| MeSH term | MeSH ID | Detail |
|---|---|---|
| Airway Obstruction | D000402 | 13 associated lipids |
| Asbestosis | D001195 | 8 associated lipids |
| Aspergillosis, Allergic Bronchopulmonary | D001229 | 2 associated lipids |
| Asthma, Exercise-Induced | D001250 | 10 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Coronary Artery Disease | D003324 | 47 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Glomerulonephritis | D005921 | 35 associated lipids |
| Leukemia | D007938 | 74 associated lipids |
| Respiratory Hypersensitivity | D012130 | 18 associated lipids |
| Sneezing | D012912 | 6 associated lipids |
| Carotid Stenosis | D016893 | 15 associated lipids |
| Endotoxemia | D019446 | 27 associated lipids |
Ltd4
Ltd4 is a lipid of Fatty Acyls (FA) class. Ltd4 is associated with abnormalities such as Inflammatory Bowel Diseases, Inflammatory disorder, Pneumonia, Asthma and Virus Diseases. The involved functions are known as uptake, Phosphorylation, Signal Transduction, symporter activity and Regulation. Ltd4 often locates in Protoplasm, Mucous Membrane, Membrane, Extracellular and Epithelium. The associated genes with Ltd4 are TYRO3 gene, RAF1 gene, serine-borate complex, ITGAM gene and ITGB2 gene. The related lipids are Lipopolysaccharides.
Cross Reference
Introduction
To understand associated biological information of Ltd4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Ltd4?
Ltd4 is suspected in Asthma, Inflammatory Bowel Diseases, Inflammatory disorder, Pneumonia, Virus Diseases and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Ltd4
PubChem Associated disorders and diseases
What pathways are associated with Ltd4
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Ltd4?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Ltd4?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Ltd4?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with Ltd4?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Ltd4?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Ltd4
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Mehta KA et al. | Effect of formulation and process variables on porosity parameters and release rates from a multi unit erosion matrix of a poorly soluble drug. | 2000 | J Control Release | pmid:10640593 |
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| Fukuyama S et al. | Effect of eotaxin and platelet-activating factor on airway inflammation and hyperresponsiveness in guinea pigs in vivo. | 2000 | Am. J. Respir. Crit. Care Med. | pmid:10852755 |
| Ballart B et al. | Synthesis and pharmacological evaluation of new 4-2-(7-heterocyclemethoxynaftalen-2-ylmethoxy)ethylbenzoic acids as LTD(4)-antagonists. | 2000 | Eur J Med Chem | pmid:10858604 |
| Blain JF and Sirois P | Involvement of LTD(4)in allergic pulmonary inflammation in mice: modulation by cysLT(1)antagonist MK-571. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10913229 |
| Kivity S et al. | Eosinophil influx into the airways in patients with exercise-induced asthma. | 2000 | Respir Med | pmid:11192956 |
| Tran HS et al. | The cardiovascular hemodynamics and leukotriene kinetics during prostacyclin and anti-prostacyclin antibody infusions in septic shock. | 2000 | Shock | pmid:10847636 |
| Davis HM et al. | Human granulocyte CD11b expression as a pharmacodynamic biomarker of inflammation. | 2000 | J. Immunol. Methods | pmid:10854607 |
| Mayatepek E et al. | Defects in the synthesis of cysteinyl leukotrienes: a new group of inborn errors of metabolism. | 2000 | J. Inherit. Metab. Dis. | pmid:10896305 |
| Lopes LR et al. | Reduced inflammatory response in rats fed fat-rich diets: role of leukotrienes. | 2000 | Life Sci. | pmid:10896024 |
| Mayatepek E et al. | Analysis of leukotrienes in cerebrospinal fluid of a reference population and patients with inborn errors of metabolism: further evidence for a pathognomonic profile in LTC(4)-synthesis deficiency. | 2000 | Clin. Chim. Acta | pmid:10686285 |
| Muccitelli RM et al. | Cysteinyl leukotriene receptor assays. | 2001 | Curr Protoc Pharmacol | pmid:22293965 |
| Aoki M et al. | Studies on mechanisms of low emetogenicity of YM976, a novel phosphodiesterase type 4 inhibitor. | 2001 | J. Pharmacol. Exp. Ther. | pmid:11504812 |
| Bäck M et al. | An alternative pathway for metabolism of leukotriene D(4): effects on contractions to cysteinyl-leukotrienes in the guinea-pig trachea. | 2001 | Br. J. Pharmacol. | pmid:11487525 |
| Fukuishi N et al. | Antiallergic effect of ardisiaquinone A, a potent 5-lipoxygenase inhibitor. | 2001 | Phytomedicine | pmid:11824521 |
| Oliveira SH et al. | SCF-induced airway hyperreactivity is dependent on leukotriene production. | 2001 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:11350804 |
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| Aoki M et al. | Antiasthmatic effect of YM976, a novel PDE4 inhibitor, in guinea pigs. | 2001 | J. Pharmacol. Exp. Ther. | pmid:11259541 |
