2-hydroxyglutaric acid

Cross Reference

There are no associated biomedical information in the current reference collection.

Current reference collection contains 1586 references associated with 2-hydroxyglutaric acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.

Here are additional resources we collected from PubChem and MeSH for 2-hydroxyglutaric acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 2-hydroxyglutaric acid

MeSH term MeSH ID Detail
Metabolic Diseases D008659 12 associated lipids
Phenylketonurias D010661 7 associated lipids
Hyperoxaluria D006959 3 associated lipids
Canavan Disease D017825 2 associated lipids
Tyrosinemias D020176 2 associated lipids
Total 5

PubChem Associated disorders and diseases

PubChem Biomolecular Interactions and Pathways

NCBI Entrez Crosslinks

All references with 2-hydroxyglutaric acid

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Authors Title Published Journal PubMed Link
Tateishi K et al. Extreme Vulnerability of IDH1 Mutant Cancers to NAD+ Depletion. 2015 Cancer Cell pmid:26678339
Churchill H et al. Discordant intracellular and plasma D-2-hydroxyglutarate levels in a patient with IDH2 mutated angioimmunoblastic T-cell lymphoma. 2015 Int J Clin Exp Pathol pmid:26617922
Li F et al. NADP(+)-IDH Mutations Promote Hypersuccinylation that Impairs Mitochondria Respiration and Induces Apoptosis Resistance. 2015 Mol. Cell pmid:26585387
Cheng QY et al. Sensitive Determination of Onco-metabolites of D- and L-2-hydroxyglutarate Enantiomers by Chiral Derivatization Combined with Liquid Chromatography/Mass Spectrometry Analysis. 2015 Sci Rep pmid:26458332
Nadtochiy SM et al. Metabolomic profiling of the heart during acute ischemic preconditioning reveals a role for SIRT1 in rapid cardioprotective metabolic adaptation. 2015 J. Mol. Cell. Cardiol. pmid:26388263
Li L et al. Treatment with a Small Molecule Mutant IDH1 Inhibitor Suppresses Tumorigenic Activity and Decreases Production of the Oncometabolite 2-Hydroxyglutarate in Human Chondrosarcoma Cells. 2015 PLoS ONE pmid:26368816
Wu F et al. Inhibition of Cancer-Associated Mutant Isocitrate Dehydrogenases by 2-Thiohydantoin Compounds. 2015 J. Med. Chem. pmid:26280302
Evans B and Griner E Registered report: Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases. 2015 Elife pmid:26231040
Intlekofer AM et al. Hypoxia Induces Production of L-2-Hydroxyglutarate. 2015 Cell Metab. pmid:26212717
Oldham WM et al. Hypoxia-Mediated Increases in L-2-hydroxyglutarate Coordinate the Metabolic Response to Reductive Stress. 2015 Cell Metab. pmid:26212716
Hirata M et al. Mutant IDH is sufficient to initiate enchondromatosis in mice. 2015 Proc. Natl. Acad. Sci. U.S.A. pmid:25730874
Charitou P et al. FOXOs support the metabolic requirements of normal and tumor cells by promoting IDH1 expression. 2015 EMBO Rep. pmid:25648147
Chan SM et al. Isocitrate dehydrogenase 1 and 2 mutations induce BCL-2 dependence in acute myeloid leukemia. 2015 Nat. Med. pmid:25599133
Fan J et al. Human phosphoglycerate dehydrogenase produces the oncometabolite D-2-hydroxyglutarate. 2015 ACS Chem. Biol. pmid:25406093
Reitman ZJ et al. Genetic dissection of leukemia-associated IDH1 and IDH2 mutants and D-2-hydroxyglutarate in Drosophila. 2015 Blood pmid:25398939
Patay Z et al. Successive distinct high-grade gliomas in L-2-hydroxyglutaric aciduria. 2015 J. Inherit. Metab. Dis. pmid:25338511
Wen H et al. Metabolomic comparison between cells over-expressing isocitrate dehydrogenase 1 and 2 mutants and the effects of an inhibitor on the metabolism. 2015 J. Neurochem. pmid:25251602
Suijker J et al. Inhibition of mutant IDH1 decreases D-2-HG levels without affecting tumorigenic properties of chondrosarcoma cell lines. 2015 Oncotarget pmid:25895133
Worth AJ et al. Rotenone Stereospecifically Increases (S)-2-Hydroxyglutarate in SH-SY5Y Neuronal Cells. 2015 Chem. Res. Toxicol. pmid:25800467
Deng G et al. Selective inhibition of mutant isocitrate dehydrogenase 1 (IDH1) via disruption of a metal binding network by an allosteric small molecule. 2015 J. Biol. Chem. pmid:25391653