2-hydroxyglutaric acid

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There are no associated biomedical information in the current reference collection.

Current reference collection contains 1586 references associated with 2-hydroxyglutaric acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

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Here are additional resources we collected from PubChem and MeSH for 2-hydroxyglutaric acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 2-hydroxyglutaric acid

MeSH term MeSH ID Detail
Canavan Disease D017825 2 associated lipids
Tyrosinemias D020176 2 associated lipids
Hyperoxaluria D006959 3 associated lipids
Phenylketonurias D010661 7 associated lipids
Metabolic Diseases D008659 12 associated lipids
Total 5

PubChem Associated disorders and diseases

PubChem Biomolecular Interactions and Pathways

NCBI Entrez Crosslinks

All references with 2-hydroxyglutaric acid

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Authors Title Published Journal PubMed Link
Nadtochiy SM et al. Metabolomic profiling of the heart during acute ischemic preconditioning reveals a role for SIRT1 in rapid cardioprotective metabolic adaptation. 2015 J. Mol. Cell. Cardiol. pmid:26388263
Tarhonskaya H et al. Studies on the Interaction of the Histone Demethylase KDM5B with Tricarboxylic Acid Cycle Intermediates. 2017 J. Mol. Biol. pmid:28827149
Penderis J et al. L-2-hydroxyglutaric aciduria: characterisation of the molecular defect in a spontaneous canine model. 2007 J. Med. Genet. pmid:17475916
Wu F et al. Inhibition of Cancer-Associated Mutant Isocitrate Dehydrogenases by 2-Thiohydantoin Compounds. 2015 J. Med. Chem. pmid:26280302
Liu Z et al. Inhibition of cancer-associated mutant isocitrate dehydrogenases: synthesis, structure-activity relationship, and selective antitumor activity. 2014 J. Med. Chem. pmid:25271760
Lee JS et al. A Korean girl with alpha-aminoadipic and alpha-ketoadipic aciduria accompanied with elevation of 2-hydroxyglutarate and glutarate. 2001 J. Inherit. Metab. Dis. pmid:11596655
Struys EA et al. Kinetic characterization of human hydroxyacid-oxoacid transhydrogenase: relevance to D-2-hydroxyglutaric and gamma-hydroxybutyric acidurias. 2005 J. Inherit. Metab. Dis. pmid:16435184
Read MH et al. Clinical, biochemical, magnetic resonance imaging (MRI) and proton magnetic resonance spectroscopy (1H MRS) findings in a fourth case of combined D- and L-2 hydroxyglutaric aciduria. 2005 J. Inherit. Metab. Dis. pmid:16435212
Patay Z et al. Successive distinct high-grade gliomas in L-2-hydroxyglutaric aciduria. 2015 J. Inherit. Metab. Dis. pmid:25338511
Kranendijk M et al. Progress in understanding 2-hydroxyglutaric acidurias. 2012 J. Inherit. Metab. Dis. pmid:22391998
Bosch AM et al. Brown-Vialetto-Van Laere and Fazio Londe syndrome is associated with a riboflavin transporter defect mimicking mild MADD: a new inborn error of metabolism with potential treatment. 2011 J. Inherit. Metab. Dis. pmid:21110228
Kölker S et al. Diagnosis and management of glutaric aciduria type I--revised recommendations. 2011 J. Inherit. Metab. Dis. pmid:21431622
Brauburger K et al. The sodium-dependent di- and tricarboxylate transporter, NaCT, is not responsible for the uptake of D-, L-2-hydroxyglutarate and 3-hydroxyglutarate into neurons. 2011 J. Inherit. Metab. Dis. pmid:21264516
Gross S et al. Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate dehydrogenase 1 and 2 mutations. 2010 J. Exp. Med. pmid:20142433
Maxmen A Cancers converge at 2-HG. 2010 J. Exp. Med. pmid:20142426
Abdel-Wahab O and Levine RL Metabolism and the leukemic stem cell. 2010 J. Exp. Med. pmid:20368582
Yan W et al. Oncogene addiction in gliomas: implications for molecular targeted therapy. 2011 J. Exp. Clin. Cancer Res. pmid:21575270
Kochevenko A and Fernie AR The genetic architecture of branched-chain amino acid accumulation in tomato fruits. 2011 J. Exp. Bot. pmid:21436187
Choi C et al. Prospective Longitudinal Analysis of 2-Hydroxyglutarate Magnetic Resonance Spectroscopy Identifies Broad Clinical Utility for the Management of Patients With IDH-Mutant Glioma. 2016 J. Clin. Oncol. pmid:28248126
Lucca LE and Hafler DA Resisting fatal attraction: a glioma oncometabolite prevents CD8+ T cell recruitment. 2017 J. Clin. Invest. pmid:28319049
Terunuma A et al. MYC-driven accumulation of 2-hydroxyglutarate is associated with breast cancer prognosis. 2014 J. Clin. Invest. pmid:24316975
McKenney AS and Levine RL Isocitrate dehydrogenase mutations in leukemia. 2013 J. Clin. Invest. pmid:23999441
Andronesi OC et al. Detection of oncogenic IDH1 mutations using magnetic resonance spectroscopy of 2-hydroxyglutarate. 2013 J. Clin. Invest. pmid:23999439
