Lärfars G et al. |
Activation of nitric oxide release and oxidative metabolism by leukotrienes B4, C4, and D4 in human polymorphonuclear leukocytes. |
1999 |
Blood |
pmid:9949184
|
Ohbayashi H et al. |
Neutral endopeptidase 3.4.24.11 inhibition potentiates the inhibitory effects of type-C natriuretic peptide on leukotriene D4-induced airway changes. |
1998 |
Clin. Exp. Pharmacol. Physiol. |
pmid:9887994
|
Yang XX et al. |
Strain dependence of the airway response to dry-gas hyperpnea challenge in the rat. |
1999 |
J. Appl. Physiol. |
pmid:9887125
|
Chambers RJ et al. |
Development of new chromanol antagonists of leukotriene D4. |
1998 |
Bioorg. Med. Chem. Lett. |
pmid:9873435
|
von Sprecher A et al. |
Synthesis and SAR of a novel, potent and structurally simple LTD4 antagonist of the quinoline class. |
1998 |
Bioorg. Med. Chem. Lett. |
pmid:9871521
|
Venugopalan CS et al. |
Responses of guinea-pig lung parenchymal strips to tracheobronchial lavage fluid from horses affected with summer pasture-associated obstructive pulmonary disease. |
1998 |
Vet. Res. Commun. |
pmid:9868763
|
Underwood DC et al. |
Antiasthmatic activity of the second-generation phosphodiesterase 4 (PDE4) inhibitor SB 207499 (Ariflo) in the guinea pig. |
1998 |
J. Pharmacol. Exp. Ther. |
pmid:9864284
|
Lane SJ |
Leukotriene antagonism in asthma and rhinitis. |
1998 |
Respir Med |
pmid:9850362
|
Kawashima Y et al. |
Surface-modified antiasthmatic dry powder aerosols inhaled intratracheally reduce the pharmacologically effective dose. |
1998 |
Pharm. Res. |
pmid:9833999
|
Fujimura M et al. |
A partial involvement of histamine in ultrasonically nebulized distilled water-induced bronchoconstriction in guinea-pigs. |
1998 |
Br. J. Pharmacol. |
pmid:9831931
|
Kjellström S et al. |
On-line coupling of microdialysis sampling with liquid chromatography for the determination of peptide and non-peptide leukotrienes. |
1998 |
J Chromatogr A |
pmid:9818423
|
Arakida Y et al. |
In vitro pharmacologic profile of YM158, a new dual antagonist for LTD4 and TXA2 receptors. |
1998 |
J. Pharmacol. Exp. Ther. |
pmid:9808690
|
Sciuto AM et al. |
Post-exposure treatment with isoproterenol attenuates pulmonary edema in phosgene-exposed rabbits. |
1998 Sep-Oct |
J Appl Toxicol |
pmid:9804432
|
Grönroos E et al. |
Leukotriene D4 induces a rapid increase in cAMP in the human epithelial cell line, Int 407: a potential role for this signal in the regulation of calcium influx through the plasma membrane. |
1998 |
Cell Calcium |
pmid:9793684
|
Tsang F et al. |
Effects of mitogen-activated protein kinase kinase inhibitor PD 098059 on antigen challenge of guinea-pig airways in vitro. |
1998 |
Br. J. Pharmacol. |
pmid:9776345
|
Wen FQ et al. |
Eicosanoid profile in cultured human pulmonary artery smooth muscle cells treated with IL-1 beta and TNF alpha. |
1998 |
Prostaglandins Leukot. Essent. Fatty Acids |
pmid:9758210
|
Kim N et al. |
Leukotriene D4-induced contraction of cat esophageal and lower esophageal sphincter circular smooth muscle. |
1998 |
Gastroenterology |
pmid:9753495
|
Nagayama S et al. |
Increased sensitivity to vincristine of MDR cells by the leukotriene D4 receptor antagonist, ONO-1078. |
1998 |
Cancer Lett. |
pmid:9751271
|
Geirsson A et al. |
Potentiating effects of pertussis toxin on leukotriene C4 induced formation of inositol phosphate and prostacyclin in human umbilical vein endothelial cells. |
1998 |
J. Cell. Physiol. |
pmid:9731750
|
Panettieri RA et al. |
Effects of LTD4 on human airway smooth muscle cell proliferation, matrix expression, and contraction In vitro: differential sensitivity to cysteinyl leukotriene receptor antagonists. |
