2-hydroxyglutaric acid

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There are no associated biomedical information in the current reference collection.

Current reference collection contains 1586 references associated with 2-hydroxyglutaric acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

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Here are additional resources we collected from PubChem and MeSH for 2-hydroxyglutaric acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 2-hydroxyglutaric acid

MeSH term MeSH ID Detail
Metabolic Diseases D008659 12 associated lipids
Phenylketonurias D010661 7 associated lipids
Hyperoxaluria D006959 3 associated lipids
Canavan Disease D017825 2 associated lipids
Tyrosinemias D020176 2 associated lipids
Total 5

PubChem Associated disorders and diseases

PubChem Biomolecular Interactions and Pathways

NCBI Entrez Crosslinks

All references with 2-hydroxyglutaric acid

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Authors Title Published Journal PubMed Link
Takahashi S Current findings for recurring mutations in acute myeloid leukemia. 2011 J Hematol Oncol pmid:21917154
pmid:21939466
Schulz N et al. Role of medium- and short-chain L-3-hydroxyacyl-CoA dehydrogenase in the regulation of body weight and thermogenesis. 2011 Endocrinology pmid:21990309
Vogel RF et al. Genomic analysis reveals Lactobacillus sanfranciscensis as stable element in traditional sourdoughs. 2011 Microb. Cell Fact. pmid:21995419
Ward PS et al. Identification of additional IDH mutations associated with oncometabolite R(-)-2-hydroxyglutarate production. 2012 Oncogene pmid:21996744
Guo C et al. Isocitrate dehydrogenase mutations in gliomas: mechanisms, biomarkers and therapeutic target. 2011 Curr. Opin. Neurol. pmid:22002076
Pope WB et al. Non-invasive detection of 2-hydroxyglutarate and other metabolites in IDH1 mutant glioma patients using magnetic resonance spectroscopy. 2012 J. Neurooncol. pmid:22015945
pmid:22025298
pmid:22030381
pmid:22057236
Borodovsky A et al. Altered cancer cell metabolism in gliomas with mutant IDH1 or IDH2. 2012 Curr Opin Oncol pmid:22080945
Nieto-Sampedro M et al. Inhibitors of Glioma Growth that Reveal the Tumour to the Immune System. 2011 Clin Med Insights Oncol pmid:22084619
Kaelin WG Cancer and altered metabolism: potential importance of hypoxia-inducible factor and 2-oxoglutarate-dependent dioxygenases. 2011 Cold Spring Harb. Symp. Quant. Biol. pmid:22089927
pmid:22105553
Luchman HA et al. An in vivo patient-derived model of endogenous IDH1-mutant glioma. 2012 Neuro-oncology pmid:22166263
pmid:22166653
Borger DR et al. Frequent mutation of isocitrate dehydrogenase (IDH)1 and IDH2 in cholangiocarcinoma identified through broad-based tumor genotyping. 2012 Oncologist pmid:22180306
Willquist K et al. Reassessment of hydrogen tolerance in Caldicellulosiruptor saccharolyticus. 2011 Microb. Cell Fact. pmid:22189215
Li Y et al. Combined inactivation of the Clostridium cellulolyticum lactate and malate dehydrogenase genes substantially increases ethanol yield from cellulose and switchgrass fermentations. 2012 Biotechnol Biofuels pmid:22214220
Cairns RA et al. IDH2 mutations are frequent in angioimmunoblastic T-cell lymphoma. 2012 Blood pmid:22215888
D'Alò F et al. Similarities and differences between therapy-related and elderly acute myeloid leukemia. 2011 Mediterr J Hematol Infect Dis pmid:22220249
Muñoz-Pinedo C et al. Cancer metabolism: current perspectives and future directions. 2012 Cell Death Dis pmid:22237205
Andronesi OC et al. Detection of 2-hydroxyglutarate in IDH-mutated glioma patients by in vivo spectral-editing and 2D correlation magnetic resonance spectroscopy. 2012 Sci Transl Med pmid:22238332
