(2r, 3s)-2-hydroxybutane-1,2,3-tricarboxylate;2-hydroxybutane-1,2,3-tricarboxylate;2-methylcitrate

(2r, 3s)-2-hydroxybutane-1,2,3-tricarboxylate;2-hydroxybutane-1,2,3-tricarboxylate;2-methylcitrate is a lipid of Fatty Acyls (FA) class.

Cross Reference

There are no associated biomedical information in the current reference collection.

Current reference collection contains 221 references associated with (2r, 3s)-2-hydroxybutane-1,2,3-tricarboxylate;2-hydroxybutane-1,2,3-tricarboxylate;2-methylcitrate in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.

Here are additional resources we collected from PubChem and MeSH for (2r, 3s)-2-hydroxybutane-1,2,3-tricarboxylate;2-hydroxybutane-1,2,3-tricarboxylate;2-methylcitrate

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with (2r, 3s)-2-hydroxybutane-1,2,3-tricarboxylate;2-hydroxybutane-1,2,3-tricarboxylate;2-methylcitrate

MeSH term MeSH ID Detail
Vision Disorders D014786 10 associated lipids
Metabolism, Inborn Errors D008661 46 associated lipids
Amino Acid Metabolism, Inborn Errors D000592 16 associated lipids
Pregnancy Complications D011248 19 associated lipids
Mitochondrial Diseases D028361 25 associated lipids
Total 5

PubChem Biomolecular Interactions and Pathways

All references with (2r, 3s)-2-hydroxybutane-1,2,3-tricarboxylate;2-hydroxybutane-1,2,3-tricarboxylate;2-methylcitrate

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Authors Title Published Journal PubMed Link
Pronk JT et al. Propionate metabolism in Saccharomyces cerevisiae: implications for the metabolon hypothesis. 1994 Microbiology (Reading, Engl.) pmid:7912143
Brämer CO and Steinbüchel A The methylcitric acid pathway in Ralstonia eutropha: new genes identified involved in propionate metabolism. 2001 Microbiology (Reading, Engl.) pmid:11495997
Blank L et al. AcnC of Escherichia coli is a 2-methylcitrate dehydratase (PrpD) that can use citrate and isocitrate as substrates. 2002 Microbiology (Reading, Engl.) pmid:11782506
Palacios S and Escalante-Semerena JC 2-Methylcitrate-dependent activation of the propionate catabolic operon (prpBCDE) of Salmonella enterica by the PrpR protein. 2004 Microbiology (Reading, Engl.) pmid:15528672
Limenitakis J et al. The 2-methylcitrate cycle is implicated in the detoxification of propionate in Toxoplasma gondii. 2013 Mol. Microbiol. pmid:23279335
Henning BF et al. Evidence of altered homocysteine metabolism in chronic renal failure. 1999 Nephron pmid:10575293
Jafari P et al. Brain damage in methylmalonic aciduria: 2-methylcitrate induces cerebral ammonium accumulation and apoptosis in 3D organotypic brain cell cultures. 2013 Orphanet J Rare Dis pmid:23298464
Kasahara M et al. Living-donor liver transplantation for propionic acidemia. 2012 Pediatr Transplant pmid:22151065
Rocco CJ et al. Construction and use of new cloning vectors for the rapid isolation of recombinant proteins from Escherichia coli. 2008 Plasmid pmid:18295882
Monostori P et al. Simultaneous determination of 3-hydroxypropionic acid, methylmalonic acid and methylcitric acid in dried blood spots: Second-tier LC-MS/MS assay for newborn screening of propionic acidemia, methylmalonic acidemias and combined remethylation disorders. 2017 PLoS ONE pmid:28915261
Dutta S et al. Root exudate-induced alterations in Bacillus cereus cell wall contribute to root colonization and plant growth promotion. 2013 PLoS ONE pmid:24205213
Masiewicz P et al. A novel role of the PrpR as a transcription factor involved in the regulation of methylcitrate pathway in Mycobacterium tuberculosis. 2012 PLoS ONE pmid:22916289
Eoh H and Rhee KY Methylcitrate cycle defines the bactericidal essentiality of isocitrate lyase for survival of Mycobacterium tuberculosis on fatty acids. 2014 Proc. Natl. Acad. Sci. U.S.A. pmid:24639517
Garvey GS et al. The three-dimensional crystal structure of the PrpF protein of Shewanella oneidensis complexed with trans-aconitate: insights into its biological function. 2007 Protein Sci. pmid:17567742

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