Muth A et al. Simultaneous enantioselective analysis of chiral urinary metabolites in patients with Zellweger syndrome. 2003 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:12860034
Hans M et al. Spectroscopic evidence for an all-ferrous [4Fe-4S]0 cluster in the superreduced activator of 2-hydroxyglutaryl-CoA dehydratase from Acidaminococcus fermentans. 2008 J. Biol. Inorg. Chem. pmid:18274792
Nadtochiy SM et al. Acidic pH Is a Metabolic Switch for 2-Hydroxyglutarate Generation and Signaling. 2016 J. Biol. Chem. pmid:27510037
Becker-Kettern J et al. Saccharomyces cerevisiae Forms D-2-Hydroxyglutarate and Couples Its Degradation to D-Lactate Formation via a Cytosolic Transhydrogenase. 2016 J. Biol. Chem. pmid:26774271
Engqvist M et al. Two D-2-hydroxy-acid dehydrogenases in Arabidopsis thaliana with catalytic capacities to participate in the last reactions of the methylglyoxal and beta-oxidation pathways. 2009 J. Biol. Chem. pmid:19586914
Reitman ZJ et al. Cancer-associated isocitrate dehydrogenase 1 (IDH1) R132H mutation and d-2-hydroxyglutarate stimulate glutamine metabolism under hypoxia. 2014 J. Biol. Chem. pmid:24986863
Ward PS et al. The potential for isocitrate dehydrogenase mutations to produce 2-hydroxyglutarate depends on allele specificity and subcellular compartmentalization. 2013 J. Biol. Chem. pmid:23264629
Grassian AR et al. Isocitrate dehydrogenase (IDH) mutations promote a reversible ZEB1/microRNA (miR)-200-dependent epithelial-mesenchymal transition (EMT). 2012 J. Biol. Chem. pmid:23038259
Deng G et al. Selective inhibition of mutant isocitrate dehydrogenase 1 (IDH1) via disruption of a metal binding network by an allosteric small molecule. 2015 J. Biol. Chem. pmid:25391653
Kaufman EE et al. Isolation and characterization of a hydroxyacid-oxoacid transhydrogenase from rat kidney mitochondria. 1988 J. Biol. Chem. pmid:3182820
Leonardi R et al. Cancer-associated isocitrate dehydrogenase mutations inactivate NADPH-dependent reductive carboxylation. 2012 J. Biol. Chem. pmid:22442146
Kleessen S et al. Model-based confirmation of alternative substrates of mitochondrial electron transport chain. 2012 J. Biol. Chem. pmid:22334689
Engqvist MK et al. Plant D-2-hydroxyglutarate dehydrogenase participates in the catabolism of lysine especially during senescence. 2011 J. Biol. Chem. pmid:21296880
Pearson LA et al. Characterization of the 2-hydroxy-acid dehydrogenase McyI, encoded within the microcystin biosynthesis gene cluster of Microcystis aeruginosa PCC7806. 2007 J. Biol. Chem. pmid:17142460
Albers E et al. Ser3p (Yer081wp) and Ser33p (Yil074cp) are phosphoglycerate dehydrogenases in Saccharomyces cerevisiae. 2003 J. Biol. Chem. pmid:12525494
Kalliri E et al. Identification of Escherichia coli YgaF as an L-2-hydroxyglutarate oxidase. 2008 J. Bacteriol. pmid:18390652
Zhao G and Winkler ME A novel alpha-ketoglutarate reductase activity of the serA-encoded 3-phosphoglycerate dehydrogenase of Escherichia coli K-12 and its possible implications for human 2-hydroxyglutaric aciduria. 1996 J. Bacteriol. pmid:8550422
REEVES HC et al. ALPHA-HYDROXYGLUTARATE: PRODUCT OF AN ENZYMATIC BETA-CONDENSATION BETWEEN GLYOXYLATE AND PROPIONYL-COENZYME A. 1963 J. Bacteriol. pmid:14086118
Zhang C and Gänzle MG Metabolic pathway of α-ketoglutarate in Lactobacillus sanfranciscensis and Lactobacillus reuteri during sourdough fermentation. 2010 J. Appl. Microbiol. pmid:20477886
Obayashi H et al. Plasma 2-hydroxyglutarate and hexanoylcarnitine levels are potential biomarkers for skeletal muscle toxicity in male Fischer 344 rats. 2017 J Toxicol Sci pmid:28717097
Chotirat S et al. Molecular alterations of isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) metabolic genes and additional genetic mutations in newly diagnosed acute myeloid leukemia patients. 2012 J Hematol Oncol pmid:22397365
Takahashi S Current findings for recurring mutations in acute myeloid leukemia. 2011 J Hematol Oncol pmid:21917154
Capper D et al. 2-Hydroxyglutarate concentration in serum from patients with gliomas does not correlate with IDH1/2 mutation status or tumor size. 2012 Int. J. Cancer pmid:21913188
Churchill H et al. Discordant intracellular and plasma D-2-hydroxyglutarate levels in a patient with IDH2 mutated angioimmunoblastic T-cell lymphoma. 2015 Int J Clin Exp Pathol pmid:26617922
Smolková K and Ježek P The Role of Mitochondrial NADPH-Dependent Isocitrate Dehydrogenase in Cancer Cells. 2012 Int J Cell Biol pmid:22675360
Kranendijk M et al. Evidence for genetic heterogeneity in D-2-hydroxyglutaric aciduria. 2010 Hum. Mutat. pmid:20020533
Kingsbury JM et al. Cancer-associated isocitrate dehydrogenase mutations induce mitochondrial DNA instability. 2016 Hum. Mol. Genet. pmid:27427385