Elkhaled A et al. Magnetic resonance of 2-hydroxyglutarate in IDH1-mutated low-grade gliomas. 2012 Sci Transl Med pmid:22238333
Shaw RJ and Cantley LC Decoding key nodes in the metabolism of cancer cells: sugar & spice and all things nice. 2012 F1000 Biol Rep pmid:22242042
Bleeker FE et al. Recent advances in the molecular understanding of glioblastoma. 2012 J. Neurooncol. pmid:22270850
Bhatia S et al. Mycosporine and mycosporine-like amino acids: A paramount tool against ultra violet irradiation. 2011 Pharmacogn Rev pmid:22279371
Choi C et al. 2-hydroxyglutarate detection by magnetic resonance spectroscopy in IDH-mutated patients with gliomas. 2012 Nat. Med. pmid:22281806
Chow LM and Baker SJ Capturing the molecular and biological diversity of high-grade astrocytoma in genetically engineered mouse models. 2012 Oncotarget pmid:22287481
Kleessen S et al. Model-based confirmation of alternative substrates of mitochondrial electron transport chain. 2012 J. Biol. Chem. pmid:22334689
Koivunen P et al. Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation. 2012 Nature pmid:22343896
Lu C et al. IDH mutation impairs histone demethylation and results in a block to cell differentiation. 2012 Nature pmid:22343901
Kunimoto H et al. Tet2 disruption leads to enhanced self-renewal and altered differentiation of fetal liver hematopoietic stem cells. 2012 Sci Rep pmid:22355785
Constantin A et al. Identifying malignant transformations in recurrent low grade gliomas using high resolution magic angle spinning spectroscopy. 2012 Artif Intell Med pmid:22387185
Kranendijk M et al. Progress in understanding 2-hydroxyglutaric acidurias. 2012 J. Inherit. Metab. Dis. pmid:22391998
Chotirat S et al. Molecular alterations of isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) metabolic genes and additional genetic mutations in newly diagnosed acute myeloid leukemia patients. 2012 J Hematol Oncol pmid:22397365
pmid:22399191
Lecoeur H et al. HIV-1 Tat protein directly induces mitochondrial membrane permeabilization and inactivates cytochrome c oxidase. 2012 Cell Death Dis pmid:22419111
Kalinina J et al. Detection of "oncometabolite" 2-hydroxyglutarate by magnetic resonance analysis as a biomarker of IDH1/2 mutations in glioma. 2012 J. Mol. Med. pmid:22426639
Leonardi R et al. Cancer-associated isocitrate dehydrogenase mutations inactivate NADPH-dependent reductive carboxylation. 2012 J. Biol. Chem. pmid:22442146
pmid:22639207
Tohge T et al. From models to crop species: caveats and solutions for translational metabolomics. 2011 Front Plant Sci pmid:22639601
Maier A et al. Transgenic Introduction of a Glycolate Oxidative Cycle into A. thaliana Chloroplasts Leads to Growth Improvement. 2012 Front Plant Sci pmid:22639647
Fernie AR and Klee HJ The use of natural genetic diversity in the understanding of metabolic organization and regulation. 2011 Front Plant Sci pmid:22645543
Rellán-Álvarez R et al. Metabolite profile changes in xylem sap and leaf extracts of strategy I plants in response to iron deficiency and resupply. 2011 Front Plant Sci pmid:22645546
Smolková K and Ježek P The Role of Mitochondrial NADPH-Dependent Isocitrate Dehydrogenase in Cancer Cells. 2012 Int J Cell Biol pmid:22675360
Pollyea DA et al. 2-Hydroxyglutarate in IDH mutant acute myeloid leukemia: predicting patient responses, minimal residual disease and correlations with methylcytosine and hydroxymethylcytosine levels. 2013 Leuk. Lymphoma pmid:22680765
pmid:22683334
Mascarenhas J et al. Epigenetic abnormalities in myeloproliferative neoplasms: a target for novel therapeutic strategies. 2011 Clin Epigenetics pmid:22704337
Riedel TJ et al. 4-Hydroxy-2-oxoglutarate aldolase inactivity in primary hyperoxaluria type 3 and glyoxylate reductase inhibition. 2012 Biochim. Biophys. Acta pmid:22771891