| MeSH term | MeSH ID | Detail |
|---|---|---|
| Eosinophilia | D004802 | 4 associated lipids |
| Tendon Injuries | D013708 | 4 associated lipids |
| Toxoplasmosis, Animal | D014124 | 5 associated lipids |
| Klebsiella Infections | D007710 | 7 associated lipids |
| Toxoplasmosis | D014123 | 9 associated lipids |
| Immune Complex Diseases | D007105 | 9 associated lipids |
| Osteitis | D010000 | 10 associated lipids |
| Acute-Phase Reaction | D000210 | 12 associated lipids |
| Disease Susceptibility | D004198 | 12 associated lipids |
| Carotid Stenosis | D016893 | 15 associated lipids |
15-epi-lxa4;15r-lxa4
15-epi-lxa4;15r-lxa4 is a lipid of Fatty Acyls (FA) class. 15-epi-lxa4;15r-lxa4 is associated with abnormalities such as Pneumonia, Septicemia, Cystic Fibrosis, Subarachnoid Hemorrhage and Obesity. The involved functions are known as Protective Agents, Signal Transduction, cytokine biosynthesis, Inflammation and Anabolism. 15-epi-lxa4;15r-lxa4 often locates in Blood, Immune system and Heart tissue. The associated genes with 15-epi-lxa4;15r-lxa4 are IL2 gene, CXCL13 gene and CMKLR1 gene. The related lipids are Steroids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of 15-epi-lxa4;15r-lxa4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 15-epi-lxa4;15r-lxa4?
15-epi-lxa4;15r-lxa4 is suspected in Cystic Fibrosis, Asthma, Chagas Cardiomyopathy, Pneumonia, Septicemia, Subarachnoid Hemorrhage and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Immunol. (2)
- Am. J. Physiol. Lung Cell Mol. Physiol. (1)
- Antimicrob. Agents Chemother. (1)
- Others (6)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 15-epi-lxa4;15r-lxa4
PubChem Associated disorders and diseases
What pathways are associated with 15-epi-lxa4;15r-lxa4
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 15-epi-lxa4;15r-lxa4?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with 15-epi-lxa4;15r-lxa4?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with 15-epi-lxa4;15r-lxa4?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with 15-epi-lxa4;15r-lxa4?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with 15-epi-lxa4;15r-lxa4?
Knock-out
Knock-out are used in the study 'Aspirin-triggered 15-epi-lipoxin A4 regulates neutrophil-platelet aggregation and attenuates acute lung injury in mice.' (Ortiz-Muñoz G et al., 2014).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with 15-epi-lxa4;15r-lxa4
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Anuforo OUU et al. | Natural killer cells play an essential role in resolution of antigen-induced inflammation in mice. | 2018 | Mol. Immunol. | pmid:29112834 |
| Muralikumar S et al. | Probing the intermolecular interactions of PPARγ-LBD with polyunsaturated fatty acids and their anti-inflammatory metabolites to infer most potential binding moieties. | 2017 | Lipids Health Dis | pmid:28109294 |
| Singh A et al. | Lipoxin A4, a 5-lipoxygenase pathway metabolite, modulates immune response during acute respiratory tularemia. | 2017 | J. Leukoc. Biol. | pmid:27630217 |
| Reis MB et al. | Lipoxin A4 encapsulated in PLGA microparticles accelerates wound healing of skin ulcers. | 2017 | PLoS ONE | pmid:28753648 |
| Yang Y et al. | The effects of different frequency treadmill exercise on lipoxin A4 and articular cartilage degeneration in an experimental model of monosodium iodoacetate-induced osteoarthritis in rats. | 2017 | PLoS ONE | pmid:28594958 |
| Shi Y et al. | Lipoxin A4 mitigates experimental autoimmune myocarditis by regulating inflammatory response, NF-κB and PI3K/Akt signaling pathway in mice. | 2017 | Eur Rev Med Pharmacol Sci | pmid:28485793 |
| Wu SH et al. | Signal transduction involved in lipoxin A4‑induced protection of tubular epithelial cells against hypoxia/reoxygenation injury. | 2017 | Mol Med Rep | pmid:28259922 |
