15-epi-lxa4;15r-lxa4 is a lipid of Fatty Acyls (FA) class. 15-epi-lxa4;15r-lxa4 is associated with abnormalities such as Pneumonia, Septicemia, Cystic Fibrosis, Subarachnoid Hemorrhage and Obesity. The involved functions are known as Protective Agents, Signal Transduction, cytokine biosynthesis, Inflammation and Anabolism. 15-epi-lxa4;15r-lxa4 often locates in Blood, Immune system and Heart tissue. The associated genes with 15-epi-lxa4;15r-lxa4 are IL2 gene, CXCL13 gene and CMKLR1 gene. The related lipids are Steroids. The related experimental models are Knock-out.
To understand associated biological information of 15-epi-lxa4;15r-lxa4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
15-epi-lxa4;15r-lxa4 is suspected in Cystic Fibrosis, Asthma, Chagas Cardiomyopathy, Pneumonia, Septicemia, Subarachnoid Hemorrhage and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with 15-epi-lxa4;15r-lxa4
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Knock-out are used in the study 'Aspirin-triggered 15-epi-lipoxin A4 regulates neutrophil-platelet aggregation and attenuates acute lung injury in mice.' (Ortiz-Muñoz G et al., 2014).
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Authors | Title | Published | Journal | PubMed Link |
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Tornhamre S et al. | 15-Lipoxygenation of leukotriene A(4). Studies Of 12- and 15-lipoxygenase efficiency to catalyze lipoxin formation. | 2000 | Biochim. Biophys. Acta | pmid:10760478 |
Pouliot M et al. | Lipoxin A(4) analogues inhibit leukocyte recruitment to Porphyromonas gingivalis: a role for cyclooxygenase-2 and lipoxins in periodontal disease. | 2000 | Biochemistry | pmid:10769133 |
Clish CB et al. | Local and systemic delivery of an aspirin-triggered lipoxin stable analog inhibits neutrophil trafficking. | 2000 | Ann. N. Y. Acad. Sci. | pmid:10818463 |
Clish CB et al. | Oxidoreductases in lipoxin A4 metabolic inactivation: a novel role for 15-onoprostaglandin 13-reductase/leukotriene B4 12-hydroxydehydrogenase in inflammation. | 2000 | J. Biol. Chem. | pmid:10837478 |
Denizot Y et al. | Effect of cytokines and lipid mediators on the synthesis of interleukin 1 beta by human bone marrow stromal cells. | 2000 | Cytokine | pmid:10857767 |
McMahon B et al. | Lipoxin A4 antagonizes the mitogenic effects of leukotriene D4 in human renal mesangial cells. Differential activation of MAP kinases through distinct receptors. | 2000 | J. Biol. Chem. | pmid:10869343 |
Sanak M et al. | Aspirin-tolerant asthmatics generate more lipoxins than aspirin-intolerant asthmatics. | 2000 | Eur. Respir. J. | pmid:10933083 |
Serhan CN and Clish CB | Aspirin triggered lipid mediators: novel inhibitors of leucocyte trafficking. | 2000 | Thorax | pmid:10992546 |
Maderna P et al. | Influence of lipoxin A(4) and other lipoxygenase-derived eicosanoids on tissue factor expression. | 2000 | Am. J. Physiol., Cell Physiol. | pmid:11003574 |
Kang Y et al. | Mutations of serine 236-237 and tyrosine 302 residues in the human lipoxin A4 receptor intracellular domains result in sustained signaling. | 2000 | Biochemistry | pmid:11063592 |