1998 |
Am. J. Respir. Cell Mol. Biol. |
pmid:9730873
|
Massoumi R and Sjölander A |
The inflammatory mediator leukotriene D4 triggers a rapid reorganisation of the actin cytoskeleton in human intestinal epithelial cells. |
1998 |
Eur. J. Cell Biol. |
pmid:9716265
|
Shirasaki H et al. |
The effect of a cysteinyl leukotriene antagonist, ONO-1078 (pranlukast) on agonist- and antigen-induced nasal microvascular leakage in guinea pigs. |
1998 |
Rhinology |
pmid:9695159
|
Smith LJ et al. |
A single dose of zafirlukast reduces LTD4-induced bronchoconstriction in patients on maintenance inhaled corticosteroid therapy. |
1998 |
Ann. Allergy Asthma Immunol. |
pmid:9690572
|
Liu YC et al. |
Effects of the cysteinyl leukotriene receptor antagonists pranlukast and zafirlukast on tracheal mucus secretion in ovalbumin-sensitized guinea-pigs in vitro. |
1998 |
Br. J. Pharmacol. |
pmid:9647482
|
Traianedes K et al. |
5-Lipoxygenase metabolites inhibit bone formation in vitro. |
1998 |
Endocrinology |
pmid:9645691
|
Allen S et al. |
Differential leukotriene constrictor responses in human atherosclerotic coronary arteries. |
1998 |
Circulation |
pmid:9641692
|
Nagase T and Ludwig MS |
Antigen-induced responses in lung parenchymal strips during sinusoidal oscillation. |
1998 |
Can. J. Physiol. Pharmacol. |
pmid:9635157
|
Kohno S |
[Role of peptide-leukotrienes in bronchial asthma]. |
1998 |
Nippon Yakurigaku Zasshi |
pmid:9618707
|
Ohbayashi H et al. |
Compared effects of natriuretic peptides on ovalbumin-induced asthmatic model. |
1998 |
Eur. J. Pharmacol. |
pmid:9617752
|
Sato E et al. |
Acetylcholine stimulates alveolar macrophages to release inflammatory cell chemotactic activity. |
1998 |
Am. J. Physiol. |
pmid:9609736
|
Jonsson EW |
Functional characterisation of receptors for cysteinyl leukotrienes in smooth muscle. |
1998 |
Acta Physiol Scand Suppl |
pmid:9597121
|
Dahlén B et al. |
Benefits from adding the 5-lipoxygenase inhibitor zileuton to conventional therapy in aspirin-intolerant asthmatics. |
1998 |
Am. J. Respir. Crit. Care Med. |
pmid:9563738
|
Habib GM et al. |
Leukotriene D4 and cystinyl-bis-glycine metabolism in membrane-bound dipeptidase-deficient mice. |
1998 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:9560193
|
Cyrus CB et al. |
Leukotrienes C4 and D4 increase the ciliary beat frequency in human upper airway mucosa in vitro. |
1998 |
Otolaryngol Head Neck Surg |
pmid:9560097
|
Zwaagstra ME et al. |
Synthesis and structure-activity relationships of carboxyflavones as structurally rigid CysLT1 (LTD4) receptor antagonists. |
1998 |
J. Med. Chem. |
pmid:9554876
|
Przylipiak A et al. |
Influence of leukotrienes on in vitro growth of human mammary carcinoma cell line MCF-7. |
1998 |
Eur. J. Obstet. Gynecol. Reprod. Biol. |
pmid:9550202
|
Capra V et al. |
Identification and characterization of two cysteinyl-leukotriene high affinity binding sites with receptor characteristics in human lung parenchyma. |
1998 |
Mol. Pharmacol. |
pmid:9547367
|
Daugschies A and Ruttkowski B |
Modulation of migration of Oesophagostomum dentatum larvae by inhibitors and products of eicosanoid metabolism. |
1998 |
Int. J. Parasitol. |
pmid:9513001
|
Kimura K et al. |
Modulation of platelet activating factor-induced glycogenolysis in the perfused rat liver after administration of endotoxin in vivo. |
1998 |
J. Biochem. |
pmid:9504421
|
Capra V et al. |
Pharmacological characterization of the cysteinyl-leukotriene antagonists CGP 45715A (iralukast) and CGP 57698 in human airways in vitro. |
