Ltd4

Ltd4 is a lipid of Fatty Acyls (FA) class. Ltd4 is associated with abnormalities such as Inflammatory Bowel Diseases, Inflammatory disorder, Pneumonia, Asthma and Virus Diseases. The involved functions are known as uptake, Phosphorylation, Signal Transduction, symporter activity and Regulation. Ltd4 often locates in Protoplasm, Mucous Membrane, Membrane, Extracellular and Epithelium. The associated genes with Ltd4 are TYRO3 gene, RAF1 gene, serine-borate complex, ITGAM gene and ITGB2 gene. The related lipids are Lipopolysaccharides.

Cross Reference

Introduction

To understand associated biological information of Ltd4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Ltd4?

Ltd4 is suspected in Asthma, Inflammatory Bowel Diseases, Inflammatory disorder, Pneumonia, Virus Diseases and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Ltd4

MeSH term MeSH ID Detail
Airway Obstruction D000402 13 associated lipids
Asbestosis D001195 8 associated lipids
Aspergillosis, Allergic Bronchopulmonary D001229 2 associated lipids
Asthma, Exercise-Induced D001250 10 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Coronary Artery Disease D003324 47 associated lipids
Edema D004487 152 associated lipids
Glomerulonephritis D005921 35 associated lipids
Leukemia D007938 74 associated lipids
Respiratory Hypersensitivity D012130 18 associated lipids
Per page 10 20 | Total 13

PubChem Associated disorders and diseases

What pathways are associated with Ltd4

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Ltd4?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Ltd4?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Ltd4?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Ltd4?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Ltd4?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Ltd4

