2-hydroxyglutaric acid

Cross Reference

There are no associated biomedical information in the current reference collection.

Current reference collection contains 1586 references associated with 2-hydroxyglutaric acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

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Here are additional resources we collected from PubChem and MeSH for 2-hydroxyglutaric acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 2-hydroxyglutaric acid

MeSH term MeSH ID Detail
Metabolic Diseases D008659 12 associated lipids
Phenylketonurias D010661 7 associated lipids
Hyperoxaluria D006959 3 associated lipids
Canavan Disease D017825 2 associated lipids
Tyrosinemias D020176 2 associated lipids
Total 5

PubChem Associated disorders and diseases

PubChem Biomolecular Interactions and Pathways

NCBI Entrez Crosslinks

All references with 2-hydroxyglutaric acid

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Authors Title Published Journal PubMed Link
Lucca LE and Hafler DA Resisting fatal attraction: a glioma oncometabolite prevents CD8+ T cell recruitment. 2017 J. Clin. Invest. pmid:28319049
Intlekofer AM et al. L-2-Hydroxyglutarate production arises from noncanonical enzyme function at acidic pH. 2017 Nat. Chem. Biol. pmid:28263965
Chaturvedi A et al. Pan-mutant-IDH1 inhibitor BAY1436032 is highly effective against human IDH1 mutant acute myeloid leukemia in vivo. 2017 Leukemia pmid:28232670
Ma S et al. L2hgdh Deficiency Accumulates l-2-Hydroxyglutarate with Progressive Leukoencephalopathy and Neurodegeneration. 2017 Mol. Cell. Biol. pmid:28137912
Chen F et al. Oncometabolites d- and l-2-Hydroxyglutarate Inhibit the AlkB Family DNA Repair Enzymes under Physiological Conditions. 2017 Chem. Res. Toxicol. pmid:28269980
Tarhonskaya H et al. Studies on the Interaction of the Histone Demethylase KDM5B with Tricarboxylic Acid Cycle Intermediates. 2017 J. Mol. Biol. pmid:28827149
Obayashi H et al. Plasma 2-hydroxyglutarate and hexanoylcarnitine levels are potential biomarkers for skeletal muscle toxicity in male Fischer 344 rats. 2017 J Toxicol Sci pmid:28717097
Amatangelo MD et al. Enasidenib induces acute myeloid leukemia cell differentiation to promote clinical response. 2017 Blood pmid:28588019
Ansó E et al. The mitochondrial respiratory chain is essential for haematopoietic stem cell function. 2017 Nat. Cell Biol. pmid:28504706
Jiang B et al. IDH1 Mutation Promotes Tumorigenesis by Inhibiting JNK Activation and Apoptosis Induced by Serum Starvation. 2017 Cell Rep pmid:28402860
Kim H et al. In-Vivo Proton Magnetic Resonance Spectroscopy of 2-Hydroxyglutarate in Isocitrate Dehydrogenase-Mutated Gliomas: A Technical Review for Neuroradiologists. 2016 Sep-Oct Korean J Radiol pmid:27587950
Fujii T et al. Targeting isocitrate dehydrogenase (IDH) in cancer. 2016 Discov Med pmid:27355333
Ricoult SJ et al. Sterol Regulatory Element Binding Protein Regulates the Expression and Metabolic Functions of Wild-Type and Oncogenic IDH1. 2016 Mol. Cell. Biol. pmid:27354064
Teng X et al. Lactate Dehydrogenase C Produces S-2-Hydroxyglutarate in Mouse Testis. 2016 ACS Chem. Biol. pmid:27333189
Nagashima H et al. Diagnostic value of glutamate with 2-hydroxyglutarate in magnetic resonance spectroscopy for IDH1 mutant glioma. 2016 Neuro-oncology pmid:27154922
Chaturvedi A et al. Enantiomer-specific and paracrine leukemogenicity of mutant IDH metabolite 2-hydroxyglutarate. 2016 Leukemia pmid:27063596
Fiehn O et al. Registered report: The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate. 2016 Elife pmid:26943899
Fathi AT et al. Elevation of Urinary 2-Hydroxyglutarate in IDH-Mutant Glioma. 2016 Oncologist pmid:26834160
Heo H et al. On the Utility of Short Echo Time (TE) Single Voxel 1H-MRS in Non-Invasive Detection of 2-Hydroxyglutarate (2HG); Challenges and Potential Improvement Illustrated with Animal Models Using MRUI and LCModel. 2016 PLoS ONE pmid:26820720
Becker-Kettern J et al. Saccharomyces cerevisiae Forms D-2-Hydroxyglutarate and Couples Its Degradation to D-Lactate Formation via a Cytosolic Transhydrogenase. 2016 J. Biol. Chem. pmid:26774271