Gronert K et al. |
Selectivity of recombinant human leukotriene D(4), leukotriene B(4), and lipoxin A(4) receptors with aspirin-triggered 15-epi-LXA(4) and regulation of vascular and inflammatory responses. |
2001 |
Am. J. Pathol. |
pmid:11141472
|
Mehta KA et al. |
Effect of formulation and process variables on porosity parameters and release rates from a multi unit erosion matrix of a poorly soluble drug. |
2000 |
J Control Release |
pmid:10640593
|
Ahmed T et al. |
Inhibition of allergic late airway responses by inhaled heparin-derived oligosaccharides. |
2000 |
J. Appl. Physiol. |
pmid:10797135
|
Thivierge M et al. |
IL-5 up-regulates cysteinyl leukotriene 1 receptor expression in HL-60 cells differentiated into eosinophils. |
2000 |
J. Immunol. |
pmid:11046055
|
Babu KS and Salvi SS |
Aspirin and asthma. |
2000 |
Chest |
pmid:11083703
|
Kalf GF |
Utility of a mouse model for studying the effects of benzene on the myeloid lineage: effects of hydroquinone on a model myeloid system. |
2000 |
J. Toxicol. Environ. Health Part A |
pmid:11086946
|
Macfarlane AJ et al. |
Sputum cysteinyl leukotrienes increase 24 hours after allergen inhalation in atopic asthmatics. |
2000 |
Am. J. Respir. Crit. Care Med. |
pmid:10806153
|
Titos E et al. |
Hepatocyte-derived cysteinyl leukotrienes modulate vascular tone in experimental cirrhosis. |
2000 |
Gastroenterology |
pmid:10982774
|
Ménard G and Bissonnette EY |
Priming of alveolar macrophages by leukotriene D(4): potentiation of inflammation. |
2000 |
Am. J. Respir. Cell Mol. Biol. |
pmid:11017925
|
Arakida Y et al. |
In vivo pharmacologic profile of YM158, a new dual antagonist for leukotriene D4 and thromboxane A2 receptors. |
2000 |
Jpn. J. Pharmacol. |
pmid:10887942
|
McMahon B et al. |
Lipoxin A4 antagonizes the mitogenic effects of leukotriene D4 in human renal mesangial cells. Differential activation of MAP kinases through distinct receptors. |
2000 |
J. Biol. Chem. |
pmid:10869343
|
Turner DJ et al. |
Bradykinin-induced airway constriction in guinea-pigs: role of leukotriene D(4). |
2000 |
Pulm Pharmacol Ther |
pmid:10930357
|
Fukuyama S et al. |
Effect of eotaxin and platelet-activating factor on airway inflammation and hyperresponsiveness in guinea pigs in vivo. |
2000 |
Am. J. Respir. Crit. Care Med. |
pmid:10852755
|
Ballart B et al. |
Synthesis and pharmacological evaluation of new 4-2-(7-heterocyclemethoxynaftalen-2-ylmethoxy)ethylbenzoic acids as LTD(4)-antagonists. |
2000 |
Eur J Med Chem |
pmid:10858604
|
Blain JF and Sirois P |
Involvement of LTD(4)in allergic pulmonary inflammation in mice: modulation by cysLT(1)antagonist MK-571. |
2000 |
Prostaglandins Leukot. Essent. Fatty Acids |
pmid:10913229
|
Laberge S et al. |
Antigen-induced airway inflammation and hyper-responsiveness does not enhance airway responses to a subsequent antigen challenge in rats. |
2000 |
Respir Med |
pmid:10714478
|
Thodeti CK et al. |
Leukotriene D(4) triggers an association between gbetagamma subunits and phospholipase C-gamma1 in intestinal epithelial cells. |
2000 |
J. Biol. Chem. |
pmid:10734140
|
Underwood DC et al. |
SB 239063, a potent p38 MAP kinase inhibitor, reduces inflammatory cytokine production, airways eosinophil infiltration, and persistence. |
2000 |
J. Pharmacol. Exp. Ther. |
pmid:10734180
|
Kivity S et al. |
Eosinophil influx into the airways in patients with exercise-induced asthma. |
2000 |
Respir Med |
pmid:11192956
|
Ravasi S et al. |
A kinetic binding study to evaluate the pharmacological profile of a specific leukotriene C(4) binding site not coupled to contraction in human lung parenchyma. |