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Per page 10 20 50 100 | Total 562
Authors Title Published Journal PubMed Link
Ishimura M et al. Effects of KP-496, a novel dual antagonist for leukotriene D4 and thromboxane A2 receptors, on contractions induced by various agonists in the guinea pig trachea. 2006 Allergol Int pmid:17130683
Thivierge M et al. Toll-like receptor agonists differentially regulate cysteinyl-leukotriene receptor 1 expression and function in human dendritic cells. 2006 J. Allergy Clin. Immunol. pmid:16675346
Abe M et al. A novel method for preserving human lungs using a super-cooling system. 2006 Ann. Thorac. Surg. pmid:16928543
Hoopes C Invited commentary. 2006 Ann. Thorac. Surg. pmid:16928544
Dahlén SE Treatment of asthma with antileukotrienes: first line or last resort therapy? 2006 Eur. J. Pharmacol. pmid:16510137
Gyllfors P et al. Bronchial responsiveness to leukotriene D4 is resistant to inhaled fluticasone propionate. 2006 J. Allergy Clin. Immunol. pmid:16815141
Hemelaers L et al. Cysteinyl-leukotrienes contribute to sputum eosinophil chemotactic activity in asthmatics. 2006 Allergy pmid:16364169
Mezhybovska M et al. The inflammatory mediator leukotriene D4 induces beta-catenin signaling and its association with antiapoptotic Bcl-2 in intestinal epithelial cells. 2006 J. Biol. Chem. pmid:16407243
Cui S et al. Effects of platelet-activating factor, thromboxane A2 and leukotriene D4 on isolated perfused rat liver. 2006 Prostaglandins Other Lipid Mediat. pmid:16846785
Rovati GE et al. Cysteinyl-leukotrienes in the regulation of beta2-adrenoceptor function: an in vitro model of asthma. 2006 Respir. Res. pmid:16875498
Lamoureux J et al. Leukotriene D4 enhances immunoglobulin production in CD40-activated human B lymphocytes. 2006 J. Allergy Clin. Immunol. pmid:16630953
Guo HF and Zhong Y Requirement of Akt to mediate long-term synaptic depression in Drosophila. 2006 J. Neurosci. pmid:16611817
Ravasi S et al. CysLT1 receptor-induced human airway smooth muscle cells proliferation requires ROS generation, EGF receptor transactivation and ERK1/2 phosphorylation. 2006 Respir. Res. pmid:16553950
Bouchelouche K and Bouchelouche P Cysteinyl leukotriene D4 increases human detrusor muscle responsiveness to histamine. 2006 J. Urol. pmid:16753444
Thompson C et al. CysLT1 receptor engagement induces activator protein-1- and NF-kappaB-dependent IL-8 expression. 2006 Am. J. Respir. Cell Mol. Biol. pmid:16809637
Paruchuri S et al. Endogenous production of leukotriene D4 mediates autocrine survival and proliferation via CysLT1 receptor signalling in intestinal epithelial cells. 2006 Oncogene pmid:16715140
Shimoda H et al. Anti type I allergic property of Japanese butterbur extract and its mast cell degranulation inhibitory ingredients. 2006 J. Agric. Food Chem. pmid:16608208
Yoshisue H et al. Cysteinyl leukotrienes synergize with growth factors to induce proliferation of human bronchial fibroblasts. 2007 J. Allergy Clin. Immunol. pmid:17208594
Lee KS et al. Cysteinyl leukotriene upregulates IL-11 expression in allergic airway disease of mice. 2007 J. Allergy Clin. Immunol. pmid:17208595
Skogvall S et al. Effects of capsazepine on human small airway responsiveness unravel a novel class of bronchorelaxants. 2007 Pulm Pharmacol Ther pmid:16731017
Kopp MV et al. Omalizumab (Xolair) in children with seasonal allergic rhinitis: leukotriene release as a potential in vitro parameter to monitor therapeutic effects. 2007 Pediatr Allergy Immunol pmid:17680911
Capra V et al. Cysteinyl-leukotrienes and their receptors in asthma and other inflammatory diseases: critical update and emerging trends. 2007 Med Res Rev pmid:16894531
Shirasaki H et al. Agonist- and T(H)2 cytokine-induced up-regulation of cysteinyl leukotriene receptor messenger RNA in human monocytes. 2007 Ann. Allergy Asthma Immunol. pmid:17941281
Tokuriki S et al. Leukotriene D(4) enhances the function of endothelin-1-primed fibroblasts. 2007 Clin. Immunol. pmid:17627891
Lötzer K et al. 5-Lipoxygenase/cyclooxygenase-2 cross-talk through cysteinyl leukotriene receptor 2 in endothelial cells. 2007 Prostaglandins Other Lipid Mediat. pmid:17991613
Jiang Y et al. CysLT2 receptors interact with CysLT1 receptors and down-modulate cysteinyl leukotriene dependent mitogenic responses of mast cells. 2007 Blood pmid:17693579
