Ltd4

Ltd4 is a lipid of Fatty Acyls (FA) class. Ltd4 is associated with abnormalities such as Inflammatory Bowel Diseases, Inflammatory disorder, Pneumonia, Asthma and Virus Diseases. The involved functions are known as uptake, Phosphorylation, Signal Transduction, symporter activity and Regulation. Ltd4 often locates in Protoplasm, Mucous Membrane, Membrane, Extracellular and Epithelium. The associated genes with Ltd4 are TYRO3 gene, RAF1 gene, serine-borate complex, ITGAM gene and ITGB2 gene. The related lipids are Lipopolysaccharides.

Cross Reference

Introduction

To understand associated biological information of Ltd4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Ltd4?

Ltd4 is suspected in Asthma, Inflammatory Bowel Diseases, Inflammatory disorder, Pneumonia, Virus Diseases and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Ltd4

MeSH term MeSH ID Detail
Airway Obstruction D000402 13 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Edema D004487 152 associated lipids
Leukemia D007938 74 associated lipids
Glomerulonephritis D005921 35 associated lipids
Respiratory Hypersensitivity D012130 18 associated lipids
Coronary Artery Disease D003324 47 associated lipids
Carotid Stenosis D016893 15 associated lipids
Asthma, Exercise-Induced D001250 10 associated lipids
Endotoxemia D019446 27 associated lipids
Per page 10 20 | Total 13

PubChem Associated disorders and diseases

What pathways are associated with Ltd4

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Ltd4?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Ltd4?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Ltd4?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Ltd4?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Ltd4?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Ltd4

