Ltd4

Ltd4 is a lipid of Fatty Acyls (FA) class. Ltd4 is associated with abnormalities such as Inflammatory Bowel Diseases, Inflammatory disorder, Pneumonia, Asthma and Virus Diseases. The involved functions are known as uptake, Phosphorylation, Signal Transduction, symporter activity and Regulation. Ltd4 often locates in Protoplasm, Mucous Membrane, Membrane, Extracellular and Epithelium. The associated genes with Ltd4 are TYRO3 gene, RAF1 gene, serine-borate complex, ITGAM gene and ITGB2 gene. The related lipids are Lipopolysaccharides.

Cross Reference

Introduction

To understand associated biological information of Ltd4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Ltd4?

Ltd4 is suspected in Asthma, Inflammatory Bowel Diseases, Inflammatory disorder, Pneumonia, Virus Diseases and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Ltd4

MeSH term MeSH ID Detail
Sneezing D012912 6 associated lipids
Carotid Stenosis D016893 15 associated lipids
Endotoxemia D019446 27 associated lipids
Per page 10 20 | Total 13

PubChem Associated disorders and diseases

What pathways are associated with Ltd4

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Ltd4?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with Ltd4?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Ltd4?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Ltd4?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Ltd4?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Ltd4

Download all related citations
Per page 10 20 50 100 | Total 562
Authors Title Published Journal PubMed Link
Bäck M et al. An alternative pathway for metabolism of leukotriene D(4): effects on contractions to cysteinyl-leukotrienes in the guinea-pig trachea. 2001 Br. J. Pharmacol. pmid:11487525
Wunder F et al. Pharmacological characterization of the first potent and selective antagonist at the cysteinyl leukotriene 2 (CysLT(2)) receptor. 2010 Br. J. Pharmacol. pmid:20423349
Tsang F et al. Effects of mitogen-activated protein kinase kinase inhibitor PD 098059 on antigen challenge of guinea-pig airways in vitro. 1998 Br. J. Pharmacol. pmid:9776345
Liu YC et al. Effects of the cysteinyl leukotriene receptor antagonists pranlukast and zafirlukast on tracheal mucus secretion in ovalbumin-sensitized guinea-pigs in vitro. 1998 Br. J. Pharmacol. pmid:9647482
Fujimura M et al. A partial involvement of histamine in ultrasonically nebulized distilled water-induced bronchoconstriction in guinea-pigs. 1998 Br. J. Pharmacol. pmid:9831931
Snetkov VA et al. Mechanisms of leukotriene D4-induced constriction in human small bronchioles. 2001 Br. J. Pharmacol. pmid:11350860
Bäck M et al. Update on leukotriene, lipoxin and oxoeicosanoid receptors: IUPHAR Review 7. 2014 Br. J. Pharmacol. pmid:24588652
Yamashita T and Kokubun S Nonselective cationic currents activated by acetylcholine in swine tracheal smooth muscle cells. 1999 Can. J. Physiol. Pharmacol. pmid:10588484
Nagase T and Ludwig MS Antigen-induced responses in lung parenchymal strips during sinusoidal oscillation. 1998 Can. J. Physiol. Pharmacol. pmid:9635157
Nagayama S et al. Increased sensitivity to vincristine of MDR cells by the leukotriene D4 receptor antagonist, ONO-1078. 1998 Cancer Lett. pmid:9751271
Nielsen CK et al. A novel localization of the G-protein-coupled CysLT1 receptor in the nucleus of colorectal adenocarcinoma cells. 2005 Cancer Res. pmid:15705869
Parhamifar L et al. Activation of cPLA2 is required for leukotriene D4-induced proliferation in colon cancer cells. 2005 Carcinogenesis pmid:15975962
Zhou G et al. Atorvastatin reduces plaque vulnerability in an atherosclerotic rabbit model by altering the 5-lipoxygenase pathway. 2010 Cardiology pmid:20234134
Finkensieper A et al. The 5-lipoxygenase pathway regulates vasculogenesis in differentiating mouse embryonic stem cells. 2010 Cardiovasc. Res. pmid:19965960
Chen C et al. Impaired motor coordination correlates with persistent multiple climbing fiber innervation in PKC gamma mutant mice. 1995 Cell pmid:8548809
Robbiani DF et al. The leukotriene C(4) transporter MRP1 regulates CCL19 (MIP-3beta, ELC)-dependent mobilization of dendritic cells to lymph nodes. 2000 Cell pmid:11114332
Fukai F et al. Transcellular biosynthesis of cysteinyl leukotrienes by Kupffer cell-hepatocyte cooperation in rat liver. 1996 Cell Biol. Int. pmid:8858827
Grönroos E et al. The regulation of leukotriene D4-induced calcium influx in human epithelial cells involves protein tyrosine phosphorylation. 1995 Cell Calcium pmid:7621531
Grönroos E et al. Leukotriene D4 induces a rapid increase in cAMP in the human epithelial cell line, Int 407: a potential role for this signal in the regulation of calcium influx through the plasma membrane. 1998 Cell Calcium pmid:9793684
Jørgensen ST et al. Double mutation at the putative protein kinase C phosphorylation sites Thr151 plus Thr323 in the mouse leukotrieneD4 receptor eliminates homologous desensitization. 2013 Cell. Physiol. Biochem. pmid:23485744
