(2r, 3s)-2-hydroxybutane-1,2,3-tricarboxylate;2-hydroxybutane-1,2,3-tricarboxylate;2-methylcitrate

(2r, 3s)-2-hydroxybutane-1,2,3-tricarboxylate;2-hydroxybutane-1,2,3-tricarboxylate;2-methylcitrate is a lipid of Fatty Acyls (FA) class.

Cross Reference

There are no associated biomedical information in the current reference collection.

Current reference collection contains 221 references associated with (2r, 3s)-2-hydroxybutane-1,2,3-tricarboxylate;2-hydroxybutane-1,2,3-tricarboxylate;2-methylcitrate in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.

Here are additional resources we collected from PubChem and MeSH for (2r, 3s)-2-hydroxybutane-1,2,3-tricarboxylate;2-hydroxybutane-1,2,3-tricarboxylate;2-methylcitrate

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with (2r, 3s)-2-hydroxybutane-1,2,3-tricarboxylate;2-hydroxybutane-1,2,3-tricarboxylate;2-methylcitrate

MeSH term MeSH ID Detail
Vision Disorders D014786 10 associated lipids
Metabolism, Inborn Errors D008661 46 associated lipids
Amino Acid Metabolism, Inborn Errors D000592 16 associated lipids
Pregnancy Complications D011248 19 associated lipids
Mitochondrial Diseases D028361 25 associated lipids
Total 5

PubChem Biomolecular Interactions and Pathways

All references with (2r, 3s)-2-hydroxybutane-1,2,3-tricarboxylate;2-hydroxybutane-1,2,3-tricarboxylate;2-methylcitrate

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Authors Title Published Journal PubMed Link
Plassmeier J et al. Investigation of central carbon metabolism and the 2-methylcitrate cycle in Corynebacterium glutamicum by metabolic profiling using gas chromatography-mass spectrometry. 2007 J. Biotechnol. pmid:17586079
Plassmeier J et al. Molecular characterization of PrpR, the transcriptional activator of propionate catabolism in Corynebacterium glutamicum. 2012 J. Biotechnol. pmid:21933687
Krawczyk H and Gradowska W 1H NMR spectra of methylcitric acid in urine. 2007 J. Inherit. Metab. Dis. pmid:17295121
Amaral AU et al. 2-Methylcitric acid impairs glutamate metabolism and induces permeability transition in brain mitochondria. 2016 J. Neurochem. pmid:26800654
Zwart SR et al. Vision changes after spaceflight are related to alterations in folate- and vitamin B-12-dependent one-carbon metabolism. 2012 J. Nutr. pmid:22298570
Chittori S et al. Crystal structure of Salmonella typhimurium 2-methylcitrate synthase: Insights on domain movement and substrate specificity. 2011 J. Struct. Biol. pmid:20970504
Naurath HJ et al. Effects of vitamin B12, folate, and vitamin B6 supplements in elderly people with normal serum vitamin concentrations. 1995 Lancet pmid:7603218
Allen RH et al. Elevation of 2-methylcitric acid I and II levels in serum, urine, and cerebrospinal fluid of patients with cobalamin deficiency. 1993 Metab. Clin. Exp. pmid:8345822
Ewering C et al. Metabolic engineering of strains of Ralstonia eutropha and Pseudomonas putida for biotechnological production of 2-methylcitric acid. 2006 Metab. Eng. pmid:16876450
Pronk JT et al. Propionate metabolism in Saccharomyces cerevisiae: implications for the metabolon hypothesis. 1994 Microbiology (Reading, Engl.) pmid:7912143
Domin N et al. Methylcitrate cycle activation during adaptation of Fusarium solani and Fusarium verticillioides to propionyl-CoA-generating carbon sources. 2009 Microbiology (Reading, Engl.) pmid:19661181
Brämer CO and Steinbüchel A The methylcitric acid pathway in Ralstonia eutropha: new genes identified involved in propionate metabolism. 2001 Microbiology (Reading, Engl.) pmid:11495997
Blank L et al. AcnC of Escherichia coli is a 2-methylcitrate dehydratase (PrpD) that can use citrate and isocitrate as substrates. 2002 Microbiology (Reading, Engl.) pmid:11782506
Palacios S and Escalante-Semerena JC 2-Methylcitrate-dependent activation of the propionate catabolic operon (prpBCDE) of Salmonella enterica by the PrpR protein. 2004 Microbiology (Reading, Engl.) pmid:15528672
Limenitakis J et al. The 2-methylcitrate cycle is implicated in the detoxification of propionate in Toxoplasma gondii. 2013 Mol. Microbiol. pmid:23279335
Henning BF et al. Evidence of altered homocysteine metabolism in chronic renal failure. 1999 Nephron pmid:10575293
Jafari P et al. Brain damage in methylmalonic aciduria: 2-methylcitrate induces cerebral ammonium accumulation and apoptosis in 3D organotypic brain cell cultures. 2013 Orphanet J Rare Dis pmid:23298464
Kasahara M et al. Living-donor liver transplantation for propionic acidemia. 2012 Pediatr Transplant pmid:22151065
Rocco CJ et al. Construction and use of new cloning vectors for the rapid isolation of recombinant proteins from Escherichia coli. 2008 Plasmid pmid:18295882
Dutta S et al. Root exudate-induced alterations in Bacillus cereus cell wall contribute to root colonization and plant growth promotion. 2013 PLoS ONE pmid:24205213

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