Ltd4

Ltd4 is a lipid of Fatty Acyls (FA) class. Ltd4 is associated with abnormalities such as Inflammatory Bowel Diseases, Inflammatory disorder, Pneumonia, Asthma and Virus Diseases. The involved functions are known as uptake, Phosphorylation, Signal Transduction, symporter activity and Regulation. Ltd4 often locates in Protoplasm, Mucous Membrane, Membrane, Extracellular and Epithelium. The associated genes with Ltd4 are TYRO3 gene, RAF1 gene, serine-borate complex, ITGAM gene and ITGB2 gene. The related lipids are Lipopolysaccharides.

Cross Reference

Introduction

To understand associated biological information of Ltd4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Ltd4?

Ltd4 is suspected in Asthma, Inflammatory Bowel Diseases, Inflammatory disorder, Pneumonia, Virus Diseases and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Ltd4

MeSH term MeSH ID Detail
Airway Obstruction D000402 13 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Edema D004487 152 associated lipids
Leukemia D007938 74 associated lipids
Glomerulonephritis D005921 35 associated lipids
Respiratory Hypersensitivity D012130 18 associated lipids
Coronary Artery Disease D003324 47 associated lipids
Carotid Stenosis D016893 15 associated lipids
Asthma, Exercise-Induced D001250 10 associated lipids
Endotoxemia D019446 27 associated lipids
Per page 10 20 | Total 13

PubChem Associated disorders and diseases

What pathways are associated with Ltd4

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Ltd4?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Ltd4?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Ltd4?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Ltd4?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Ltd4?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Ltd4

