| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Peritonitis | D010538 | 38 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Hyperplasia | D006965 | 34 associated lipids |
| Leukemia, Myelogenous, Chronic, BCR-ABL Positive | D015464 | 17 associated lipids |
| Glomerulonephritis | D005921 | 35 associated lipids |
| Cystic Fibrosis | D003550 | 65 associated lipids |
| Nasal Polyps | D009298 | 26 associated lipids |
| Hyperalgesia | D006930 | 42 associated lipids |
| Toxoplasmosis | D014123 | 9 associated lipids |
15-epi-lxa4;15r-lxa4
15-epi-lxa4;15r-lxa4 is a lipid of Fatty Acyls (FA) class. 15-epi-lxa4;15r-lxa4 is associated with abnormalities such as Pneumonia, Septicemia, Cystic Fibrosis, Subarachnoid Hemorrhage and Obesity. The involved functions are known as Protective Agents, Signal Transduction, cytokine biosynthesis, Inflammation and Anabolism. 15-epi-lxa4;15r-lxa4 often locates in Blood, Immune system and Heart tissue. The associated genes with 15-epi-lxa4;15r-lxa4 are IL2 gene, CXCL13 gene and CMKLR1 gene. The related lipids are Steroids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of 15-epi-lxa4;15r-lxa4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 15-epi-lxa4;15r-lxa4?
15-epi-lxa4;15r-lxa4 is suspected in Cystic Fibrosis, Asthma, Chagas Cardiomyopathy, Pneumonia, Septicemia, Subarachnoid Hemorrhage and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 15-epi-lxa4;15r-lxa4
PubChem Associated disorders and diseases
What pathways are associated with 15-epi-lxa4;15r-lxa4
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 15-epi-lxa4;15r-lxa4?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with 15-epi-lxa4;15r-lxa4?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with 15-epi-lxa4;15r-lxa4?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with 15-epi-lxa4;15r-lxa4?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with 15-epi-lxa4;15r-lxa4?
Knock-out
Knock-out are used in the study 'Aspirin-triggered 15-epi-lipoxin A4 regulates neutrophil-platelet aggregation and attenuates acute lung injury in mice.' (Ortiz-Muñoz G et al., 2014).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with 15-epi-lxa4;15r-lxa4
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Yu D et al. | Inverse Relationship between Serum Lipoxin A4 Level and the Risk of Metabolic Syndrome in a Middle-Aged Chinese Population. | 2015 | PLoS ONE | pmid:26565966 |
| Wenceslau CF et al. | Lipoxin A4 mediates aortic contraction via RHOA/RHO kinase, endothelial dysfunction and reactive oxygen species. | 2014 | J. Vasc. Res. | pmid:25612650 |
| Yang F et al. | Regional arterial infusion with lipoxin A4 attenuates experimental severe acute pancreatitis. | 2014 | PLoS ONE | pmid:25265022 |
| Ono E et al. | Lipoxin generation is related to soluble epoxide hydrolase activity in severe asthma. | 2014 | Am. J. Respir. Crit. Care Med. | pmid:25162465 |
| Ortiz-Muñoz G et al. | Aspirin-triggered 15-epi-lipoxin A4 regulates neutrophil-platelet aggregation and attenuates acute lung injury in mice. | 2014 | Blood | pmid:25143486 |
| Andersson P et al. | Inhibition of neutrophil-dependent cytotoxicity for human endothelial cells by ACE inhibitors. | 2014 | Scand. J. Immunol. | pmid:25124788 |
| Wu R et al. | Lipoxin A4 suppresses the development of endometriosis in an ALX receptor-dependent manner via the p38 MAPK pathway. | 2014 | Br. J. Pharmacol. | pmid:24923883 |
| Zhou XL et al. | Protective effects of lipoxin A4 in testis injury following testicular torsion and detorsion in rats. | 2014 | Mediators Inflamm. | pmid:24904198 |
| Martin CR et al. | Resolvin D1 and lipoxin A4 improve alveolarization and normalize septal wall thickness in a neonatal murine model of hyperoxia-induced lung injury. | 2014 | PLoS ONE | pmid:24892762 |
| Tani Y et al. | Eosinophils control the resolution of inflammation and draining lymph node hypertrophy through the proresolving mediators and CXCL13 pathway in mice. | 2014 | FASEB J. | pmid:24891522 |
| Wu H et al. | Lipoxin A4 and platelet activating factor are involved in E. coli or LPS-induced lung inflammation in CFTR-deficient mice. | 2014 | PLoS ONE | pmid:24671173 |
| Kumar R et al. | Lipoxin Aâ‚„ prevents the progression of de novo and established endometriosis in a mouse model by attenuating prostaglandin Eâ‚‚ production and estrogen signaling. | 2014 | PLoS ONE | pmid:24587003 |
| Yao C et al. | Aspirin-triggered lipoxin A4 attenuates lipopolysaccharide induced inflammatory response in primary astrocytes. | 2014 | Int. Immunopharmacol. | pmid:24269179 |
| Nanhwan MK et al. | Chronic treatment with ticagrelor limits myocardial infarct size: an adenosine and cyclooxygenase-2-dependent effect. | 2014 | Arterioscler. Thromb. Vasc. Biol. | pmid:25012137 |
| Leo LM et al. | Age-dependent relevance of endogenous 5-lipoxygenase derivatives in anxiety-like behavior in mice. | 2014 | PLoS ONE | pmid:24416334 |
| Hamza B et al. | Retrotaxis of human neutrophils during mechanical confinement inside microfluidic channels. | 2014 | Integr Biol (Camb) | pmid:24419464 |
| Ueda T et al. | Combination therapy of 15-epi-lipoxin A4 with antibiotics protects mice from Escherichia coli-induced sepsis*. | 2014 | Crit. Care Med. | pmid:24463858 |
| Tateishi N et al. | Dietary supplementation of arachidonic acid increases arachidonic acid and lipoxin Aâ‚„ contents in colon, but does not affect severity or prostaglandin Eâ‚‚ content in murine colitis model. | 2014 | Lipids Health Dis | pmid:24507383 |
| Fischer CD et al. | Tulathromycin exerts proresolving effects in bovine neutrophils by inhibiting phospholipases and altering leukotriene B4, prostaglandin E2, and lipoxin A4 production. | 2014 | Antimicrob. Agents Chemother. | pmid:24820086 |
| Ringholz FC et al. | Reduced 15-lipoxygenase 2 and lipoxin A4/leukotriene B4 ratio in children with cystic fibrosis. | 2014 | Eur. Respir. J. | pmid:24696116 |