| MeSH term | MeSH ID | Detail |
|---|---|---|
| Tuberculosis | D014376 | 20 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
| Lung Diseases | D008171 | 37 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Colitis | D003092 | 69 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Osteitis | D010000 | 10 associated lipids |
| Asthma | D001249 | 52 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Peritonitis | D010538 | 38 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Hyperplasia | D006965 | 34 associated lipids |
| Leukemia, Myelogenous, Chronic, BCR-ABL Positive | D015464 | 17 associated lipids |
| Glomerulonephritis | D005921 | 35 associated lipids |
| Cystic Fibrosis | D003550 | 65 associated lipids |
| Nasal Polyps | D009298 | 26 associated lipids |
| Hyperalgesia | D006930 | 42 associated lipids |
| Toxoplasmosis | D014123 | 9 associated lipids |
15-epi-lxa4;15r-lxa4
15-epi-lxa4;15r-lxa4 is a lipid of Fatty Acyls (FA) class. 15-epi-lxa4;15r-lxa4 is associated with abnormalities such as Pneumonia, Septicemia, Cystic Fibrosis, Subarachnoid Hemorrhage and Obesity. The involved functions are known as Protective Agents, Signal Transduction, cytokine biosynthesis, Inflammation and Anabolism. 15-epi-lxa4;15r-lxa4 often locates in Blood, Immune system and Heart tissue. The associated genes with 15-epi-lxa4;15r-lxa4 are IL2 gene, CXCL13 gene and CMKLR1 gene. The related lipids are Steroids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of 15-epi-lxa4;15r-lxa4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 15-epi-lxa4;15r-lxa4?
15-epi-lxa4;15r-lxa4 is suspected in Cystic Fibrosis, Asthma, Chagas Cardiomyopathy, Pneumonia, Septicemia, Subarachnoid Hemorrhage and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Immunol. (2)
- Am. J. Physiol. Lung Cell Mol. Physiol. (1)
- Antimicrob. Agents Chemother. (1)
- Others (6)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 15-epi-lxa4;15r-lxa4
PubChem Associated disorders and diseases
What pathways are associated with 15-epi-lxa4;15r-lxa4
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 15-epi-lxa4;15r-lxa4?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with 15-epi-lxa4;15r-lxa4?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with 15-epi-lxa4;15r-lxa4?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with 15-epi-lxa4;15r-lxa4?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with 15-epi-lxa4;15r-lxa4?
Knock-out
Knock-out are used in the study 'Aspirin-triggered 15-epi-lipoxin A4 regulates neutrophil-platelet aggregation and attenuates acute lung injury in mice.' (Ortiz-Muñoz G et al., 2014).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with 15-epi-lxa4;15r-lxa4
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Wu Y et al. | Aspirin-triggered lipoxin Aâ‚„ attenuates lipopolysaccharide-induced intracellular ROS in BV2 microglia cells by inhibiting the function of NADPH oxidase. | 2012 | Neurochem. Res. | pmid:22552474 |
| Scully M et al. | Protective role of cyclooxygenase (COX)-2 in experimental lung injury: evidence of a lipoxin A4-mediated effect. | 2012 | J. Surg. Res. | pmid:21944479 |
| Krönke G et al. | The 12/15-lipoxygenase pathway counteracts fibroblast activation and experimental fibrosis. | 2012 | Ann. Rheum. Dis. | pmid:22267335 |
| Birnbaum Y et al. | Phosphodiesterase III inhibition increases cAMP levels and augments the infarct size limiting effect of a DPP-4 inhibitor in mice with type-2 diabetes mellitus. | 2012 | Cardiovasc Drugs Ther | pmid:22936458 |
| Gangemi S et al. | Ultrarush venom immunotherapy and the lipoxin a4 inflammation resolution pathway. | 2012 | Ann. Allergy Asthma Immunol. | pmid:22920084 |
| Xu Z et al. | Lipoxin A4 inhibits the development of endometriosis in mice: the role of anti-inflammation and anti-angiogenesis. | 2012 | Am. J. Reprod. Immunol. | pmid:22229383 |