| González-Herrera F et al. | Simvastatin Attenuates Endothelial Activation through 15-Epi-Lipoxin A4 Production in Murine Chronic Chagas Cardiomyopathy. | 2017 | Antimicrob. Agents Chemother. | pmid:27993857 |
| Hodges RR et al. | Lipoxin A4 activates ALX/FPR2 receptor to regulate conjunctival goblet cell secretion. | 2017 | Mucosal Immunol | pmid:27072607 |
| Zong L et al. | Lipoxin A4 Attenuates Cell Invasion by Inhibiting ROS/ERK/MMP Pathway in Pancreatic Cancer. | 2016 | Oxid Med Cell Longev | pmid:26649143 |
| Colby JK et al. | Lipoxin Signaling in Murine Lung Host Responses to Cryptococcus neoformans Infection. | 2016 | Am. J. Respir. Cell Mol. Biol. | pmid:26039320 |
| Pedruzzi G et al. | Understanding PGE2, LXA4 and LTB4 balance during Mycobacterium tuberculosis infection through mathematical model. | 2016 | J. Theor. Biol. | pmid:26551160 |
| Diaz-Gerevini GT et al. | Beneficial action of resveratrol: How and why? | 2016 | Nutrition | pmid:26706021 |
| Elias I et al. | ALOX5AP Overexpression in Adipose Tissue Leads to LXA4 Production and Protection Against Diet-Induced Obesity and Insulin Resistance. | 2016 | Diabetes | pmid:27207555 |
| Havixbeck JJ et al. | Neutrophil contributions to the induction and regulation of the acute inflammatory response in teleost fish. | 2016 | J. Leukoc. Biol. | pmid:26292979 |
| Pazdrak K et al. | Cytokine-Induced Glucocorticoid Resistance from Eosinophil Activation: Protein Phosphatase 5 Modulation of Glucocorticoid Receptor Phosphorylation and Signaling. | 2016 | J. Immunol. | pmid:27742828 |
| Chandrasekharan JA et al. | Altering the Anti-inflammatory Lipoxin Microenvironment: a New Insight into Kaposi's Sarcoma-Associated Herpesvirus Pathogenesis. | 2016 | J. Virol. | pmid:27681120 |
| Han X et al. | Lipoxin A4 Preconditioning Attenuates Intestinal Ischemia Reperfusion Injury through Keap1/Nrf2 Pathway in a Lipoxin A4 Receptor Independent Manner. | 2016 | Oxid Med Cell Longev | pmid:27375835 |
| Brigatte P et al. | Walker 256 Tumor Growth Suppression by Crotoxin Involves Formyl Peptide Receptors and Lipoxin Aâ‚„. | 2016 | Mediators Inflamm. | pmid:27190493 |
| Higgins G et al. | Lipoxin A4 prevents tight junction disruption and delays the colonization of cystic fibrosis bronchial epithelial cells by Pseudomonas aeruginosa. | 2016 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:27084849 |
| Wang CS et al. | ALX/FPR2 Modulates Anti-Inflammatory Responses in Mouse Submandibular Gland. | 2016 | Sci Rep | pmid:27064029 |
| Martini AC et al. | Lipoxin A4 inhibits microglial activation and reduces neuroinflammation and neuropathic pain after spinal cord hemisection. | 2016 | J Neuroinflammation | pmid:27059991 |
| Tahan F et al. | Increased Postexercise Lipoxin A4 Levels in Exhaled Breath Condensate in Asthmatic Children With Exercise-Induced Bronchoconstriction. | 2016 | J Investig Allergol Clin Immunol | pmid:27012012 |
| Wu B et al. | Lipoxin A4 augments host defense in sepsis and reduces Pseudomonas aeruginosa virulence through quorum sensing inhibition. | 2016 | FASEB J. | pmid:26965685 |
| Das UN | Inflammatory bowel disease as a disorder of an imbalance between pro- and anti-inflammatory molecules and deficiency of resolution bioactive lipids. | 2016 | Lipids Health Dis | pmid:26762544 |
| Guo Z et al. | Lipoxin A4 Reduces Inflammation Through Formyl Peptide Receptor 2/p38 MAPK Signaling Pathway in Subarachnoid Hemorrhage Rats. | 2016 | Stroke | pmid:26732571 |
| Li L et al. | New development in studies of formyl-peptide receptors: critical roles in host defense. | 2016 | J. Leukoc. Biol. | pmid:26701131 |
| Yu D et al. | Inverse Relationship between Serum Lipoxin A4 Level and the Risk of Metabolic Syndrome in a Middle-Aged Chinese Population. | 2015 | PLoS ONE | pmid:26565966 |
| Dakin SG et al. | Inflammation activation and resolution in human tendon disease. | 2015 | Sci Transl Med | pmid:26511510 |
