2-hydroxyglutaric acid

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There are no associated biomedical information in the current reference collection.

Current reference collection contains 1586 references associated with 2-hydroxyglutaric acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

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Here are additional resources we collected from PubChem and MeSH for 2-hydroxyglutaric acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 2-hydroxyglutaric acid

MeSH term MeSH ID Detail
Phenylketonurias D010661 7 associated lipids
Canavan Disease D017825 2 associated lipids
Metabolic Diseases D008659 12 associated lipids
Tyrosinemias D020176 2 associated lipids
Hyperoxaluria D006959 3 associated lipids
Total 5

PubChem Associated disorders and diseases

PubChem Biomolecular Interactions and Pathways

NCBI Entrez Crosslinks

All references with 2-hydroxyglutaric acid

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Authors Title Published Journal PubMed Link
Gross S et al. Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate dehydrogenase 1 and 2 mutations. 2010 J. Exp. Med. pmid:20142433
Maxmen A Cancers converge at 2-HG. 2010 J. Exp. Med. pmid:20142426
Araújo WL et al. Identification of the 2-hydroxyglutarate and isovaleryl-CoA dehydrogenases as alternative electron donors linking lysine catabolism to the electron transport chain of Arabidopsis mitochondria. 2010 Plant Cell pmid:20501910
Figueroa ME et al. Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation. 2010 Cancer Cell pmid:21130701
Seltzer MJ et al. Inhibition of glutaminase preferentially slows growth of glioma cells with mutant IDH1. 2010 Cancer Res. pmid:21045145
Kranendijk M et al. IDH2 mutations in patients with D-2-hydroxyglutaric aciduria. 2010 Science pmid:20847235
Riemenschneider MJ et al. Molecular diagnostics of gliomas: state of the art. 2010 Acta Neuropathol. pmid:20714900
Yang I and Liau LM American Association for Cancer Research Genetics and Biology of Brain Cancers 2009, December 13-15, 2009, San Diego, CA. 2010 J. Neurooncol. pmid:20714783
Dang L et al. Cancer-associated IDH1 mutations produce 2-hydroxyglutarate. 2010 Nature pmid:20559394
Reitman ZJ and Yan H Isocitrate dehydrogenase 1 and 2 mutations in cancer: alterations at a crossroads of cellular metabolism. 2010 J. Natl. Cancer Inst. pmid:20513808
Tefferi A et al. IDH1 and IDH2 mutation studies in 1473 patients with chronic-, fibrotic- or blast-phase essential thrombocythemia, polycythemia vera or myelofibrosis. 2010 Leukemia pmid:20508616
Patnaik MM et al. WHO-defined 'myelodysplastic syndrome with isolated del(5q)' in 88 consecutive patients: survival data, leukemic transformation rates and prevalence of JAK2, MPL and IDH mutations. 2010 Leukemia pmid:20485371
Engqvist M et al. Two D-2-hydroxy-acid dehydrogenases in Arabidopsis thaliana with catalytic capacities to participate in the last reactions of the methylglyoxal and beta-oxidation pathways. 2009 J. Biol. Chem. pmid:19586914
Dang L et al. Cancer-associated IDH1 mutations produce 2-hydroxyglutarate. 2009 Nature pmid:19935646
Van Deun K et al. A structured overview of simultaneous component based data integration. 2009 BMC Bioinformatics pmid:19671149
Wang Y and Zhang YH Cell-free protein synthesis energized by slowly-metabolized maltodextrin. 2009 BMC Biotechnol. pmid:19558718
Chovatia M et al. Complete genome sequence of Thermanaerovibrio acidaminovorans type strain (Su883). 2009 Stand Genomic Sci pmid:21304665
Jansen EE et al. Neurotransmitter alterations in embryonic succinate semialdehyde dehydrogenase (SSADH) deficiency suggest a heightened excitatory state during development. 2008 BMC Dev. Biol. pmid:19040727
Bal D et al. Investigation of a wide spectrum of inherited metabolic disorders by 13C NMR spectroscopy. 2008 Acta Biochim. Pol. pmid:18217108
Kalliri E et al. Identification of Escherichia coli YgaF as an L-2-hydroxyglutarate oxidase. 2008 J. Bacteriol. pmid:18390652
Hagos Y et al. Organic anion transporters OAT1 and OAT4 mediate the high affinity transport of glutarate derivatives accumulating in patients with glutaric acidurias. 2008 Pflugers Arch. pmid:18365245
Hageman JA et al. Simplivariate models: ideas and first examples. 2008 PLoS ONE pmid:18810272
Rönicke R et al. Abeta mediated diminution of MTT reduction--an artefact of single cell culture? 2008 PLoS ONE pmid:18800168
Kahmen A et al. Foliar delta(15)N values characterize soil N cycling and reflect nitrate or ammonium preference of plants along a temperate grassland gradient. 2008 Oecologia pmid:18414899