1998 |
Br. J. Pharmacol. |
pmid:9504401
|
Basavappa S et al. |
Swelling-induced arachidonic acid release via the 85-kDa cPLA2 in human neuroblastoma cells. |
1998 |
J. Neurophysiol. |
pmid:9497423
|
Yamaya M et al. |
Dipeptidase inhibitor and epithelial removal potentiate leukotriene D4-induced human tracheal smooth muscle contraction. |
1998 |
Respir Physiol |
pmid:9496476
|
Francis HP et al. |
The effects of a novel sulphidopeptide leukotriene antagonist, BAY x7195, against elicited bronchoconstriction in the anaesthetized guinea-pig. |
1998 |
Br. J. Pharmacol. |
pmid:9484852
|
Hoshino M et al. |
Leukotriene D4 activates mitogen-activated protein kinase through a protein kinase Calpha-Raf-1-dependent pathway in human monocytic leukemia THP-1 cells. |
1998 |
J. Biol. Chem. |
pmid:9478929
|
Fujita M et al. |
Cysteinyl leukotrienes induce nasal symptoms of allergic rhinitis via a receptor-mediated mechanism in guinea pigs. |
1997 |
Jpn. J. Pharmacol. |
pmid:9469641
|
Gorenne I et al. |
Leukotriene D4 contractions in human airways are blocked by SK&F 96365, an inhibitor of receptor-mediated calcium entry. |
1998 |
J. Pharmacol. Exp. Ther. |
pmid:9454796
|
Cibulsky SM and Thompson DC |
Absence of tachykinin involvement in leukotriene D4 and antigen-induced contraction of guinea pig isolated bronchus. |
1997 |
J. Pharmacol. Exp. Ther. |
pmid:9399982
|
Kagoshima M et al. |
Effect of Y-24180, a long-acting antagonist to platelet-activating factor (PAF), on PAF-induced reactions: a relationship between the partial structure of the compound and its duration of the action. |
1997 |
Pharmacology |
pmid:9380772
|
Beckh K et al. |
Effects of nitric oxide on leukotriene D4 decreased bile secretion in the perfused rat liver. |
1997 |
Life Sci. |
pmid:9364199
|
Wong WS et al. |
Effects of tyrosine kinase inhibitors on antigen challenge of guinea pig lung in vitro. |
1997 |
J. Pharmacol. Exp. Ther. |
pmid:9336317
|
Spector SL |
Leukotriene activity modulation in asthma. |
1997 |
Drugs |
pmid:9279501
|
Cincu RN et al. |
S-adenosyl-L-methionine protects the liver against the cholestatic, cytotoxic, and vasoactive effects of leukotriene D4: a study with isolated and perfused rat liver. |
1997 |
Hepatology |
pmid:9252142
|
Kanli H and Terreros DA |
Transepithelial transport and cell volume control in proximal renal tubules from the teleost Carassius auratus. |
1997 |
Acta Physiol. Scand. |
pmid:9246390
|
Honda I et al. |
Tachykinin antagonist FK224 inhibits neurokinin A-, substance P- and capsaicin-induced human bronchial contraction. |
1997 |
Fundam Clin Pharmacol |
pmid:9243258
|
O'Shaughnessy TC et al. |
Effect of pranlukast, an oral leukotriene receptor antagonist, on leukotriene D4 (LTD4) challenge in normal volunteers. |
1997 |
Thorax |
pmid:9227717
|
Sampson SE et al. |
Effect of inhaled prostaglandin D2 in normal and atopic subjects, and of pretreatment with leukotriene D4. |
1997 |
Thorax |
pmid:9227716
|
Meng XJ et al. |
Leukotriene D4 activates a chloride conductance in hepatocytes from lipopolysaccharide-treated rats. |
1997 |
J. Clin. Invest. |
pmid:9185515
|
Goldhill J et al. |
Interleukin-4 modulates cholinergic neural control of mouse small intestinal longitudinal muscle. |
1997 |
Am. J. Physiol. |
pmid:9176223
|
Joki S et al. |
Effect of leukotriene D4 on ciliary activity in human, guinea-pig and rat respiratory mucosa. |
1996 |
Pulm Pharmacol |
pmid:9160411
|
Pedersen KE et al. |
Cysteinyl leukotrienes induce P-selectin expression in human endothelial cells via a non-CysLT1 receptor-mediated mechanism. |