| Chinthamani S et al. | Lipoxin A4 inhibits immune cell binding to salivary epithelium and vascular endothelium. | 2012 | Am. J. Physiol., Cell Physiol. | pmid:22205391 |
| Das UN | Is lipoxins A₄ a better alternative to anti-VEGF and anti-TNF-α antibody to prevent and treat age-related macular degeneration, diabetic macular edema and retinopathy? | 2012 | Med. Sci. Monit. | pmid:22207123 |
| Bozinovski S et al. | Serum amyloid A opposes lipoxin Aâ‚„ to mediate glucocorticoid refractory lung inflammation in chronic obstructive pulmonary disease. | 2012 | Proc. Natl. Acad. Sci. U.S.A. | pmid:22215599 |
| Vong L et al. | Up-regulation of Annexin-A1 and lipoxin A(4) in individuals with ulcerative colitis may promote mucosal homeostasis. | 2012 | PLoS ONE | pmid:22723974 |
| Zhou CH et al. | [Protective effects and possible mechanism of lipoxin A(4) analogue in rats with acute pancreatitis]. | 2012 | Zhonghua Yi Xue Za Zhi | pmid:22781577 |
| Gilbert NC et al. | Conversion of human 5-lipoxygenase to a 15-lipoxygenase by a point mutation to mimic phosphorylation at Serine-663. | 2012 | FASEB J. | pmid:22516296 |
| Gutierrez AD et al. | The effect of pioglitazone treatment on 15-epi-lipoxin A4 levels in patients with type 2 diabetes. | 2012 | Atherosclerosis | pmid:22687642 |
| Börgeson E et al. | Lipoxin A4 attenuates adipose inflammation. | 2012 | FASEB J. | pmid:22700871 |
| Esper L et al. | Role of SOCS2 in modulating heart damage and function in a murine model of acute Chagas disease. | 2012 | Am. J. Pathol. | pmid:22658486 |
| Verrière V et al. | Lipoxin A4 stimulates calcium-activated chloride currents and increases airway surface liquid height in normal and cystic fibrosis airway epithelia. | 2012 | PLoS ONE | pmid:22662206 |
| Jin H et al. | Lipoxin A4 analog attenuates morphine antinociceptive tolerance, withdrawal-induced hyperalgesia, and glial reaction and cytokine expression in the spinal cord of rat. | 2012 | Neuroscience | pmid:22366510 |
| Gras D et al. | An ex vivo model of severe asthma using reconstituted human bronchial epithelium. | 2012 | J. Allergy Clin. Immunol. | pmid:22409990 |
| Mumm JP | Single-molecule microscopy of Cre recombination. | 2012 | Proc. Natl. Acad. Sci. U.S.A. | pmid:23204438 |
| Pertwee RG | Lipoxin A4 is an allosteric endocannabinoid that strengthens anandamide-induced CB1 receptor activation. | 2012 | Proc. Natl. Acad. Sci. U.S.A. | pmid:23204441 |
| Pamplona FA et al. | Anti-inflammatory lipoxin A4 is an endogenous allosteric enhancer of CB1 cannabinoid receptor. | 2012 | Proc. Natl. Acad. Sci. U.S.A. | pmid:23150578 |
| Lin F et al. | Treatment of Lipoxin A(4) and its analogue on low-dose endotoxin induced preeclampsia in rat and possible mechanisms. | 2012 | Reprod. Toxicol. | pmid:23063943 |
| Sun T et al. | LipoxinA(4) induced antinociception and decreased expression of NF-κB and pro-inflammatory cytokines after chronic dorsal root ganglia compression in rats. | 2012 | Eur J Pain | pmid:21658981 |
| Dakin SG et al. | Macrophage sub-populations and the lipoxin A4 receptor implicate active inflammation during equine tendon repair. | 2012 | PLoS ONE | pmid:22384219 |
| Tsai WH et al. | Role of lipoxin A4 in the cell-to-cell interaction between all-trans retinoic acid-treated acute promyelocytic leukemic cells and alveolar macrophages. | 2012 | J. Cell. Physiol. | pmid:21567401 |
| Zimmerman JJ | Exhaled breath condensate: a breathalyzer for lung inflammation. | 2012 | Pediatr Crit Care Med | pmid:22391827 |
| Wu L et al. | Lipoxin A4 inhibits 5-lipoxygenase translocation and leukotrienes biosynthesis to exert a neuroprotective effect in cerebral ischemia/reperfusion injury. | 2012 | J. Mol. Neurosci. | pmid:22661361 |
