2-hydroxyglutaric acid

Cross Reference

There are no associated biomedical information in the current reference collection.

Current reference collection contains 1586 references associated with 2-hydroxyglutaric acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.

Here are additional resources we collected from PubChem and MeSH for 2-hydroxyglutaric acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 2-hydroxyglutaric acid

MeSH term MeSH ID Detail
Metabolic Diseases D008659 12 associated lipids
Phenylketonurias D010661 7 associated lipids
Hyperoxaluria D006959 3 associated lipids
Canavan Disease D017825 2 associated lipids
Tyrosinemias D020176 2 associated lipids
Total 5

PubChem Associated disorders and diseases

PubChem Biomolecular Interactions and Pathways

NCBI Entrez Crosslinks

All references with 2-hydroxyglutaric acid

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Authors Title Published Journal PubMed Link
Johannessen TA et al. Rapid Conversion of Mutant IDH1 from Driver to Passenger in a Model of Human Gliomagenesis. 2016 Mol. Cancer Res. pmid:27430238
Kingsbury JM et al. Cancer-associated isocitrate dehydrogenase mutations induce mitochondrial DNA instability. 2016 Hum. Mol. Genet. pmid:27427385
Jafari-Khouzani K et al. Volumetric relationship between 2-hydroxyglutarate and FLAIR hyperintensity has potential implications for radiotherapy planning of mutant IDH glioma patients. 2016 Neuro-oncology pmid:27382115
Hirata M et al. Mutant IDH is sufficient to initiate enchondromatosis in mice. 2015 Proc. Natl. Acad. Sci. U.S.A. pmid:25730874
Charitou P et al. FOXOs support the metabolic requirements of normal and tumor cells by promoting IDH1 expression. 2015 EMBO Rep. pmid:25648147
Chan SM et al. Isocitrate dehydrogenase 1 and 2 mutations induce BCL-2 dependence in acute myeloid leukemia. 2015 Nat. Med. pmid:25599133
Fan J et al. Human phosphoglycerate dehydrogenase produces the oncometabolite D-2-hydroxyglutarate. 2015 ACS Chem. Biol. pmid:25406093
Reitman ZJ et al. Genetic dissection of leukemia-associated IDH1 and IDH2 mutants and D-2-hydroxyglutarate in Drosophila. 2015 Blood pmid:25398939
Patay Z et al. Successive distinct high-grade gliomas in L-2-hydroxyglutaric aciduria. 2015 J. Inherit. Metab. Dis. pmid:25338511
Wen H et al. Metabolomic comparison between cells over-expressing isocitrate dehydrogenase 1 and 2 mutants and the effects of an inhibitor on the metabolism. 2015 J. Neurochem. pmid:25251602