1997 |
J. Pharmacol. Exp. Ther. |
pmid:9152370
|
Takano T et al. |
Aspirin-triggered 15-epi-lipoxin A4 (LXA4) and LXA4 stable analogues are potent inhibitors of acute inflammation: evidence for anti-inflammatory receptors. |
1997 |
J. Exp. Med. |
pmid:9151906
|
Hazel BA et al. |
Induction of granulocytic differentiation in a mouse model by benzene and hydroquinone. |
1996 |
Environ. Health Perspect. |
pmid:9118902
|
Maehr H and Yang R |
Structure optimization of a leukotriene D4 antagonist by combinatorial chemistry in solution. |
1997 |
Bioorg. Med. Chem. |
pmid:9113326
|
Muñoz NM et al. |
Eosinophil chemotaxis inhibited by 5-lipoxygenase blockade and leukotriene receptor antagonism. |
1997 |
Am. J. Respir. Crit. Care Med. |
pmid:9105085
|
Diamant Z et al. |
The effect of inhaled leukotriene D4 and methacholine on sputum cell differentials in asthma. |
1997 |
Am. J. Respir. Crit. Care Med. |
pmid:9105062
|
Joki S and Saano V |
Influence of ageing on ciliary beat frequency and on ciliary response to leukotriene D4 in guinea-pig tracheal epithelium. |
1997 |
Clin. Exp. Pharmacol. Physiol. |
pmid:9075591
|
Dumitriu D et al. |
Mechanism of action of leukotriene D4 on guinea pig tracheal smooth muscle cells: roles of Ca++ influx and intracellular Ca++ release. |
1997 |
J. Pharmacol. Exp. Ther. |
pmid:9067324
|
Wang Y et al. |
Induction of LTD in the dentate gyrus in vitro is NMDA receptor independent, but dependent on Ca2+ influx via low-voltage-activated Ca2+ channels and release of Ca2+ from intracellular stores. |
1997 |
J. Neurophysiol. |
pmid:9065852
|
Tvaermose-Nielsen O et al. |
Discovery of OT4003, a novel, potent, and orally active cys-LT1 receptor antagonist. |
1997 |
Bioorg. Med. Chem. |
pmid:9061206
|
Kageyama N et al. |
Role of endogenous nitric oxide in airway microvascular leakage induced by inflammatory mediators. |
1997 |
Eur. Respir. J. |
pmid:9032485
|
Kubes P |
Nitric oxide and microvascular permeability: a continuing dilemma. |
1997 |
Eur. Respir. J. |
pmid:9032483
|
Gissurarson SR et al. |
Effect of lobaric acid on cysteinyl-leukotriene formation and contractile activity of guinea pig taenia coli. |
1997 |
J. Pharmacol. Exp. Ther. |
pmid:9023290
|
Rajah R et al. |
Leukotriene D4 induces MMP-1, which functions as an IGFBP protease in human airway smooth muscle cells. |
1996 |
Am. J. Physiol. |
pmid:8997273
|
Garcia C et al. |
Effects of synthetic peptido-leukotrienes on bone resorption in vitro. |
1996 |
J. Bone Miner. Res. |
pmid:8992883
|
Bäck M et al. |
The cysteinyl-leukotriene receptor antagonist BAY u9773 is a competitive antagonist of leukotriene C4 in the guinea-pig ileum. |
1996 |
Eur. J. Pharmacol. |
pmid:8982726
|
Nagase T et al. |
Airway and tissue behavior during early response in sensitized rats: role of 5-HT and LTD4. |
1996 |
J. Appl. Physiol. |
pmid:8929602
|
Ganbo T et al. |
The effects of leukotrienes C4 and D4 on ciliary activity of human paranasal sinus mucosa in vitro. |
1995 |
Rhinology |
pmid:8919211
|
Kang BC et al. |
Experimental asthma developed by room air contamination with cockroach allergen. |
1996 |
Int. Arch. Allergy Immunol. |
pmid:8917126
|
Nagase T et al. |
Roles of calcitonin gene-related peptide (CGRP) in hyperpnea-induced constriction in guinea pigs. |
1996 |
Am. J. Respir. Crit. Care Med. |
pmid:8912779
|
Gyömber E et al. |
Effect of lipoxygenase inhibitors and leukotriene antagonists on acute and chronic gastric haemorrhagic mucosal lesions in ulcer models in the rat. |
1996 |
J. Gastroenterol. Hepatol. |
pmid:8912128
|
Kaminuma O et al. |