| Prieto P et al. | Activation of autophagy in macrophages by pro-resolving lipid mediators. | 2015 | Autophagy | pmid:26506892 |
| Gao Y et al. | Female-Specific Downregulation of Tissue Polymorphonuclear Neutrophils Drives Impaired Regulatory T Cell and Amplified Effector T Cell Responses in Autoimmune Dry Eye Disease. | 2015 | J. Immunol. | pmid:26324767 |
| Qi W et al. | Lipoxin A4 activates alveolar epithelial sodium channel gamma via the microRNA-21/PTEN/AKT pathway in lipopolysaccharide-induced inflammatory lung injury. | 2015 | Lab. Invest. | pmid:26302186 |
| Higgins G et al. | Physiological impact of abnormal lipoxin Aâ‚„ production on cystic fibrosis airway epithelium and therapeutic potential. | 2015 | Biomed Res Int | pmid:25866809 |
| Kong X et al. | Roles of lipoxin A4 receptor activation and anti-interleukin-1β antibody on the toll-like receptor 2/mycloid differentiation factor 88/nuclear factor-κB pathway in airway inflammation induced by ovalbumin. | 2015 | Mol Med Rep | pmid:25760938 |
| Barnig C and Levy BD | Innate immunity is a key factor for the resolution of inflammation in asthma. | 2015 | Eur Respir Rev | pmid:25726564 |
| Souza MC et al. | Lipoxin A4 attenuates endothelial dysfunction during experimental cerebral malaria. | 2015 | Int. Immunopharmacol. | pmid:25576659 |
| Rinaldi SF et al. | 15-epi-lipoxin A4 reduces the mortality of prematurely born pups in a mouse model of infection-induced preterm birth. | 2015 | Mol. Hum. Reprod. | pmid:25567326 |
| Petri MH et al. | Aspirin-triggered 15-epi-lipoxin Aâ‚„ signals through FPR2/ALX in vascular smooth muscle cells and protects against intimal hyperplasia after carotid ligation. | 2015 | Int. J. Cardiol. | pmid:25464488 |
| Alvarez AM et al. | Aspirin-triggered lipoxin prevents antiphospholipid antibody effects on human trophoblast migration and endothelial cell interactions. | 2015 | pmid:25370166 | |
| Gobbetti T et al. | Protective effects of n-6 fatty acids-enriched diet on intestinal ischaemia/reperfusion injury involve lipoxin A4 and its receptor. | 2015 | Br. J. Pharmacol. | pmid:25296998 |
| Awji EG et al. | Wood smoke enhances cigarette smoke-induced inflammation by inducing the aryl hydrocarbon receptor repressor in airway epithelial cells. | 2015 | Am. J. Respir. Cell Mol. Biol. | pmid:25137396 |
| Dunn HC et al. | Restoration of lipoxin A4 signaling reduces Alzheimer's disease-like pathology in the 3xTg-AD mouse model. | 2015 | J. Alzheimers Dis. | pmid:25125468 |
| Karra L et al. | Lipoxin Bâ‚„ promotes the resolution of allergic inflammation in the upper and lower airways of mice. | 2015 | Mucosal Immunol | pmid:25465102 |
| Wang X et al. | Resolution of inflammation is altered in Alzheimer's disease. | 2015 | Alzheimers Dement | pmid:24530025 |
| Lee JY et al. | Immune parameters differentiating active from latent tuberculosis infection in humans. | 2015 | Tuberculosis (Edinb) | pmid:26520601 |
| Homann J et al. | In Vivo Availability of Pro-Resolving Lipid Mediators in Oxazolone Induced Dermal Inflammation in the Mouse. | 2015 | PLoS ONE | pmid:26599340 |
| Zhang C et al. | Growth inhibitory effect of polyunsaturated fatty acids (PUFAs) on colon cancer cells via their growth inhibitory metabolites and fatty acid composition changes. | 2015 | PLoS ONE | pmid:25886460 |
| Tateishi N et al. | Dietary supplementation with arachidonic acid increases arachidonic acid content in paw, but does not affect arthritis severity or prostaglandin E2 content in rat adjuvant-induced arthritis model. | 2015 | Lipids Health Dis | pmid:25595700 |
| Fahel JS et al. | 5-Lipoxygenase negatively regulates Th1 response during Brucella abortus infection in mice. | 2015 | Infect. Immun. | pmid:25583526 |
| Ribeiro LR et al. | Lipoxin Inhibits Fungal Uptake by Macrophages and Reduces the Severity of Acute Pulmonary Infection Caused by Paracoccidioides brasiliensis. | 2015 | Mediators Inflamm. | pmid:26635449 |