| MeSH term | MeSH ID | Detail |
|---|---|---|
| Airway Obstruction | D000402 | 13 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Leukemia | D007938 | 74 associated lipids |
| Glomerulonephritis | D005921 | 35 associated lipids |
| Respiratory Hypersensitivity | D012130 | 18 associated lipids |
| Coronary Artery Disease | D003324 | 47 associated lipids |
| Carotid Stenosis | D016893 | 15 associated lipids |
| Asthma, Exercise-Induced | D001250 | 10 associated lipids |
| Endotoxemia | D019446 | 27 associated lipids |
Ltd4
Ltd4 is a lipid of Fatty Acyls (FA) class. Ltd4 is associated with abnormalities such as Inflammatory Bowel Diseases, Inflammatory disorder, Pneumonia, Asthma and Virus Diseases. The involved functions are known as uptake, Phosphorylation, Signal Transduction, symporter activity and Regulation. Ltd4 often locates in Protoplasm, Mucous Membrane, Membrane, Extracellular and Epithelium. The associated genes with Ltd4 are TYRO3 gene, RAF1 gene, serine-borate complex, ITGAM gene and ITGB2 gene. The related lipids are Lipopolysaccharides.
Cross Reference
Introduction
To understand associated biological information of Ltd4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Ltd4?
Ltd4 is suspected in Asthma, Inflammatory Bowel Diseases, Inflammatory disorder, Pneumonia, Virus Diseases and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Ltd4
PubChem Associated disorders and diseases
What pathways are associated with Ltd4
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Ltd4?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Ltd4?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Ltd4?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with Ltd4?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Ltd4?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Ltd4
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid: | ||||
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| White IJ et al. | A continuous fluorometric assay for leukotriene D4 hydrolase. | 1999 | Anal. Biochem. | pmid:10075814 |
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| Pitt CM and Nally JE | Angiotensin II-mediated potentiation of endothelin-1-evoked bronchial contractions: a role for leukotrienes? | 1999 | Pulm Pharmacol Ther | pmid:10208831 |
| Mulder A et al. | Effect of inhaled leukotriene D4 on airway eosinophilia and airway hyperresponsiveness in asthmatic subjects. | 1999 | Am. J. Respir. Crit. Care Med. | pmid:10228127 |
| Lynch KR et al. | Characterization of the human cysteinyl leukotriene CysLT1 receptor. | 1999 | Nature | pmid:10391245 |
| Clish CB et al. | Local and systemic delivery of a stable aspirin-triggered lipoxin prevents neutrophil recruitment in vivo. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10393980 |
| Han HJ et al. | Leukotriene D4 inhibits Na+ uptake through cAMP and PLC pathways in primary cultured renal proximal tubular cells. | 1999 | Kidney Blood Press. Res. | pmid:10394108 |
| Busse WW et al. | Leukotriene pathway inhibitors in asthma and chronic obstructive pulmonary disease. | 1999 | Clin. Exp. Allergy | pmid:10421833 |
| Olszewski MA et al. | Pre- and postjunctional effects of inflammatory mediators in horse airways. | 1999 | Am. J. Physiol. | pmid:10444527 |
| Takizawa T et al. | Effects of a new antiallergic agent, VUF-K-8788, on experimental asthmatic reactions in guinea pigs. | 1999 | Pharmacology | pmid:10450067 |
| Sarau HM et al. | Identification, molecular cloning, expression, and characterization of a cysteinyl leukotriene receptor. | 1999 | Mol. Pharmacol. | pmid:10462554 |
| Lankisch TO et al. | High-affinity cholecystokinin type A receptor/cytosolic phospholipase A2 pathways mediate Ca2+ oscillations via a positive feedback regulation by calmodulin kinase in pancreatic acini. | 1999 | Eur. J. Cell Biol. | pmid:10535305 |
| Yang XX et al. | The beta(2)-agonist salbutamol inhibits bronchoconstriction and leukotriene D(4) synthesis after dry gas hyperpnea in the guinea-pig. | 1999 | Pulm Pharmacol Ther | pmid:10545287 |
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| Underwood DC et al. | SB 239063, a potent p38 MAP kinase inhibitor, reduces inflammatory cytokine production, airways eosinophil infiltration, and persistence. | 2000 | J. Pharmacol. Exp. Ther. | pmid:10734180 |
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| Macfarlane AJ et al. | Sputum cysteinyl leukotrienes increase 24 hours after allergen inhalation in atopic asthmatics. | 2000 | Am. J. Respir. Crit. Care Med. | pmid:10806153 |