Babu KS and Salvi SS Aspirin and asthma. 2000 Chest pmid:11083703
Dayyat E et al. Leukotriene pathways and in vitro adenotonsillar cell proliferation in children with obstructive sleep apnea. 2009 Chest pmid:19118273
Obase Y et al. Effects of pranlukast on chemical mediators in induced sputum on provocation tests in atopic and aspirin-intolerant asthmatic patients. 2002 Chest pmid:11796443
Nathan RA et al. Inhaled ICI 204,219 blocks antigen-induced bronchoconstriction in subjects with bronchial asthma. 1994 Chest pmid:8306751
Kanwar S et al. Leukotriene C4/D4 induces P-selectin and sialyl Lewis(x)-dependent alterations in leukocyte kinetics in vivo. 1995 Circ. Res. pmid:7554141
Allen S et al. Differential leukotriene constrictor responses in human atherosclerotic coronary arteries. 1998 Circulation pmid:9641692
Datta YH et al. Peptido-leukotrienes are potent agonists of von Willebrand factor secretion and P-selectin surface expression in human umbilical vein endothelial cells. 1995 Circulation pmid:7586318
Schain F et al. Differential expression of cysteinyl leukotriene receptor 1 and 15-lipoxygenase-1 in non-Hodgkin lymphomas. 2008 Clin Lymphoma Myeloma pmid:19064398
Celik D et al. Cysteinyl leukotrienes in exhaled breath condensate of smoking asthmatics. 2013 Clin. Chem. Lab. Med. pmid:23045385
Mayatepek E et al. Analysis of leukotrienes in cerebrospinal fluid of a reference population and patients with inborn errors of metabolism: further evidence for a pathognomonic profile in LTC(4)-synthesis deficiency. 2000 Clin. Chim. Acta pmid:10686285
Ichiyama T et al. Cysteinyl leukotrienes induce monocyte chemoattractant protein 1 in human monocytes/macrophages. 2005 Clin. Exp. Allergy pmid:16164450
Busse WW et al. Leukotriene pathway inhibitors in asthma and chronic obstructive pulmonary disease. 1999 Clin. Exp. Allergy pmid:10421833
Bossé Y et al. Leukotriene D4-induced, epithelial cell-derived transforming growth factor beta1 in human bronchial smooth muscle cell proliferation. 2008 Clin. Exp. Allergy pmid:18028462
Ichiyama T et al. Pranlukast inhibits NF-kappa B activation in human monocytes/macrophages and T cells. 2003 Clin. Exp. Allergy pmid:12801316
Mechiche H et al. Effects of cysteinyl leukotrienes in small human bronchus and antagonist activity of montelukast and its metabolites. 2003 Clin. Exp. Allergy pmid:12859443
Kurosawa M et al. Inhibition by a novel peptide leukotriene receptor antagonist ONO-1078 of airway wall thickening and airway hyperresponsiveness to histamine induced by leukotriene C4 or leukotriene D4 in guinea-pigs. 1994 Clin. Exp. Allergy pmid:7842366
Shirasaki H et al. Expression and localization of the cysteinyl leukotriene 1 receptor in human nasal mucosa. 2002 Clin. Exp. Allergy pmid:12100046
Heimbürger M and Palmblad JE Effects of leukotriene C4 and D4, histamine and bradykinin on cytosolic calcium concentrations and adhesiveness of endothelial cells and neutrophils. 1996 Clin. Exp. Immunol. pmid:8608646
Joki S and Saano V Influence of ageing on ciliary beat frequency and on ciliary response to leukotriene D4 in guinea-pig tracheal epithelium. 1997 Clin. Exp. Pharmacol. Physiol. pmid:9075591
Ohbayashi H et al. Neutral endopeptidase 3.4.24.11 inhibition potentiates the inhibitory effects of type-C natriuretic peptide on leukotriene D4-induced airway changes. 1998 Clin. Exp. Pharmacol. Physiol. pmid:9887994
Trandafir CC et al. Cysteinyl leukotrienes and leukotriene B mediate vasoconstriction to arginine vasopressin in rat basilar artery. 2005 Clin. Exp. Pharmacol. Physiol. pmid:16445567
Tokuriki S et al. Leukotriene D(4) enhances the function of endothelin-1-primed fibroblasts. 2007 Clin. Immunol. pmid:17627891
Kato J et al. Leukotriene D4 potentiates fibronectin-induced migration of human lung fibroblasts. 2005 Clin. Immunol. pmid:16109507
Smith LJ et al. Inhibition of leukotriene D4-induced bronchoconstriction in subjects with asthma: a concentration-effect study of ICI 204,219. 1993 Clin. Pharmacol. Ther. pmid:8222486
Yang YY et al. Effect of chronic CB1 cannabinoid receptor antagonism on livers of rats with biliary cirrhosis. 2007 Clin. Sci. pmid:17176248
Wooltorton E Asthma drug zafirlukast (Accolate): serious hepatic events. 2004 CMAJ pmid:15159361
Patel JP et al. Beneficial effects of combined thromboxane and leukotriene receptor antagonism in hemorrhagic shock. 1995 Crit. Care Med. pmid:7867347
Guan W et al. Leukotriene D4 bronchial provocation test: methodology and diagnostic value. 2012 Curr Med Res Opin pmid:22435894
Muccitelli RM et al. Cysteinyl leukotriene receptor assays. 2001 Curr Protoc Pharmacol pmid:22293965
Haneda Y et al. Leukotriene D4 enhances tumor necrosis factor-α-induced vascular endothelial growth factor production in human monocytes/macrophages. 2011 Cytokine pmid:21482134