2-hydroxyglutaric acid

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There are no associated biomedical information in the current reference collection.

Current reference collection contains 1586 references associated with 2-hydroxyglutaric acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

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Here are additional resources we collected from PubChem and MeSH for 2-hydroxyglutaric acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 2-hydroxyglutaric acid

MeSH term MeSH ID Detail
Phenylketonurias D010661 7 associated lipids
Canavan Disease D017825 2 associated lipids
Metabolic Diseases D008659 12 associated lipids
Tyrosinemias D020176 2 associated lipids
Hyperoxaluria D006959 3 associated lipids
Total 5

PubChem Associated disorders and diseases

PubChem Biomolecular Interactions and Pathways

NCBI Entrez Crosslinks

All references with 2-hydroxyglutaric acid

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Authors Title Published Journal PubMed Link
Parthasarathy A et al. Substrate specificity of 2-hydroxyglutaryl-CoA dehydratase from Clostridium symbiosum: toward a bio-based production of adipic acid. 2011 Biochemistry pmid:21434666
Reitman ZJ et al. Profiling the effects of isocitrate dehydrogenase 1 and 2 mutations on the cellular metabolome. 2011 Proc. Natl. Acad. Sci. U.S.A. pmid:21289278
Mascarenhas J et al. Epigenetic abnormalities in myeloproliferative neoplasms: a target for novel therapeutic strategies. 2011 Clin Epigenetics pmid:22704337
D'Alò F et al. Similarities and differences between therapy-related and elderly acute myeloid leukemia. 2011 Mediterr J Hematol Infect Dis pmid:22220249
Bosch AM et al. Brown-Vialetto-Van Laere and Fazio Londe syndrome is associated with a riboflavin transporter defect mimicking mild MADD: a new inborn error of metabolism with potential treatment. 2011 J. Inherit. Metab. Dis. pmid:21110228
Willquist K et al. Reassessment of hydrogen tolerance in Caldicellulosiruptor saccharolyticus. 2011 Microb. Cell Fact. pmid:22189215
Kaelin WG Cancer and altered metabolism: potential importance of hypoxia-inducible factor and 2-oxoglutarate-dependent dioxygenases. 2011 Cold Spring Harb. Symp. Quant. Biol. pmid:22089927
Nieto-Sampedro M et al. Inhibitors of Glioma Growth that Reveal the Tumour to the Immune System. 2011 Clin Med Insights Oncol pmid:22084619
Vogel RF et al. Genomic analysis reveals Lactobacillus sanfranciscensis as stable element in traditional sourdoughs. 2011 Microb. Cell Fact. pmid:21995419
Guo C et al. Isocitrate dehydrogenase mutations in gliomas: mechanisms, biomarkers and therapeutic target. 2011 Curr. Opin. Neurol. pmid:22002076
Schulz N et al. Role of medium- and short-chain L-3-hydroxyacyl-CoA dehydrogenase in the regulation of body weight and thermogenesis. 2011 Endocrinology pmid:21990309
Takahashi S Current findings for recurring mutations in acute myeloid leukemia. 2011 J Hematol Oncol pmid:21917154
Haffner MC et al. Global 5-hydroxymethylcytosine content is significantly reduced in tissue stem/progenitor cell compartments and in human cancers. 2011 Oncotarget pmid:21896958
Kranendijk M et al. A lymphoblast model for IDH2 gain-of-function activity in d-2-hydroxyglutaric aciduria type II: novel avenues for biochemical and therapeutic studies. 2011 Biochim. Biophys. Acta pmid:21889589
Khorassani R et al. Citramalic acid and salicylic acid in sugar beet root exudates solubilize soil phosphorus. 2011 BMC Plant Biol. pmid:21871058
Ohka F et al. The global DNA methylation surrogate LINE-1 methylation is correlated with MGMT promoter methylation and is a better prognostic factor for glioma. 2011 PLoS ONE pmid:21829728
Marie SK and Shinjo SM Metabolism and brain cancer. 2011 Clinics (Sao Paulo) pmid:21779721
Araújo WL et al. Analysis of a range of catabolic mutants provides evidence that phytanoyl-coenzyme A does not act as a substrate of the electron-transfer flavoprotein/electron-transfer flavoprotein:ubiquinone oxidoreductase complex in Arabidopsis during dark-induced senescence. 2011 Plant Physiol. pmid:21788362
Scott JG et al. Production of 2-hydroxyglutarate by isocitrate dehydrogenase 1-mutated gliomas: an evolutionary alternative to the Warburg shift? 2011 Neuro-oncology pmid:21784755
Bralten LB et al. Absence of common somatic alterations in genes on 1p and 19q in oligodendrogliomas. 2011 PLoS ONE pmid:21760942
Krell D et al. Screen for IDH1, IDH2, IDH3, D2HGDH and L2HGDH mutations in glioblastoma. 2011 PLoS ONE pmid:21625441
Yan W et al. Oncogene addiction in gliomas: implications for molecular targeted therapy. 2011 J. Exp. Clin. Cancer Res. pmid:21575270