| Hasan RA et al. | Lipoxin A(4) and 8-isoprostane in the exhaled breath condensate of children hospitalized for status asthmaticus. | 2012 | Pediatr Crit Care Med | pmid:21666533 |
| Jones CN et al. | Microfluidic chambers for monitoring leukocyte trafficking and humanized nano-proresolving medicines interactions. | 2012 | Proc. Natl. Acad. Sci. U.S.A. | pmid:23185003 |
| Su X et al. | Dysfunction of inflammation-resolving pathways is associated with exaggerated postoperative cognitive decline in a rat model of the metabolic syndrome. | 2012 | Mol. Med. | pmid:23296426 |
| Bitto A et al. | Flavocoxid, a dual inhibitor of COX-2 and 5-LOX of natural origin, attenuates the inflammatory response and protects mice from sepsis. | 2012 | Crit Care | pmid:22356547 |
| Dakin SG et al. | Inflamm-aging and arachadonic acid metabolite differences with stage of tendon disease. | 2012 | PLoS ONE | pmid:23155437 |
| Rozsasi A et al. | Cyclooxygenase 2 and lipoxin Aâ‚„ in nasal polyps in cystic fibrosis. | 2011 Nov-Dec | Am J Rhinol Allergy | pmid:22185734 |
| Levy BD et al. | The endogenous pro-resolving mediators lipoxin A4 and resolvin E1 preserve organ function in allograft rejection. | 2011 Jan-Feb | Prostaglandins Leukot. Essent. Fatty Acids | pmid:20869861 |
| Zheng S et al. | Novel biphasic role of LipoxinA(4) on expression of cyclooxygenase-2 in lipopolysaccharide-stimulated lung fibroblasts. | 2011 | Mediators Inflamm. | pmid:21765620 |
| Börgeson E et al. | Lipoxin A₄ and benzo-lipoxin A₄ attenuate experimental renal fibrosis. | 2011 | FASEB J. | pmid:21628447 |
| Walker J et al. | Lipoxin a4 increases survival by decreasing systemic inflammation and bacterial load in sepsis. | 2011 | Shock | pmid:21701419 |
| Hao H et al. | Lipoxin A4 and its analog suppress hepatocellular carcinoma via remodeling tumor microenvironment. | 2011 | Cancer Lett. | pmid:21683517 |
| Ni CM et al. | Serum levels of lipoxin A(4) do not predict the development of subsequent asthma among young children with acute bronchiolitis. | 2011 | J Asthma | pmid:21671842 |
| Chen H et al. | Lipoxin A(4), a potential anti-inflammatory drug targeting the skin. | 2011 | J. Dermatol. Sci. | pmid:21334856 |
| Wu J et al. | Lipoxin A4 inhibits the production of proinflammatory cytokines induced by β-amyloid in vitro and in vivo. | 2011 | Biochem. Biophys. Res. Commun. | pmid:21501589 |
| Das UN | Lipoxin A4 may function as an endogenous anti-arrhythmic molecule. | 2011 | Med. Hypotheses | pmid:20833483 |
| Maldonado-Pérez D et al. | A role for lipoxin A4 as anti-inflammatory and proresolution mediator in human parturition. | 2011 | FASEB J. | pmid:20959513 |
| Zhou M et al. | The protective effects of Lipoxin A4 during the early phase of severe acute pancreatitis in rats. | 2011 | Scand. J. Gastroenterol. | pmid:20950211 |
| Khau T et al. | Annexin-1 signals mitogen-stimulated breast tumor cell proliferation by activation of the formyl peptide receptors (FPRs) 1 and 2. | 2011 | FASEB J. | pmid:20930115 |
| Das UN | Lipoxins as biomarkers of lupus and other inflammatory conditions. | 2011 | Lipids Health Dis | pmid:21569625 |
| Pang HY et al. | [Effect of lipoxin A(4) on lipopolysaccharide-induced endothelial hyperpermeability in human umbilical vein endothelial cell]. | 2011 | Zhonghua Fu Chan Ke Za Zhi | pmid:21575454 |
| Russell R et al. | Lipoxin A4 is a novel estrogen receptor modulator. | 2011 | FASEB J. | pmid:21885654 |
| Wang YP et al. | Aspirin-triggered lipoxin A4 attenuates LPS-induced pro-inflammatory responses by inhibiting activation of NF-κB and MAPKs in BV-2 microglial cells. | 2011 | J Neuroinflammation | pmid:21831303 |
| Wan M et al. | Leukotriene B4/antimicrobial peptide LL-37 proinflammatory circuits are mediated by BLT1 and FPR2/ALX and are counterregulated by lipoxin A4 and resolvin E1. | 2011 | FASEB J. | pmid:21307335 |