2000 |
Mol. Pharmacol. |
pmid:10825389
|
Ohd JF et al. |
Leukotrienes induce cell-survival signaling in intestinal epithelial cells. |
2000 |
Gastroenterology |
pmid:11040187
|
Robbiani DF et al. |
The leukotriene C(4) transporter MRP1 regulates CCL19 (MIP-3beta, ELC)-dependent mobilization of dendritic cells to lymph nodes. |
2000 |
Cell |
pmid:11114332
|
Hisamatsu K and Nakajima M |
Pranlukast protects leukotriene C4- and D4-induced epithelial cell impairment of the nasal mucosa in vitro. |
2000 |
Life Sci. |
pmid:11105993
|
Nothacker HP et al. |
Molecular cloning and characterization of a second human cysteinyl leukotriene receptor: discovery of a subtype selective agonist. |
2000 |
Mol. Pharmacol. |
pmid:11093801
|
Bäck M et al. |
Antagonist resistant contractions of the porcine pulmonary artery by cysteinyl-leukotrienes. |
2000 |
Eur. J. Pharmacol. |
pmid:10936497
|
Kodani M et al. |
Intratracheal administration of anaphylatoxin C5a potentiates antigen-induced pulmonary reactions through the prolonged production of cysteinyl-leukotrienes. |
2000 |
Immunopharmacology |
pmid:10996024
|
Tran HS et al. |
The cardiovascular hemodynamics and leukotriene kinetics during prostacyclin and anti-prostacyclin antibody infusions in septic shock. |
2000 |
Shock |
pmid:10847636
|
Davis HM et al. |
Human granulocyte CD11b expression as a pharmacodynamic biomarker of inflammation. |
2000 |
J. Immunol. Methods |
pmid:10854607
|
Heise CE et al. |
Characterization of the human cysteinyl leukotriene 2 receptor. |
2000 |
J. Biol. Chem. |
pmid:10851239
|
Bäck M et al. |
Prostacyclin modulation of contractions of the human pulmonary artery by cysteinyl-leukotrienes. |
2000 |
Eur. J. Pharmacol. |
pmid:10936498
|
Mayatepek E et al. |
Defects in the synthesis of cysteinyl leukotrienes: a new group of inborn errors of metabolism. |
2000 |
J. Inherit. Metab. Dis. |
pmid:10896305
|
Takasaki J et al. |
The molecular characterization and tissue distribution of the human cysteinyl leukotriene CysLT(2) receptor. |
2000 |
Biochem. Biophys. Res. Commun. |
pmid:10913337
|
Lopes LR et al. |
Reduced inflammatory response in rats fed fat-rich diets: role of leukotrienes. |
2000 |
Life Sci. |
pmid:10896024
|
Mayatepek E et al. |
Analysis of leukotrienes in cerebrospinal fluid of a reference population and patients with inborn errors of metabolism: further evidence for a pathognomonic profile in LTC(4)-synthesis deficiency. |
2000 |
Clin. Chim. Acta |
pmid:10686285
|
Yamashita T and Kokubun S |
Nonselective cationic currents activated by acetylcholine in swine tracheal smooth muscle cells. |
1999 |
Can. J. Physiol. Pharmacol. |
pmid:10588484
|
Lärfars G et al. |
Activation of nitric oxide release and oxidative metabolism by leukotrienes B4, C4, and D4 in human polymorphonuclear leukocytes. |
1999 |
Blood |
pmid:9949184
|
Lankisch TO et al. |
High-affinity cholecystokinin type A receptor/cytosolic phospholipase A2 pathways mediate Ca2+ oscillations via a positive feedback regulation by calmodulin kinase in pancreatic acini. |
1999 |
Eur. J. Cell Biol. |
pmid:10535305
|
Sarau HM et al. |
Identification, molecular cloning, expression, and characterization of a cysteinyl leukotriene receptor. |
1999 |
Mol. Pharmacol. |
pmid:10462554
|
Lynch KR et al. |
Characterization of the human cysteinyl leukotriene CysLT1 receptor. |
1999 |
Nature |
pmid:10391245
|
Busse WW et al. |
Leukotriene pathway inhibitors in asthma and chronic obstructive pulmonary disease. |
1999 |
Clin. Exp. Allergy |
pmid:10421833
|
Han HJ et al. |
