2-hydroxyglutaric acid

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There are no associated biomedical information in the current reference collection.

Current reference collection contains 1586 references associated with 2-hydroxyglutaric acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

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Here are additional resources we collected from PubChem and MeSH for 2-hydroxyglutaric acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 2-hydroxyglutaric acid

MeSH term MeSH ID Detail
Tyrosinemias D020176 2 associated lipids
Canavan Disease D017825 2 associated lipids
Hyperoxaluria D006959 3 associated lipids
Phenylketonurias D010661 7 associated lipids
Metabolic Diseases D008659 12 associated lipids
Total 5

PubChem Associated disorders and diseases

PubChem Biomolecular Interactions and Pathways

NCBI Entrez Crosslinks

All references with 2-hydroxyglutaric acid

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Authors Title Published Journal PubMed Link
Nota B et al. Deficiency in SLC25A1, encoding the mitochondrial citrate carrier, causes combined D-2- and L-2-hydroxyglutaric aciduria. 2013 Am. J. Hum. Genet. pmid:23561848
Struys EA et al. Mutations in the D-2-hydroxyglutarate dehydrogenase gene cause D-2-hydroxyglutaric aciduria. 2005 Am. J. Hum. Genet. pmid:15609246
Hwang VJ et al. The cpk model of recessive PKD shows glutamine dependence associated with the production of the oncometabolite 2-hydroxyglutarate. 2015 Am. J. Physiol. Renal Physiol. pmid:26155843
Işıkay S et al. A child with L-2 hydroxyglutaric aciduria presenting with dilated cardiomyopathy: coincidence or a new syndrome? 2014 Anadolu Kardiyol Derg pmid:24382499
Pichumani K et al. Conditions for (13)C NMR detection of 2-hydroxyglutarate in tissue extracts from isocitrate dehydrogenase-mutated gliomas. 2015 Anal. Biochem. pmid:25908561
van der Knaap MS et al. D-2-Hydroxyglutaric aciduria: biochemical marker or clinical disease entity? 1999 Ann. Neurol. pmid:9894884
González R et al. Growth and final product formation by Bifidobacterium infantis in aerated fermentations. 2004 Appl. Microbiol. Biotechnol. pmid:15085297
Constantin A et al. Identifying malignant transformations in recurrent low grade gliomas using high resolution magic angle spinning spectroscopy. 2012 Artif Intell Med pmid:22387185
Achouri Y et al. Identification of a dehydrogenase acting on D-2-hydroxyglutarate. 2004 Biochem. J. pmid:15070399
Parthasarathy A et al. Substrate specificity of 2-hydroxyglutaryl-CoA dehydratase from Clostridium symbiosum: toward a bio-based production of adipic acid. 2011 Biochemistry pmid:21434666
Roymoulik I et al. Rearrangement of L-2-hydroxyglutarate to L-threo-3-methylmalate catalyzed by adenosylcobalamin-dependent glutamate mutase. 2000 Biochemistry pmid:10956023
Riedel TJ et al. 4-Hydroxy-2-oxoglutarate aldolase inactivity in primary hyperoxaluria type 3 and glyoxylate reductase inhibition. 2012 Biochim. Biophys. Acta pmid:22771891
Kranendijk M et al. A lymphoblast model for IDH2 gain-of-function activity in d-2-hydroxyglutaric aciduria type II: novel avenues for biochemical and therapeutic studies. 2011 Biochim. Biophys. Acta pmid:21889589
da Silva CG et al. Inhibition of cytochrome c oxidase activity in rat cerebral cortex and human skeletal muscle by D-2-hydroxyglutaric acid in vitro. 2002 Biochim. Biophys. Acta pmid:11781152
Fernández-Briera A and Garrido-Pertierra A A degradation pathway of propionate in Salmonella typhimurium LT-2. 1988 Biochimie pmid:2844305
Li Y et al. Combined inactivation of the Clostridium cellulolyticum lactate and malate dehydrogenase genes substantially increases ethanol yield from cellulose and switchgrass fermentations. 2012 Biotechnol Biofuels pmid:22214220
Shi X et al. Functions of idh1 and its mutation in the regulation of developmental hematopoiesis in zebrafish. 2015 Blood pmid:25778530
Reitman ZJ et al. Genetic dissection of leukemia-associated IDH1 and IDH2 mutants and D-2-hydroxyglutarate in Drosophila. 2015 Blood pmid:25398939
DiNardo CD et al. Serum 2-hydroxyglutarate levels predict isocitrate dehydrogenase mutations and clinical outcome in acute myeloid leukemia. 2013 Blood pmid:23641016
Fathi AT et al. Prospective serial evaluation of 2-hydroxyglutarate, during treatment of newly diagnosed acute myeloid leukemia, to assess disease activity and therapeutic response. 2012 Blood pmid:23074281
