Ltd4

Ltd4 is a lipid of Fatty Acyls (FA) class. Ltd4 is associated with abnormalities such as Inflammatory Bowel Diseases, Inflammatory disorder, Pneumonia, Asthma and Virus Diseases. The involved functions are known as uptake, Phosphorylation, Signal Transduction, symporter activity and Regulation. Ltd4 often locates in Protoplasm, Mucous Membrane, Membrane, Extracellular and Epithelium. The associated genes with Ltd4 are TYRO3 gene, RAF1 gene, serine-borate complex, ITGAM gene and ITGB2 gene. The related lipids are Lipopolysaccharides.

Cross Reference

Introduction

To understand associated biological information of Ltd4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Ltd4?

Ltd4 is suspected in Asthma, Inflammatory Bowel Diseases, Inflammatory disorder, Pneumonia, Virus Diseases and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Ltd4

PubChem Associated disorders and diseases

What pathways are associated with Ltd4

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Ltd4?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with Ltd4?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Ltd4?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Ltd4?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Ltd4?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Ltd4

Download all related citations
Per page 10 20 50 100 | Total 562
Authors Title Published Journal PubMed Link
Shikada K and Tanaka S Effect of the K+ channel openers NIP-121 and cromakalim on melittin-induced relaxation of guinea-pig isolated trachea. 1996 Prostaglandins pmid:8792445
Hisamatsu K et al. Effect of leukotriene C4 exposure on ciliated cells of the nasal mucosa. 1996 Prostaglandins pmid:8900445
Kelefiotis D et al. Eicosanoid-induced growth and signaling events in rat glomerular mesangial cells. 1995 Prostaglandins pmid:7659782
Ramondt J et al. Sensitivity of ovine myometrial tissue to various eicosanoids in vitro. 1995 Prostaglandins pmid:7792392
Tanaka H et al. The effect of a novel leukotriene C4/D4 antagonist, BAY-x-7195, on experimental allergic reactions. 1995 Nov-Dec Prostaglandins pmid:8838238
Wen FQ et al. Eicosanoid profile in cultured human pulmonary artery smooth muscle cells treated with IL-1 beta and TNF alpha. 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:9758210
Patry C et al. Leukotriene receptors in HL-60 cells differentiated into eosinophils, monocytes and neutrophils. 1996 Prostaglandins Leukot. Essent. Fatty Acids pmid:8832765
Blain JF and Sirois P Involvement of LTD(4)in allergic pulmonary inflammation in mice: modulation by cysLT(1)antagonist MK-571. 2000 Prostaglandins Leukot. Essent. Fatty Acids pmid:10913229
Rehni AK and Singh TG Modulation of leukotriene D4 attenuates the development of seizures in mice. 2011 Prostaglandins Leukot. Essent. Fatty Acids pmid:21641195
Yudina Y et al. Regulation of the eicosanoid pathway by tumour necrosis factor alpha and leukotriene D4 in intestinal epithelial cells. 2008 Prostaglandins Leukot. Essent. Fatty Acids pmid:19042113
Capra V et al. Involvement of prenylated proteins in calcium signaling induced by LTD4 in differentiated U937 cells. 2003 Prostaglandins Other Lipid Mediat. pmid:14518564
Claesson HE On the biosynthesis and biological role of eoxins and 15-lipoxygenase-1 in airway inflammation and Hodgkin lymphoma. 2009 Prostaglandins Other Lipid Mediat. pmid:19130894
Selg E et al. Two different mechanisms for modulation of bronchoconstriction in guinea-pigs by cyclooxygenase metabolites. 2009 Prostaglandins Other Lipid Mediat. pmid:19103301
Bengtsson AM et al. Leukotriene D(4) induces AP-1 but not NFkappaB signaling in intestinal epithelial cells. 2008 Prostaglandins Other Lipid Mediat. pmid:18083053
Lötzer K et al. 5-Lipoxygenase/cyclooxygenase-2 cross-talk through cysteinyl leukotriene receptor 2 in endothelial cells. 2007 Prostaglandins Other Lipid Mediat. pmid:17991613
Nakanishi Y et al. Synergism between cysteinyl leukotrienes and thromboxane A2 to induce allergic late phase nasal blockage in guinea pigs. 2004 Prostaglandins Other Lipid Mediat. pmid:15560121
Cui S et al. Effects of platelet-activating factor, thromboxane A2 and leukotriene D4 on isolated perfused rat liver. 2006 Prostaglandins Other Lipid Mediat. pmid:16846785
Tanaka Y et al. Different mechanisms between thromboxane A2- and leukotriene D4-induced nasal blockage in guinea pigs. 2006 Prostaglandins Other Lipid Mediat. pmid:16939879
Evans JF Cysteinyl leukotriene receptors. 2002 Prostaglandins Other Lipid Mediat. pmid:12432945
Nishimura H et al. Acute effects of prostaglandin D2 to induce airflow obstruction and airway microvascular leakage in guinea pigs: role of thromboxane A2 receptors. 2001 Prostaglandins Other Lipid Mediat. pmid:11519790
