal structure of the PrpF protein of Shewanella oneidensis complexed with trans-aconitate: insights into its biological function. 2007 Protein Sci. pmid:17567742
Plassmeier J et al. Investigation of central carbon metabolism and the 2-methylcitrate cycle in Corynebacterium glutamicum by metabolic profiling using gas chromatography-mass spectrometry. 2007 J. Biotechnol. pmid:17586079
Rocco CJ et al. Construction and use of new cloning vectors for the rapid isolation of recombinant proteins from Escherichia coli. 2008 Plasmid pmid:18295882
Zhang Y et al. Prenatal diagnosis of methylmalonic aciduria by analysis of organic acids and total homocysteine in amniotic fluid. 2008 Chin. Med. J. pmid:18298912
pmid:18343209
Lee SH et al. Roles of the glyoxylate and methylcitrate cycles in sexual development and virulence in the cereal pathogen Gibberella zeae. 2009 Eukaryotic Cell pmid:19525419
Domin N et al. Methylcitrate cycle activation during adaptation of Fusarium solani and Fusarium verticillioides to propionyl-CoA-generating carbon sources. 2009 Microbiology (Reading, Engl.) pmid:19661181
Pereira EM et al. Disruption of the 2-methylcitric acid cycle and evaluation of poly-3-hydroxybutyrate-co-3-hydroxyvalerate biosynthesis suggest alternate catabolic pathways of propionate in Burkholderia sacchari. 2009 Can. J. Microbiol. pmid:19767840
Rocco CJ and Escalante-Semerena JC In Salmonella enterica, 2-methylcitrate blocks gluconeogenesis. 2010 J. Bacteriol. pmid:19948794
pmid:20155770
Turgeon CT et al. Determination of total homocysteine, methylmalonic acid, and 2-methylcitric acid in dried blood spots by tandem mass spectrometry. 2010 Clin. Chem. pmid:20807894
Peplinski K et al. Investigations on the microbial catabolism of the organic sulfur compounds TDP and DTDP in Ralstonia eutropha H16 employing DNA microarrays. 2010 Appl. Microbiol. Biotechnol. pmid:20924576
Chandler RJ et al. Adeno-associated virus serotype 8 gene transfer rescues a neonatal lethal murine model of propionic acidemia. 2011 Hum. Gene Ther. pmid:20950151
Chittori S et al. Crystal structure of Salmonella typhimurium 2-methylcitrate synthase: Insights on domain movement and substrate specificity. 2011 J. Struct. Biol. pmid:20970504
Park JM et al. Genome-scale reconstruction and in silico analysis of the Ralstonia eutropha H16 for polyhydroxyalkanoate synthesis, lithoautotrophic growth, and 2-methyl citric acid production. 2011 BMC Syst Biol pmid:21711532
Plassmeier J et al. Molecular characterization of PrpR, the transcriptional activator of propionate catabolism in Corynebacterium glutamicum. 2012 J. Biotechnol. pmid:21933687
Kasahara M et al. Living-donor liver transplantation for propionic acidemia. 2012 Pediatr Transplant pmid:22151065
Zwart SR et al. Vision changes after spaceflight are related to alterations in folate- and vitamin B-12-dependent one-carbon metabolism. 2012 J. Nutr. pmid:22298570

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