Leukotriene D4 inhibits Na+ uptake through cAMP and PLC pathways in primary cultured renal proximal tubular cells. |
1999 |
Kidney Blood Press. Res. |
pmid:10394108
|
Mulder A et al. |
Effect of inhaled leukotriene D4 on airway eosinophilia and airway hyperresponsiveness in asthmatic subjects. |
1999 |
Am. J. Respir. Crit. Care Med. |
pmid:10228127
|
Pitt CM and Nally JE |
Angiotensin II-mediated potentiation of endothelin-1-evoked bronchial contractions: a role for leukotrienes? |
1999 |
Pulm Pharmacol Ther |
pmid:10208831
|
Clish CB et al. |
Local and systemic delivery of a stable aspirin-triggered lipoxin prevents neutrophil recruitment in vivo. |
1999 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:10393980
|
Olszewski MA et al. |
Mediators of anaphylaxis but not activated neutrophils augment cholinergic responses of equine small airways. |
1999 |
Am. J. Physiol. |
pmid:10070118
|
White IJ et al. |
A continuous fluorometric assay for leukotriene D4 hydrolase. |
1999 |
Anal. Biochem. |
pmid:10075814
|
Takami M and Tsukada W |
Effect of DP-1904, a thromboxane synthetase inhibitor, on antigen- and spasmogen-induced bronchoconstriction in rodents. |
1999 |
Eur. J. Pharmacol. |
pmid:10082207
|
Yang XX et al. |
The beta(2)-agonist salbutamol inhibits bronchoconstriction and leukotriene D(4) synthesis after dry gas hyperpnea in the guinea-pig. |
1999 |
Pulm Pharmacol Ther |
pmid:10545287
|
Olszewski MA et al. |
Pre- and postjunctional effects of inflammatory mediators in horse airways. |
1999 |
Am. J. Physiol. |
pmid:10444527
|
Takizawa T et al. |
Effects of a new antiallergic agent, VUF-K-8788, on experimental asthmatic reactions in guinea pigs. |
1999 |
Pharmacology |
pmid:10450067
|
Yang XX et al. |
Strain dependence of the airway response to dry-gas hyperpnea challenge in the rat. |
1999 |
J. Appl. Physiol. |
pmid:9887125
|
Sciuto AM et al. |
Post-exposure treatment with isoproterenol attenuates pulmonary edema in phosgene-exposed rabbits. |
1998 Sep-Oct |
J Appl Toxicol |
pmid:9804432
|
Wen FQ et al. |
Eicosanoid profile in cultured human pulmonary artery smooth muscle cells treated with IL-1 beta and TNF alpha. |
1998 |
Prostaglandins Leukot. Essent. Fatty Acids |
pmid:9758210
|
Francis HP et al. |
The effects of a novel sulphidopeptide leukotriene antagonist, BAY x7195, against elicited bronchoconstriction in the anaesthetized guinea-pig. |
1998 |
Br. J. Pharmacol. |
pmid:9484852
|
Ohbayashi H et al. |
Compared effects of natriuretic peptides on ovalbumin-induced asthmatic model. |
1998 |
Eur. J. Pharmacol. |
pmid:9617752
|
Kohno S |
[Role of peptide-leukotrienes in bronchial asthma]. |
1998 |
Nippon Yakurigaku Zasshi |
pmid:9618707
|
Gorenne I et al. |
Leukotriene D4 contractions in human airways are blocked by SK&F 96365, an inhibitor of receptor-mediated calcium entry. |
1998 |
J. Pharmacol. Exp. Ther. |
pmid:9454796
|
Kimura K et al. |
Modulation of platelet activating factor-induced glycogenolysis in the perfused rat liver after administration of endotoxin in vivo. |
1998 |
J. Biochem. |
pmid:9504421
|
Capra V et al. |
Identification and characterization of two cysteinyl-leukotriene high affinity binding sites with receptor characteristics in human lung parenchyma. |
1998 |
Mol. Pharmacol. |
pmid:9547367
|
Cyrus CB et al. |
Leukotrienes C4 and D4 increase the ciliary beat frequency in human upper airway mucosa in vitro. |
1998 |
Otolaryngol Head Neck Surg |
pmid:9560097
|
von Sprecher A et al. |
Synthesis and SAR of a novel, potent and structurally simple LTD4 antagonist of the quinoline class. |
1998 |
Bioorg. Med. Chem. Lett. |
pmid:9871521
|
Dahlén B et al. |
