| MeSH term | MeSH ID | Detail |
|---|---|---|
| Airway Obstruction | D000402 | 13 associated lipids |
| Asbestosis | D001195 | 8 associated lipids |
| Aspergillosis, Allergic Bronchopulmonary | D001229 | 2 associated lipids |
| Asthma, Exercise-Induced | D001250 | 10 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Coronary Artery Disease | D003324 | 47 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Glomerulonephritis | D005921 | 35 associated lipids |
| Leukemia | D007938 | 74 associated lipids |
| Respiratory Hypersensitivity | D012130 | 18 associated lipids |
Ltd4
Ltd4 is a lipid of Fatty Acyls (FA) class. Ltd4 is associated with abnormalities such as Inflammatory Bowel Diseases, Inflammatory disorder, Pneumonia, Asthma and Virus Diseases. The involved functions are known as uptake, Phosphorylation, Signal Transduction, symporter activity and Regulation. Ltd4 often locates in Protoplasm, Mucous Membrane, Membrane, Extracellular and Epithelium. The associated genes with Ltd4 are TYRO3 gene, RAF1 gene, serine-borate complex, ITGAM gene and ITGB2 gene. The related lipids are Lipopolysaccharides.
Cross Reference
Introduction
To understand associated biological information of Ltd4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Ltd4?
Ltd4 is suspected in Asthma, Inflammatory Bowel Diseases, Inflammatory disorder, Pneumonia, Virus Diseases and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Ltd4
PubChem Associated disorders and diseases
What pathways are associated with Ltd4
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Ltd4?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Ltd4?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Ltd4?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Ltd4?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Ltd4?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Ltd4
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Ganbo T et al. | Leukotriene C4 inhibits ciliary activity in the presence of gamma-glutamyl transpeptidase. | 1996 | Am. J. Physiol. | pmid:8770059 |
| Talukder JR et al. | Mechanism of leukotriene D4 inhibition of Na-alanine cotransport in intestinal epithelial cells. | 2008 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:18436626 |
| Liu P et al. | Cysteinyl leukotriene-dependent [Ca2+]i responses to angiotensin II in cardiomyocytes. | 2003 | Am. J. Physiol. Heart Circ. Physiol. | pmid:12531730 |
| Carbajal V et al. | LTD4 induces hyperresponsiveness to histamine in bovine airway smooth muscle: role of SR-ATPase Ca2+ pump and tyrosine kinase. | 2005 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:15377496 |
| Yang G et al. | Transgenic smooth muscle expression of the human CysLT1 receptor induces enhanced responsiveness of murine airways to leukotriene D4. | 2004 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:15064240 |
| McGovern T et al. | LTDâ‚„ induces HB-EGF-dependent CXCL8 release through EGFR activation in human bronchial epithelial cells. | 2010 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:20889674 |
| Oliveira SH et al. | SCF-induced airway hyperreactivity is dependent on leukotriene production. | 2001 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:11350804 |
| Nagase T et al. | A potent inhibitor of cytosolic phospholipase A2, arachidonyl trifluoromethyl ketone, attenuates LPS-induced lung injury in mice. | 2003 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:12505870 |
| Pugliese AM et al. | Functional characterization of two isoforms of the P2Y-like receptor GPR17: [35S]GTPgammaS binding and electrophysiological studies in 1321N1 cells. | 2009 | Am. J. Physiol., Cell Physiol. | pmid:19625605 |
| Arthur S and Sundaram U | Protein kinase C-mediated phosphorylation of RKIP regulates inhibition of Na-alanine cotransport by leukotriene D(4) in intestinal epithelial cells. | 2014 | Am. J. Physiol., Cell Physiol. | pmid:25231108 |
| Minobe E et al. | A new phosphorylation site in cardiac L-type Ca2+ channels (Cav1.2) responsible for its cAMP-mediated modulation. | 2014 | Am. J. Physiol., Cell Physiol. | pmid:25209265 |
| Potter-Perigo S et al. | Regulation of proteoglycan synthesis by leukotriene d4 and epidermal growth factor in bronchial smooth muscle cells. | 2004 | Am. J. Respir. Cell Mol. Biol. | pmid:12855404 |
| Undem BJ et al. | Recombinant stem cell factor-induced mast cell activation and smooth muscle contraction in human bronchi. | 1994 | Am. J. Respir. Cell Mol. Biol. | pmid:7524570 |
| Ménard G and Bissonnette EY | Priming of alveolar macrophages by leukotriene D(4): potentiation of inflammation. | 2000 | Am. J. Respir. Cell Mol. Biol. | pmid:11017925 |
| Panettieri RA et al. | Effects of LTD4 on human airway smooth muscle cell proliferation, matrix expression, and contraction In vitro: differential sensitivity to cysteinyl leukotriene receptor antagonists. | 1998 | Am. J. Respir. Cell Mol. Biol. | pmid:9730873 |
| Thompson C et al. | Leukotriene D4 up-regulates furin expression through CysLT1 receptor signaling. | 2008 | Am. J. Respir. Cell Mol. Biol. | pmid:18323532 |
| Funayama T et al. | Role of Leukotriene-degrading enzymes in pulmonary response to antigen infusion in sensitized guinea pigs in vivo. | 1996 | Am. J. Respir. Cell Mol. Biol. | pmid:8703483 |
| Thompson C et al. | CysLT1 receptor engagement induces activator protein-1- and NF-kappaB-dependent IL-8 expression. | 2006 | Am. J. Respir. Cell Mol. Biol. | pmid:16809637 |
| Dahlén B et al. | Benefits from adding the 5-lipoxygenase inhibitor zileuton to conventional therapy in aspirin-intolerant asthmatics. | 1998 | Am. J. Respir. Crit. Care Med. | pmid:9563738 |
| Echazarreta AL et al. | Pulmonary gas exchange and sputum cellular responses to inhaled leukotriene D(4) in asthma. | 2001 | Am. J. Respir. Crit. Care Med. | pmid:11463588 |