2-hydroxyglutaric acid

There are no associated biomedical information in the current reference collection.

Current reference collection contains 1586 references associated with 2-hydroxyglutaric acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.


Here are additional resources we collected from PubChem and MeSH for 2-hydroxyglutaric acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 2-hydroxyglutaric acid

MeSH term MeSH ID Detail
Metabolic Diseases D008659 12 associated lipids
Phenylketonurias D010661 7 associated lipids
Hyperoxaluria D006959 3 associated lipids
Canavan Disease D017825 2 associated lipids
Tyrosinemias D020176 2 associated lipids
Total 5

PubChem Associated disorders and diseases

PubChem Biomolecular Interactions and Pathways

NCBI Entrez Crosslinks

All references with 2-hydroxyglutaric acid

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Authors Title Published Journal PubMed Link
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Ma S et al. L2hgdh Deficiency Accumulates l-2-Hydroxyglutarate with Progressive Leukoencephalopathy and Neurodegeneration. 2017 Mol. Cell. Biol. pmid:28137912
pmid:28148839
Chaturvedi A et al. Pan-mutant-IDH1 inhibitor BAY1436032 is highly effective against human IDH1 mutant acute myeloid leukemia in vivo. 2017 Leukemia pmid:28232670
Choi C et al. Prospective Longitudinal Analysis of 2-Hydroxyglutarate Magnetic Resonance Spectroscopy Identifies Broad Clinical Utility for the Management of Patients With IDH-Mutant Glioma. 2016 J. Clin. Oncol. pmid:28248126
Intlekofer AM et al. L-2-Hydroxyglutarate production arises from noncanonical enzyme function at acidic pH. 2017 Nat. Chem. Biol. pmid:28263965
Chen F et al. Oncometabolites d- and l-2-Hydroxyglutarate Inhibit the AlkB Family DNA Repair Enzymes under Physiological Conditions. 2017 Chem. Res. Toxicol. pmid:28269980
Lucca LE and Hafler DA Resisting fatal attraction: a glioma oncometabolite prevents CD8+ T cell recruitment. 2017 J. Clin. Invest. pmid:28319049
pmid:28346139
pmid:28375741
pmid:28396261
Jiang B et al. IDH1 Mutation Promotes Tumorigenesis by Inhibiting JNK Activation and Apoptosis Induced by Serum Starvation. 2017 Cell Rep pmid:28402860
pmid:28404805
Fernández-Briera A and Garrido-Pertierra A A degradation pathway of propionate in Salmonella typhimurium LT-2. 1988 Biochimie pmid:2844305
Ansó E et al. The mitochondrial respiratory chain is essential for haematopoietic stem cell function. 2017 Nat. Cell Biol. pmid:28504706
pmid:28564603
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Amatangelo MD et al. Enasidenib induces acute myeloid leukemia cell differentiation to promote clinical response. 2017 Blood pmid:28588019
pmid:28653623
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Obayashi H et al. Plasma 2-hydroxyglutarate and hexanoylcarnitine levels are potential biomarkers for skeletal muscle toxicity in male Fischer 344 rats. 2017 J Toxicol Sci pmid:28717097
pmid:28783731
Tarhonskaya H et al. Studies on the Interaction of the Histone Demethylase KDM5B with Tricarboxylic Acid Cycle Intermediates. 2017 J. Mol. Biol. pmid:28827149
pmid:29038145
Kaufman EE et al. Isolation and characterization of a hydroxyacid-oxoacid transhydrogenase from rat kidney mitochondria. 1988 J. Biol. Chem. pmid:3182820
Verhaeghe BJ et al. Solid-phase extraction with strong anion-exchange columns for selective isolation and concentration of urinary organic acids. 1988 Clin. Chem. pmid:3378323
Kuhara T et al. Studies of urinary organic acid profiles of a patient with dihydrolipoyl dehydrogenase deficiency. 1983 Clin. Chim. Acta pmid:6688766
Buckel W The reversible dehydration of (R)-2-hydroxyglutarate to (E)-glutaconate. 1980 Eur. J. Biochem. pmid:7398622
pmid:7515241
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Zhao G and Winkler ME A novel alpha-ketoglutarate reductase activity of the serA-encoded 3-phosphoglycerate dehydrogenase of Escherichia coli K-12 and its possible implications for human 2-hydroxyglutaric aciduria. 1996 J. Bacteriol. pmid:8550422
pmid:8639495
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van der Knaap MS et al. D-2-Hydroxyglutaric aciduria: biochemical marker or clinical disease entity? 1999 Ann. Neurol. pmid:9894884