MeSH term | MeSH ID | Detail |
---|---|---|
Body Weight | D001835 | 333 associated lipids |
Glucose Intolerance | D018149 | 13 associated lipids |
To understand associated biological information of (2s,3r,4r,6e)-2-amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxo-6-eicosenoic acid;isp-i;thermozymocidin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
There are no associated biomedical information in the current reference collection.
We collected disease MeSH terms mapped to the references associated with (2s,3r,4r,6e)-2-amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxo-6-eicosenoic acid;isp-i;thermozymocidin
MeSH term | MeSH ID | Detail |
---|---|---|
Body Weight | D001835 | 333 associated lipids |
Glucose Intolerance | D018149 | 13 associated lipids |
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Kodedová M and Sychrová H | Synthetic antimicrobial peptides of the halictines family disturb the membrane integrity of Candida cells. | 2017 | Biochim. Biophys. Acta | pmid:28600071 |
Blachnio-Zabielska AU et al. | The Crucial Role of C18-Cer in Fat-Induced Skeletal Muscle Insulin Resistance. | 2016 | Cell. Physiol. Biochem. | pmid:27960149 |
Aburasayn H et al. | Targeting ceramide metabolism in obesity. | 2016 | Am. J. Physiol. Endocrinol. Metab. | pmid:27382035 |
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Mallela SK et al. | Functions of Ceramide Synthase Paralogs YPR114w and YJR116w of Saccharomyces cerevisiae. | 2016 | PLoS ONE | pmid:26752183 |
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Babenko NA and Kharchenko VS | Effects of inhibitors of key enzymes of sphingolipid metabolism on insulin-induced glucose uptake and glycogen synthesis in liver cells of old rats. | 2015 | Biochemistry Mosc. | pmid:25754045 |
Cozza G et al. | A new role for sphingosine: Up-regulation of Fam20C, the genuine casein kinase that phosphorylates secreted proteins. | 2015 | Biochim. Biophys. Acta | pmid:25936777 |
Wang J et al. | Fungal metabolite myriocin promotes human herpes simplex virus-2 infection. | 2015 | Life Sci. | pmid:25447452 |
MartÃnez L et al. | Myristic acid potentiates palmitic acid-induced lipotoxicity and steatohepatitis associated with lipodystrophy by sustaning de novo ceramide synthesis. | 2015 | Oncotarget | pmid:26539645 |
Hodson AE et al. | Insulin treatment increases myocardial ceramide accumulation and disrupts cardiometabolic function. | 2015 | Cardiovasc Diabetol | pmid:26682540 |
Perdoni F et al. | Antifungal activity of Myriocin on clinically relevant Aspergillus fumigatus strains producing biofilm. | 2015 | BMC Microbiol. | pmid:26519193 |
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Hamada Y et al. | Involvement of de novo ceramide synthesis in pro-inflammatory adipokine secretion and adipocyte-macrophage interaction. | 2014 | J. Nutr. Biochem. | pmid:25283329 |
Chow SE et al. | Resveratrol induced ER expansion and ER caspase-mediated apoptosis in human nasopharyngeal carcinoma cells. | 2014 | Apoptosis | pmid:24264887 |
Swinnen E et al. | The protein kinase Sch9 is a key regulator of sphingolipid metabolism in Saccharomyces cerevisiae. | 2014 | Mol. Biol. Cell | pmid:24196832 |
Tippetts TS et al. | Cigarette smoke increases cardiomyocyte ceramide accumulation and inhibits mitochondrial respiration. | 2014 | BMC Cardiovasc Disord | pmid:25416336 |
Raichur S et al. | CerS2 haploinsufficiency inhibits β-oxidation and confers susceptibility to diet-induced steatohepatitis and insulin resistance. | 2014 | Cell Metab. | pmid:25295789 |
Thatcher MO et al. | Ceramides mediate cigarette smoke-induced metabolic disruption in mice. | 2014 | Am. J. Physiol. Endocrinol. Metab. | pmid:25269485 |
Surlow BA et al. | Loss of Ypk1, the yeast homolog to the human serum- and glucocorticoid-induced protein kinase, accelerates phospholipase B1-mediated phosphatidylcholine deacylation. | 2014 | J. Biol. Chem. | pmid:25258318 |
