2-hydroxyglutaric acid

There are no associated biomedical information in the current reference collection.

Current reference collection contains 1586 references associated with 2-hydroxyglutaric acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.


Here are additional resources we collected from PubChem and MeSH for 2-hydroxyglutaric acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 2-hydroxyglutaric acid

MeSH term MeSH ID Detail
Phenylketonurias D010661 7 associated lipids
Canavan Disease D017825 2 associated lipids
Metabolic Diseases D008659 12 associated lipids
Tyrosinemias D020176 2 associated lipids
Hyperoxaluria D006959 3 associated lipids
Total 5

PubChem Associated disorders and diseases

PubChem Biomolecular Interactions and Pathways

NCBI Entrez Crosslinks

All references with 2-hydroxyglutaric acid

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Authors Title Published Journal PubMed Link
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Roymoulik I et al. Rearrangement of L-2-hydroxyglutarate to L-threo-3-methylmalate catalyzed by adenosylcobalamin-dependent glutamate mutase. 2000 Biochemistry pmid:10956023
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Lee JS et al. A Korean girl with alpha-aminoadipic and alpha-ketoadipic aciduria accompanied with elevation of 2-hydroxyglutarate and glutarate. 2001 J. Inherit. Metab. Dis. pmid:11596655
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da Silva CG et al. Inhibition of cytochrome c oxidase activity in rat cerebral cortex and human skeletal muscle by D-2-hydroxyglutaric acid in vitro. 2002 Biochim. Biophys. Acta pmid:11781152
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Albers E et al. Ser3p (Yer081wp) and Ser33p (Yil074cp) are phosphoglycerate dehydrogenases in Saccharomyces cerevisiae. 2003 J. Biol. Chem. pmid:12525494
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Vinogradov E et al. Structure of the polysaccharide chain of the lipopolysaccharide from Flexibacter maritimus. 2003 Eur. J. Biochem. pmid:12694194
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Das AM Regulation of the mitochondrial ATP-synthase in health and disease. 2003 Mol. Genet. Metab. pmid:12809636
Struys EA et al. Disease-related metabolites in culture medium of fibroblasts from patients with D-2-hydroxyglutaric aciduria, L-2-hydroxyglutaric aciduria, and combined D/L-2-hydroxyglutaric aciduria. 2003 Clin. Chem. pmid:12816910
Muth A et al. Simultaneous enantioselective analysis of chiral urinary metabolites in patients with Zellweger syndrome. 2003 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:12860034
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REEVES HC et al. ALPHA-HYDROXYGLUTARATE: PRODUCT OF AN ENZYMATIC BETA-CONDENSATION BETWEEN GLYOXYLATE AND PROPIONYL-COENZYME A. 1963 J. Bacteriol. pmid:14086118
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Mau CJ et al. Protein farnesyltransferase inhibitors interfere with farnesyl diphosphate binding by rubber transferase. 2003 Eur. J. Biochem. pmid:14511375
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Struys EA et al. Investigations by mass isotopomer analysis of the formation of D-2-hydroxyglutarate by cultured lymphoblasts from two patients with D-2-hydroxyglutaric aciduria. 2004 FEBS Lett. pmid:14741351
Achouri Y et al. Identification of a dehydrogenase acting on D-2-hydroxyglutarate. 2004 Biochem. J. pmid:15070399
González R et al. Growth and final product formation by Bifidobacterium infantis in aerated fermentations. 2004 Appl. Microbiol. Biotechnol. pmid:15085297
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Struys EA et al. Measurement of urinary D- and L-2-hydroxyglutarate enantiomers by stable-isotope-dilution liquid chromatography-tandem mass spectrometry after derivatization with diacetyl-L-tartaric anhydride. 2004 Clin. Chem. pmid:15166110