Peres CM et al. Specific leukotriene receptors couple to distinct G proteins to effect stimulation of alveolar macrophage host defense functions. 2007 J. Immunol. pmid:17911632
Goto HG et al. Induction of apoptosis in an estrogen-responsive mouse Leydig tumor cell by leukotriene. 2007 Oncol. Rep. pmid:17143502
Stengel PW et al. Inhaled anandamide reduces leukotriene D4-induced airway obstruction in guinea pigs. 2007 Eur. J. Pharmacol. pmid:17166495
Chiba Y et al. Regional differences in vascular responsiveness of nasal mucosae isolated from naive guinea pigs. 2007 Auris Nasus Larynx pmid:17056219
Yang YY et al. Effect of chronic CB1 cannabinoid receptor antagonism on livers of rats with biliary cirrhosis. 2007 Clin. Sci. pmid:17176248
Bai CH et al. The inhibitory effect of the leukotriene receptor antagonist on leukotriene D4-induced MUC2/5AC gene expression and mucin secretion in human airway epithelial cells. 2007 Auris Nasus Larynx pmid:17223000
Taylor-Clark TE et al. Leukotriene D4 increases the excitability of capsaicin-sensitive nasal sensory nerves to electrical and chemical stimuli. 2008 Br. J. Pharmacol. pmid:18500362
Woszczek G et al. IL-10 inhibits cysteinyl leukotriene-induced activation of human monocytes and monocyte-derived dendritic cells. 2008 J. Immunol. pmid:18490762
Tamaoka M et al. The epidermal growth factor receptor mediates allergic airway remodelling in the rat. 2008 Eur. Respir. J. pmid:18653647
Schain F et al. Evidence for a pathophysiological role of cysteinyl leukotrienes in classical Hodgkin lymphoma. 2008 Int. J. Cancer pmid:18704935
Woszczek G et al. Leukotriene D(4) induces gene expression in human monocytes through cysteinyl leukotriene type I receptor. 2008 J. Allergy Clin. Immunol. pmid:18028998
Maekawa A et al. Functional recognition of a distinct receptor preferential for leukotriene E4 in mice lacking the cysteinyl leukotriene 1 and 2 receptors. 2008 Proc. Natl. Acad. Sci. U.S.A. pmid:18931305
Lecca D et al. The recently identified P2Y-like receptor GPR17 is a sensor of brain damage and a new target for brain repair. 2008 PLoS ONE pmid:18974869
Claesson HE et al. Hodgkin Reed-Sternberg cells express 15-lipoxygenase-1 and are putative producers of eoxins in vivo: novel insight into the inflammatory features of classical Hodgkin lymphoma. 2008 FEBS J. pmid:18647347
Rehni AK et al. Pharmacological modulation of leukotriene D(4) attenuates the development of opioid dependence in a mouse model of naloxone-induced opioid withdrawal syndrome. 2008 Eur. J. Pharmacol. pmid:18840427
Schain F et al. Differential expression of cysteinyl leukotriene receptor 1 and 15-lipoxygenase-1 in non-Hodgkin lymphomas. 2008 Clin Lymphoma Myeloma pmid:19064398
Yudina Y et al. Regulation of the eicosanoid pathway by tumour necrosis factor alpha and leukotriene D4 in intestinal epithelial cells. 2008 Prostaglandins Leukot. Essent. Fatty Acids pmid:19042113
Huang XJ et al. Activation of CysLT receptors induces astrocyte proliferation and death after oxygen-glucose deprivation. 2008 Glia pmid:17910051
Skogvall S et al. Discovery of a potent and long-acting bronchorelaxing capsazepinoid, RESPIR 4-95. 2008 Pulm Pharmacol Ther pmid:17374498
Schelfhout V et al. The effect of the leukotriene receptor antagonist zafirlukast on neurokinin A-induced bronchoconstriction in patients with asthma--A comparison with leukotriene D4 induced broncoconstriction. 2008 Pulm Pharmacol Ther pmid:17611132
Bengtsson AM et al. Leukotriene D(4) induces AP-1 but not NFkappaB signaling in intestinal epithelial cells. 2008 Prostaglandins Other Lipid Mediat. pmid:18083053
Bossé Y et al. Leukotriene D4-induced, epithelial cell-derived transforming growth factor beta1 in human bronchial smooth muscle cell proliferation. 2008 Clin. Exp. Allergy pmid:18028462
Ishimura M et al. Effects of KP-496, a novel dual antagonist at the cysteinyl leukotriene receptor 1 and the thromboxane A(2) receptor, on airway obstruction in guinea pigs. 2008 Br. J. Pharmacol. pmid:18037905
Mizutani N et al. Involvement of peroxynitrite in pollen-induced nasal blockage in guinea pigs. 2008 Eur. J. Pharmacol. pmid:18191833
Wienkötter N et al. The effect of nigellone and thymoquinone on inhibiting trachea contraction and mucociliary clearance. 2008 Planta Med. pmid:18219598
