15-epi-lxa4;15r-lxa4

15-epi-lxa4;15r-lxa4 is a lipid of Fatty Acyls (FA) class. 15-epi-lxa4;15r-lxa4 is associated with abnormalities such as Pneumonia, Septicemia, Cystic Fibrosis, Subarachnoid Hemorrhage and Obesity. The involved functions are known as Protective Agents, Signal Transduction, cytokine biosynthesis, Inflammation and Anabolism. 15-epi-lxa4;15r-lxa4 often locates in Blood, Immune system and Heart tissue. The associated genes with 15-epi-lxa4;15r-lxa4 are IL2 gene, CXCL13 gene and CMKLR1 gene. The related lipids are Steroids. The related experimental models are Knock-out.

Cross Reference

Introduction

To understand associated biological information of 15-epi-lxa4;15r-lxa4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 15-epi-lxa4;15r-lxa4?

15-epi-lxa4;15r-lxa4 is suspected in Cystic Fibrosis, Asthma, Chagas Cardiomyopathy, Pneumonia, Septicemia, Subarachnoid Hemorrhage and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 15-epi-lxa4;15r-lxa4

MeSH term MeSH ID Detail
Eosinophilia D004802 4 associated lipids
Tendon Injuries D013708 4 associated lipids
Toxoplasmosis, Animal D014124 5 associated lipids
Klebsiella Infections D007710 7 associated lipids
Immune Complex Diseases D007105 9 associated lipids
Toxoplasmosis D014123 9 associated lipids
Osteitis D010000 10 associated lipids
Acute-Phase Reaction D000210 12 associated lipids
Disease Susceptibility D004198 12 associated lipids
Carotid Stenosis D016893 15 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with 15-epi-lxa4;15r-lxa4

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with 15-epi-lxa4;15r-lxa4?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with 15-epi-lxa4;15r-lxa4?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with 15-epi-lxa4;15r-lxa4?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with 15-epi-lxa4;15r-lxa4?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with 15-epi-lxa4;15r-lxa4?

Knock-out

Knock-out are used in the study 'Aspirin-triggered 15-epi-lipoxin A4 regulates neutrophil-platelet aggregation and attenuates acute lung injury in mice.' (Ortiz-Muñoz G et al., 2014).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with 15-epi-lxa4;15r-lxa4

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Per page 10 20 50 100 | Total 602
Authors Title Published Journal PubMed Link
pmid:
Gewirtz AT et al. LXA4, aspirin-triggered 15-epi-LXA4, and their analogs selectively downregulate PMN azurophilic degranulation. 1999 Am. J. Physiol. pmid:10199831
Levy BD et al. Polyisoprenyl phosphate (PIPP) signaling regulates phospholipase D activity: a 'stop' signaling switch for aspirin-triggered lipoxin A4. 1999 FASEB J. pmid:10224233
Spokas EG et al. Leukotrienes, lipoxins, and hydroxyeicosatetraenoic acids. 1999 Methods Mol. Biol. pmid:10343320
Serhan CN et al. Lipoxin and aspirin-triggered 15-epi-lipoxin cellular interactions anti-inflammatory lipid mediators. 1999 Clin. Chem. Lab. Med. pmid:10353476
Schaldach CM et al. Lipoxin A4: a new class of ligand for the Ah receptor. 1999 Biochemistry pmid:10360957
Hachicha M et al. Lipoxin (LX)A4 and aspirin-triggered 15-epi-LXA4 inhibit tumor necrosis factor 1alpha-initiated neutrophil responses and trafficking: regulators of a cytokine-chemokine axis. 1999 J. Exp. Med. pmid:10377187
Clish CB et al. Local and systemic delivery of a stable aspirin-triggered lipoxin prevents neutrophil recruitment in vivo. 1999 Proc. Natl. Acad. Sci. U.S.A. pmid:10393980
Besse A et al. Prostaglandin E2 regulates macrophage colony stimulating factor secretion by human bone marrow stromal cells. 1999 Biochim. Biophys. Acta pmid:10395955
Chiang N et al. Leukotriene B4 receptor transgenic mice reveal novel protective roles for lipoxins and aspirin-triggered lipoxins in reperfusion. 1999 J. Clin. Invest. pmid:10430612