Ltd4

Ltd4 is a lipid of Fatty Acyls (FA) class. Ltd4 is associated with abnormalities such as Inflammatory Bowel Diseases, Inflammatory disorder, Pneumonia, Asthma and Virus Diseases. The involved functions are known as uptake, Phosphorylation, Signal Transduction, symporter activity and Regulation. Ltd4 often locates in Protoplasm, Mucous Membrane, Membrane, Extracellular and Epithelium. The associated genes with Ltd4 are TYRO3 gene, RAF1 gene, serine-borate complex, ITGAM gene and ITGB2 gene. The related lipids are Lipopolysaccharides.

Cross Reference

Introduction

To understand associated biological information of Ltd4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Ltd4?

Ltd4 is suspected in Asthma, Inflammatory Bowel Diseases, Inflammatory disorder, Pneumonia, Virus Diseases and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Ltd4

MeSH term MeSH ID Detail
Airway Obstruction D000402 13 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Edema D004487 152 associated lipids
Leukemia D007938 74 associated lipids
Glomerulonephritis D005921 35 associated lipids
Respiratory Hypersensitivity D012130 18 associated lipids
Coronary Artery Disease D003324 47 associated lipids
Carotid Stenosis D016893 15 associated lipids
Asthma, Exercise-Induced D001250 10 associated lipids
Endotoxemia D019446 27 associated lipids
Per page 10 20 | Total 13

PubChem Associated disorders and diseases

What pathways are associated with Ltd4

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Ltd4?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Ltd4?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Ltd4?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Ltd4?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Ltd4?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Ltd4

