| MeSH term | MeSH ID | Detail |
|---|---|---|
| Acute-Phase Reaction | D000210 | 12 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Asthma | D001249 | 52 associated lipids |
| Colitis | D003092 | 69 associated lipids |
| Cystic Fibrosis | D003550 | 65 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Disease Susceptibility | D004198 | 12 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Eosinophilia | D004802 | 4 associated lipids |
| Glomerulonephritis | D005921 | 35 associated lipids |
15-epi-lxa4;15r-lxa4
15-epi-lxa4;15r-lxa4 is a lipid of Fatty Acyls (FA) class. 15-epi-lxa4;15r-lxa4 is associated with abnormalities such as Pneumonia, Septicemia, Cystic Fibrosis, Subarachnoid Hemorrhage and Obesity. The involved functions are known as Protective Agents, Signal Transduction, cytokine biosynthesis, Inflammation and Anabolism. 15-epi-lxa4;15r-lxa4 often locates in Blood, Immune system and Heart tissue. The associated genes with 15-epi-lxa4;15r-lxa4 are IL2 gene, CXCL13 gene and CMKLR1 gene. The related lipids are Steroids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of 15-epi-lxa4;15r-lxa4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 15-epi-lxa4;15r-lxa4?
15-epi-lxa4;15r-lxa4 is suspected in Cystic Fibrosis, Asthma, Chagas Cardiomyopathy, Pneumonia, Septicemia, Subarachnoid Hemorrhage and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Immunol. (2)
- Am. J. Physiol. Lung Cell Mol. Physiol. (1)
- Antimicrob. Agents Chemother. (1)
- Others (6)
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 15-epi-lxa4;15r-lxa4
PubChem Associated disorders and diseases
What pathways are associated with 15-epi-lxa4;15r-lxa4
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 15-epi-lxa4;15r-lxa4?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with 15-epi-lxa4;15r-lxa4?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with 15-epi-lxa4;15r-lxa4?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with 15-epi-lxa4;15r-lxa4?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with 15-epi-lxa4;15r-lxa4?
Knock-out
Knock-out are used in the study 'Aspirin-triggered 15-epi-lipoxin A4 regulates neutrophil-platelet aggregation and attenuates acute lung injury in mice.' (Ortiz-Muñoz G et al., 2014).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with 15-epi-lxa4;15r-lxa4
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Yamaguchi H et al. | Urinary concentrations of 15-epimer of lipoxin A(4) are lower in patients with aspirin-intolerant compared with aspirin-tolerant asthma. | 2011 | Clin. Exp. Allergy | pmid:22093074 |
| Brancaleone V et al. | Evidence for an anti-inflammatory loop centered on polymorphonuclear leukocyte formyl peptide receptor 2/lipoxin A4 receptor and operative in the inflamed microvasculature. | 2011 | J. Immunol. | pmid:21398608 |
| Börgeson E et al. | Lipoxin A₄ inhibits porphyromonas gingivalis-induced aggregation and reactive oxygen species production by modulating neutrophil-platelet interaction and CD11b expression. | 2011 | Infect. Immun. | pmid:21263017 |
| Kenchegowda S et al. | EGF stimulates lipoxin A4 synthesis and modulates repair in corneal epithelial cells through ERK and p38 activation. | 2011 | Invest. Ophthalmol. Vis. Sci. | pmid:21220563 |
| He J et al. | Aspirin-triggered lipoxin A4 (15-epi-LXA4) increases the endothelial viability of human corneas storage in Optisol-GS. | 2011 | J Ocul Pharmacol Ther | pmid:21548792 |
| Pang H et al. | Effect of lipoxin A4 on lipopolysaccharide-induced endothelial hyperpermeability. | 2011 | ScientificWorldJournal | pmid:21552771 |
| Macdonald LJ et al. | A role for lipoxin Aâ‚„ as an anti-inflammatory mediator in the human endometrium. | 2011 | Reproduction | pmid:21555360 |