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Per page 10 20 50 100 | Total 562
Authors Title Published Journal PubMed Link
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Kanaoka Y et al. Identification of GPR99 protein as a potential third cysteinyl leukotriene receptor with a preference for leukotriene E4 ligand. 2013 J. Biol. Chem. pmid:23504326
Kang KH et al. Protection of dopaminergic neurons by 5-lipoxygenase inhibitor. 2013 Neuropharmacology pmid:23800665
Cummings HE et al. Cutting edge: Leukotriene C4 activates mouse platelets in plasma exclusively through the type 2 cysteinyl leukotriene receptor. 2013 J. Immunol. pmid:24244016
Ahmed T et al. Inhibition of allergic airway responses by heparin derived oligosaccharides: identification of a tetrasaccharide sequence. 2012 Respir. Res. pmid:22269021
Provost V et al. Leukotriene D4 and interleukin-13 cooperate to increase the release of eotaxin-3 by airway epithelial cells. 2012 PLoS ONE pmid:22952702
Dahlén B et al. Salbutamol but not ipratropium abolishes leukotriene D4-induced gas exchange abnormalities in asthma. 2012 Eur. J. Clin. Pharmacol. pmid:22457014
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Forsell PK et al. Metabolism of anandamide into eoxamides by 15-lipoxygenase-1 and glutathione transferases. 2012 Lipids pmid:22684912
Parmentier CN et al. Human T(H)2 cells respond to cysteinyl leukotrienes through selective expression of cysteinyl leukotriene receptor 1. 2012 J. Allergy Clin. Immunol. pmid:22391114
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Huang XQ et al. Transforming growth factor β1-induced astrocyte migration is mediated in part by activating 5-lipoxygenase and cysteinyl leukotriene receptor 1. 2012 J Neuroinflammation pmid:22734808
Dannull J et al. Leukotriene C4 induces migration of human monocyte-derived dendritic cells without loss of immunostimulatory function. 2012 Blood pmid:22323449
Mizutani N et al. Effect of Ganoderma lucidum on pollen-induced biphasic nasal blockage in a guinea pig model of allergic rhinitis. 2012 Phytother Res pmid:21698671
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Drost AC et al. The G protein-coupled receptor CysLT1 mediates chemokine-like effects and prolongs survival in chronic lymphocytic leukemia. 2012 Leuk. Lymphoma pmid:21936770
Huang SC Leukotriene-induced contraction is mediated by cysteinyl leukotriene receptor CysLT1 in guinea pig fundus but by CysLT1 and CysLT2 in antrum. 2011 Life Sci. pmid:21396378
Yan D et al. Differential signaling of cysteinyl leukotrienes and a novel cysteinyl leukotriene receptor 2 (CysLT₂) agonist, N-methyl-leukotriene C₄, in calcium reporter and β arrestin assays. 2011 Mol. Pharmacol. pmid:21078884
Brochu-Bourque A et al. Differential signaling defects associated with the M201V polymorphism in the cysteinyl leukotriene type 2 receptor. 2011 J. Pharmacol. Exp. Ther. pmid:20966037
Zhou Y et al. Circulating LTD4 in patients with hepatocellular carcinoma. 2011 Tumour Biol. pmid:20820981
Rehni AK and Singh TG Modulation of leukotriene D4 attenuates the development of seizures in mice. 2011 Prostaglandins Leukot. Essent. Fatty Acids pmid:21641195
Haneda Y et al. Leukotriene D4 enhances tumor necrosis factor-α-induced vascular endothelial growth factor production in human monocytes/macrophages. 2011 Cytokine pmid:21482134
Daniele S et al. Agonist-induced desensitization/resensitization of human G protein-coupled receptor 17: a functional cross-talk between purinergic and cysteinyl-leukotriene ligands. 2011 J. Pharmacol. Exp. Ther. pmid:21531793
Carnini C et al. Synthesis of cysteinyl leukotrienes in human endothelial cells: subcellular localization and autocrine signaling through the CysLT2 receptor. 2011 FASEB J. pmid:21753081
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McGovern T et al. LTDâ‚„ induces HB-EGF-dependent CXCL8 release through EGFR activation in human bronchial epithelial cells. 2010 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:20889674
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Kim MH et al. Effect of leukotriene D4 on mouse embryonic stem cell migration and proliferation: involvement of PI3K/Akt as well as GSK-3β/β-catenin signaling pathways. 2010 J. Cell. Biochem. pmid:20589831
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Campos MR et al. Differential kinase requirement for enhancement of Fc gammaR-mediated phagocytosis in alveolar macrophages by leukotriene B4 vs. D4. 2009 Mol. Immunol. pmid:19223078
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Yuan YM et al. Leukotriene D4 stimulates the migration but not proliferation of endothelial cells mediated by the cysteinyl leukotriene cyslt(1) receptor via the extracellular signal-regulated kinase pathway. 2009 J. Pharmacol. Sci. pmid:19234368
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Boehmler AM et al. The CysLT1 ligand leukotriene D4 supports alpha4beta1- and alpha5beta1-mediated adhesion and proliferation of CD34+ hematopoietic progenitor cells. 2009 J. Immunol. pmid:19454674
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Mezhybovska M et al. Beta-catenin is involved in alterations in mitochondrial activity in non-transformed intestinal epithelial and colon cancer cells. 2009 Br. J. Cancer pmid:19826421
Thivierge M et al. Cysteinyl-leukotriene receptor type 1 expression and function is down-regulated during monocyte-derived dendritic cell maturation with zymosan: involvement of IL-10 and prostaglandins. 2009 J. Immunol. pmid:19846883
Kim SH et al. Regulation of monocyte chemoattractant protein 1 by cysteinyl leukotriene D4 in human lung epithelial A549 cells. 2009 Ann. Allergy Asthma Immunol. pmid:19852204
Schäper C et al. Effects of fexofenadine on inflammatory mediators in nasal lavage fluid in intermittent allergic rhinitis. 2009 J Investig Allergol Clin Immunol pmid:20128420
Selg E et al. Two different mechanisms for modulation of bronchoconstriction in guinea-pigs by cyclooxygenase metabolites. 2009 Prostaglandins Other Lipid Mediat. pmid:19103301