Hans M et al. Spectroscopic evidence for an all-ferrous [4Fe-4S]0 cluster in the superreduced activator of 2-hydroxyglutaryl-CoA dehydratase from Acidaminococcus fermentans. 2008 J. Biol. Inorg. Chem. pmid:18274792
Butler JE et al. Genomic and microarray analysis of aromatics degradation in Geobacter metallireducens and comparison to a Geobacter isolate from a contaminated field site. 2007 BMC Genomics pmid:17578578
Penderis J et al. L-2-hydroxyglutaric aciduria: characterisation of the molecular defect in a spontaneous canine model. 2007 J. Med. Genet. pmid:17475916
Pearson LA et al. Characterization of the 2-hydroxy-acid dehydrogenase McyI, encoded within the microcystin biosynthesis gene cluster of Microcystis aeruginosa PCC7806. 2007 J. Biol. Chem. pmid:17142460
Struys EA et al. D-2-hydroxyglutaric aciduria in three patients with proven SSADH deficiency: genetic coincidence or a related biochemical epiphenomenon? 2006 Mol. Genet. Metab. pmid:16442322
Heux S et al. Cofactor engineering in Saccharomyces cerevisiae: Expression of a H2O-forming NADH oxidase and impact on redox metabolism. 2006 Metab. Eng. pmid:16473032
Struys EA et al. Kinetic characterization of human hydroxyacid-oxoacid transhydrogenase: relevance to D-2-hydroxyglutaric and gamma-hydroxybutyric acidurias. 2005 J. Inherit. Metab. Dis. pmid:16435184
Read MH et al. Clinical, biochemical, magnetic resonance imaging (MRI) and proton magnetic resonance spectroscopy (1H MRS) findings in a fourth case of combined D- and L-2 hydroxyglutaric aciduria. 2005 J. Inherit. Metab. Dis. pmid:16435212
Boiangiu CD et al. Sodium ion pumps and hydrogen production in glutamate fermenting anaerobic bacteria. 2005 J. Mol. Microbiol. Biotechnol. pmid:16645308
Martins BM et al. Structural basis for stereo-specific catalysis in NAD(+)-dependent (R)-2-hydroxyglutarate dehydrogenase from Acidaminococcus fermentans. 2005 FEBS J. pmid:15634349
Struys EA et al. Mutations in the D-2-hydroxyglutarate dehydrogenase gene cause D-2-hydroxyglutaric aciduria. 2005 Am. J. Hum. Genet. pmid:15609246
Mahfoud A et al. [L-2-hydroxyglutaric aciduria: clinical, biochemical and neuroradiological findings in two Venezuelan patients]. 2004 Aug 16-31 Rev Neurol pmid:15340893
González R et al. Growth and final product formation by Bifidobacterium infantis in aerated fermentations. 2004 Appl. Microbiol. Biotechnol. pmid:15085297
Owens WE and Okun MS Dystonia, tremor, and parkinsonism in a 54 year old man with 2-hydroxyglutaric aciduria. 2004 J. Neurol. Neurosurg. Psychiatry pmid:15314137
Rzem R et al. A gene encoding a putative FAD-dependent L-2-hydroxyglutarate dehydrogenase is mutated in L-2-hydroxyglutaric aciduria. 2004 Proc. Natl. Acad. Sci. U.S.A. pmid:15548604
Struys EA et al. Measurement of urinary D- and L-2-hydroxyglutarate enantiomers by stable-isotope-dilution liquid chromatography-tandem mass spectrometry after derivatization with diacetyl-L-tartaric anhydride. 2004 Clin. Chem. pmid:15166110
Achouri Y et al. Identification of a dehydrogenase acting on D-2-hydroxyglutarate. 2004 Biochem. J. pmid:15070399
Struys EA et al. Investigations by mass isotopomer analysis of the formation of D-2-hydroxyglutarate by cultured lymphoblasts from two patients with D-2-hydroxyglutaric aciduria. 2004 FEBS Lett. pmid:14741351
Das AM Regulation of the mitochondrial ATP-synthase in health and disease. 2003 Mol. Genet. Metab. pmid:12809636
Muth A et al. Simultaneous enantioselective analysis of chiral urinary metabolites in patients with Zellweger syndrome. 2003 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:12860034
Mau CJ et al. Protein farnesyltransferase inhibitors interfere with farnesyl diphosphate binding by rubber transferase. 2003 Eur. J. Biochem. pmid:14511375
Struys EA et al. Disease-related metabolites in culture medium of fibroblasts from patients with D-2-hydroxyglutaric aciduria, L-2-hydroxyglutaric aciduria, and combined D/L-2-hydroxyglutaric aciduria. 2003 Clin. Chem. pmid:12816910
Vinogradov E et al. Structure of the polysaccharide chain of the lipopolysaccharide from Flexibacter maritimus. 2003 Eur. J. Biochem. pmid:12694194
Albers E et al. Ser3p (Yer081wp) and Ser33p (Yil074cp) are phosphoglycerate dehydrogenases in Saccharomyces cerevisiae. 2003 J. Biol. Chem. pmid:12525494
da Silva CG et al. Inhibition of cytochrome c oxidase activity in rat cerebral cortex and human skeletal muscle by D-2-hydroxyglutaric acid in vitro. 2002 Biochim. Biophys. Acta pmid:11781152
Lee JS et al. A Korean girl with alpha-aminoadipic and alpha-ketoadipic aciduria accompanied with elevation of 2-hydroxyglutarate and glutarate. 2001 J. Inherit. Metab. Dis. pmid:11596655