Cairns RA et al. IDH2 mutations are frequent in angioimmunoblastic T-cell lymphoma. 2012 Blood pmid:22215888
Amatangelo MD et al. Enasidenib induces acute myeloid leukemia cell differentiation to promote clinical response. 2017 Blood pmid:28588019
Keum YS and Choi BY Isocitrate dehydrogenase mutations: new opportunities for translational research. 2015 BMB Rep pmid:25787993
Van Deun K et al. A structured overview of simultaneous component based data integration. 2009 BMC Bioinformatics pmid:19671149
Wang Y and Zhang YH Cell-free protein synthesis energized by slowly-metabolized maltodextrin. 2009 BMC Biotechnol. pmid:19558718
Jansen EE et al. Neurotransmitter alterations in embryonic succinate semialdehyde dehydrogenase (SSADH) deficiency suggest a heightened excitatory state during development. 2008 BMC Dev. Biol. pmid:19040727
Calduch-Giner JA et al. Use of microarray technology to assess the time course of liver stress response after confinement exposure in gilthead sea bream (Sparus aurata L.). 2010 BMC Genomics pmid:20307314
Butler JE et al. Genomic and microarray analysis of aromatics degradation in Geobacter metallireducens and comparison to a Geobacter isolate from a contaminated field site. 2007 BMC Genomics pmid:17578578
Tai H and Zhang Z A novel compound heterozygous mutation in a Chinese boy with L-2-hydroxyglutaric aciduria: a case study. 2015 BMC Neurol pmid:26208971
Khorassani R et al. Citramalic acid and salicylic acid in sugar beet root exudates solubilize soil phosphorus. 2011 BMC Plant Biol. pmid:21871058
Farias FH et al. A L2HGDH initiator methionine codon mutation in a Yorkshire terrier with L-2-hydroxyglutaric aciduria. 2012 BMC Vet. Res. pmid:22834903
Tateishi K et al. Extreme Vulnerability of IDH1 Mutant Cancers to NAD+ Depletion. 2015 Cancer Cell pmid:26678339
Xu W et al. Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases. 2011 Cancer Cell pmid:21251613
Figueroa ME et al. Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation. 2010 Cancer Cell pmid:21130701
Ward PS et al. The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate. 2010 Cancer Cell pmid:20171147
Frezza C et al. IDH1 mutations in gliomas: when an enzyme loses its grip. 2010 Cancer Cell pmid:20129244
Macaulay RJ Impending Impact of Molecular Pathology on Classifying Adult Diffuse Gliomas. 2015 Cancer Control pmid:26068765
Shim EH et al. L-2-Hydroxyglutarate: an epigenetic modifier and putative oncometabolite in renal cancer. 2014 Cancer Discov pmid:25182153
Elhammali A et al. A high-throughput fluorimetric assay for 2-hydroxyglutarate identifies Zaprinast as a glutaminase inhibitor. 2014 Cancer Discov pmid:24740997
Cairns RA and Mak TW Oncogenic isocitrate dehydrogenase mutations: mechanisms, models, and clinical opportunities. 2013 Cancer Discov pmid:23796461
Liesenfeld DB et al. Aspirin Reduces Plasma Concentrations of the Oncometabolite 2-Hydroxyglutarate: Results of a Randomized, Double-Blind, Crossover Trial. 2016 Cancer Epidemiol. Biomarkers Prev. pmid:26585118
Emir UE et al. Noninvasive Quantification of 2-Hydroxyglutarate in Human Gliomas with IDH1 and IDH2 Mutations. 2016 Cancer Res. pmid:26669865
Izquierdo-Garcia JL et al. IDH1 Mutation Induces Reprogramming of Pyruvate Metabolism. 2015 Cancer Res. pmid:26045167
Jin G et al. Disruption of wild-type IDH1 suppresses D-2-hydroxyglutarate production in IDH1-mutated gliomas. 2013 Cancer Res. pmid:23204232
Seltzer MJ et al. Inhibition of glutaminase preferentially slows growth of glioma cells with mutant IDH1. 2010 Cancer Res. pmid:21045145
Kato Kaneko M et al. Isocitrate dehydrogenase mutation is frequently observed in giant cell tumor of bone. 2014 Cancer Sci. pmid:24898068
Menendez JA et al. Gerometabolites: the pseudohypoxic aging side of cancer oncometabolites. 2014 Cell Cycle pmid:24526120
Durán RV and Hall MN Glutaminolysis feeds mTORC1. 2012 Cell Cycle pmid:23095634
Oizel K et al. D-2-Hydroxyglutarate does not mimic all the IDH mutation effects, in particular the reduced etoposide-triggered apoptosis mediated by an alteration in mitochondrial NADH. 2015 Cell Death Dis pmid:25811801
Lecoeur H et al. HIV-1 Tat protein directly induces mitochondrial membrane permeabilization and inactivates cytochrome c oxidase. 2012 Cell Death Dis pmid:22419111