2-hydroxyglutaric acid

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There are no associated biomedical information in the current reference collection.

Current reference collection contains 1586 references associated with 2-hydroxyglutaric acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

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Here are additional resources we collected from PubChem and MeSH for 2-hydroxyglutaric acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 2-hydroxyglutaric acid

MeSH term MeSH ID Detail
Metabolic Diseases D008659 12 associated lipids
Phenylketonurias D010661 7 associated lipids
Hyperoxaluria D006959 3 associated lipids
Tyrosinemias D020176 2 associated lipids
Canavan Disease D017825 2 associated lipids
Total 5

PubChem Associated disorders and diseases

PubChem Biomolecular Interactions and Pathways

NCBI Entrez Crosslinks

All references with 2-hydroxyglutaric acid

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Authors Title Published Journal PubMed Link
Ward PS et al. Identification of additional IDH mutations associated with oncometabolite R(-)-2-hydroxyglutarate production. 2012 Oncogene pmid:21996744
Fathi AT et al. Elevation of Urinary 2-Hydroxyglutarate in IDH-Mutant Glioma. 2016 Oncologist pmid:26834160
Lombardi G et al. Diagnostic value of plasma and urinary 2-hydroxyglutarate to identify patients with isocitrate dehydrogenase-mutated glioma. 2015 Oncologist pmid:25862748
Fathi AT et al. Isocitrate dehydrogenase 1 (IDH1) mutation in breast adenocarcinoma is associated with elevated levels of serum and urine 2-hydroxyglutarate. 2014 Oncologist pmid:24760710
Borger DR et al. Frequent mutation of isocitrate dehydrogenase (IDH)1 and IDH2 in cholangiocarcinoma identified through broad-based tumor genotyping. 2012 Oncologist pmid:22180306
Suijker J et al. The oncometabolite D-2-hydroxyglutarate induced by mutant IDH1 or -2 blocks osteoblast differentiation in vitro and in vivo. 2015 Oncotarget pmid:26046462
Ma S et al. D-2-hydroxyglutarate is essential for maintaining oncogenic property of mutant IDH-containing cancer cells but dispensable for cell growth. 2015 Oncotarget pmid:25825982
Chittaranjan S et al. Mutations in CIC and IDH1 cooperatively regulate 2-hydroxyglutarate levels and cell clonogenicity. 2014 Oncotarget pmid:25277207
Suijker J et al. Inhibition of mutant IDH1 decreases D-2-HG levels without affecting tumorigenic properties of chondrosarcoma cell lines. 2015 Oncotarget pmid:25895133
Chow LM and Baker SJ Capturing the molecular and biological diversity of high-grade astrocytoma in genetically engineered mouse models. 2012 Oncotarget pmid:22287481
Haffner MC et al. Global 5-hydroxymethylcytosine content is significantly reduced in tissue stem/progenitor cell compartments and in human cancers. 2011 Oncotarget pmid:21896958
Passamonti F et al. Myeloproliferative neoplasms: from JAK2 mutations discovery to JAK2 inhibitor therapies. 2011 Oncotarget pmid:21646683
Hagos Y et al. Organic anion transporters OAT1 and OAT4 mediate the high affinity transport of glutarate derivatives accumulating in patients with glutaric acidurias. 2008 Pflugers Arch. pmid:18365245
Bhatia S et al. Mycosporine and mycosporine-like amino acids: A paramount tool against ultra violet irradiation. 2011 Pharmacogn Rev pmid:22279371
Araújo WL et al. Identification of the 2-hydroxyglutarate and isovaleryl-CoA dehydrogenases as alternative electron donors linking lysine catabolism to the electron transport chain of Arabidopsis mitochondria. 2010 Plant Cell pmid:20501910
Araújo WL et al. Antisense inhibition of the iron-sulphur subunit of succinate dehydrogenase enhances photosynthesis and growth in tomato via an organic acid-mediated effect on stomatal aperture. 2011 Plant Cell pmid:21307286
Araújo WL et al. Analysis of a range of catabolic mutants provides evidence that phytanoyl-coenzyme A does not act as a substrate of the electron-transfer flavoprotein/electron-transfer flavoprotein:ubiquinone oxidoreductase complex in Arabidopsis during dark-induced senescence. 2011 Plant Physiol. pmid:21788362
Lu Y et al. Chloroplast 2010: a database for large-scale phenotypic screening of Arabidopsis mutants. 2011 Plant Physiol. pmid:21224340
Heo H et al. On the Utility of Short Echo Time (TE) Single Voxel 1H-MRS in Non-Invasive Detection of 2-Hydroxyglutarate (2HG); Challenges and Potential Improvement Illustrated with Animal Models Using MRUI and LCModel. 2016 PLoS ONE pmid:26820720