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Owens WE and Okun MS Dystonia, tremor, and parkinsonism in a 54 year old man with 2-hydroxyglutaric aciduria. 2004 J. Neurol. Neurosurg. Psychiatry pmid:15314137
Mahfoud A et al. [L-2-hydroxyglutaric aciduria: clinical, biochemical and neuroradiological findings in two Venezuelan patients]. 2004 Aug 16-31 Rev Neurol pmid:15340893
pmid:15385440
Rzem R et al. A gene encoding a putative FAD-dependent L-2-hydroxyglutarate dehydrogenase is mutated in L-2-hydroxyglutaric aciduria. 2004 Proc. Natl. Acad. Sci. U.S.A. pmid:15548604
pmid:15602086
Struys EA et al. Mutations in the D-2-hydroxyglutarate dehydrogenase gene cause D-2-hydroxyglutaric aciduria. 2005 Am. J. Hum. Genet. pmid:15609246
Martins BM et al. Structural basis for stereo-specific catalysis in NAD(+)-dependent (R)-2-hydroxyglutarate dehydrogenase from Acidaminococcus fermentans. 2005 FEBS J. pmid:15634349
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Struys EA et al. Kinetic characterization of human hydroxyacid-oxoacid transhydrogenase: relevance to D-2-hydroxyglutaric and gamma-hydroxybutyric acidurias. 2005 J. Inherit. Metab. Dis. pmid:16435184
Read MH et al. Clinical, biochemical, magnetic resonance imaging (MRI) and proton magnetic resonance spectroscopy (1H MRS) findings in a fourth case of combined D- and L-2 hydroxyglutaric aciduria. 2005 J. Inherit. Metab. Dis. pmid:16435212
Struys EA et al. D-2-hydroxyglutaric aciduria in three patients with proven SSADH deficiency: genetic coincidence or a related biochemical epiphenomenon? 2006 Mol. Genet. Metab. pmid:16442322
pmid:16460720
Heux S et al. Cofactor engineering in Saccharomyces cerevisiae: Expression of a H2O-forming NADH oxidase and impact on redox metabolism. 2006 Metab. Eng. pmid:16473032
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Boiangiu CD et al. Sodium ion pumps and hydrogen production in glutamate fermenting anaerobic bacteria. 2005 J. Mol. Microbiol. Biotechnol. pmid:16645308
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Pearson LA et al. Characterization of the 2-hydroxy-acid dehydrogenase McyI, encoded within the microcystin biosynthesis gene cluster of Microcystis aeruginosa PCC7806. 2007 J. Biol. Chem. pmid:17142460
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Penderis J et al. L-2-hydroxyglutaric aciduria: characterisation of the molecular defect in a spontaneous canine model. 2007 J. Med. Genet. pmid:17475916
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Butler JE et al. Genomic and microarray analysis of aromatics degradation in Geobacter metallireducens and comparison to a Geobacter isolate from a contaminated field site. 2007 BMC Genomics pmid:17578578
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Bal D et al. Investigation of a wide spectrum of inherited metabolic disorders by 13C NMR spectroscopy. 2008 Acta Biochim. Pol. pmid:18217108
Hans M et al. Spectroscopic evidence for an all-ferrous [4Fe-4S]0 cluster in the superreduced activator of 2-hydroxyglutaryl-CoA dehydratase from Acidaminococcus fermentans. 2008 J. Biol. Inorg. Chem. pmid:18274792
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Hagos Y et al. Organic anion transporters OAT1 and OAT4 mediate the high affinity transport of glutarate derivatives accumulating in patients with glutaric acidurias. 2008 Pflugers Arch. pmid:18365245
Kalliri E et al. Identification of Escherichia coli YgaF as an L-2-hydroxyglutarate oxidase. 2008 J. Bacteriol. pmid:18390652
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Kahmen A et al. Foliar delta(15)N values characterize soil N cycling and reflect nitrate or ammonium preference of plants along a temperate grassland gradient. 2008 Oecologia pmid:18414899
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Rönicke R et al. Abeta mediated diminution of MTT reduction--an artefact of single cell culture? 2008 PLoS ONE pmid:18800168
Hageman JA et al. Simplivariate models: ideas and first examples. 2008 PLoS ONE pmid:18810272
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