Download all related citations
Per page 10 20 50 100 | Total 562
Authors Title Published Journal PubMed Link
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Tudoric N et al. Effects of halothane and isoflurane on antigen- and leukotriene-D4-induced constriction of guinea pig trachea. 1995 Acta Anaesthesiol Scand pmid:8607320
Neu IS et al. Leukotrienes in patients with clinically active multiple sclerosis. 2002 Acta Neurol. Scand. pmid:11903112
Yu SY et al. Cysteinyl leukotriene receptor 1 mediates LTD4-induced activation of mouse microglial cells in vitro. 2014 Acta Pharmacol. Sin. pmid:24141567
Jonsson EW Functional characterisation of receptors for cysteinyl leukotrienes in smooth muscle. 1998 Acta Physiol Scand Suppl pmid:9597121
Kanli H and Terreros DA Transepithelial transport and cell volume control in proximal renal tubules from the teleost Carassius auratus. 1997 Acta Physiol. Scand. pmid:9246390
Karaman O et al. The comparison of the efficacy of fluticasone propionate with cetirizine in perennial allergic rhinitis. 2001 Mar-Apr Allergol Immunopathol (Madr) pmid:11420028
Ishimura M et al. Effects of KP-496, a novel dual antagonist for leukotriene D4 and thromboxane A2 receptors, on contractions induced by various agonists in the guinea pig trachea. 2006 Allergol Int pmid:17130683
Sekioka T et al. Expression of CysLT2 receptors in asthma lung, and their possible role in bronchoconstriction. 2015 Allergol Int pmid:26433531
Noguchi T et al. Effect of beta2-adrenergic agonists on eosinophil adhesion, superoxide anion generation, and degranulation. 2015 Allergol Int pmid:26344080
Mills K et al. Vitamin E, γ-tocopherol, diminishes ex vivo basophil response to dust mite allergen. 2014 Allergy pmid:24697338
Hemelaers L et al. Cysteinyl-leukotrienes contribute to sputum eosinophil chemotactic activity in asthmatics. 2006 Allergy pmid:16364169
Chen LY et al. Cooperative and redundant signaling of leukotriene B4 and leukotriene D4 in human monocytes. 2011 Allergy pmid:21605126
Han B et al. Gamma-glutamyl leukotrienase, a novel endothelial membrane protein, is specifically responsible for leukotriene D(4) formation in vivo. 2002 Am. J. Pathol. pmid:12163373
Gronert K et al. Selectivity of recombinant human leukotriene D(4), leukotriene B(4), and lipoxin A(4) receptors with aspirin-triggered 15-epi-LXA(4) and regulation of vascular and inflammatory responses. 2001 Am. J. Pathol. pmid:11141472
Cohen P et al. Leukotriene D4 facilitates airway smooth muscle cell proliferation via modulation of the IGF axis. 1995 Am. J. Physiol. pmid:7544535
Goldhill J et al. Interleukin-4 modulates cholinergic neural control of mouse small intestinal longitudinal muscle. 1997 Am. J. Physiol. pmid:9176223
Rajah R et al. Leukotriene D4 induces MMP-1, which functions as an IGFBP protease in human airway smooth muscle cells. 1996 Am. J. Physiol. pmid:8997273
Olszewski MA et al. Mediators of anaphylaxis but not activated neutrophils augment cholinergic responses of equine small airways. 1999 Am. J. Physiol. pmid:10070118
Olszewski MA et al. Pre- and postjunctional effects of inflammatory mediators in horse airways. 1999 Am. J. Physiol. pmid:10444527
Hyun CS and Binder HJ Mechanism of leukotriene D4 stimulation of Cl- secretion in rat distal colon in vitro. 1993 Am. J. Physiol. pmid:8214069
Pawloski JR and Chapnick BM Antagonism of LTD4-evoked relaxation in canine renal artery and vein. 1993 Am. J. Physiol. pmid:8214135
Fiorucci S et al. Effect of NSAIDs on pepsinogen secretion and calcium mobilization in isolated chief cells. 1995 Am. J. Physiol. pmid:7611418
Sato E et al. Acetylcholine stimulates alveolar macrophages to release inflammatory cell chemotactic activity. 1998 Am. J. Physiol. pmid:9609736
Han H et al. Effects of LTD4 and its specific antagonist L-660,711 in isolated rat hearts with chronic myocardial infarction. 1994 Am. J. Physiol. pmid:8203604
Abela A and Daniel EE Neural and myogenic effects of leukotrienes C4, D4, and E4 on canine bronchial smooth muscle. 1994 Am. J. Physiol. pmid:8179018
Ganbo T et al. Leukotriene C4 inhibits ciliary activity in the presence of gamma-glutamyl transpeptidase. 1996 Am. J. Physiol. pmid:8770059
Talukder JR et al. Mechanism of leukotriene D4 inhibition of Na-alanine cotransport in intestinal epithelial cells. 2008 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:18436626
Liu P et al. Cysteinyl leukotriene-dependent [Ca2+]i responses to angiotensin II in cardiomyocytes. 2003 Am. J. Physiol. Heart Circ. Physiol. pmid:12531730
Carbajal V et al. LTD4 induces hyperresponsiveness to histamine in bovine airway smooth muscle: role of SR-ATPase Ca2+ pump and tyrosine kinase. 2005 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:15377496
Yang G et al. Transgenic smooth muscle expression of the human CysLT1 receptor induces enhanced responsiveness of murine airways to leukotriene D4. 2004 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:15064240
McGovern T et al. LTDâ‚„ induces HB-EGF-dependent CXCL8 release through EGFR activation in human bronchial epithelial cells. 2010 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:20889674
Oliveira SH et al. SCF-induced airway hyperreactivity is dependent on leukotriene production. 2001 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:11350804
Nagase T et al. A potent inhibitor of cytosolic phospholipase A2, arachidonyl trifluoromethyl ketone, attenuates LPS-induced lung injury in mice. 2003 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:12505870
Arthur S and Sundaram U Protein kinase C-mediated phosphorylation of RKIP regulates inhibition of Na-alanine cotransport by leukotriene D(4) in intestinal epithelial cells. 2014 Am. J. Physiol., Cell Physiol. pmid:25231108
Minobe E et al. A new phosphorylation site in cardiac L-type Ca2+ channels (Cav1.2) responsible for its cAMP-mediated modulation. 2014 Am. J. Physiol., Cell Physiol. pmid:25209265