| Forsman H et al. | What formyl peptide receptors, if any, are triggered by compound 43 and lipoxin A4? | 2011 | Scand. J. Immunol. | pmid:21535079 |
| Norling LV et al. | Cutting edge: Humanized nano-proresolving medicines mimic inflammation-resolution and enhance wound healing. | 2011 | J. Immunol. | pmid:21460209 |
| Basselin M et al. | Anti-inflammatory effects of chronic aspirin on brain arachidonic acid metabolites. | 2011 | Neurochem. Res. | pmid:20981485 |
| Tang K et al. | Microparticles mediate enzyme transfer from platelets to mast cells: a new pathway for lipoxin A4 biosynthesis. | 2010 | Biochem. Biophys. Res. Commun. | pmid:20801099 |
| Das UN | Is lipoxins A4 a better alternative to anti-TNF-alpha antibody to prevent and treat diabetic macular edema and retinopathy? | 2010 | Med. Sci. Monit. | pmid:20802423 |
| Wu SH et al. | Lipoxin A(4) inhibits transition of epithelial to mesenchymal cells in proximal tubules. | 2010 | Am. J. Nephrol. | pmid:20714129 |
| Chen Y et al. | Lipoxin A4 and its analogue suppress the tumor growth of transplanted H22 in mice: the role of antiangiogenesis. | 2010 | Mol. Cancer Ther. | pmid:20682645 |
| Zhang B et al. | Depletion of regulatory T cells facilitates growth of established tumors: a mechanism involving the regulation of myeloid-derived suppressor cells by lipoxin A4. | 2010 | J. Immunol. | pmid:21068404 |
| Spite M and Serhan CN | Novel lipid mediators promote resolution of acute inflammation: impact of aspirin and statins. | 2010 | Circ. Res. | pmid:21071715 |
| Conte FP et al. | Lipoxin A(4) attenuates zymosan-induced arthritis by modulating endothelin-1 and its effects. | 2010 | Br. J. Pharmacol. | pmid:20860668 |
| Yin PL et al. | [Reversed changes of the 15-lipoxygenase product lipoxin Aâ‚„ and the 5-lipoxygenase product leukotriene Câ‚„ in children with asthma]. | 2010 | Zhonghua Jie He He Hu Xi Za Zhi | pmid:20979801 |
| Planagumà A et al. | Lovastatin decreases acute mucosal inflammation via 15-epi-lipoxin A4. | 2010 | Mucosal Immunol | pmid:20130564 |
| Wang J et al. | Effect of lipoxin A₄ on IL-1β production of monocytes and its possible mechanism in severe preeclampsia. | 2010 | J. Huazhong Univ. Sci. Technol. Med. Sci. | pmid:21181369 |
| Leemans J et al. | Prophylactic effects of omega-3 polyunsaturated fatty acids and luteolin on airway hyperresponsiveness and inflammation in cats with experimentally-induced asthma. | 2010 | Vet. J. | pmid:19231257 |
| Chen QH et al. | 15-Epi-lipoxin A(4) inhibits the progression of endometriosis in a murine model. | 2010 | Fertil. Steril. | pmid:19268934 |
| Wu Y et al. | Neuroprotective effect of lipoxin A4 methyl ester in a rat model of permanent focal cerebral ischemia. | 2010 | J. Mol. Neurosci. | pmid:20401639 |
| Kure I et al. | Lipoxin A(4) reduces lipopolysaccharide-induced inflammation in macrophages and intestinal epithelial cells through inhibition of nuclear factor-kappaB activation. | 2010 | J. Pharmacol. Exp. Ther. | pmid:19846590 |
| Leedom AJ et al. | Endogenous LXA4 circuits are determinants of pathological angiogenesis in response to chronic injury. | 2010 | Am. J. Pathol. | pmid:20008149 |
| Bhavsar PK et al. | Corticosteroid suppression of lipoxin A4 and leukotriene B4 from alveolar macrophages in severe asthma. | 2010 | Respir. Res. | pmid:20529300 |
| Chan MM and Moore AR | Resolution of inflammation in murine autoimmune arthritis is disrupted by cyclooxygenase-2 inhibition and restored by prostaglandin E2-mediated lipoxin A4 production. | 2010 | J. Immunol. | pmid:20435922 |
| Wu SH et al. | Reversed changes of lipoxin A4 and leukotrienes in children with asthma in different severity degree. | 2010 | Pediatr. Pulmonol. | pmid:20232472 |
| Zhou G et al. | Atorvastatin reduces plaque vulnerability in an atherosclerotic rabbit model by altering the 5-lipoxygenase pathway. | 2010 | Cardiology | pmid:20234134 |
