2-hydroxyglutaric acid

Cross Reference

There are no associated biomedical information in the current reference collection.

Current reference collection contains 1586 references associated with 2-hydroxyglutaric acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

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Here are additional resources we collected from PubChem and MeSH for 2-hydroxyglutaric acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 2-hydroxyglutaric acid

MeSH term MeSH ID Detail
Phenylketonurias D010661 7 associated lipids
Canavan Disease D017825 2 associated lipids
Metabolic Diseases D008659 12 associated lipids
Tyrosinemias D020176 2 associated lipids
Hyperoxaluria D006959 3 associated lipids
Total 5

PubChem Associated disorders and diseases

PubChem Biomolecular Interactions and Pathways

NCBI Entrez Crosslinks

All references with 2-hydroxyglutaric acid

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REEVES HC et al. ALPHA-HYDROXYGLUTARATE: PRODUCT OF AN ENZYMATIC BETA-CONDENSATION BETWEEN GLYOXYLATE AND PROPIONYL-COENZYME A. 1963 J. Bacteriol. pmid:14086118
Buckel W The reversible dehydration of (R)-2-hydroxyglutarate to (E)-glutaconate. 1980 Eur. J. Biochem. pmid:7398622
Kuhara T et al. Studies of urinary organic acid profiles of a patient with dihydrolipoyl dehydrogenase deficiency. 1983 Clin. Chim. Acta pmid:6688766
Verhaeghe BJ et al. Solid-phase extraction with strong anion-exchange columns for selective isolation and concentration of urinary organic acids. 1988 Clin. Chem. pmid:3378323
Kaufman EE et al. Isolation and characterization of a hydroxyacid-oxoacid transhydrogenase from rat kidney mitochondria. 1988 J. Biol. Chem. pmid:3182820
Fernández-Briera A and Garrido-Pertierra A A degradation pathway of propionate in Salmonella typhimurium LT-2. 1988 Biochimie pmid:2844305
Zhao G and Winkler ME A novel alpha-ketoglutarate reductase activity of the serA-encoded 3-phosphoglycerate dehydrogenase of Escherichia coli K-12 and its possible implications for human 2-hydroxyglutaric aciduria. 1996 J. Bacteriol. pmid:8550422
van der Knaap MS et al. D-2-Hydroxyglutaric aciduria: biochemical marker or clinical disease entity? 1999 Ann. Neurol. pmid:9894884
Roymoulik I et al. Rearrangement of L-2-hydroxyglutarate to L-threo-3-methylmalate catalyzed by adenosylcobalamin-dependent glutamate mutase. 2000 Biochemistry pmid:10956023
Lee JS et al. A Korean girl with alpha-aminoadipic and alpha-ketoadipic aciduria accompanied with elevation of 2-hydroxyglutarate and glutarate. 2001 J. Inherit. Metab. Dis. pmid:11596655
da Silva CG et al. Inhibition of cytochrome c oxidase activity in rat cerebral cortex and human skeletal muscle by D-2-hydroxyglutaric acid in vitro. 2002 Biochim. Biophys. Acta pmid:11781152