2-hydroxyglutaric acid

Cross Reference

There are no associated biomedical information in the current reference collection.

Current reference collection contains 1586 references associated with 2-hydroxyglutaric acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.

Here are additional resources we collected from PubChem and MeSH for 2-hydroxyglutaric acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 2-hydroxyglutaric acid

MeSH term MeSH ID Detail
Metabolic Diseases D008659 12 associated lipids
Phenylketonurias D010661 7 associated lipids
Hyperoxaluria D006959 3 associated lipids
Canavan Disease D017825 2 associated lipids
Tyrosinemias D020176 2 associated lipids
Total 5

PubChem Associated disorders and diseases

PubChem Biomolecular Interactions and Pathways

NCBI Entrez Crosslinks

All references with 2-hydroxyglutaric acid

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Authors Title Published Journal PubMed Link
Tai H and Zhang Z A novel compound heterozygous mutation in a Chinese boy with L-2-hydroxyglutaric aciduria: a case study. 2015 BMC Neurol pmid:26208971
Fu X et al. 2-Hydroxyglutarate Inhibits ATP Synthase and mTOR Signaling. 2015 Cell Metab. pmid:26190651
Hwang VJ et al. The cpk model of recessive PKD shows glutamine dependence associated with the production of the oncometabolite 2-hydroxyglutarate. 2015 Am. J. Physiol. Renal Physiol. pmid:26155843
Macaulay RJ Impending Impact of Molecular Pathology on Classifying Adult Diffuse Gliomas. 2015 Cancer Control pmid:26068765
Suijker J et al. The oncometabolite D-2-hydroxyglutarate induced by mutant IDH1 or -2 blocks osteoblast differentiation in vitro and in vivo. 2015 Oncotarget pmid:26046462
Izquierdo-Garcia JL et al. IDH1 Mutation Induces Reprogramming of Pyruvate Metabolism. 2015 Cancer Res. pmid:26045167
Pichumani K et al. Conditions for (13)C NMR detection of 2-hydroxyglutarate in tissue extracts from isocitrate dehydrogenase-mutated gliomas. 2015 Anal. Biochem. pmid:25908561
Lombardi G et al. Diagnostic value of plasma and urinary 2-hydroxyglutarate to identify patients with isocitrate dehydrogenase-mutated glioma. 2015 Oncologist pmid:25862748
Natsumeda M et al. Accumulation of 2-hydroxyglutarate in gliomas correlates with survival: a study by 3.0-tesla magnetic resonance spectroscopy. 2014 Acta Neuropathol Commun pmid:25376594
Chittaranjan S et al. Mutations in CIC and IDH1 cooperatively regulate 2-hydroxyglutarate levels and cell clonogenicity. 2014 Oncotarget pmid:25277207
Liu Z et al. Inhibition of cancer-associated mutant isocitrate dehydrogenases: synthesis, structure-activity relationship, and selective antitumor activity. 2014 J. Med. Chem. pmid:25271760
Shim EH et al. L-2-Hydroxyglutarate: an epigenetic modifier and putative oncometabolite in renal cancer. 2014 Cancer Discov pmid:25182153
Saha SK et al. Mutant IDH inhibits HNF-4α to block hepatocyte differentiation and promote biliary cancer. 2014 Nature pmid:25043045
Pope WB Intraoperative mass spectrometry of tumor metabolites. 2014 Proc. Natl. Acad. Sci. U.S.A. pmid:25028494
Reitman ZJ et al. Cancer-associated isocitrate dehydrogenase 1 (IDH1) R132H mutation and d-2-hydroxyglutarate stimulate glutamine metabolism under hypoxia. 2014 J. Biol. Chem. pmid:24986863
Santagata S et al. Intraoperative mass spectrometry mapping of an onco-metabolite to guide brain tumor surgery. 2014 Proc. Natl. Acad. Sci. U.S.A. pmid:24982150
Kato Kaneko M et al. Isocitrate dehydrogenase mutation is frequently observed in giant cell tumor of bone. 2014 Cancer Sci. pmid:24898068
Fathi AT et al. Isocitrate dehydrogenase 1 (IDH1) mutation in breast adenocarcinoma is associated with elevated levels of serum and urine 2-hydroxyglutarate. 2014 Oncologist pmid:24760710
Elhammali A et al. A high-throughput fluorimetric assay for 2-hydroxyglutarate identifies Zaprinast as a glutaminase inhibitor. 2014 Cancer Discov pmid:24740997
Gilbert MR et al. Autophagy and oxidative stress in gliomas with IDH1 mutations. 2014 Acta Neuropathol. pmid:24150401