Ge H et al. Elucidation of signaling and functional activities of an orphan GPCR, GPR81. 2008 J. Lipid Res. pmid:18174606
Suzuki S et al. Leukotriene D4 upregulates MUC2 gene transcription in human epithelial cells. 2008 Pharmacology pmid:18176092
Morishima H et al. Ligation of Toll-like receptor 3 differentially regulates M2 and M3 muscarinic receptor expression and function in human airway smooth muscle cells. 2008 Int. Arch. Allergy Immunol. pmid:17851256
Profita M et al. Cysteinyl leukotriene-1 receptor activation in a human bronchial epithelial cell line leads to signal transducer and activator of transcription 1-mediated eosinophil adhesion. 2008 J. Pharmacol. Exp. Ther. pmid:18305014
Thompson C et al. Leukotriene D4 up-regulates furin expression through CysLT1 receptor signaling. 2008 Am. J. Respir. Cell Mol. Biol. pmid:18323532
Macdonald D et al. Substituted 2,2-bisaryl-bicycloheptanes as novel and potent inhibitors of 5-lipoxygenase activating protein. 2008 Bioorg. Med. Chem. Lett. pmid:18276139
Talukder JR et al. Mechanism of leukotriene D4 inhibition of Na-alanine cotransport in intestinal epithelial cells. 2008 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:18436626
Ito Y et al. Guinea pig cysteinyl leukotriene receptor 2 (gpCysLT2) mediates cell proliferation and intracellular calcium mobilization by LTC4 and LTD4. 2008 BMB Rep pmid:18315950
Paruchuri S et al. Leukotriene E4 activates peroxisome proliferator-activated receptor gamma and induces prostaglandin D2 generation by human mast cells. 2008 J. Biol. Chem. pmid:18411276
Campos MR et al. Differential kinase requirement for enhancement of Fc gammaR-mediated phagocytosis in alveolar macrophages by leukotriene B4 vs. D4. 2009 Mol. Immunol. pmid:19223078
Lee SP et al. Crosstalk between prostaglandin E2 and leukotriene B4 regulates phagocytosis in alveolar macrophages via combinatorial effects on cyclic AMP. 2009 J. Immunol. pmid:19109185
Lee TH et al. Leukotriene E4: perspective on the forgotten mediator. 2009 J. Allergy Clin. Immunol. pmid:19482346
Austen KF et al. The leukotriene E4 puzzle: finding the missing pieces and revealing the pathobiologic implications. 2009 J. Allergy Clin. Immunol. pmid:19647860
Theron AJ et al. Leukotrienes C4 and D4 sensitize human neutrophils for hyperreactivity to chemoattractants. 2009 Inflamm. Res. pmid:19184354
Farias S et al. Injury-related production of cysteinyl leukotrienes contributes to brain damage following experimental traumatic brain injury. 2009 J. Neurotrauma pmid:19886806
Hashimoto K et al. Cysteinyl leukotrienes induce monocyte chemoattractant protein-1 in human monocyte/macrophages via mitogen-activated protein kinase and nuclear factor-kappaB pathways. 2009 Int. Arch. Allergy Immunol. pmid:19218821
Muraki M et al. Inhaled montelukast inhibits cysteinyl-leukotriene-induced bronchoconstriction in ovalbumin-sensitized guinea-pigs: the potential as a new asthma medication. 2009 Int. Immunopharmacol. pmid:19706339
Yuan YM et al. Leukotriene D4 stimulates the migration but not proliferation of endothelial cells mediated by the cysteinyl leukotriene cyslt(1) receptor via the extracellular signal-regulated kinase pathway. 2009 J. Pharmacol. Sci. pmid:19234368
Baker N et al. Lipoxin A4: anti-inflammatory and anti-angiogenic impact on endothelial cells. 2009 J. Immunol. pmid:19265161
Mizutani N et al. Effect of TA-270, a novel quinolinone derivative, on antigen-induced nasal blockage in a guinea pig model of allergic rhinitis. 2009 Eur. J. Pharmacol. pmid:19022242
Fang SH et al. Pranlukast attenuates ischemia-like injury in endothelial cells via inhibiting reactive oxygen species production and nuclear factor-kappaB activation. 2009 J. Cardiovasc. Pharmacol. pmid:19129732
Claesson HE On the biosynthesis and biological role of eoxins and 15-lipoxygenase-1 in airway inflammation and Hodgkin lymphoma. 2009 Prostaglandins Other Lipid Mediat. pmid:19130894
Dayyat E et al. Leukotriene pathways and in vitro adenotonsillar cell proliferation in children with obstructive sleep apnea. 2009 Chest pmid:19118273
Boehmler AM et al. The CysLT1 ligand leukotriene D4 supports alpha4beta1- and alpha5beta1-mediated adhesion and proliferation of CD34+ hematopoietic progenitor cells. 2009 J. Immunol. pmid:19454674
Mori M et al. Eosinophil superoxide anion generation induced by adhesion molecules and leukotriene D4. 2009 Int. Arch. Allergy Immunol. pmid:19494502
