Churchill H et al. |
Discordant intracellular and plasma D-2-hydroxyglutarate levels in a patient with IDH2 mutated angioimmunoblastic T-cell lymphoma. |
2015 |
Int J Clin Exp Pathol |
pmid:26617922
|
Li F et al. |
NADP(+)-IDH Mutations Promote Hypersuccinylation that Impairs Mitochondria Respiration and Induces Apoptosis Resistance. |
2015 |
Mol. Cell |
pmid:26585387
|
Cheng QY et al. |
Sensitive Determination of Onco-metabolites of D- and L-2-hydroxyglutarate Enantiomers by Chiral Derivatization Combined with Liquid Chromatography/Mass Spectrometry Analysis. |
2015 |
Sci Rep |
pmid:26458332
|
Nadtochiy SM et al. |
Metabolomic profiling of the heart during acute ischemic preconditioning reveals a role for SIRT1 in rapid cardioprotective metabolic adaptation. |
2015 |
J. Mol. Cell. Cardiol. |
pmid:26388263
|
Li L et al. |
Treatment with a Small Molecule Mutant IDH1 Inhibitor Suppresses Tumorigenic Activity and Decreases Production of the Oncometabolite 2-Hydroxyglutarate in Human Chondrosarcoma Cells. |
2015 |
PLoS ONE |
pmid:26368816
|
Wu F et al. |
Inhibition of Cancer-Associated Mutant Isocitrate Dehydrogenases by 2-Thiohydantoin Compounds. |
2015 |
J. Med. Chem. |
pmid:26280302
|
Evans B and Griner E |
Registered report: Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases. |
2015 |
Elife |
pmid:26231040
|
Keum YS and Choi BY |
Isocitrate dehydrogenase mutations: new opportunities for translational research. |
2015 |
BMB Rep |
pmid:25787993
|
Shi X et al. |
Functions of idh1 and its mutation in the regulation of developmental hematopoiesis in zebrafish. |
2015 |
Blood |
pmid:25778530
|
Rzem R et al. |
A mouse model of L-2-hydroxyglutaric aciduria, a disorder of metabolite repair. |
2015 |
PLoS ONE |
pmid:25763823
|
Hirata M et al. |
Mutant IDH is sufficient to initiate enchondromatosis in mice. |
2015 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:25730874
|
Charitou P et al. |
FOXOs support the metabolic requirements of normal and tumor cells by promoting IDH1 expression. |
2015 |
EMBO Rep. |
pmid:25648147
|
Chan SM et al. |
Isocitrate dehydrogenase 1 and 2 mutations induce BCL-2 dependence in acute myeloid leukemia. |
2015 |
Nat. Med. |
pmid:25599133
|
Fan J et al. |
Human phosphoglycerate dehydrogenase produces the oncometabolite D-2-hydroxyglutarate. |
2015 |
ACS Chem. Biol. |
pmid:25406093
|
Reitman ZJ et al. |
Genetic dissection of leukemia-associated IDH1 and IDH2 mutants and D-2-hydroxyglutarate in Drosophila. |
2015 |
Blood |
pmid:25398939
|
Patay Z et al. |
Successive distinct high-grade gliomas in L-2-hydroxyglutaric aciduria. |
2015 |
J. Inherit. Metab. Dis. |
pmid:25338511
|
Wen H et al. |
Metabolomic comparison between cells over-expressing isocitrate dehydrogenase 1 and 2 mutants and the effects of an inhibitor on the metabolism. |
2015 |
J. Neurochem. |
pmid:25251602
|
Suijker J et al. |
Inhibition of mutant IDH1 decreases D-2-HG levels without affecting tumorigenic properties of chondrosarcoma cell lines. |
2015 |
Oncotarget |
pmid:25895133
|
Worth AJ et al. |
Rotenone Stereospecifically Increases (S)-2-Hydroxyglutarate in SH-SY5Y Neuronal Cells. |
2015 |
Chem. Res. Toxicol. |
pmid:25800467
|
Deng G et al. |
Selective inhibition of mutant isocitrate dehydrogenase 1 (IDH1) via disruption of a metal binding network by an allosteric small molecule. |
2015 |
J. Biol. Chem. |
pmid:25391653
|