| Campos MG et al. | Galphimia glauca organic fraction antagonizes LTD(4)-induced contraction in guinea pig airways. | 2001 | J Ethnopharmacol | pmid:11137344 |
| Thodeti CK et al. | The epsilon isoform of protein kinase C is involved in regulation of the LTD(4)-induced calcium signal in human intestinal epithelial cells. | 2001 | Exp. Cell Res. | pmid:11139333 |
| Hele DJ et al. | Mediator involvement in antigen-induced bronchospasm and microvascular leakage in the airways of ovalbumin sensitized Brown Norway rats. | 2001 | Br. J. Pharmacol. | pmid:11159698 |
| Mehta KA et al. | Release performance of a poorly soluble drug from a novel, Eudragit-based multi-unit erosion matrix. | 2001 | Int J Pharm | pmid:11165089 |
| Ro JY et al. | The inhibitory mechanism of rebamipide on the mediator release in the guinea pig lung mast cells activated with specific antigen-antibody reactions. | 2001 | Pharmacology | pmid:11598424 |
| Thivierge M et al. | IL-13 and IL-4 up-regulate cysteinyl leukotriene 1 receptor expression in human monocytes and macrophages. | 2001 | J. Immunol. | pmid:11509632 |
| Echazarreta AL et al. | Pulmonary gas exchange and sputum cellular responses to inhaled leukotriene D(4) in asthma. | 2001 | Am. J. Respir. Crit. Care Med. | pmid:11463588 |
| Shi ZZ et al. | Disruption of gamma-glutamyl leukotrienase results in disruption of leukotriene D(4) synthesis in vivo and attenuation of the acute inflammatory response. | 2001 | Mol. Cell. Biol. | pmid:11463821 |
| Möhle R et al. | Transendothelial migration of hematopoietic progenitor cells. Role of chemotactic factors. | 2001 | Ann. N. Y. Acad. Sci. | pmid:11458515 |
| Mizutani N et al. | Markedly increased nasal blockage by intranasal leukotriene D4 in an experimental allergic rhinitis model: contribution of dilated mucosal blood vessels. | 2001 | Jpn. J. Pharmacol. | pmid:11459119 |
| Kawada N et al. | The effect of leukotriene D(4) inhalation on the antigen-induced airway hyperresponsiveness and inflammation in 5-lipoxygenase gene-deficient mice. | 2001 | Int. Arch. Allergy Immunol. | pmid:11815738 |
| Young RN | Discovery of montelukast: a once-a-day oral antagonist of leukotriene D4 for the treatment of chronic asthma. | 2001 | Prog Med Chem | pmid:11774796 |
| Bouchelouche K et al. | The action of cysteinyl-leukotrienes on intracellular calcium mobilization in human detrusor myocytes. | 2001 | BJU Int. | pmid:11350414 |
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| Maekawa A et al. | Identification in mice of two isoforms of the cysteinyl leukotriene 1 receptor that result from alternative splicing. | 2001 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11226226 |
| Saegusa S et al. | Leukotriene D(4)-induced Rho-mediated actin reorganization in human bronchial smooth muscle cells. | 2001 | Eur. J. Pharmacol. | pmid:11226389 |
| Bautz F et al. | Chemotaxis and transendothelial migration of CD34(+) hematopoietic progenitor cells induced by the inflammatory mediator leukotriene D4 are mediated by the 7-transmembrane receptor CysLT1. | 2001 | Blood | pmid:11369634 |
| Bouchelouche K et al. | Calcium signaling in cultured human detrusor smooth muscle cells from patients with interstitial cystitis. | 2001 | Urology | pmid:11378073 |
| Bouchelouche K et al. | Cysteinyl-leukotriene D(4) receptors in smooth muscle cells. | 2001 | Urology | pmid:11378074 |
| Nabe T et al. | Comparison of cedar pollen-induced allergic rhinitis in passively and actively sensitized guinea pigs. | 2001 | Jpn. J. Pharmacol. | pmid:11388645 |
| Ruck LM et al. | Synergistic antiallergic activity of combined histamine H1- and cysteinyl leukotriene1-receptor blockade in human bronchus. | 2001 | Life Sci. | pmid:11432448 |
| Simons FE et al. | Suppression of the early and late cutaneous allergic responses using fexofenadine and montelukast. | 2001 | Ann. Allergy Asthma Immunol. | pmid:11206237 |
| Accomazzo MR et al. | Leukotriene D4-induced activation of smooth-muscle cells from human bronchi is partly Ca2+-independent. | 2001 | Am. J. Respir. Crit. Care Med. | pmid:11208655 |
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| Hui Y et al. | The murine cysteinyl leukotriene 2 (CysLT2) receptor. cDNA and genomic cloning, alternative splicing, and in vitro characterization. | 2001 | J. Biol. Chem. | pmid:11591709 |
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| Karaman O et al. | The comparison of the efficacy of fluticasone propionate with cetirizine in perennial allergic rhinitis. | 2001 Mar-Apr | Allergol Immunopathol (Madr) | pmid:11420028 |
| McMahon B et al. | Lipoxin, leukotriene, and PDGF receptors cross-talk to regulate mesangial cell proliferation. | 2002 | FASEB J. | pmid:12223454 |
| Ohshima N et al. | A functional study on CysLT(1) receptors in human eosinophils. | 2002 | Int. Arch. Allergy Immunol. | pmid:12373000 |
| Uemura M et al. | Cysteinyl leukotrienes in the bile of patients with obstructive jaundice. | 2002 | J. Gastroenterol. | pmid:12424566 |