Inhibitory effect of a novel phosphodiesterase IV inhibitor, T-440, on antigen- and chemical mediator-induced bronchoconstrictions in guinea pigs in vivo. |
1996 |
Jpn. J. Pharmacol. |
pmid:8902593
|
Martin CA et al. |
In vitro pharmacological effects of S 12370 (2-[4-benzhydryloxypiperidinoethyl]isoxindole; an antibronchoconstrictor agent) in normal and sensitized tissue. |
1996 |
Fundam Clin Pharmacol |
pmid:8902549
|
Hisamatsu K et al. |
Effect of leukotriene C4 exposure on ciliated cells of the nasal mucosa. |
1996 |
Prostaglandins |
pmid:8900445
|
Chong K et al. |
Drug substance manufacture process control: application of flow injection analysis and HPLC for monitoring an enantiospecific synthesis. |
1996 |
J Pharm Biomed Anal |
pmid:8895082
|
Omori C et al. |
Eicosanoids modulate hyperpnea-induced bronchoconstriction in canine peripheral airways. |
1996 |
J. Appl. Physiol. |
pmid:8889761
|
Underwood DC et al. |
Persistent airway eosinophilia after leukotriene (LT) D4 administration in the guinea pig: modulation by the LTD4 receptor antagonist, pranlukast, or an interleukin-5 monoclonal antibody. |
1996 |
Am. J. Respir. Crit. Care Med. |
pmid:8887574
|
Burghardt JS et al. |
Lipid mediators in oxygen-induced airway remodeling and hyperresponsiveness in newborn rats. |
1996 |
Am. J. Respir. Crit. Care Med. |
pmid:8887572
|
Tai S et al. |
Effect of leukotriene D4 on tracheal mucociliary transport velocity in quails. |
1996 |
Jpn. J. Pharmacol. |
pmid:8866758
|
Wensing G et al. |
Pharmacodynamics and pharmacokinetics of BAY x 7195 aerosol, a new and selective receptor antagonist of cysteinyl-leukotrienes, in normal volunteers. |
1996 |
Br J Clin Pharmacol |
pmid:8864314
|
Fukai F et al. |
Transcellular biosynthesis of cysteinyl leukotrienes by Kupffer cell-hepatocyte cooperation in rat liver. |
1996 |
Cell Biol. Int. |
pmid:8858827
|
Abraham WM et al. |
Effect of TYB-2285 on antigen-induced airway responses in sheep. |
1996 |
Pulm Pharmacol |
pmid:8843510
|
Tanaka H et al. |
The effect of a novel leukotriene C4/D4 antagonist, BAY-x-7195, on experimental allergic reactions. |
1995 Nov-Dec |
Prostaglandins |
pmid:8838238
|
Patry C et al. |
Leukotriene receptors in HL-60 cells differentiated into eosinophils, monocytes and neutrophils. |
1996 |
Prostaglandins Leukot. Essent. Fatty Acids |
pmid:8832765
|
Reiss TF et al. |
Effects of montelukast (MK-0476), a new potent cysteinyl leukotriene (LTD4) receptor antagonist, in patients with chronic asthma. |
1996 |
J. Allergy Clin. Immunol. |
pmid:8828530
|
Hendeles L and Marshik PL |
Zileuton: a new therapy for asthma or just the first of a new class of drugs. |
1996 Jul-Aug |
Ann Pharmacother |
pmid:8826576
|
Herron DK et al. |
Visualization and comparison of molecular dynamics simulations of leukotriene C4, leukotriene D4, and leukotriene E4. |
1995 |
J Mol Graph |
pmid:8820302
|
Tominaga M et al. |
ONO-1078 antagonizes diarrhea-causing changes in ion transport and smooth muscle contraction induced by peptidoleukotrienes in rat and human colon in vitro. |
1996 |
J. Pharmacol. Exp. Ther. |
pmid:8819486
|
Madsen F et al. |
Challenge interval determines tachyphylaxis to aerosolized LTD4. |
1995 |
Pulm Pharmacol |
pmid:8819178
|
Adolfsson JL et al. |
Leukotriene D4-induced activation and translocation of the G-protein alpha i3-subunit in human epithelial cells. |
1996 |
Biochem. Biophys. Res. Commun. |
pmid:8806649
|
Shikada K and Tanaka S |
Effect of the K+ channel openers NIP-121 and cromakalim on melittin-induced relaxation of guinea-pig isolated trachea. |
1996 |
Prostaglandins |
pmid:8792445
|