Download all related citations
Per page 10 20 50 100 | Total 562
Authors Title Published Journal PubMed Link
Guan W et al. Leukotriene D4 bronchial provocation test: methodology and diagnostic value. 2012 Curr Med Res Opin pmid:22435894
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Drost AC et al. The G protein-coupled receptor CysLT1 mediates chemokine-like effects and prolongs survival in chronic lymphocytic leukemia. 2012 Leuk. Lymphoma pmid:21936770
Huang SC Leukotriene-induced contraction is mediated by cysteinyl leukotriene receptor CysLT1 in guinea pig fundus but by CysLT1 and CysLT2 in antrum. 2011 Life Sci. pmid:21396378
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Rehni AK and Singh TG Modulation of leukotriene D4 attenuates the development of seizures in mice. 2011 Prostaglandins Leukot. Essent. Fatty Acids pmid:21641195
Haneda Y et al. Leukotriene D4 enhances tumor necrosis factor-α-induced vascular endothelial growth factor production in human monocytes/macrophages. 2011 Cytokine pmid:21482134
Daniele S et al. Agonist-induced desensitization/resensitization of human G protein-coupled receptor 17: a functional cross-talk between purinergic and cysteinyl-leukotriene ligands. 2011 J. Pharmacol. Exp. Ther. pmid:21531793
Carnini C et al. Synthesis of cysteinyl leukotrienes in human endothelial cells: subcellular localization and autocrine signaling through the CysLT2 receptor. 2011 FASEB J. pmid:21753081
Itagaki K et al. Eicosanoid-induced store-operated calcium entry in dendritic cells. 2011 J. Surg. Res. pmid:20080257
Ni NC et al. A selective cysteinyl leukotriene receptor 2 antagonist blocks myocardial ischemia/reperfusion injury and vascular permeability in mice. 2011 J. Pharmacol. Exp. Ther. pmid:21903747
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McGovern T et al. LTDâ‚„ induces HB-EGF-dependent CXCL8 release through EGFR activation in human bronchial epithelial cells. 2010 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:20889674
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Kim MH et al. Effect of leukotriene D4 on mouse embryonic stem cell migration and proliferation: involvement of PI3K/Akt as well as GSK-3β/β-catenin signaling pathways. 2010 J. Cell. Biochem. pmid:20589831
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Campos MR et al. Differential kinase requirement for enhancement of Fc gammaR-mediated phagocytosis in alveolar macrophages by leukotriene B4 vs. D4. 2009 Mol. Immunol. pmid:19223078
Lee SP et al. Crosstalk between prostaglandin E2 and leukotriene B4 regulates phagocytosis in alveolar macrophages via combinatorial effects on cyclic AMP. 2009 J. Immunol. pmid:19109185
Lee TH et al. Leukotriene E4: perspective on the forgotten mediator. 2009 J. Allergy Clin. Immunol. pmid:19482346
Theron AJ et al. Leukotrienes C4 and D4 sensitize human neutrophils for hyperreactivity to chemoattractants. 2009 Inflamm. Res. pmid:19184354
Farias S et al. Injury-related production of cysteinyl leukotrienes contributes to brain damage following experimental traumatic brain injury. 2009 J. Neurotrauma pmid:19886806
Hashimoto K et al. Cysteinyl leukotrienes induce monocyte chemoattractant protein-1 in human monocyte/macrophages via mitogen-activated protein kinase and nuclear factor-kappaB pathways. 2009 Int. Arch. Allergy Immunol. pmid:19218821
Muraki M et al. Inhaled montelukast inhibits cysteinyl-leukotriene-induced bronchoconstriction in ovalbumin-sensitized guinea-pigs: the potential as a new asthma medication. 2009 Int. Immunopharmacol. pmid:19706339
Yuan YM et al. Leukotriene D4 stimulates the migration but not proliferation of endothelial cells mediated by the cysteinyl leukotriene cyslt(1) receptor via the extracellular signal-regulated kinase pathway. 2009 J. Pharmacol. Sci. pmid:19234368
Baker N et al. Lipoxin A4: anti-inflammatory and anti-angiogenic impact on endothelial cells. 2009 J. Immunol. pmid:19265161
Mizutani N et al. Effect of TA-270, a novel quinolinone derivative, on antigen-induced nasal blockage in a guinea pig model of allergic rhinitis. 2009 Eur. J. Pharmacol. pmid:19022242
Fang SH et al. Pranlukast attenuates ischemia-like injury in endothelial cells via inhibiting reactive oxygen species production and nuclear factor-kappaB activation. 2009 J. Cardiovasc. Pharmacol. pmid:19129732
Claesson HE On the biosynthesis and biological role of eoxins and 15-lipoxygenase-1 in airway inflammation and Hodgkin lymphoma. 2009 Prostaglandins Other Lipid Mediat. pmid:19130894
Dayyat E et al. Leukotriene pathways and in vitro adenotonsillar cell proliferation in children with obstructive sleep apnea. 2009 Chest pmid:19118273
Boehmler AM et al. The CysLT1 ligand leukotriene D4 supports alpha4beta1- and alpha5beta1-mediated adhesion and proliferation of CD34+ hematopoietic progenitor cells. 2009 J. Immunol. pmid:19454674
Mori M et al. Eosinophil superoxide anion generation induced by adhesion molecules and leukotriene D4. 2009 Int. Arch. Allergy Immunol. pmid:19494502
Yang HS et al. [Effects of leukotriene receptor antagonists on vascular endothelial growth factor and its receptors in a sensitized rat model]. 2009 Zhonghua Jie He He Hu Xi Za Zhi pmid:19575935
Maekawa A et al. GPR17 is a negative regulator of the cysteinyl leukotriene 1 receptor response to leukotriene D4. 2009 Proc. Natl. Acad. Sci. U.S.A. pmid:19561298
Pugliese AM et al. Functional characterization of two isoforms of the P2Y-like receptor GPR17: [35S]GTPgammaS binding and electrophysiological studies in 1321N1 cells. 2009 Am. J. Physiol., Cell Physiol. pmid:19625605
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Thivierge M et al. Cysteinyl-leukotriene receptor type 1 expression and function is down-regulated during monocyte-derived dendritic cell maturation with zymosan: involvement of IL-10 and prostaglandins. 2009 J. Immunol. pmid:19846883
Kim SH et al. Regulation of monocyte chemoattractant protein 1 by cysteinyl leukotriene D4 in human lung epithelial A549 cells. 2009 Ann. Allergy Asthma Immunol. pmid:19852204
Schäper C et al. Effects of fexofenadine on inflammatory mediators in nasal lavage fluid in intermittent allergic rhinitis. 2009 J Investig Allergol Clin Immunol pmid:20128420
Selg E et al. Two different mechanisms for modulation of bronchoconstriction in guinea-pigs by cyclooxygenase metabolites. 2009 Prostaglandins Other Lipid Mediat. pmid:19103301