Li W et al. | Endogenous ceramide contributes to the transcytosis of oxLDL across endothelial cells and promotes its subendothelial retention in vascular wall. | 2014 | Oxid Med Cell Longev | pmid:24817993 |
Correnti JM et al. | Pharmacological ceramide reduction alleviates alcohol-induced steatosis and hepatomegaly in adiponectin knockout mice. | 2014 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:24742988 |
Kurek K et al. | Inhibition of ceramide de novo synthesis with myriocin affects lipid metabolism in the liver of rats with streptozotocin-induced type 1 diabetes. | 2014 | Biomed Res Int | pmid:24701589 |
Curto MÃ et al. | Membrane organization and cell fusion during mating in fission yeast requires multipass membrane protein Prm1. | 2014 | Genetics | pmid:24514900 |
Yamane-Sando Y et al. | Fpk1/2 kinases regulate cellular sphingoid long-chain base abundance and alter cellular resistance to LCB elevation or depletion. | 2014 | Microbiologyopen | pmid:24510621 |
Tong M et al. | Therapeutic reversal of chronic alcohol-related steatohepatitis with the ceramide inhibitor myriocin. | 2014 | Int J Exp Pathol | pmid:24456332 |
Caretti A et al. | Anti-inflammatory action of lipid nanocarrier-delivered myriocin: therapeutic potential in cystic fibrosis. | 2014 | Biochim. Biophys. Acta | pmid:24141140 |
Kasumov T et al. | 2H2O-based high-density lipoprotein turnover method for the assessment of dynamic high-density lipoprotein function in mice. | 2013 | Arterioscler. Thromb. Vasc. Biol. | pmid:23766259 |
Meszaros P et al. | Long term myriocin treatment increases MRP1 transport activity. | 2013 | Int. J. Biochem. Cell Biol. | pmid:23178537 |
Zhang O et al. | Sphingosine kinase A is a pleiotropic and essential enzyme for Leishmania survival and virulence. | 2013 | Mol. Microbiol. | pmid:23980754 |
Mikłosz A et al. | Effects of inhibition of serine palmitoyltransferase (SPT) and sphingosine kinase 1 (SphK1) on palmitate induced insulin resistance in L6 myotubes. | 2013 | PLoS ONE | pmid:24376889 |
de Melo NR et al. | Myriocin significantly increases the mortality of a non-mammalian model host during Candida pathogenesis. | 2013 | PLoS ONE | pmid:24260135 |
Lizarazo D et al. | Ceramide inhibitor myriocin restores insulin/insulin growth factor signaling for liver remodeling in experimental alcohol-related steatohepatitis. | 2013 | J. Gastroenterol. Hepatol. | pmid:23802886 |
Liu J et al. | Reducing sphingolipid synthesis orchestrates global changes to extend yeast lifespan. | 2013 | Aging Cell | pmid:23725375 |
Worgall TS et al. | Impaired sphingolipid synthesis in the respiratory tract induces airway hyperreactivity. | 2013 | Sci Transl Med | pmid:23698380 |
Huang X et al. | Reducing signs of aging and increasing lifespan by drug synergy. | 2013 | Aging Cell | pmid:23601176 |
Tafesse FG et al. | Intact sphingomyelin biosynthetic pathway is essential for intracellular transport of influenza virus glycoproteins. | 2013 | Proc. Natl. Acad. Sci. U.S.A. | pmid:23576732 |
Dekker MJ et al. | Inhibition of sphingolipid synthesis improves dyslipidemia in the diet-induced hamster model of insulin resistance: evidence for the role of sphingosine and sphinganine in hepatic VLDL-apoB100 overproduction. | 2013 | Atherosclerosis | pmid:23466071 |
Chiba K and Adachi K | Discovery of fingolimod, the sphingosine 1-phosphate receptor modulator and its application for the therapy of multiple sclerosis. | 2012 | Future Med Chem | pmid:22530640 |
Podbielska M et al. | Signaling and regulatory functions of bioactive sphingolipids as therapeutic targets in multiple sclerosis. | 2012 | Neurochem. Res. | pmid:22451227 |
Shin KO et al. | Terpene alcohols inhibit de novo sphingolipid biosynthesis. | 2012 | Planta Med. | pmid:22274813 |