Ramezani M et al. Glutamate racemization and catabolism in Fusobacterium varium. 2011 FEBS J. pmid:21575137
Zhang Y Biology of the Mi-2/NuRD Complex in SLAC (Stemness, Longevity/Ageing, and Cancer). 2011 Gene Regul Syst Bio pmid:21523247
Chowdhury R et al. The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases. 2011 EMBO Rep. pmid:21460794
Kochevenko A and Fernie AR The genetic architecture of branched-chain amino acid accumulation in tomato fruits. 2011 J. Exp. Bot. pmid:21436187
Kölker S et al. Diagnosis and management of glutaric aciduria type I--revised recommendations. 2011 J. Inherit. Metab. Dis. pmid:21431622
Jin G et al. 2-hydroxyglutarate production, but not dominant negative function, is conferred by glioma-derived NADP-dependent isocitrate dehydrogenase mutations. 2011 PLoS ONE pmid:21326614
Araújo WL et al. Antisense inhibition of the iron-sulphur subunit of succinate dehydrogenase enhances photosynthesis and growth in tomato via an organic acid-mediated effect on stomatal aperture. 2011 Plant Cell pmid:21307286
Frezza C et al. Inborn and acquired metabolic defects in cancer. 2011 J. Mol. Med. pmid:21301796
Engqvist MK et al. Plant D-2-hydroxyglutarate dehydrogenase participates in the catabolism of lysine especially during senescence. 2011 J. Biol. Chem. pmid:21296880
Brauburger K et al. The sodium-dependent di- and tricarboxylate transporter, NaCT, is not responsible for the uptake of D-, L-2-hydroxyglutarate and 3-hydroxyglutarate into neurons. 2011 J. Inherit. Metab. Dis. pmid:21264516
Xu W et al. Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases. 2011 Cancer Cell pmid:21251613
Lu Y et al. Chloroplast 2010: a database for large-scale phenotypic screening of Arabidopsis mutants. 2011 Plant Physiol. pmid:21224340
Rellán-Álvarez R et al. Metabolite profile changes in xylem sap and leaf extracts of strategy I plants in response to iron deficiency and resupply. 2011 Front Plant Sci pmid:22645546
Fernie AR and Klee HJ The use of natural genetic diversity in the understanding of metabolic organization and regulation. 2011 Front Plant Sci pmid:22645543
Tohge T et al. From models to crop species: caveats and solutions for translational metabolomics. 2011 Front Plant Sci pmid:22639601
Paravati AJ et al. Radiotherapy and temozolomide for newly diagnosed glioblastoma and anaplastic astrocytoma: validation of Radiation Therapy Oncology Group-Recursive Partitioning Analysis in the IMRT and temozolomide era. 2011 J. Neurooncol. pmid:21181233
O'Keefe LV et al. Drosophila orthologue of WWOX, the chromosomal fragile site FRA16D tumour suppressor gene, functions in aerobic metabolism and regulates reactive oxygen species. 2011 Hum. Mol. Genet. pmid:21075834
Araújo WL et al. Identification of the 2-hydroxyglutarate and isovaleryl-CoA dehydrogenases as alternative electron donors linking lysine catabolism to the electron transport chain of Arabidopsis mitochondria. 2010 Plant Cell pmid:20501910
Reitman ZJ and Yan H Isocitrate dehydrogenase 1 and 2 mutations in cancer: alterations at a crossroads of cellular metabolism. 2010 J. Natl. Cancer Inst. pmid:20513808
Tefferi A et al. IDH1 and IDH2 mutation studies in 1473 patients with chronic-, fibrotic- or blast-phase essential thrombocythemia, polycythemia vera or myelofibrosis. 2010 Leukemia pmid:20508616
Patnaik MM et al. WHO-defined 'myelodysplastic syndrome with isolated del(5q)' in 88 consecutive patients: survival data, leukemic transformation rates and prevalence of JAK2, MPL and IDH mutations. 2010 Leukemia pmid:20485371
Zhang C and Gänzle MG Metabolic pathway of α-ketoglutarate in Lactobacillus sanfranciscensis and Lactobacillus reuteri during sourdough fermentation. 2010 J. Appl. Microbiol. pmid:20477886
Mardis ER Cancer genomics identifies determinants of tumor biology. 2010 Genome Biol. pmid:20441611
Tefferi A Novel mutations and their functional and clinical relevance in myeloproliferative neoplasms: JAK2, MPL, TET2, ASXL1, CBL, IDH and IKZF1. 2010 Leukemia pmid:20428194
Calduch-Giner JA et al. Use of microarray technology to assess the time course of liver stress response after confinement exposure in gilthead sea bream (Sparus aurata L.). 2010 BMC Genomics pmid:20307314
Ward PS et al. The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate. 2010 Cancer Cell pmid:20171147
Frezza C et al. IDH1 mutations in gliomas: when an enzyme loses its grip. 2010 Cancer Cell pmid:20129244
Bleeker FE et al. The prognostic IDH1( R132 ) mutation is associated with reduced NADP+-dependent IDH activity in glioblastoma. 2010 Acta Neuropathol. pmid:20127344