Yang HS et al. [Effects of leukotriene receptor antagonists on vascular endothelial growth factor and its receptors in a sensitized rat model]. 2009 Zhonghua Jie He He Hu Xi Za Zhi pmid:19575935
Maekawa A et al. GPR17 is a negative regulator of the cysteinyl leukotriene 1 receptor response to leukotriene D4. 2009 Proc. Natl. Acad. Sci. U.S.A. pmid:19561298
Pugliese AM et al. Functional characterization of two isoforms of the P2Y-like receptor GPR17: [35S]GTPgammaS binding and electrophysiological studies in 1321N1 cells. 2009 Am. J. Physiol., Cell Physiol. pmid:19625605
Hori M et al. NT-702 (parogrelil hydrochloride, NM-702), a novel and potent phosphodiesterase 3 inhibitor, suppress the asthmatic response in guinea pigs, with both bronchodilating and anti-inflammatory effects. 2009 Eur. J. Pharmacol. pmid:19616537
Mezhybovska M et al. Beta-catenin is involved in alterations in mitochondrial activity in non-transformed intestinal epithelial and colon cancer cells. 2009 Br. J. Cancer pmid:19826421
Thivierge M et al. Cysteinyl-leukotriene receptor type 1 expression and function is down-regulated during monocyte-derived dendritic cell maturation with zymosan: involvement of IL-10 and prostaglandins. 2009 J. Immunol. pmid:19846883
Kim SH et al. Regulation of monocyte chemoattractant protein 1 by cysteinyl leukotriene D4 in human lung epithelial A549 cells. 2009 Ann. Allergy Asthma Immunol. pmid:19852204
Schäper C et al. Effects of fexofenadine on inflammatory mediators in nasal lavage fluid in intermittent allergic rhinitis. 2009 J Investig Allergol Clin Immunol pmid:20128420
Selg E et al. Two different mechanisms for modulation of bronchoconstriction in guinea-pigs by cyclooxygenase metabolites. 2009 Prostaglandins Other Lipid Mediat. pmid:19103301
McGovern T et al. LTDâ‚„ induces HB-EGF-dependent CXCL8 release through EGFR activation in human bronchial epithelial cells. 2010 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:20889674
Meliton AY et al. Leukotriene D4 activates {beta}2-integrin adhesion in human polymorphonuclear leukocytes. 2010 Eur. Respir. J. pmid:19679609
Julius P et al. sCD14 in bronchoalveolar lavage 18, 42 and 162 hours after segmental allergen provocation. 2010 Scand. J. Immunol. pmid:20384875
Wunder F et al. Pharmacological characterization of the first potent and selective antagonist at the cysteinyl leukotriene 2 (CysLT(2)) receptor. 2010 Br. J. Pharmacol. pmid:20423349
Lieber G et al. Concomitant activity of histamine and cysteinyl leukotrienes on porcine nasal mucosal vessels and nasal inflammation in the rat. 2010 Pharmacology pmid:20453555
Zhou G et al. Atorvastatin reduces plaque vulnerability in an atherosclerotic rabbit model by altering the 5-lipoxygenase pathway. 2010 Cardiology pmid:20234134
Kim MH et al. Effect of leukotriene D4 on mouse embryonic stem cell migration and proliferation: involvement of PI3K/Akt as well as GSK-3β/β-catenin signaling pathways. 2010 J. Cell. Biochem. pmid:20589831
Sakai H et al. Augmented venous responsiveness to leukotriene D(4) in nasal septal mucosae of repeatedly antigen-challenged rats. 2010 Eur. J. Pharmacol. pmid:20638382
Li R et al. [Analysis of the nasopharyngeal aspirates in children with different severities of bronchiolitis]. 2010 Zhongguo Dang Dai Er Ke Za Zhi pmid:20497653
Finkensieper A et al. The 5-lipoxygenase pathway regulates vasculogenesis in differentiating mouse embryonic stem cells. 2010 Cardiovasc. Res. pmid:19965960
Huang SC Leukotriene-induced contraction is mediated by cysteinyl leukotriene receptor CysLT1 in guinea pig fundus but by CysLT1 and CysLT2 in antrum. 2011 Life Sci. pmid:21396378
Yan D et al. Differential signaling of cysteinyl leukotrienes and a novel cysteinyl leukotriene receptor 2 (CysLT₂) agonist, N-methyl-leukotriene C₄, in calcium reporter and β arrestin assays. 2011 Mol. Pharmacol. pmid:21078884
Zhou Y et al. Circulating LTD4 in patients with hepatocellular carcinoma. 2011 Tumour Biol. pmid:20820981
Rehni AK and Singh TG Modulation of leukotriene D4 attenuates the development of seizures in mice. 2011 Prostaglandins Leukot. Essent. Fatty Acids pmid:21641195
Haneda Y et al. Leukotriene D4 enhances tumor necrosis factor-α-induced vascular endothelial growth factor production in human monocytes/macrophages. 2011 Cytokine pmid:21482134