Kubo T et al. | Chlamydia trachomatis serovar L2 infection model using human lymphoid Jurkat cells. | 2012 | Microb. Pathog. | pmid:22516802 |
Babenko NA and Kharchenko VS | Ceramides inhibit phospholipase D-dependent insulin signaling in liver cells of old rats. | 2012 | Biochemistry Mosc. | pmid:22348478 |
Mizukoshi K et al. | The essential structures of ISP-I that influence serine palmitoyltransferase inhibition in Chinese hamster ovary cells. | 2012 | Biol. Pharm. Bull. | pmid:22863936 |
Lee YJ et al. | Sphingolipid signaling mediates iron toxicity. | 2012 | Cell Metab. | pmid:22768841 |
Ussher JR et al. | Inhibition of serine palmitoyl transferase I reduces cardiac ceramide levels and increases glycolysis rates following diet-induced insulin resistance. | 2012 | PLoS ONE | pmid:22629445 |
Zhang QJ et al. | Ceramide mediates vascular dysfunction in diet-induced obesity by PP2A-mediated dephosphorylation of the eNOS-Akt complex. | 2012 | Diabetes | pmid:22586587 |
Car H et al. | Ceramide profiles in the brain of rats with diabetes induced by streptozotocin. | 2012 | FEBS J. | pmid:22429392 |
Huang X et al. | Down-regulating sphingolipid synthesis increases yeast lifespan. | 2012 | PLoS Genet. | pmid:22319457 |
Gorshkova I et al. | Inhibition of serine palmitoyltransferase delays the onset of radiation-induced pulmonary fibrosis through the negative regulation of sphingosine kinase-1 expression. | 2012 | J. Lipid Res. | pmid:22615416 |
Meyer SG et al. | Myriocin, an inhibitor of serine palmitoyl transferase, impairs the uptake of transferrin and low-density lipoprotein in mammalian cells. | 2012 | Arch. Biochem. Biophys. | pmid:22841978 |
Schwan C et al. | Cholesterol- and sphingolipid-rich microdomains are essential for microtubule-based membrane protrusions induced by Clostridium difficile transferase (CDT). | 2011 | J. Biol. Chem. | pmid:21705797 |
Yeung BK | Natural product drug discovery: the successful optimization of ISP-1 and halichondrin B. | 2011 | Curr Opin Chem Biol | pmid:21684798 |
Chun L et al. | Inhibition of ceramide synthesis reverses endothelial dysfunction and atherosclerosis in streptozotocin-induced diabetic rats. | 2011 | Diabetes Res. Clin. Pract. | pmid:21492950 |
Strader CR et al. | Fingolimod (FTY720): a recently approved multiple sclerosis drug based on a fungal secondary metabolite. | 2011 | J. Nat. Prod. | pmid:21456524 |
Lee YS et al. | Serine palmitoyltransferase inhibitor myriocin induces growth inhibition of B16F10 melanoma cells through G(2) /M phase arrest. | 2011 | Cell Prolif. | pmid:21645154 |
Jiang XC et al. | Sphingolipids and cardiovascular diseases: lipoprotein metabolism, atherosclerosis and cardiomyopathy. | 2011 | Adv. Exp. Med. Biol. | pmid:21910080 |
Roelants FM et al. | Protein kinase Ypk1 phosphorylates regulatory proteins Orm1 and Orm2 to control sphingolipid homeostasis in Saccharomyces cerevisiae. | 2011 | Proc. Natl. Acad. Sci. U.S.A. | pmid:22080611 |
Lattif AA et al. | Lipidomics of Candida albicans biofilms reveals phase-dependent production of phospholipid molecular classes and role for lipid rafts in biofilm formation. | 2011 | Microbiology (Reading, Engl.) | pmid:21903752 |
Mizukoshi K et al. | Effects of serine palmitoyltransferase inhibitor ISP-I on the stratum corneum of intact mouse skin. | 2011 | Biol. Pharm. Bull. | pmid:21881222 |
Xiao ZH et al. | [Effect of myriocin on the expression of cyclinD1 in high glucose-induced hypertrophy mesangial cells]. | 2011 | Zhongguo Dang Dai Er Ke Za Zhi | pmid:21849123 |
Caviglia JM et al. | Different fatty acids inhibit apoB100 secretion by different pathways: unique roles for ER stress, ceramide, and autophagy. | 2011 | J. Lipid Res. | pmid:21719579 |
Schmitz-Peiffer C | Targeting ceramide synthesis to reverse insulin resistance. | 2010 | Diabetes | pmid:20876726 |