Li L et al. Treatment with a Small Molecule Mutant IDH1 Inhibitor Suppresses Tumorigenic Activity and Decreases Production of the Oncometabolite 2-Hydroxyglutarate in Human Chondrosarcoma Cells. 2015 PLoS ONE pmid:26368816
Rzem R et al. A mouse model of L-2-hydroxyglutaric aciduria, a disorder of metabolite repair. 2015 PLoS ONE pmid:25763823
Saccenti E et al. Simplivariate models: uncovering the underlying biology in functional genomics data. 2011 PLoS ONE pmid:21698241
Fong MY et al. Identification of metabolites in the normal ovary and their transformation in primary and metastatic ovarian cancer. 2011 PLoS ONE pmid:21625518
Ohka F et al. The global DNA methylation surrogate LINE-1 methylation is correlated with MGMT promoter methylation and is a better prognostic factor for glioma. 2011 PLoS ONE pmid:21829728
Bralten LB et al. Absence of common somatic alterations in genes on 1p and 19q in oligodendrogliomas. 2011 PLoS ONE pmid:21760942
Lages E et al. MicroRNA and target protein patterns reveal physiopathological features of glioma subtypes. 2011 PLoS ONE pmid:21655185
Krell D et al. Screen for IDH1, IDH2, IDH3, D2HGDH and L2HGDH mutations in glioblastoma. 2011 PLoS ONE pmid:21625441
Jin G et al. 2-hydroxyglutarate production, but not dominant negative function, is conferred by glioma-derived NADP-dependent isocitrate dehydrogenase mutations. 2011 PLoS ONE pmid:21326614
Hageman JA et al. Simplivariate models: ideas and first examples. 2008 PLoS ONE pmid:18810272
Rönicke R et al. Abeta mediated diminution of MTT reduction--an artefact of single cell culture? 2008 PLoS ONE pmid:18800168
Hirata M et al. Mutant IDH is sufficient to initiate enchondromatosis in mice. 2015 Proc. Natl. Acad. Sci. U.S.A. pmid:25730874
Pope WB Intraoperative mass spectrometry of tumor metabolites. 2014 Proc. Natl. Acad. Sci. U.S.A. pmid:25028494
Santagata S et al. Intraoperative mass spectrometry mapping of an onco-metabolite to guide brain tumor surgery. 2014 Proc. Natl. Acad. Sci. U.S.A. pmid:24982150
Wang JH et al. Prognostic significance of 2-hydroxyglutarate levels in acute myeloid leukemia in China. 2013 Proc. Natl. Acad. Sci. U.S.A. pmid:24082129
Reitman ZJ et al. Profiling the effects of isocitrate dehydrogenase 1 and 2 mutations on the cellular metabolome. 2011 Proc. Natl. Acad. Sci. U.S.A. pmid:21289278
Rzem R et al. A gene encoding a putative FAD-dependent L-2-hydroxyglutarate dehydrogenase is mutated in L-2-hydroxyglutaric aciduria. 2004 Proc. Natl. Acad. Sci. U.S.A. pmid:15548604
Mahfoud A et al. [L-2-hydroxyglutaric aciduria: clinical, biochemical and neuroradiological findings in two Venezuelan patients]. 2004 Aug 16-31 Rev Neurol pmid:15340893
Cheng QY et al. Sensitive Determination of Onco-metabolites of D- and L-2-hydroxyglutarate Enantiomers by Chiral Derivatization Combined with Liquid Chromatography/Mass Spectrometry Analysis. 2015 Sci Rep pmid:26458332
Kunimoto H et al. Tet2 disruption leads to enhanced self-renewal and altered differentiation of fetal liver hematopoietic stem cells. 2012 Sci Rep pmid:22355785
Elkhaled A et al. Magnetic resonance of 2-hydroxyglutarate in IDH1-mutated low-grade gliomas. 2012 Sci Transl Med pmid:22238333
Andronesi OC et al. Detection of 2-hydroxyglutarate in IDH-mutated glioma patients by in vivo spectral-editing and 2D correlation magnetic resonance spectroscopy. 2012 Sci Transl Med pmid:22238332
Wang F et al. Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation. 2013 Science pmid:23558173
Rohle D et al. An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells. 2013 Science pmid:23558169
Losman JA et al. (R)-2-hydroxyglutarate is sufficient to promote leukemogenesis and its effects are reversible. 2013 Science pmid:23393090
Kranendijk M et al. IDH2 mutations in patients with D-2-hydroxyglutaric aciduria. 2010 Science pmid:20847235
Chang YJ et al. Complete genome sequence of Acidaminococcus fermentans type strain (VR4). 2010 Stand Genomic Sci pmid:21304687
Chovatia M et al. Complete genome sequence of Thermanaerovibrio acidaminovorans type strain (Su883). 2009 Stand Genomic Sci pmid:21304665
Tomlinson L et al. Cannabinoid receptor antagonist-induced striated muscle toxicity and ethylmalonic-adipic aciduria in beagle dogs. 2012 Toxicol. Sci. pmid:22821849