| Ravasi S et al. | A kinetic binding study to evaluate the pharmacological profile of a specific leukotriene C(4) binding site not coupled to contraction in human lung parenchyma. | 2000 | Mol. Pharmacol. | pmid:10825389 |
| Tran HS et al. | The cardiovascular hemodynamics and leukotriene kinetics during prostacyclin and anti-prostacyclin antibody infusions in septic shock. | 2000 | Shock | pmid:10847636 |
| Heise CE et al. | Characterization of the human cysteinyl leukotriene 2 receptor. | 2000 | J. Biol. Chem. | pmid:10851239 |
| Fukuyama S et al. | Effect of eotaxin and platelet-activating factor on airway inflammation and hyperresponsiveness in guinea pigs in vivo. | 2000 | Am. J. Respir. Crit. Care Med. | pmid:10852755 |
| Davis HM et al. | Human granulocyte CD11b expression as a pharmacodynamic biomarker of inflammation. | 2000 | J. Immunol. Methods | pmid:10854607 |
| Ballart B et al. | Synthesis and pharmacological evaluation of new 4-2-(7-heterocyclemethoxynaftalen-2-ylmethoxy)ethylbenzoic acids as LTD(4)-antagonists. | 2000 | Eur J Med Chem | pmid:10858604 |
| McMahon B et al. | Lipoxin A4 antagonizes the mitogenic effects of leukotriene D4 in human renal mesangial cells. Differential activation of MAP kinases through distinct receptors. | 2000 | J. Biol. Chem. | pmid:10869343 |
| Arakida Y et al. | In vivo pharmacologic profile of YM158, a new dual antagonist for leukotriene D4 and thromboxane A2 receptors. | 2000 | Jpn. J. Pharmacol. | pmid:10887942 |
| Lopes LR et al. | Reduced inflammatory response in rats fed fat-rich diets: role of leukotrienes. | 2000 | Life Sci. | pmid:10896024 |
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| Takasaki J et al. | The molecular characterization and tissue distribution of the human cysteinyl leukotriene CysLT(2) receptor. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10913337 |
| Turner DJ et al. | Bradykinin-induced airway constriction in guinea-pigs: role of leukotriene D(4). | 2000 | Pulm Pharmacol Ther | pmid:10930357 |
| Bäck M et al. | Antagonist resistant contractions of the porcine pulmonary artery by cysteinyl-leukotrienes. | 2000 | Eur. J. Pharmacol. | pmid:10936497 |
| Bäck M et al. | Prostacyclin modulation of contractions of the human pulmonary artery by cysteinyl-leukotrienes. | 2000 | Eur. J. Pharmacol. | pmid:10936498 |
| Titos E et al. | Hepatocyte-derived cysteinyl leukotrienes modulate vascular tone in experimental cirrhosis. | 2000 | Gastroenterology | pmid:10982774 |
| Kodani M et al. | Intratracheal administration of anaphylatoxin C5a potentiates antigen-induced pulmonary reactions through the prolonged production of cysteinyl-leukotrienes. | 2000 | Immunopharmacology | pmid:10996024 |
| Ménard G and Bissonnette EY | Priming of alveolar macrophages by leukotriene D(4): potentiation of inflammation. | 2000 | Am. J. Respir. Cell Mol. Biol. | pmid:11017925 |
| Ohd JF et al. | Leukotrienes induce cell-survival signaling in intestinal epithelial cells. | 2000 | Gastroenterology | pmid:11040187 |
| Thivierge M et al. | IL-5 up-regulates cysteinyl leukotriene 1 receptor expression in HL-60 cells differentiated into eosinophils. | 2000 | J. Immunol. | pmid:11046055 |
| Babu KS and Salvi SS | Aspirin and asthma. | 2000 | Chest | pmid:11083703 |
| Kalf GF | Utility of a mouse model for studying the effects of benzene on the myeloid lineage: effects of hydroquinone on a model myeloid system. | 2000 | J. Toxicol. Environ. Health Part A | pmid:11086946 |
| Nothacker HP et al. | Molecular cloning and characterization of a second human cysteinyl leukotriene receptor: discovery of a subtype selective agonist. | 2000 | Mol. Pharmacol. | pmid:11093801 |
| Hisamatsu K and Nakajima M | Pranlukast protects leukotriene C4- and D4-induced epithelial cell impairment of the nasal mucosa in vitro. | 2000 | Life Sci. | pmid:11105993 |
| Robbiani DF et al. | The leukotriene C(4) transporter MRP1 regulates CCL19 (MIP-3beta, ELC)-dependent mobilization of dendritic cells to lymph nodes. | 2000 | Cell | pmid:11114332 |
| Campos MG et al. | Galphimia glauca organic fraction antagonizes LTD(4)-induced contraction in guinea pig airways. | 2001 | J Ethnopharmacol | pmid:11137344 |
| Thodeti CK et al. | The epsilon isoform of protein kinase C is involved in regulation of the LTD(4)-induced calcium signal in human intestinal epithelial cells. | 2001 | Exp. Cell Res. | pmid:11139333 |