Ltd4

Ltd4 is a lipid of Fatty Acyls (FA) class. Ltd4 is associated with abnormalities such as Inflammatory Bowel Diseases, Inflammatory disorder, Pneumonia, Asthma and Virus Diseases. The involved functions are known as uptake, Phosphorylation, Signal Transduction, symporter activity and Regulation. Ltd4 often locates in Protoplasm, Mucous Membrane, Membrane, Extracellular and Epithelium. The associated genes with Ltd4 are TYRO3 gene, RAF1 gene, serine-borate complex, ITGAM gene and ITGB2 gene. The related lipids are Lipopolysaccharides.

Cross Reference

Introduction

To understand associated biological information of Ltd4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Ltd4?

Ltd4 is suspected in Asthma, Inflammatory Bowel Diseases, Inflammatory disorder, Pneumonia, Virus Diseases and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Ltd4

MeSH term MeSH ID Detail
Airway Obstruction D000402 13 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Edema D004487 152 associated lipids
Leukemia D007938 74 associated lipids
Glomerulonephritis D005921 35 associated lipids
Respiratory Hypersensitivity D012130 18 associated lipids
Coronary Artery Disease D003324 47 associated lipids
Carotid Stenosis D016893 15 associated lipids
Asthma, Exercise-Induced D001250 10 associated lipids
Endotoxemia D019446 27 associated lipids
Per page 10 20 | Total 13

PubChem Associated disorders and diseases

What pathways are associated with Ltd4

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Ltd4?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Ltd4?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Ltd4?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Ltd4?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Ltd4?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Ltd4

