Ltd4

Ltd4 is a lipid of Fatty Acyls (FA) class. Ltd4 is associated with abnormalities such as Inflammatory Bowel Diseases, Inflammatory disorder, Pneumonia, Asthma and Virus Diseases. The involved functions are known as uptake, Phosphorylation, Signal Transduction, symporter activity and Regulation. Ltd4 often locates in Protoplasm, Mucous Membrane, Membrane, Extracellular and Epithelium. The associated genes with Ltd4 are TYRO3 gene, RAF1 gene, serine-borate complex, ITGAM gene and ITGB2 gene. The related lipids are Lipopolysaccharides.

Cross Reference

Introduction

To understand associated biological information of Ltd4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Ltd4?

Ltd4 is suspected in Asthma, Inflammatory Bowel Diseases, Inflammatory disorder, Pneumonia, Virus Diseases and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Ltd4

MeSH term MeSH ID Detail
Sneezing D012912 6 associated lipids
Carotid Stenosis D016893 15 associated lipids
Endotoxemia D019446 27 associated lipids
Per page 10 20 | Total 13

PubChem Associated disorders and diseases

What pathways are associated with Ltd4

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Ltd4?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with Ltd4?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Ltd4?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Ltd4?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Ltd4?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Ltd4

Download all related citations
Per page 10 20 50 100 | Total 562
Authors Title Published Journal PubMed Link
Kondeti V et al. Leukotriene D4 and prostaglandin E2 signals synergize and potentiate vascular inflammation in a mast cell-dependent manner through cysteinyl leukotriene receptor 1 and E-prostanoid receptor 3. 2016 J. Allergy Clin. Immunol. pmid:26255103
Kawano T et al. Cysteinyl leukotrienes induce nuclear factor kappa b activation and RANTES production in a murine model of asthma. 2003 J. Allergy Clin. Immunol. pmid:12897744
Shimoda H et al. Anti type I allergic property of Japanese butterbur extract and its mast cell degranulation inhibitory ingredients. 2006 J. Agric. Food Chem. pmid:16608208
Carlton RA et al. Preparation and characterization of polymorphs for an LTD4 antagonist, RG 12525. 1996 J Pharm Sci pmid:8742935
Ramis I et al. Application of totally automated on-line sample clean up system for extraction and high-performance liquid chromatography separation of peptide leukotrienes. 1993 Nov-Dec J Pharm Biomed Anal pmid:8123725
Chong K et al. Drug substance manufacture process control: application of flow injection analysis and HPLC for monitoring an enantiospecific synthesis. 1996 J Pharm Biomed Anal pmid:8895082
Syslová K et al. Immunomagnetic molecular probe with UHPLC-MS/MS: a promising way for reliable bronchial asthma diagnostics based on quantification of cysteinyl leukotrienes. 2013 Jul-Aug J Pharm Biomed Anal pmid:23644905
Huang XQ et al. Transforming growth factor β1-induced astrocyte migration is mediated in part by activating 5-lipoxygenase and cysteinyl leukotriene receptor 1. 2012 J Neuroinflammation pmid:22734808
Herron DK et al. Visualization and comparison of molecular dynamics simulations of leukotriene C4, leukotriene D4, and leukotriene E4. 1995 J Mol Graph pmid:8820302
Schäper C et al. Effects of fexofenadine on inflammatory mediators in nasal lavage fluid in intermittent allergic rhinitis. 2009 J Investig Allergol Clin Immunol pmid:20128420
O'Brien E et al. Bisphenol A at concentrations relevant to human exposure enhances histamine and cysteinyl leukotriene release from bone marrow-derived mast cells. 2014 Jan-Mar J Immunotoxicol pmid:23782309
Inada T et al. Intravenous anesthetic propofol suppresses prostaglandin E2 and cysteinyl leukotriene production and reduces edema formation in arachidonic acid-induced ear inflammation. J Immunotoxicol pmid:25046027
Campos MG et al. Galphimia glauca organic fraction antagonizes LTD(4)-induced contraction in guinea pig airways. 2001 J Ethnopharmacol pmid:11137344
Mehta KA et al. Effect of formulation and process variables on porosity parameters and release rates from a multi unit erosion matrix of a poorly soluble drug. 2000 J Control Release pmid:10640593
Kjellström S et al. On-line coupling of microdialysis sampling with liquid chromatography for the determination of peptide and non-peptide leukotrienes. 1998 J Chromatogr A pmid:9818423
Sciuto AM et al. Post-exposure treatment with isoproterenol attenuates pulmonary edema in phosgene-exposed rabbits. 1998 Sep-Oct J Appl Toxicol pmid:9804432
Krauss AH and Woodward DF Polymorphonuclear leukocyte infiltration into the subretinal choroid and optic nerve in response to leukotrienes. 1993 Invest. Ophthalmol. Vis. Sci. pmid:8258528
Daugschies A and Ruttkowski B Modulation of migration of Oesophagostomum dentatum larvae by inhibitors and products of eicosanoid metabolism. 1998 Int. J. Parasitol. pmid:9513001
Meier HL et al. Simultaneous initiation of degranulation and inhibition of leukotriene release by soman in human basophils. 1995 Int. J. Immunopharmacol. pmid:7545649
Schain F et al. Evidence for a pathophysiological role of cysteinyl leukotrienes in classical Hodgkin lymphoma. 2008 Int. J. Cancer pmid:18704935
