Ltd4

Ltd4 is a lipid of Fatty Acyls (FA) class. Ltd4 is associated with abnormalities such as Inflammatory Bowel Diseases, Inflammatory disorder, Pneumonia, Asthma and Virus Diseases. The involved functions are known as uptake, Phosphorylation, Signal Transduction, symporter activity and Regulation. Ltd4 often locates in Protoplasm, Mucous Membrane, Membrane, Extracellular and Epithelium. The associated genes with Ltd4 are TYRO3 gene, RAF1 gene, serine-borate complex, ITGAM gene and ITGB2 gene. The related lipids are Lipopolysaccharides.

Cross Reference

Introduction

To understand associated biological information of Ltd4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Ltd4?

Ltd4 is suspected in Asthma, Inflammatory Bowel Diseases, Inflammatory disorder, Pneumonia, Virus Diseases and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Ltd4

MeSH term MeSH ID Detail
Airway Obstruction D000402 13 associated lipids
Asbestosis D001195 8 associated lipids
Aspergillosis, Allergic Bronchopulmonary D001229 2 associated lipids
Asthma, Exercise-Induced D001250 10 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Coronary Artery Disease D003324 47 associated lipids
Edema D004487 152 associated lipids
Glomerulonephritis D005921 35 associated lipids
Leukemia D007938 74 associated lipids
Respiratory Hypersensitivity D012130 18 associated lipids
Sneezing D012912 6 associated lipids
Carotid Stenosis D016893 15 associated lipids
Endotoxemia D019446 27 associated lipids
Per page 10 20 | Total 13

PubChem Associated disorders and diseases

What pathways are associated with Ltd4

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Ltd4?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Ltd4?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Ltd4?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Ltd4?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Ltd4?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Ltd4

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Per page 10 20 50 100 | Total 562
Authors Title Published Journal PubMed Link
Kimura K et al. Modulation of platelet activating factor-induced glycogenolysis in the perfused rat liver after administration of endotoxin in vivo. 1998 J. Biochem. pmid:9504421
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Titos E et al. Hepatocyte-derived cysteinyl leukotrienes modulate vascular tone in experimental cirrhosis. 2000 Gastroenterology pmid:10982774
Ménard G and Bissonnette EY Priming of alveolar macrophages by leukotriene D(4): potentiation of inflammation. 2000 Am. J. Respir. Cell Mol. Biol. pmid:11017925
Arakida Y et al. In vivo pharmacologic profile of YM158, a new dual antagonist for leukotriene D4 and thromboxane A2 receptors. 2000 Jpn. J. Pharmacol. pmid:10887942
McMahon B et al. Lipoxin A4 antagonizes the mitogenic effects of leukotriene D4 in human renal mesangial cells. Differential activation of MAP kinases through distinct receptors. 2000 J. Biol. Chem. pmid:10869343
Laberge S et al. Antigen-induced airway inflammation and hyper-responsiveness does not enhance airway responses to a subsequent antigen challenge in rats. 2000 Respir Med pmid:10714478
Thodeti CK et al. Leukotriene D(4) triggers an association between gbetagamma subunits and phospholipase C-gamma1 in intestinal epithelial cells. 2000 J. Biol. Chem. pmid:10734140
Underwood DC et al. SB 239063, a potent p38 MAP kinase inhibitor, reduces inflammatory cytokine production, airways eosinophil infiltration, and persistence. 2000 J. Pharmacol. Exp. Ther. pmid:10734180
Kivity S et al. Eosinophil influx into the airways in patients with exercise-induced asthma. 2000 Respir Med pmid:11192956
Ravasi S et al. A kinetic binding study to evaluate the pharmacological profile of a specific leukotriene C(4) binding site not coupled to contraction in human lung parenchyma. 2000 Mol. Pharmacol. pmid:10825389
Ohd JF et al. Leukotrienes induce cell-survival signaling in intestinal epithelial cells. 2000 Gastroenterology pmid:11040187
Robbiani DF et al. The leukotriene C(4) transporter MRP1 regulates CCL19 (MIP-3beta, ELC)-dependent mobilization of dendritic cells to lymph nodes. 2000 Cell pmid:11114332
Hisamatsu K and Nakajima M Pranlukast protects leukotriene C4- and D4-induced epithelial cell impairment of the nasal mucosa in vitro. 2000 Life Sci. pmid:11105993
Nothacker HP et al. Molecular cloning and characterization of a second human cysteinyl leukotriene receptor: discovery of a subtype selective agonist. 2000 Mol. Pharmacol. pmid:11093801
Bäck M et al. Antagonist resistant contractions of the porcine pulmonary artery by cysteinyl-leukotrienes. 2000 Eur. J. Pharmacol. pmid:10936497
Kodani M et al. Intratracheal administration of anaphylatoxin C5a potentiates antigen-induced pulmonary reactions through the prolonged production of cysteinyl-leukotrienes. 2000 Immunopharmacology pmid:10996024
Heise CE et al. Characterization of the human cysteinyl leukotriene 2 receptor. 2000 J. Biol. Chem. pmid:10851239
Bäck M et al. Prostacyclin modulation of contractions of the human pulmonary artery by cysteinyl-leukotrienes. 2000 Eur. J. Pharmacol. pmid:10936498
Takasaki J et al. The molecular characterization and tissue distribution of the human cysteinyl leukotriene CysLT(2) receptor. 2000 Biochem. Biophys. Res. Commun. pmid:10913337