Sheller J et al. The prostaglandin E agonist, misoprostol, inhibits airway IL-5 production in atopic asthmatics. 2002 Prostaglandins Other Lipid Mediat. pmid:12428688
Abraham WM et al. Effect of TYB-2285 on antigen-induced airway responses in sheep. 1996 Pulm Pharmacol pmid:8843510
Joki S et al. Effect of leukotriene D4 on ciliary activity in human, guinea-pig and rat respiratory mucosa. 1996 Pulm Pharmacol pmid:9160411
Callaghan DH et al. Respiratory tract eicosanoid measurement using microdialysis sampling and GC/MS detection. 1994 Pulm Pharmacol pmid:8003850
Madsen F et al. Challenge interval determines tachyphylaxis to aerosolized LTD4. 1995 Pulm Pharmacol pmid:8819178
Capra V and Rovati GE Rosuvastatin inhibits human airway smooth muscle cells mitogenic response to eicosanoid contractile agents. 2014 Pulm Pharmacol Ther pmid:23806820
Turner DJ et al. Bradykinin-induced airway constriction in guinea-pigs: role of leukotriene D(4). 2000 Pulm Pharmacol Ther pmid:10930357
Skogvall S et al. Effects of capsazepine on human small airway responsiveness unravel a novel class of bronchorelaxants. 2007 Pulm Pharmacol Ther pmid:16731017
Pitt CM and Nally JE Angiotensin II-mediated potentiation of endothelin-1-evoked bronchial contractions: a role for leukotrienes? 1999 Pulm Pharmacol Ther pmid:10208831
Skogvall S et al. Discovery of a potent and long-acting bronchorelaxing capsazepinoid, RESPIR 4-95. 2008 Pulm Pharmacol Ther pmid:17374498
Yang XX et al. The beta(2)-agonist salbutamol inhibits bronchoconstriction and leukotriene D(4) synthesis after dry gas hyperpnea in the guinea-pig. 1999 Pulm Pharmacol Ther pmid:10545287
Schelfhout V et al. The effect of the leukotriene receptor antagonist zafirlukast on neurokinin A-induced bronchoconstriction in patients with asthma--A comparison with leukotriene D4 induced broncoconstriction. 2008 Pulm Pharmacol Ther pmid:17611132
Guan WJ et al. Impulse oscillometry for leukotriene D4 inhalation challenge in asthma. 2013 Respir Care pmid:23716710
Laberge S et al. Antigen-induced airway inflammation and hyper-responsiveness does not enhance airway responses to a subsequent antigen challenge in rats. 2000 Respir Med pmid:10714478
Kivity S et al. Eosinophil influx into the airways in patients with exercise-induced asthma. 2000 Respir Med pmid:11192956
Lane SJ Leukotriene antagonism in asthma and rhinitis. 1998 Respir Med pmid:9850362
Yamaya M et al. Dipeptidase inhibitor and epithelial removal potentiate leukotriene D4-induced human tracheal smooth muscle contraction. 1998 Respir Physiol pmid:9496476
Ahmed T et al. Inhibition of allergic airway responses by heparin derived oligosaccharides: identification of a tetrasaccharide sequence. 2012 Respir. Res. pmid:22269021
Rovati GE et al. Cysteinyl-leukotrienes in the regulation of beta2-adrenoceptor function: an in vitro model of asthma. 2006 Respir. Res. pmid:16875498
Ravasi S et al. CysLT1 receptor-induced human airway smooth muscle cells proliferation requires ROS generation, EGF receptor transactivation and ERK1/2 phosphorylation. 2006 Respir. Res. pmid:16553950
Tohda Y et al. Role of chemical mediators in airway hyperresponsiveness in an asthmatic model. 2001 Respiration pmid:11223734
Shirasaki H et al. The effect of a cysteinyl leukotriene antagonist, ONO-1078 (pranlukast) on agonist- and antigen-induced nasal microvascular leakage in guinea pigs. 1998 Rhinology pmid:9695159
Ganbo T et al. The effects of leukotrienes C4 and D4 on ciliary activity of human paranasal sinus mucosa in vitro. 1995 Rhinology pmid:8919211
Reims A et al. Cysteinyl leukotrienes are secretagogues in atrophic coeliac and in normal duodenal mucosa of children. 2005 Scand. J. Gastroenterol. pmid:15764146
Julius P et al. sCD14 in bronchoalveolar lavage 18, 42 and 162 hours after segmental allergen provocation. 2010 Scand. J. Immunol. pmid:20384875
Tran HS et al. The cardiovascular hemodynamics and leukotriene kinetics during prostacyclin and anti-prostacyclin antibody infusions in septic shock. 2000 Shock pmid:10847636
Hazel BA et al. Benzene and its metabolite, hydroquinone, induce granulocytic differentiation in myeloblasts by interacting with cellular signaling pathways activated by granulocyte colony-stimulating factor. 1995 Stem Cells pmid:7542115
O'Shaughnessy TC et al. Effect of pranlukast, an oral leukotriene receptor antagonist, on leukotriene D4 (LTD4) challenge in normal volunteers. 1997 Thorax pmid:9227717
Lee TH and Christie PE Leukotrienes and aspirin induced asthma. 1993 Thorax pmid:8303620
Gyllfors P et al. Relation between bronchial responsiveness to inhaled leukotriene D4 and markers of leukotriene biosynthesis. 2005 Thorax pmid:16055619