Benefits from adding the 5-lipoxygenase inhibitor zileuton to conventional therapy in aspirin-intolerant asthmatics. |
1998 |
Am. J. Respir. Crit. Care Med. |
pmid:9563738
|
Capra V et al. |
Pharmacological characterization of the cysteinyl-leukotriene antagonists CGP 45715A (iralukast) and CGP 57698 in human airways in vitro. |
1998 |
Br. J. Pharmacol. |
pmid:9504401
|
Yamaya M et al. |
Dipeptidase inhibitor and epithelial removal potentiate leukotriene D4-induced human tracheal smooth muscle contraction. |
1998 |
Respir Physiol |
pmid:9496476
|
Basavappa S et al. |
Swelling-induced arachidonic acid release via the 85-kDa cPLA2 in human neuroblastoma cells. |
1998 |
J. Neurophysiol. |
pmid:9497423
|
Hoshino M et al. |
Leukotriene D4 activates mitogen-activated protein kinase through a protein kinase Calpha-Raf-1-dependent pathway in human monocytic leukemia THP-1 cells. |
1998 |
J. Biol. Chem. |
pmid:9478929
|
Zwaagstra ME et al. |
Synthesis and structure-activity relationships of carboxyflavones as structurally rigid CysLT1 (LTD4) receptor antagonists. |
1998 |
J. Med. Chem. |
pmid:9554876
|
Habib GM et al. |
Leukotriene D4 and cystinyl-bis-glycine metabolism in membrane-bound dipeptidase-deficient mice. |
1998 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:9560193
|
Arakida Y et al. |
In vitro pharmacologic profile of YM158, a new dual antagonist for LTD4 and TXA2 receptors. |
1998 |
J. Pharmacol. Exp. Ther. |
pmid:9808690
|
Venugopalan CS et al. |
Responses of guinea-pig lung parenchymal strips to tracheobronchial lavage fluid from horses affected with summer pasture-associated obstructive pulmonary disease. |
1998 |
Vet. Res. Commun. |
pmid:9868763
|
Chambers RJ et al. |
Development of new chromanol antagonists of leukotriene D4. |
1998 |
Bioorg. Med. Chem. Lett. |
pmid:9873435
|
Nagayama S et al. |
Increased sensitivity to vincristine of MDR cells by the leukotriene D4 receptor antagonist, ONO-1078. |
1998 |
Cancer Lett. |
pmid:9751271
|
Geirsson A et al. |
Potentiating effects of pertussis toxin on leukotriene C4 induced formation of inositol phosphate and prostacyclin in human umbilical vein endothelial cells. |
1998 |
J. Cell. Physiol. |
pmid:9731750
|
Kim N et al. |
Leukotriene D4-induced contraction of cat esophageal and lower esophageal sphincter circular smooth muscle. |
1998 |
Gastroenterology |
pmid:9753495
|
Grönroos E et al. |
Leukotriene D4 induces a rapid increase in cAMP in the human epithelial cell line, Int 407: a potential role for this signal in the regulation of calcium influx through the plasma membrane. |
1998 |
Cell Calcium |
pmid:9793684
|
Tsang F et al. |
Effects of mitogen-activated protein kinase kinase inhibitor PD 098059 on antigen challenge of guinea-pig airways in vitro. |
1998 |
Br. J. Pharmacol. |
pmid:9776345
|
Panettieri RA et al. |
Effects of LTD4 on human airway smooth muscle cell proliferation, matrix expression, and contraction In vitro: differential sensitivity to cysteinyl leukotriene receptor antagonists. |
1998 |
Am. J. Respir. Cell Mol. Biol. |
pmid:9730873
|
Lane SJ |
Leukotriene antagonism in asthma and rhinitis. |
1998 |
Respir Med |
pmid:9850362
|
Smith LJ et al. |
A single dose of zafirlukast reduces LTD4-induced bronchoconstriction in patients on maintenance inhaled corticosteroid therapy. |
1998 |
Ann. Allergy Asthma Immunol. |
pmid:9690572
|
Liu YC et al. |
Effects of the cysteinyl leukotriene receptor antagonists pranlukast and zafirlukast on tracheal mucus secretion in ovalbumin-sensitized guinea-pigs in vitro. |
1998 |
Br. J. Pharmacol. |
pmid:9647482
|