| Maderna P et al. | FPR2/ALX receptor expression and internalization are critical for lipoxin A4 and annexin-derived peptide-stimulated phagocytosis. | 2010 | FASEB J. | pmid:20570963 |
| Duffy CD et al. | Synthesis and biological evaluation of pyridine-containing lipoxin A4 analogues. | 2010 | ChemMedChem | pmid:20127785 |
| Prieto P et al. | Lipoxin A4 impairment of apoptotic signaling in macrophages: implication of the PI3K/Akt and the ERK/Nrf-2 defense pathways. | 2010 | Cell Death Differ. | pmid:20094061 |
| Wu SH et al. | NF-kappaB is involved in inhibition of lipoxin A4 on dermal inflammation and hyperplasia induced by mezerein. | 2010 | Exp. Dermatol. | pmid:20100194 |
| Dufton N et al. | Anti-inflammatory role of the murine formyl-peptide receptor 2: ligand-specific effects on leukocyte responses and experimental inflammation. | 2010 | J. Immunol. | pmid:20107188 |
| Sanchez Y et al. | The unexpected role for the aryl hydrocarbon receptor on susceptibility to experimental toxoplasmosis. | 2010 | J. Biomed. Biotechnol. | pmid:20111744 |
| Pamplona FA et al. | Aspirin-triggered lipoxin induces CB1-dependent catalepsy in mice. | 2010 | Neurosci. Lett. | pmid:20036315 |
| Morris T et al. | Dichotomy in duration and severity of acute inflammatory responses in humans arising from differentially expressed proresolution pathways. | 2010 | Proc. Natl. Acad. Sci. U.S.A. | pmid:20421472 |
| Simões RL et al. | A synthetic analog of 15-epi-lipoxin A4 inhibits human monocyte apoptosis: involvement of ERK-2 and PI3-kinase. | 2010 | Prostaglandins Other Lipid Mediat. | pmid:20004734 |
| Marcheselli VL et al. | Neuroprotectin D1/protectin D1 stereoselective and specific binding with human retinal pigment epithelial cells and neutrophils. | 2010 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:19931440 |
| Sun YP et al. | Anti-inflammatory and pro-resolving properties of benzo-lipoxin A(4) analogs. | 2009 Nov-Dec | Prostaglandins Leukot. Essent. Fatty Acids | pmid:19853429 |
| Beck-Speier I et al. | Oxymetazoline inhibits and resolves inflammatory reactions in human neutrophils. | 2009 | J. Pharmacol. Sci. | pmid:19609065 |
| Calandria JM et al. | Selective survival rescue in 15-lipoxygenase-1-deficient retinal pigment epithelial cells by the novel docosahexaenoic acid-derived mediator, neuroprotectin D1. | 2009 | J. Biol. Chem. | pmid:19403949 |
| Forsman H and Dahlgren C | Lipoxin A(4) metabolites/analogues from two commercial sources have no effects on TNF-alpha-mediated priming or activation through the neutrophil formyl peptide receptors. | 2009 | Scand. J. Immunol. | pmid:19751275 |
| Carvalho RR et al. | Effect of mangiferin on the development of periodontal disease: involvement of lipoxin A4, anti-chemotaxic action in leukocyte rolling. | 2009 | Chem. Biol. Interact. | pmid:19026997 |
| Perretti M and D'Acquisto F | Annexin A1 and glucocorticoids as effectors of the resolution of inflammation. | 2009 | Nat. Rev. Immunol. | pmid:19104500 |
| El Kebir D et al. | 15-epi-lipoxin A4 inhibits myeloperoxidase signaling and enhances resolution of acute lung injury. | 2009 | Am. J. Respir. Crit. Care Med. | pmid:19483113 |
| Li G et al. | The effect of Lipoxin A4 on the interaction between macrophage and osteoblast: possible role in the treatment of aseptic loosening. | 2009 | BMC Musculoskelet Disord | pmid:19490628 |
| Ereso AQ et al. | Lipoxin a(4) attenuates microvascular fluid leak during inflammation. | 2009 | J. Surg. Res. | pmid:19524267 |
| Morris T et al. | Effects of low-dose aspirin on acute inflammatory responses in humans. | 2009 | J. Immunol. | pmid:19597002 |
| Divangahi M et al. | Mycobacterium tuberculosis evades macrophage defenses by inhibiting plasma membrane repair. | 2009 | Nat. Immunol. | pmid:19561612 |