2-hydroxyglutaric acid

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There are no associated biomedical information in the current reference collection.

Current reference collection contains 1586 references associated with 2-hydroxyglutaric acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.

Here are additional resources we collected from PubChem and MeSH for 2-hydroxyglutaric acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 2-hydroxyglutaric acid

MeSH term MeSH ID Detail
Metabolic Diseases D008659 12 associated lipids
Phenylketonurias D010661 7 associated lipids
Hyperoxaluria D006959 3 associated lipids
Tyrosinemias D020176 2 associated lipids
Canavan Disease D017825 2 associated lipids
Total 5

PubChem Associated disorders and diseases

PubChem Biomolecular Interactions and Pathways

NCBI Entrez Crosslinks

All references with 2-hydroxyglutaric acid

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Authors Title Published Journal PubMed Link
Seltzer MJ et al. Inhibition of glutaminase preferentially slows growth of glioma cells with mutant IDH1. 2010 Cancer Res. pmid:21045145
O'Keefe LV et al. Drosophila orthologue of WWOX, the chromosomal fragile site FRA16D tumour suppressor gene, functions in aerobic metabolism and regulates reactive oxygen species. 2011 Hum. Mol. Genet. pmid:21075834
pmid:21080253
Bosch AM et al. Brown-Vialetto-Van Laere and Fazio Londe syndrome is associated with a riboflavin transporter defect mimicking mild MADD: a new inborn error of metabolism with potential treatment. 2011 J. Inherit. Metab. Dis. pmid:21110228
Figueroa ME et al. Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation. 2010 Cancer Cell pmid:21130701
Paravati AJ et al. Radiotherapy and temozolomide for newly diagnosed glioblastoma and anaplastic astrocytoma: validation of Radiation Therapy Oncology Group-Recursive Partitioning Analysis in the IMRT and temozolomide era. 2011 J. Neurooncol. pmid:21181233
Lu Y et al. Chloroplast 2010: a database for large-scale phenotypic screening of Arabidopsis mutants. 2011 Plant Physiol. pmid:21224340
pmid:21225914
Xu W et al. Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases. 2011 Cancer Cell pmid:21251613
Brauburger K et al. The sodium-dependent di- and tricarboxylate transporter, NaCT, is not responsible for the uptake of D-, L-2-hydroxyglutarate and 3-hydroxyglutarate into neurons. 2011 J. Inherit. Metab. Dis. pmid:21264516
Kones R Rosuvastatin, inflammation, C-reactive protein, JUPITER, and primary prevention of cardiovascular disease--a perspective. 2010 Drug Des Devel Ther pmid:21267417
pmid:21284999
Reitman ZJ et al. Profiling the effects of isocitrate dehydrogenase 1 and 2 mutations on the cellular metabolome. 2011 Proc. Natl. Acad. Sci. U.S.A. pmid:21289278
pmid:21294161
Engqvist MK et al. Plant D-2-hydroxyglutarate dehydrogenase participates in the catabolism of lysine especially during senescence. 2011 J. Biol. Chem. pmid:21296880
Frezza C et al. Inborn and acquired metabolic defects in cancer. 2011 J. Mol. Med. pmid:21301796
Chovatia M et al. Complete genome sequence of Thermanaerovibrio acidaminovorans type strain (Su883). 2009 Stand Genomic Sci pmid:21304665
Chang YJ et al. Complete genome sequence of Acidaminococcus fermentans type strain (VR4). 2010 Stand Genomic Sci pmid:21304687
Araújo WL et al. Antisense inhibition of the iron-sulphur subunit of succinate dehydrogenase enhances photosynthesis and growth in tomato via an organic acid-mediated effect on stomatal aperture. 2011 Plant Cell pmid:21307286
Jin G et al. 2-hydroxyglutarate production, but not dominant negative function, is conferred by glioma-derived NADP-dependent isocitrate dehydrogenase mutations. 2011 PLoS ONE pmid:21326614