Rodríguez-Lagunas MJ et al. 5-Hydroxyeicosatetraenoic acid and leukotriene D4 increase intestinal epithelial paracellular permeability. 2013 Int. J. Biochem. Cell Biol. pmid:23583294
Muraki M et al. Inhaled montelukast inhibits cysteinyl-leukotriene-induced bronchoconstriction in ovalbumin-sensitized guinea-pigs: the potential as a new asthma medication. 2009 Int. Immunopharmacol. pmid:19706339
Georgitis JW et al. Chronic sinusitis: characterization of cellular influx and inflammatory mediators in sinus lavage fluid. 1995 Int. Arch. Allergy Immunol. pmid:7719157
Matsuse H et al. Differential airway inflammatory responses in asthma exacerbations induced by respiratory syncytial virus and influenza virus a. 2013 Int. Arch. Allergy Immunol. pmid:23689185
Takami M et al. Possible role of thromboxane A2 in hyperresponsiveness of isolated rat lung tissue in a Sephadex-induced eosinophilia model. 1995 Int. Arch. Allergy Immunol. pmid:7536504
Ohshima N et al. A functional study on CysLT(1) receptors in human eosinophils. 2002 Int. Arch. Allergy Immunol. pmid:12373000
Kouyama S et al. A contraction assay system using primary cultured mouse bronchial smooth muscle cells. 2013 Int. Arch. Allergy Immunol. pmid:23711859
Iwamoto I et al. Effect of a selective thromboxane A2 receptor antagonist BAY u3405 on antigen-, leukotriene C4- and leukotriene D4-induced bronchoconstriction in guinea pigs. 1995 Int. Arch. Allergy Immunol. pmid:7647588
Hashimoto K et al. Cysteinyl leukotrienes induce monocyte chemoattractant protein-1 in human monocyte/macrophages via mitogen-activated protein kinase and nuclear factor-kappaB pathways. 2009 Int. Arch. Allergy Immunol. pmid:19218821
Mori M et al. Eosinophil superoxide anion generation induced by adhesion molecules and leukotriene D4. 2009 Int. Arch. Allergy Immunol. pmid:19494502
Morishima H et al. Ligation of Toll-like receptor 3 differentially regulates M2 and M3 muscarinic receptor expression and function in human airway smooth muscle cells. 2008 Int. Arch. Allergy Immunol. pmid:17851256
Matsuse H et al. Naturally occurring parainfluenza virus 3 infection in adults induces mild exacerbation of asthma associated with increased sputum concentrations of cysteinyl leukotrienes. 2005 Int. Arch. Allergy Immunol. pmid:16215328
Kang BC et al. Experimental asthma developed by room air contamination with cockroach allergen. 1996 Int. Arch. Allergy Immunol. pmid:8917126
Tudorić N et al. Phosphoramidon augments contraction of guinea pig tracheal smooth muscle induced by histamine and leukotriene-D4. 1994 Int. Arch. Allergy Immunol. pmid:8111247
Kawada N et al. The effect of leukotriene D(4) inhalation on the antigen-induced airway hyperresponsiveness and inflammation in 5-lipoxygenase gene-deficient mice. 2001 Int. Arch. Allergy Immunol. pmid:11815738
Nagata M et al. Effect of the cysteinyl leukotriene antagonist pranlukast on transendothelial migration of eosinophils. 2005 Int. Arch. Allergy Immunol. pmid:15947477
Kato Y et al. Leukotriene D4 induces production of transforming growth factor-beta1 by eosinophils. 2005 Int. Arch. Allergy Immunol. pmid:15947480
Mehta KA et al. Release performance of a poorly soluble drug from a novel, Eudragit-based multi-unit erosion matrix. 2001 Int J Pharm pmid:11165089
Carvajal MT and Staniforth JN Interactions of water with the surfaces of crystal polymorphs. 2006 Int J Pharm pmid:16298501
Sylvin H et al. Cysteinyl leukotrienes in porcine acute allergic airway reactions: bronchial and vascular effects. 2003 Inflamm. Res. pmid:12813622
Theron AJ et al. Leukotrienes C4 and D4 sensitize human neutrophils for hyperreactivity to chemoattractants. 2009 Inflamm. Res. pmid:19184354
Pelclová D et al. Leukotrienes B4, C4, D4 and E4 in the exhaled breath condensate (EBC), blood and urine in patients with pneumoconiosis. 2012 Ind Health pmid:22785421
Kodani M et al. Intratracheal administration of anaphylatoxin C5a potentiates antigen-induced pulmonary reactions through the prolonged production of cysteinyl-leukotrienes. 2000 Immunopharmacology pmid:10996024
Wan D et al. The effects of montelukast on eosinophilic gastroenteritis in a mouse model. 2013 Immunopharmacol Immunotoxicol pmid:23240855
Wettstein M et al. Metabolism of cysteinyl leukotrienes in the perfused rat liver: the influence of endotoxin pretreatment and the cellular hydration state. 1995 Hepatology pmid:7601416
Cincu RN et al. S-adenosyl-L-methionine protects the liver against the cholestatic, cytotoxic, and vasoactive effects of leukotriene D4: a study with isolated and perfused rat liver. 1997 Hepatology pmid:9252142
Li X and Weinman SA Mrp2 modulates the activity of chloride channels in isolated hepatocytes. 2002 Hepatology pmid:12085350
Mion F et al. Short term effects of indomethacin on rat small intestinal permeability. Role of eicosanoids and platelet activating factor. 1994 Gut pmid:8174986
Huang XJ et al. Activation of CysLT receptors induces astrocyte proliferation and death after oxygen-glucose deprivation. 2008 Glia pmid:17910051
Ohd JF et al. Leukotrienes induce cell-survival signaling in intestinal epithelial cells. 2000 Gastroenterology pmid:11040187