2-hydroxyglutaric acid

Cross Reference

There are no associated biomedical information in the current reference collection.

Current reference collection contains 1586 references associated with 2-hydroxyglutaric acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.

Here are additional resources we collected from PubChem and MeSH for 2-hydroxyglutaric acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 2-hydroxyglutaric acid

MeSH term MeSH ID Detail
Metabolic Diseases D008659 12 associated lipids
Phenylketonurias D010661 7 associated lipids
Hyperoxaluria D006959 3 associated lipids
Canavan Disease D017825 2 associated lipids
Tyrosinemias D020176 2 associated lipids
Total 5

PubChem Associated disorders and diseases

PubChem Biomolecular Interactions and Pathways

NCBI Entrez Crosslinks

All references with 2-hydroxyglutaric acid

Download all related citations
Per page 10 20 50 100 | Total 448
Authors Title Published Journal PubMed Link
Durán RV and Hall MN Glutaminolysis feeds mTORC1. 2012 Cell Cycle pmid:23095634
Lazovic J et al. Detection of 2-hydroxyglutaric acid in vivo by proton magnetic resonance spectroscopy in U87 glioma cells overexpressing isocitrate dehydrogenase-1 mutation. 2012 Neuro-oncology pmid:23090985
Fathi AT et al. Prospective serial evaluation of 2-hydroxyglutarate, during treatment of newly diagnosed acute myeloid leukemia, to assess disease activity and therapeutic response. 2012 Blood pmid:23074281
Grassian AR et al. Isocitrate dehydrogenase (IDH) mutations promote a reversible ZEB1/microRNA (miR)-200-dependent epithelial-mesenchymal transition (EMT). 2012 J. Biol. Chem. pmid:23038259
Yang H et al. IDH1 and IDH2 mutations in tumorigenesis: mechanistic insights and clinical perspectives. 2012 Clin. Cancer Res. pmid:23071358
Sasaki M et al. D-2-hydroxyglutarate produced by mutant IDH1 perturbs collagen maturation and basement membrane function. 2012 Genes Dev. pmid:22925884
Yang M et al. The emerging role of fumarate as an oncometabolite. 2012 Front Oncol pmid:22866264
Farias FH et al. A L2HGDH initiator methionine codon mutation in a Yorkshire terrier with L-2-hydroxyglutaric aciduria. 2012 BMC Vet. Res. pmid:22834903
Riedel TJ et al. 4-Hydroxy-2-oxoglutarate aldolase inactivity in primary hyperoxaluria type 3 and glyoxylate reductase inhibition. 2012 Biochim. Biophys. Acta pmid:22771891
Smolková K and Ježek P The Role of Mitochondrial NADPH-Dependent Isocitrate Dehydrogenase in Cancer Cells. 2012 Int J Cell Biol pmid:22675360
Maier A et al. Transgenic Introduction of a Glycolate Oxidative Cycle into A. thaliana Chloroplasts Leads to Growth Improvement. 2012 Front Plant Sci pmid:22639647
Leonardi R et al. Cancer-associated isocitrate dehydrogenase mutations inactivate NADPH-dependent reductive carboxylation. 2012 J. Biol. Chem. pmid:22442146
Kalinina J et al. Detection of "oncometabolite" 2-hydroxyglutarate by magnetic resonance analysis as a biomarker of IDH1/2 mutations in glioma. 2012 J. Mol. Med. pmid:22426639
Li Y et al. Combined inactivation of the Clostridium cellulolyticum lactate and malate dehydrogenase genes substantially increases ethanol yield from cellulose and switchgrass fermentations. 2012 Biotechnol Biofuels pmid:22214220
Borger DR et al. Frequent mutation of isocitrate dehydrogenase (IDH)1 and IDH2 in cholangiocarcinoma identified through broad-based tumor genotyping. 2012 Oncologist pmid:22180306
Luchman HA et al. An in vivo patient-derived model of endogenous IDH1-mutant glioma. 2012 Neuro-oncology pmid:22166263
Borodovsky A et al. Altered cancer cell metabolism in gliomas with mutant IDH1 or IDH2. 2012 Curr Opin Oncol pmid:22080945
Pope WB et al. Non-invasive detection of 2-hydroxyglutarate and other metabolites in IDH1 mutant glioma patients using magnetic resonance spectroscopy. 2012 J. Neurooncol. pmid:22015945
Ward PS et al. Identification of additional IDH mutations associated with oncometabolite R(-)-2-hydroxyglutarate production. 2012 Oncogene pmid:21996744
Capper D et al. 2-Hydroxyglutarate concentration in serum from patients with gliomas does not correlate with IDH1/2 mutation status or tumor size. 2012 Int. J. Cancer pmid:21913188