Massoumi R and Sjölander A |
The inflammatory mediator leukotriene D4 triggers a rapid reorganisation of the actin cytoskeleton in human intestinal epithelial cells. |
1998 |
Eur. J. Cell Biol. |
pmid:9716265
|
Shirasaki H et al. |
The effect of a cysteinyl leukotriene antagonist, ONO-1078 (pranlukast) on agonist- and antigen-induced nasal microvascular leakage in guinea pigs. |
1998 |
Rhinology |
pmid:9695159
|
Nagase T and Ludwig MS |
Antigen-induced responses in lung parenchymal strips during sinusoidal oscillation. |
1998 |
Can. J. Physiol. Pharmacol. |
pmid:9635157
|
Kjellström S et al. |
On-line coupling of microdialysis sampling with liquid chromatography for the determination of peptide and non-peptide leukotrienes. |
1998 |
J Chromatogr A |
pmid:9818423
|
Ohbayashi H et al. |
Neutral endopeptidase 3.4.24.11 inhibition potentiates the inhibitory effects of type-C natriuretic peptide on leukotriene D4-induced airway changes. |
1998 |
Clin. Exp. Pharmacol. Physiol. |
pmid:9887994
|
Underwood DC et al. |
Antiasthmatic activity of the second-generation phosphodiesterase 4 (PDE4) inhibitor SB 207499 (Ariflo) in the guinea pig. |
1998 |
J. Pharmacol. Exp. Ther. |
pmid:9864284
|
Fujimura M et al. |
A partial involvement of histamine in ultrasonically nebulized distilled water-induced bronchoconstriction in guinea-pigs. |
1998 |
Br. J. Pharmacol. |
pmid:9831931
|
Kawashima Y et al. |
Surface-modified antiasthmatic dry powder aerosols inhaled intratracheally reduce the pharmacologically effective dose. |
1998 |
Pharm. Res. |
pmid:9833999
|
Allen S et al. |
Differential leukotriene constrictor responses in human atherosclerotic coronary arteries. |
1998 |
Circulation |
pmid:9641692
|
Przylipiak A et al. |
Influence of leukotrienes on in vitro growth of human mammary carcinoma cell line MCF-7. |
1998 |
Eur. J. Obstet. Gynecol. Reprod. Biol. |
pmid:9550202
|
Sato E et al. |
Acetylcholine stimulates alveolar macrophages to release inflammatory cell chemotactic activity. |
1998 |
Am. J. Physiol. |
pmid:9609736
|
Traianedes K et al. |
5-Lipoxygenase metabolites inhibit bone formation in vitro. |
1998 |
Endocrinology |
pmid:9645691
|
Daugschies A and Ruttkowski B |
Modulation of migration of Oesophagostomum dentatum larvae by inhibitors and products of eicosanoid metabolism. |
1998 |
Int. J. Parasitol. |
pmid:9513001
|
Jonsson EW |
Functional characterisation of receptors for cysteinyl leukotrienes in smooth muscle. |
1998 |
Acta Physiol Scand Suppl |
pmid:9597121
|
Kagoshima M et al. |
Effect of Y-24180, a long-acting antagonist to platelet-activating factor (PAF), on PAF-induced reactions: a relationship between the partial structure of the compound and its duration of the action. |
1997 |
Pharmacology |
pmid:9380772
|
O'Shaughnessy TC et al. |
Effect of pranlukast, an oral leukotriene receptor antagonist, on leukotriene D4 (LTD4) challenge in normal volunteers. |
1997 |
Thorax |
pmid:9227717
|
Meng XJ et al. |
Leukotriene D4 activates a chloride conductance in hepatocytes from lipopolysaccharide-treated rats. |
1997 |
J. Clin. Invest. |
pmid:9185515
|
Diamant Z et al. |
The effect of inhaled leukotriene D4 and methacholine on sputum cell differentials in asthma. |
1997 |
Am. J. Respir. Crit. Care Med. |
pmid:9105062
|
Wong WS et al. |
Effects of tyrosine kinase inhibitors on antigen challenge of guinea pig lung in vitro. |
1997 |
J. Pharmacol. Exp. Ther. |
pmid:9336317
|
Muñoz NM et al. |
Eosinophil chemotaxis inhibited by 5-lipoxygenase blockade and leukotriene receptor antagonism. |
1997 |
Am. J. Respir. Crit. Care Med. |
pmid:9105085
|