Kölker S et al. Diagnosis and management of glutaric aciduria type I--revised recommendations. 2011 J. Inherit. Metab. Dis. pmid:21431622
Parthasarathy A et al. Substrate specificity of 2-hydroxyglutaryl-CoA dehydratase from Clostridium symbiosum: toward a bio-based production of adipic acid. 2011 Biochemistry pmid:21434666
Kochevenko A and Fernie AR The genetic architecture of branched-chain amino acid accumulation in tomato fruits. 2011 J. Exp. Bot. pmid:21436187
pmid:21446021
Chowdhury R et al. The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases. 2011 EMBO Rep. pmid:21460794
Zhang Y Biology of the Mi-2/NuRD Complex in SLAC (Stemness, Longevity/Ageing, and Cancer). 2011 Gene Regul Syst Bio pmid:21523247
pmid:21524095
pmid:21554053
Ramezani M et al. Glutamate racemization and catabolism in Fusobacterium varium. 2011 FEBS J. pmid:21575137
Yan W et al. Oncogene addiction in gliomas: implications for molecular targeted therapy. 2011 J. Exp. Clin. Cancer Res. pmid:21575270
Krell D et al. Screen for IDH1, IDH2, IDH3, D2HGDH and L2HGDH mutations in glioblastoma. 2011 PLoS ONE pmid:21625441
Fong MY et al. Identification of metabolites in the normal ovary and their transformation in primary and metastatic ovarian cancer. 2011 PLoS ONE pmid:21625518
pmid:21631627
pmid:21641335
Passamonti F et al. Myeloproliferative neoplasms: from JAK2 mutations discovery to JAK2 inhibitor therapies. 2011 Oncotarget pmid:21646683
Lages E et al. MicroRNA and target protein patterns reveal physiopathological features of glioma subtypes. 2011 PLoS ONE pmid:21655185
Saccenti E et al. Simplivariate models: uncovering the underlying biology in functional genomics data. 2011 PLoS ONE pmid:21698241
Bralten LB et al. Absence of common somatic alterations in genes on 1p and 19q in oligodendrogliomas. 2011 PLoS ONE pmid:21760942
Marie SK and Shinjo SM Metabolism and brain cancer. 2011 Clinics (Sao Paulo) pmid:21779721
Scott JG et al. Production of 2-hydroxyglutarate by isocitrate dehydrogenase 1-mutated gliomas: an evolutionary alternative to the Warburg shift? 2011 Neuro-oncology pmid:21784755
Araújo WL et al. Analysis of a range of catabolic mutants provides evidence that phytanoyl-coenzyme A does not act as a substrate of the electron-transfer flavoprotein/electron-transfer flavoprotein:ubiquinone oxidoreductase complex in Arabidopsis during dark-induced senescence. 2011 Plant Physiol. pmid:21788362
Fathi AT and Abdel-Wahab O Mutations in epigenetic modifiers in myeloid malignancies and the prospect of novel epigenetic-targeted therapy. 2012 Adv Hematol pmid:21811504
Ohka F et al. The global DNA methylation surrogate LINE-1 methylation is correlated with MGMT promoter methylation and is a better prognostic factor for glioma. 2011 PLoS ONE pmid:21829728
pmid:21857150
Khorassani R et al. Citramalic acid and salicylic acid in sugar beet root exudates solubilize soil phosphorus. 2011 BMC Plant Biol. pmid:21871058
pmid:21885076
Kranendijk M et al. A lymphoblast model for IDH2 gain-of-function activity in d-2-hydroxyglutaric aciduria type II: novel avenues for biochemical and therapeutic studies. 2011 Biochim. Biophys. Acta pmid:21889589
Haffner MC et al. Global 5-hydroxymethylcytosine content is significantly reduced in tissue stem/progenitor cell compartments and in human cancers. 2011 Oncotarget pmid:21896958
Tefferi A et al. IDH mutations in primary myelofibrosis predict leukemic transformation and shortened survival: clinical evidence for leukemogenic collaboration with JAK2V617F. 2012 Leukemia pmid:21912393
Capper D et al. 2-Hydroxyglutarate concentration in serum from patients with gliomas does not correlate with IDH1/2 mutation status or tumor size. 2012 Int. J. Cancer pmid:21913188