Frangioudakis G et al. | Saturated- and n-6 polyunsaturated-fat diets each induce ceramide accumulation in mouse skeletal muscle: reversal and improvement of glucose tolerance by lipid metabolism inhibitors. | 2010 | Endocrinology | pmid:20660065 |
Klappe K et al. | Extensive sphingolipid depletion does not affect lipid raft integrity or lipid raft localization and efflux function of the ABC transporter MRP1. | 2010 | Biochem. J. | pmid:20604746 |
Liangpunsakul S et al. | Inhibitory effect of ethanol on AMPK phosphorylation is mediated in part through elevated ceramide levels. | 2010 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:20224005 |
Sauane M et al. | Ceramide plays a prominent role in MDA-7/IL-24-induced cancer-specific apoptosis. | 2010 | J. Cell. Physiol. | pmid:19937735 |
Lee BJ et al. | Effects of sphingolipid synthesis inhibition on cholesterol gallstone formation in C57BL/6J mice. | 2010 | J. Gastroenterol. Hepatol. | pmid:20594226 |
Mizukoshi K et al. | The effects of serine palmitoyltransferase inhibitor, ISP-I, on UV-induced barrier disruption in the stratum corneum. | 2010 | Biol. Pharm. Bull. | pmid:21139242 |
Strettoi E et al. | Inhibition of ceramide biosynthesis preserves photoreceptor structure and function in a mouse model of retinitis pigmentosa. | 2010 | Proc. Natl. Acad. Sci. U.S.A. | pmid:20937879 |
Chentouf M et al. | The lipid-modulating effects of a CD4-specific recombinant antibody correlate with ZAP-70 segregation outside membrane rafts. | 2010 | Immunol. Lett. | pmid:20659502 |
Ussher JR et al. | Inhibition of de novo ceramide synthesis reverses diet-induced insulin resistance and enhances whole-body oxygen consumption. | 2010 | Diabetes | pmid:20522596 |
Scherer M et al. | A rapid and quantitative LC-MS/MS method to profile sphingolipids. | 2010 | J. Lipid Res. | pmid:20228220 |
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Li Z et al. | Serine palmitoyltransferase (SPT) deficient mice absorb less cholesterol. | 2009 | Biochim. Biophys. Acta | pmid:19416652 |
Xiao-Yun X et al. | Ceramide mediates inhibition of the AKT/eNOS signaling pathway by palmitate in human vascular endothelial cells. | 2009 | Med. Sci. Monit. | pmid:19721393 |
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Wang W et al. | Lipid rafts play an important role in the vesicular stomatitis virus life cycle. | 2009 | Arch. Virol. | pmid:19288237 |
Yu J et al. | Determination of myriocin in natural and cultured Cordyceps cicadae using 9-fluorenylmethyl chloroformate derivatization and high-performance liquid chromatography with UV-detection. | 2009 | Anal Sci | pmid:19609022 |
Wheeler D et al. | Tumor necrosis factor-alpha-induced neutral sphingomyelinase-2 modulates synaptic plasticity by controlling the membrane insertion of NMDA receptors. | 2009 | J. Neurochem. | pmid:19476542 |
Junkin KA et al. | Resistin acutely impairs insulin-stimulated glucose transport in rodent muscle in the presence, but not absence, of palmitate. | 2009 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:19193939 |
Takahashi Y et al. | Serine palmitoyltransferase, the first step enzyme in sphingolipid biosynthesis, is involved in nonhost resistance. | 2009 | Mol. Plant Microbe Interact. | pmid:19061400 |
Park MA et al. | Vorinostat and sorafenib increase ER stress, autophagy and apoptosis via ceramide-dependent CD95 and PERK activation. | 2008 | Cancer Biol. Ther. | pmid:18787411 |
Park TS et al. | Serine palmitoyltransferase inhibitor myriocin induces the regression of atherosclerotic plaques in hyperlipidemic ApoE-deficient mice. | 2008 | Pharmacol. Res. | pmid:18611440 |
Glaros EN et al. | Myriocin slows the progression of established atherosclerotic lesions in apolipoprotein E gene knockout mice. | 2008 | J. Lipid Res. | pmid:17978313 |
Bismuth J et al. | Ceramide: a common pathway for atherosclerosis? | 2008 | Atherosclerosis | pmid:17963772 |