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Per page 10 20 50 100 | Total 562
Authors Title Published Journal PubMed Link
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Espinosa K et al. CysLT1 receptor upregulation by TGF-beta and IL-13 is associated with bronchial smooth muscle cell proliferation in response to LTD4. 2003 J. Allergy Clin. Immunol. pmid:12743568
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Ichiyama T et al. Pranlukast inhibits NF-kappa B activation in human monocytes/macrophages and T cells. 2003 Clin. Exp. Allergy pmid:12801316
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Kawano T et al. Cysteinyl leukotrienes induce nuclear factor kappa b activation and RANTES production in a murine model of asthma. 2003 J. Allergy Clin. Immunol. pmid:12897744
Paruchuri S and Sjölander A Leukotriene D4 mediates survival and proliferation via separate but parallel pathways in the human intestinal epithelial cell line Int 407. 2003 J. Biol. Chem. pmid:12912998
Sundström E et al. Interactions among three classes of mediators explain antigen-induced bronchoconstriction in the isolated perfused and ventilated guinea pig lung. 2003 J. Pharmacol. Exp. Ther. pmid:12954791
Schwartz JI et al. Oral pharmacokinetics and food interaction of the leukotriene D4 receptor antagonist verlukast. 1993 Br J Clin Pharmacol pmid:12959296
Sugahara S et al. Kinins are involved in the development of allergic nasal hyperresponsiveness in guinea pigs. 2003 Eur. J. Pharmacol. pmid:12969770
Massoumi R et al. Leukotriene D4-induced adhesion of Caco-2 cells is mediated by prostaglandin E2 and upregulation of alpha2beta1-integrin. 2003 Exp. Cell Res. pmid:14499635
Thompson MD et al. A cysteinyl leukotriene 2 receptor variant is associated with atopy in the population of Tristan da Cunha. 2003 Pharmacogenetics pmid:14515063
Capra V et al. Involvement of prenylated proteins in calcium signaling induced by LTD4 in differentiated U937 cells. 2003 Prostaglandins Other Lipid Mediat. pmid:14518564
Sloniewsky DE et al. Leukotriene D4 activates alveolar epithelial Na,K-ATPase and increases alveolar fluid clearance. 2004 Am. J. Respir. Crit. Care Med. pmid:14578215
Mayatepek E et al. Synthesis and metabolism of leukotrienes in gamma-glutamyl transpeptidase deficiency. 2004 J. Lipid Res. pmid:14754911
Wulff T et al. Co-expression of mCysLT1 receptors and IK channels in Xenopus laevis oocytes elicits LTD4-stimulated IK current, independent of an increase in [Ca2+]i. 2004 Biochim. Biophys. Acta pmid:14757222
Capra V et al. CysLT1 signal transduction in differentiated U937 cells involves the activation of the small GTP-binding protein Ras. 2004 Biochem. Pharmacol. pmid:15041474
Yang G et al. Transgenic smooth muscle expression of the human CysLT1 receptor induces enhanced responsiveness of murine airways to leukotriene D4. 2004 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:15064240
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Asakura T et al. Leukotriene D4 stimulates collagen production from myofibroblasts transformed by TGF-beta. 2004 J. Allergy Clin. Immunol. pmid:15316508
Zhao L et al. The 5-lipoxygenase pathway promotes pathogenesis of hyperlipidemia-dependent aortic aneurysm. 2004 Nat. Med. pmid:15322539
Carbajal V et al. LTD4 induces hyperresponsiveness to histamine in bovine airway smooth muscle: role of SR-ATPase Ca2+ pump and tyrosine kinase. 2005 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:15377496
Tsuji T et al. Differential effects of beta2-adrenoceptor desensitization on the IgE-dependent release of chemical mediators from cultured human mast cells. 2004 Biol. Pharm. Bull. pmid:15467193
Ishinaga H et al. Pranlukast inhibits NF-kappaB activation and MUC2 gene expression in cultured human epithelial cells. 2005 Pharmacology pmid:15475658
Pillai SG et al. A coding polymorphism in the CYSLT2 receptor with reduced affinity to LTD4 is associated with asthma. 2004 Pharmacogenetics pmid:15475736
Ferrari F et al. Pharmacological profile of CR3465, a new leukotriene CysLT1 receptor antagonist with broad anti-inflammatory activity. 2004 Eur. J. Pharmacol. pmid:15541426
Nielsen CK et al. Leukotriene D4 activates distinct G-proteins in intestinal epithelial cells to regulate stress fibre formation and to generate intracellular Ca2+ mobilisation and ERK1/2 activation. 2005 Exp. Cell Res. pmid:15541723
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Paruchuri S et al. The pro-inflammatory mediator leukotriene D4 induces phosphatidylinositol 3-kinase and Rac-dependent migration of intestinal epithelial cells. 2005 J. Biol. Chem. pmid:15657050
Nielsen CK et al. A novel localization of the G-protein-coupled CysLT1 receptor in the nucleus of colorectal adenocarcinoma cells. 2005 Cancer Res. pmid:15705869
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Chiba Y et al. Effects of 1400W, a potent selective inducible NOS inhibitor, on histamine- and leukotriene D4-induced relaxation of isolated guinea pig nasal mucosa. 2006 Nitric Oxide pmid:16442819
Trandafir CC et al. Cysteinyl leukotrienes and leukotriene B mediate vasoconstriction to arginine vasopressin in rat basilar artery. 2005 Clin. Exp. Pharmacol. Physiol. pmid:16445567
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Ravasi S et al. CysLT1 receptor-induced human airway smooth muscle cells proliferation requires ROS generation, EGF receptor transactivation and ERK1/2 phosphorylation. 2006 Respir. Res. pmid:16553950
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Lamoureux J et al. Leukotriene D4 enhances immunoglobulin production in CD40-activated human B lymphocytes. 2006 J. Allergy Clin. Immunol. pmid:16630953
Thivierge M et al. Toll-like receptor agonists differentially regulate cysteinyl-leukotriene receptor 1 expression and function in human dendritic cells. 2006 J. Allergy Clin. Immunol. pmid:16675346
Paruchuri S et al. Endogenous production of leukotriene D4 mediates autocrine survival and proliferation via CysLT1 receptor signalling in intestinal epithelial cells. 2006 Oncogene pmid:16715140
Skogvall S et al. Effects of capsazepine on human small airway responsiveness unravel a novel class of bronchorelaxants. 2007 Pulm Pharmacol Ther pmid:16731017
Bouchelouche K and Bouchelouche P Cysteinyl leukotriene D4 increases human detrusor muscle responsiveness to histamine. 2006 J. Urol. pmid:16753444
Thompson C et al. CysLT1 receptor engagement induces activator protein-1- and NF-kappaB-dependent IL-8 expression. 2006 Am. J. Respir. Cell Mol. Biol. pmid:16809637
Gyllfors P et al. Bronchial responsiveness to leukotriene D4 is resistant to inhaled fluticasone propionate. 2006 J. Allergy Clin. Immunol. pmid:16815141
Cui S et al. Effects of platelet-activating factor, thromboxane A2 and leukotriene D4 on isolated perfused rat liver. 2006 Prostaglandins Other Lipid Mediat. pmid:16846785
Rovati GE et al. Cysteinyl-leukotrienes in the regulation of beta2-adrenoceptor function: an in vitro model of asthma. 2006 Respir. Res. pmid:16875498
Capra V et al. Cysteinyl-leukotrienes and their receptors in asthma and other inflammatory diseases: critical update and emerging trends. 2007 Med Res Rev pmid:16894531